Gene AqueK121 (A.queenslandica)

AqueK121

Species: A.queenslandica
Alias: AqueK121
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK5

Sequence

Name Sequence Type Origin Length Description Download
AqueK121.AA Protein None 886 None Fasta, JSON
AqueK121.kin_dom Protein Kinase Domain None 293 None Fasta, JSON

Protein domain

Protein domains of AqueK121.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK121.AA MAPK 80-372 51 1.6e-182 612.64 In-house 1-328 (328) Show / Hide 
Range on Protein: 80-372
Range on HMM: 1-328/328
Sequence Identity: 51% (169 aa)

YTPLESIGTGAYGVVCAAKDNR------TGRKVAIKKIPRAFDEVVTAKRTYRELKILRHL-RHENVISILDVMEPP-----ENESSLQDVYVILDLMET
|..|. || |||||||.|.|.|      .|.|||||||.|.|. .. .||||||.|.|||. .|||.|..||.. |      .. ....|.|.. .||||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHHIIHSVQPLSDDHIKYFLYQIGRG--LKYIHSANIIHRDLKPSNLLINRNCELKIGDFGMARGLSSTPEDHAL----------FLTEYVATRWYRAP
|||.||.| ||||||||.||.||| ||  ||||||||.|||||||||.|.| ||.|||.|||.||.. .. ..|            ..||||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

ELMLS--FSQYDISLDMWSVGCIFAEMLG-RRQIFPGKNYVNQLQLVLSVVGTPSDEYINNIG-SERVKTYLKSL---PKKQPVDLFVLFPK----ANKV
|.||.     |. . |||||||||||||. |...||||.|..|..|...|.||||.| |..|. ||....|..||   ||......  .||.    ||  
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ALELLEKLLQLDPRKRYIAIEILGHPYL
|. ||||.|..|| ||. . | | |||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase AqueK121.AA ERK 80-372 53 9.1e-175 586.89 In-house 1-307 (307) Show / Hide 
Range on Protein: 80-372
Range on HMM: 1-307/307
Sequence Identity: 53% (165 aa)

YTPLESIGTGAYGVVCAAKDNR-----TGRKVAIKKIPRAFDEVVTAKRTYRELKILRHLR-HENVISILDVMEPPENESSLQDVYVILDLMETDLHHII
|  .. || |||||||.|.|.      || |||||||..|||  . .|||.||.|.|||.. |||.|...|.| |   | .. |.|.. .||||||| ||
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE-QYNDIYCVEELMETDLHQII

HSVQPLSDDHIKYFLYQIGRGLKYIHSANIIHRDLKPSNLLINRNCELKIGDFGMAR----GLSSTPEDHALFLTEYVATRWYRAPELMLSFSQYDISLD
.| |.|||||..||.||| .|||||||||.|||||||||.|.| || ||| ||| ||    . .. .|  . |.|||||||||||||.|||.. |. . |
NSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMD

MWSVGCIFAEMLGRRQIFPGKNYVNQLQLVLSVVGTP-SDEYINNIGSERVKTYLKSLPK--KQPVDLFVLFPKAN--KVALELLEKLLQLDPRKRYIAI
.||.||||||||||. .||||.||.|....... ||| |.| ...|.||... |.|.||.  ..|...  .||.||  . |..||||.|. || ||. . 
IWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVE

EILGHPYL
| | |||.
ECLEHPYF
Kinase AqueK121.AA ERK5 80-372 57 1.1e-168 566.75 In-house 1-295 (295) Show / Hide 
Range on Protein: 80-372
Range on HMM: 1-295/295
Sequence Identity: 57% (171 aa)

YTPLESIGTGAYGVVCAAKDNRTGRKVAIKKIPRAFDEVVTAKRTYRELKILRHLRHENVISILDVMEPPENESSLQDVYVILDLMETDLHHIIHSVQPL
| ..| ||.|||||||.|.  ..|..||||||| |||.| .||||.|||||||| ||.|.| | |.. | .  | ..||||..|||| ||| |||| ||.
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

