Gene AqueK120 (A.queenslandica)

AqueK120

Species: A.queenslandica
Alias: AqueK120
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
AqueK120.AA Protein None 743 None Fasta, JSON
AqueK120.kin_dom Protein Kinase Domain None 302 None Fasta, JSON

Protein domain

Protein domains of AqueK120.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK120.AA ERK1 29-329 35 5.1e-57 195.74 In-house 1-289 (289) Show / Hide 
Range on Protein: 29-329
Range on HMM: 1-289/289
Sequence Identity: 35% (109 aa)

YKDLEYLALGGNGLVCKALDTYTDKRVVLSKRDSLFSKTYCQRDLRELQVLSRLQKALGDDLPLPELLDLVCEPANQPLGEGTKFYVVQEAKEGTLELLL
| .|.|.. |  |.|| |.|| . .|| . |      .||||| |||...| | .        . .. |..  .. . . .    |.||.  |  |  ||
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHEN-----IINIQDIIRADTIEQMRD---VYIVQCLMETDLYKLL

QADQLPSPEQVKLLMYQLLRALKLFHSAGLLHRCLRSNDLLLDADCDLRVCDFRLAAVNGLESDPNFELLRFTDSYRVEHLHYWAPEVLLNEE-LTPVVD
.. .| | . .   .||.|| ||  |||  ||| |.   |||   |||..||| || .    .||. .   |   | |    | |||..||    |  .|
KTQHL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARI----ADPEHDHTGFLTEY-VATRWYRAPEIMLNSKGYTKSID

LWSAGCLFAELLTGKKVFGSSDVRGQLDLLVDLLGAPSPEDLAFVKGDASRTALTSV-QNSSPTFEERFKNLDPVARDLLKKMLVFNPSQRLTAEKALEH
.|| ||. ||.|  . .|       || ... .||.|| .||  .  .  |  | |.   .   ... | . |. | ||| ||| ||| .|.| |.|| |
IWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAH

EYL
 ||
PYL
Kinase AqueK120.AA CMGC 29-329 18 1.3e-48 157.37 In-house 1-513 (513) Show / Hide 
Range on Protein: 29-329
Range on HMM: 1-513/513
Sequence Identity: 18% (96 aa)

YKDLEYLALGGNGLVCKALD--------------TYTDKRVVLSKRDSLFSKTYCQ----------RDLRELQVLSRLQ-----------KALGDDLP-L
|. ....  |  | |.|. |              . |...| . |  . | .. ..          | |||.. | .|.           .  ... . .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

PELLDLVCEPANQPLGE---------GTKFYVVQEAKEGTLELLLQADQ---------LPSPEQ------------VKLLM------YQLLRALK--LFH
  |.| .  . ... ..           ..| | |  . .|  ...  |           |. .            .| .|      ||.||.||    |
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SAG--LLHRCLRSNDLLLDADCDL--------------------RVCDFRLAAVNGLESDPNFELLRF-------------TDSYRVEHLHYWAPEVLLN
|..   .|| |    .|.. .|.|                    ..||| ||   . .||..|.  ..             . . .|  ..| |||.||.
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

EEL----------TPVVDLWSAGCLFAELLTG--------KKVFGSSDV-----------RGQLDLLVDLLGAPS---------------PEDLAFVKG-
 .           |. .| ||.|| |||..||        |  |  ..              ||.. ...|| |.               .|.   ... 
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

--------------------DASRTALTS----VQNSSPTFEERFKN-----------------------------------LDPVARDLLKKMLVFNPS
                    .  |... |     .   ..... |..                                   .|| |.|||||||...|.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

QRLTAEKALEHEYL
.|.||| ||.|.|.
KRITAEQALQHPYF
Kinase AqueK120.AA nmo 114-329 33 2.7e-45 136.89 In-house 79-292 (292) Show / Hide 
Range on Protein: 114-329
Range on HMM: 79-292/292
Sequence Identity: 33% (75 aa)

YVVQEAKEGTLELLLQADQLPSPEQVKLLMYQLLRALKLFHSAGLLHRCLRSNDLLLDADCDLRVCDFRLAAVNGLESDPNFELLRFTDSYRVEHLHYWA
||| |     |  .. . |  |.. ||  .||.|| ||  |||..||| ..  .||....| |..||| || |  ..   .      |  ||       |
YVVTELMQSDLHKIIVSPQHLSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYR-------A

PEVLL-NEELTPVVDLWSAGCLFAELLTGKKVFGSSDVRGQLDLLVDLLGAPSPEDLAFVKGDASRTALTSVQNSSPTFEERFKNLD-----PVARDLLK
||.|.     |  ||.|| ||.|||||  . .|       ||....|||| || ||. .   .  .. .       | ..  ..          | .||.
PEILMGARHYTSAVDIWSVGCIFAELLGRRILFQAQSPIQQLQMITDLLGTPSMEDMKYA-CEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLC

KMLVFNPSQRLTAEKALEHEYL
.||.|.|..|. .. ||.| ||
RMLHFDPDKRISCKDALAHPYL
Kinase AqueK120.AA ERK5 29-329 30 1.9e-44 154.02 In-house 1-295 (295) Show / Hide 
Range on Protein: 29-329
Range on HMM: 1-295/295
Sequence Identity: 30% (93 aa)