SDDHIKYFLYQIGRGLKYIHSANIIHRDLKPSNLLINRNCELKIGDFGMARGLSS-TPEDHALFLTEYVATRWYRAPELMLSFSQYDISLDMWSVGCIFA
. .||.|||||| |||||.|||..|||||||||||.| |||||||||||||||.   |..| .|.|||||||||||||||.|  .|   .|.||||||| 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMLGRRQIFPGKNYVNQLQLVLSVVGTPSDEYINNIGSERVKTYLKS-LPKKQPVDLFVLFPKANKVALELLEKLLQLDPRKRYIAIEILGHPYL
||..|||.||||||..||||.. |.|.|.   |  .....|. |... .| .||.|.  ..||| . ||.|| ..|  .| .|  . . | ||.|
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase AqueK121.AA p38 80-372 50 2.6e-145 489.05 In-house 1-289 (289) Show / Hide 
Range on Protein: 80-372
Range on HMM: 1-289/289
Sequence Identity: 50% (151 aa)

YTPLESIGTGAYGVVCAAKDNRTGRK---VAIKKIPRAFDEVVTAKRTYRELKILRHLRHENVISILDVMEP-PENESSLQDVYVILDLMETDLHHIIHS
|  |. .|.|||| ||.| | ||| |   |||||. | | ... ||||||||. |.|.||||||..|||  |  ......||||..  .|..||. |.  
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMK-

VQPLSDDHIKYFLYQIGRGLKYIHSANIIHRDLKPSNLLINRNCELKIGDFGMARGLSSTPEDHALFLTEYVATRWYRAPELMLSFSQYDISLDMWSVGC
.| ||||||.. .||| |||||||||.||||||||||. .| .|||.| ||| ||         .  .|.||||||||||| ||.  .|.   |.|||||
CQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR-------HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGC

IFAEMLGRRQIFPGKNYVNQLQLVLSVVGTPSDEYINNIGSERVKTYLKSLPKKQPVDLFVLFPKANKVALELLEKLLQLDPRKRYIAIEILGHPYL
| ||.. .|  |||.....||| ...|.|||..| .. | ||. ..|..|.|. .  |.  .|..||  |..||||.|.||| ||  | | . |||.
IMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase AqueK121.AA CMGC 80-372 27 2.5e-136 450.93 In-house 1-513 (513) Show / Hide 
Range on Protein: 80-372
Range on HMM: 1-513/513
Sequence Identity: 27% (140 aa)

YTPLESIGTGAYGVVCAAKD--------------NRTGRKVAIKKIPRAFDEVVTAK----------RTYRELKILRHLR-----------------HEN
|. .. || |.||||. ..|              ..|...|||||| ..| .  .||          |..||.|||.||.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VISILDVMEPPENESSLQ-----------DVYVILDLMETDLHHIIHSVQ---------PLSDDH------------IKYFL------YQIGRGLK--YI
.....|.  .........           ..| . ..|..||...|.. |         |||. |            ||||.      ||| ||||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAN--IIHRDLKPSNLLINRNCEL--------------------KIGDFGMARGLSSTPEDHAL-----------------FLTEYVATRWYRAPELML
||..  ||||||||.|.||| ||||                    ||.|||.|| ... ...|.                  ..|.||.||||||||..|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

SFSQYD---------ISLDMWSVGCIFAEMLGR--------RQIFP-----------GKNYVNQLQLVLSVVGTP----------------SDEYINNIG
. ..|.          . ||||||||||||. .        . .||           ||....||..   | |||                ..|..| |.
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------SERVKTYLKS---LPKKQPVDLFVLFPK-----------------------------------ANKVALELLEKLLQLDP
                    || ...|..|   .|...| ..  |||.                                   ... |..||.|.||.||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

RKRYIAIEILGHPYL
 ||  | ..| |||.
DKRITAEQALQHPYF
Kinase AqueK121.AA ERK1 80-372 54 7.69999999999e-129 434.32 In-house 1-289 (289) Show / Hide 
Range on Protein: 80-372
Range on HMM: 1-289/289
Sequence Identity: 54% (161 aa)

YTPLESIGTGAYGVVCAAKDNRTGRKVAIKKIPRAFDEVVTAKRTYRELKILRHLRHENVISILDVMEPPENESSLQDVYVILDLMETDLHHIIHSVQPL
|| |. || ||||.||.| |......||||||   |.     .|| ||.|||   .|||.| | |..  .  | ...|||.. .||||||  .. . |.|
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIE-QMRDVYIVQCLMETDLYKLLKT-QHL

SDDHIKYFLYQIGRGLKYIHSANIIHRDLKPSNLLINRNCELKIGDFGMARGLSSTPEDHALFLTEYVATRWYRAPELMLSFSQYDISLDMWSVGCIFAE
| ||| |||||| ||||||||||..||||||||||.|. |.||| |||.|| ..    ||  |||||||||||||||.||    |  |.|.|||||| ||
SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAE

MLGRRQIFPGKNYVNQLQLVLSVVGTPSDEYINNIGSERVKTYLKSLPKKQPVDLFVLFPKANKVALELLEKLLQLDPRKRYIAIEILGHPYL
||  | ||||| |. || ..|.|.| || . .| |  |. . ||.||| |. | .  ||||| . ||.||.|.|   | ||    | | ||||
MLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase AqueK121.AA nmo 81-372 46 2.6e-115 356.21 In-house 2-292 (292) Show / Hide 
Range on Protein: 81-372
Range on HMM: 2-292/292
Sequence Identity: 46% (138 aa)

TPLESIGTGAYGVVCAAKDNRTGRKVAIKKIPRAFDEVVTAKRTYRELKILRHLRHENVISILDVMEPPENESSLQDVYVILDLMETDLHHIIHSVQPLS
 |   || ||.||| .  | | |..||.||.|  | ..| .|| .||||.|   .|.||.| ||...|| . . .|..||. .||  ||| || | |.||
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPP-HKDFFQEIYVVTELMQSDLHKIIVSPQHLS

DDHIKYFLYQIGRGLKYIHSANIIHRDLKPSNLLINRNCELKIGDFGMARGLSSTPEDHALFLTEYVATRWYRAPELMLSFSQYDISLDMWSVGCIFAEM
 ||.| ||||| |||||.|||||.|||.|| |||.| || ||| |||.||      .|... .|. | | .|||||...   .|   .|.|||||||||.
SDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWE---QDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAEL

LGRRQIFPGKNYVNQLQLVLSVVGTPSDEYINNIGSERVKTYLKSLPKKQPV--DLFVLFP--KANKVALELLEKLLQLDPRKRYIAIEILGHPYL
|||| .|  .. ..|||..  ..|||| | .     |  |. .   |.|.|    |. |    .|.  | .|| ..|  || ||  ... | ||||
LGRRILFQAQSPIQQLQMITDLLGTPSMEDM-KYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase AqueK121.AA ERK7 80-372 40 2.4e-113 382.86 In-house 1-292 (292) Show / Hide 
Range on Protein: 80-372
Range on HMM: 1-292/292
Sequence Identity: 40% (121 aa)

YTPLESIGTGAYGVVCAAKDNRTGRKVAIKKIPRAFDEVVTAKRTYRELKILRHLR-HENVISILDVMEPPENESSLQDVYVILDLMETDLHHIIHSVQP
|  .. .| ||||.|  | | ||.  ||.|||  || . . | ||.||  .|. .. |.|.|....|. . .|.   .|.|.. . |||||| .|  .. 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVI-RADND---RDIYLVFEFMETDLHAVIRKGNI

LSDDHIKYFLYQIGRGLKYIHSANIIHRDLKPSNLLINRNCELKIGDFGMARGLSSTP--EDHALFLTEYVATRWYRAPELMLSFSQYDISLDMWSVGCI
| | | .| .||. | .||.||.|.|||||||||.|.. .| .|. |||.|| .....  ...   |||||||||||||| .|.  .|    ||||.|||
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

FAEMLGRRQIFPGKNYVNQLQLVLSVVGTPSDEYINNIGSERVKTYLKSLPKKQPVDLFVLFPKANKVALELLEKLLQLDPRKRYIAIEILGHPYL
 .|||  . .|||   .||. ..| ... |. | |. |||.   . |........  |  ..|.. . |..|| .||.. |.||  | . | ||| 
LGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase AqueK121.AA S_TKc 80-372 28 1.9e-94 320.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 80-372
Range on HMM: 1-231/231
Sequence Identity: 28% (89 aa)

YTPLESIGTGAYGVVCAAKDNRTGRKVAIKKIPRAFDEVVTAKRTYRELKILRHLRHENVISILDVMEPPENESSLQDVYVILDLMET---DLHHIIHSV
|. |. || ||.|.|. .....|||.||||.|.         ....||..||.. .|.|.. ..||..        ...|........   ||...|.. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

QP------LSDDHIKYFLYQIGRGLKYIHSANIIHRDLKPSNLLINRNCELKIGDFGMARGLSSTPEDHALFLTEYVATRWYRAPELMLSFSQYDI-SLD
..      ..  |.....||| ..|.|.|| .||||||||.|.|...  ..||.|||.|| |           | .. |.||.|||..    .|.  . |
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL----GYGKCKCD

MWSVGCIFAEMLGRRQIFPGKNYVNQLQLVLSVVGTPSDEYINNIGSERVKTYLKSLPKKQPVDLFVLFPKANKVALELLEKLLQLDPRKRYIAIEILG-
.||.|||..||| ..  ||      |.|... ..|                                      . |.....|.|| ||.||. | |.|  
WWSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQD

------HPYL
      ||..
EWDIKCHPWF
Kinase AqueK121.AA Pkinase 80-372 29 2.1e-89 308.11 Pfam 1-293 (293) Show / Hide 
Range on Protein: 80-372
Range on HMM: 1-293/293
Sequence Identity: 29% (92 aa)

YTPLESIGTGAYGVVCAAKDNRTGRKVAIKKIPRAFDEVVTAKRTYR--ELKILRHLRHENVISILDVMEPPENESSLQDVYVILDLMET-----DLHHI
|. .. || |..|.|. ...  ||..||.|.|..  ..    ..  |  |..|...|.|.|.. ..|..|        ...|......|      ||...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

IH--SVQPL--SDDHIKYFLYQIGRGLKYIHSANIIHRDLKPSNLLINRNCEL----KIGDFGMARGLSSTPEDHALFLTEYVATRWYRAPELMLSFSQY
|.  .  ..  |....| ..||| |||.|.|| .||||||||.|.||..|...    ||.||| |. ..   . .   .| .. |.||.|||. .. . |
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYY

DISLDMWSVGCIFAEMLGRRQIFPGK----NYVNQLQLVLSVVGTPSDEYINNIGSERVKTYLKSLPKKQPVDLFVLFPKANKVALELLEKLLQLDPRKR
. . ||||.|||..||| .| .|||.    | ..|.|..  . |.| .. . .  |..  . ..  . .    . .. ..... ........|..|| ||
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKR

YIAIEILGHPYL
. | .|| ||..
PTAEQILQHPWF
Kinase AqueK121.AA JNK 80-339 38 1.8e-85 290.27 In-house 1-261 (309) Show / Hide 
Range on Protein: 80-339
Range on HMM: 1-261/309
Sequence Identity: 38% (103 aa)

YTPLESIGTGAYGVVCAAKDNRTGRKVAIKKIPRA--FDEVVTAKRTYRELKILRHLRHENVISILDVMEPPENESSLQDVYVILDLMETDLHHIIHS-V
|  | .|| || |.||.| |  |...|||||. |   |. .  .|| |||.. . .. |.|.|... .  | |. ...||||..  .|   |. .|||  
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTF

QPLSDDHIKYFLYQIGRGLKYIHSANIIHRDLKPSNLLINRNCELKIGDFGMARGLSSTPEDHALFLTEYVATRWYRAPELMLSFS-QYDISLDMWSVGC
  |  . ..|..||. .| |. ||. |||||||||| ..|  | ||| ||| ||  . |     .  | || ||.|||||  .     |  . | |||||
MELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPT-----FMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGC

IFAEMLGRRQIFPGKNYVNQLQLVLSVVGTPSDEYINNIGSERVKTYLKSL---PKKQPVDLFVLFP
|.|||.  . .|||| .  |  .. .. |||... ..  . . |..|....   |. ||     .||
IMAEMIRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQMQ-PHVRNYVENRNMDPYYQPYNFHEHFP
Kinase AqueK121.AA MAPK-Unclassified 80-230 50 4.8e-84 285.52 In-house 1-157 (575) Show / Hide 
Range on Protein: 80-230
Range on HMM: 1-157/575
Sequence Identity: 50% (79 aa)

YTPLESIGTGAYGVVCAAKDNRT-GRKVAIKKIPRAFDEVVTAKRTYRELKILRHLRHENVISILDVMEPPENES-SLQDVYVILDLMET---DLHHIIH
|.. . || ||||.|| |.|... ...|||||....|  ....||. ||. |||.| |.|.| | |. .. | .    .|.|.  |.|.|   |||.||.
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SVQ-PLSDDHIKYFLYQIGRGLKYIHSANIIHRDLKPSNLLINRNCELKIGDFGMAR
| | .... ||.||.||| |||||.|||.|||||||||||||| .| ..| ||||.|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase AqueK121.AA MAPK-Unclassified 243-372 32 7.9e-52 178.5 In-house 405-575 (575) Show / Hide 
Range on Protein: 243-372
Range on HMM: 405-575/575
Sequence Identity: 32% (55 aa)

LTEYVATRWYRAPELMLSFSQYDISLDMWSVGCIFAEMLGR-----------RQIFPGKN--------------------YVNQLQLVLSVVGTPSDEYI
.|.||.||||||||.||| . ||   |.||.|||||||. .           |..|||..                    .. |... ... |.|  | .
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

NNIGSERVKTYLKSLPKKQPVDLF-VLFPKAN---------KVALELLEKLLQLDPRKRYIAIEILGHPYL
| |.. ... |..|. .| ||.     |.||            .. .. |.|| .|.||. | ..| ||| 
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase AqueK121.AA Pkinase_Tyr 80-230 28 4.6e-18 61.81 Pfam 1-159 (270) Show / Hide 
Range on Protein: 80-230
Range on HMM: 1-159/270
Sequence Identity: 28% (46 aa)

YTPLESIGTGAYGVVCAAKDN----RTGRKVAIKKIPRAFDEVV-TAKRTYRELKILRHL-RHENVISILDVMEPPENESSLQDVYVILDLMET-DLHHI
 | .. .| ||.|.|. .. .     |. .||.|...   ..     .   ||.||...| .|.|... . |  . .  .    .|... .|.  ||.. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLDY

IHS----VQPLSDDHIKYFLYQIGRGLKYIHSANIIHRDLKPSNLLINRNCELKIGDFGMAR
 ..     |||.  ..  . .|| .|. | .| |.|||||   | |...|   ||.|||.||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase AqueK121.AA TyrKc 80-367 20 1.5e-14 12.6 SMART 1-280 (280) Show / Hide 
Range on Protein: 80-367
Range on HMM: 1-280/280
Sequence Identity: 20% (64 aa)

YTPLESIGTGAYGVVCAAKDNRTGRKVAIKKIPRAFDEVVTAKRTYRELKILRHL--RHENVISILDVMEPP-ENESSL---QDVYVILDLMET-DLHHI
 | .. .| ||.|.|. .. .   ..||.|..          .  .||..|...|  .|.|.. .. |   . .|       . ..... .|.  ||.. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN---FMYIEPLMIVMEYMPHGDLKDY

IHSVQP-LSDDHIKYFLYQIGRGLKYIHSANIIHRDLKPSNLLINRNCELKIGDFGMARGLSST-------PEDHALF--LTEY-VATRWYRAPELMLSF
... .| |. ..  .| .|| .|  |.|| |.|||||   | |...|   ||.|||..| . .           ..     . . .  ||. ||| .  .
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NY

SQYDISLDMWSVGCIFAEMLGRRQIFPGK---NYVNQLQLVLSVVGTP-SDEYINN---IGSERVKTYLKSLPKKQPVDLFVLFPKANKVALELLEKLLQ
. . .  | || |    |.. . |  .     . .   | |.  | .    .   |   .                       |. . .   .. ..  .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------FVCCPDEMYQIMKQCWH

LDPRKR---YIAIEIL
 || .|      .|..
EDPEDRPTFSEIHECF
Kinase AqueK121.AA JNK 348-372 36 0.00144 9.27 In-house 285-309 (309) Show / Hide 
Range on Protein: 348-372
Range on HMM: 285-309/309
Sequence Identity: 36% (9 aa)

LLEKLLQLDPRKRYIAIEILGHPYL
|| . |  .| .|.   ..| |||.
LLFRMLVINPDDRISVDDALQHPYI