YKDLEYLALGGNGLVCKALDTYTDKRVVLSKRDSLFSK-TYCQRDLRELQVLSRLQKALGDDLPLPELLDLVCEPANQPLGEGTKFYVVQEAKEGTLELL
|| .| .  |  | || |    . ..| . |    | . |  .| .|||..|   .      . . ..|        .|..|    ||| .  |  |  .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHD--NIIAIRDILM-----PKVPYSEMKDVYVVFDLMESDLHQI

LQADQLPSPEQVKLLMYQLLRALKLFHSAGLLHRCLRSNDLLLDADCDLRVCDFRLAAVNGLESDPNFELLRFTDSYRVEHLHYWAPEVLL-NEELTPVV
. ..|  . | ..  .||.|| ||  |||  .|| |.   ||    |.|.. || .|   ||      .   |  .| |    | |||...  .. |  .
IHSNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMAR--GLCTFSPDKHQMFMTEY-VATRWYRAPELMFSSHDYTQAI

DLWSAGCLFAELLTGKKVFGSSDVRGQLDLLVDLLGAPSPEDLAFVKGDASRTALTS-VQNSSPT-FEERFKNLDPVARDLLKKMLVFNPSQRLTAEKAL
|.|| ||.| |... ...|       ||.|... || |.|  .  |  |  .  . . . |  |  .|. .   |. | ||| .||.| ||.|.|. |||
DVWSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKAL

EHEYL
 | .|
QHPFL
Kinase AqueK120.AA ERK7 139-329 36 2.3e-43 145.99 In-house 102-292 (292) Show / Hide 
Range on Protein: 139-329
Range on HMM: 102-292/292
Sequence Identity: 36% (72 aa)

VKLLMYQLLRALKLFHSAGLLHRCLRSNDLLLDADCDLRVCDFRLA-AVNGLESDPNFELLRFTDSYRVEHLHYWAPEVLLN-EELTPVVDLWSAGCLFA
..  |||||||.|  ||. ..|| |.   .|||..| ..|||| ||  .  .|.  . .    |. | |    | |||.||  .. |. ||.|| ||  .
KQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEY-DEQNPMLTE-Y-VATRWYRAPEILLGSHRYTKGVDMWSIGCILG

ELLTGKKVF-GSSDVRGQLDLLVDLLGAPSPEDLAFVKGDASRTALTSVQNSSP-TFEERFKNLDPVARDLLKKMLVFNPSQRLTAEKALEHEYL
|.|.|| .| |.| .  |... ..... |. ||.. .. . . . | ... . . |... ...  . | ||||..||||| .|||||.||.| | 
EMLRGKPMFPGTSTMN-QIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase AqueK120.AA MAPK 213-329 38 5.5e-42 142.89 In-house 199-328 (328) Show / Hide 
Range on Protein: 213-329
Range on HMM: 199-328/328
Sequence Identity: 38% (50 aa)

APEVLLN---EELTPVVDLWSAGCLFAELLT-GKKVFGSSDVRGQLDLLVDLLGAPSPEDLAFVK-GDASRTALTSV---QNSSP-TFEERFKN----LD
|||..||    . |  || ||.|| |||.|| .|  |  .|   |. | ...|| ||.|.. ...  .. |. . |    ..  . ..|. |.|     .
APEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNAN

PVARDLLKKMLVFNPSQRLTAEKALEHEYL
| |.|||.|||||.|..|.|.| ||.|.|.
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase AqueK120.AA S_TKc 29-329 21 3.7e-31 110.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 29-329
Range on HMM: 1-231/231
Sequence Identity: 21% (67 aa)

YKDLEYLALGGNGLVCKALDTYTDKRVVLSKRDSLFSKTYCQRDLRELQVLSRLQKALGDDLPLPELLDLVCEPANQPLGEGTKFYVVQEAKEG---TLE
|. |. .  |. | |.|. .. |...| . . .        .. .||.|.|..      .   .  |.|   .         ...|.| |  .|   .| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK------HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLF

LLLQADQLP------SPEQVKLLMYQLLRALKLFHSAGLLHRCLRSNDLLLDADCDLRVCDFRLAAVNGLESDPNFELLRFTDSYRVEHLHYWAPEVLLN
 ...  . .      .. ... .|||...||.  || | .|| |    .|||    . .||| ||..                .  .  ..| |||||  
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL--

EELTP-VVDLWSAGCLFAELLTGKKVFGSSDVRGQLDLLVDLLGAPSPEDLAFVKGDASRTALTSVQNSSPTFEERFKNLDPVARDLLKKMLVFNPSQRL
   ..  .| || ||...|.|.|.  |       |.... ...|                                    .| |.|...|.|...|..|.
-GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRP

TAEKALE-------HEYL
|| .||.       |...
TA-EALQDEWDIKCHPWF
Kinase AqueK120.AA p38 211-329 38 1.3e-29 98.22 In-house 169-289 (289) Show / Hide 
Range on Protein: 211-329
Range on HMM: 169-289/289
Sequence Identity: 38% (46 aa)

YWAPEVLLNE-ELTPVVDLWSAGCLFAELLTGKKVFGSSDVRGQLDLLVDLLGAPSPEDLAFVKGDASRTALTSV-QNSSPTFEERFKNLDPVARDLLKK
| |||..||  . |  || || ||  |||.||.  |  .|   ||  .. ..| |..| .. .. ...|. . |  |     |.. |.. .| | ||| |
YRAPEIMLNWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEK

MLVFNPSQRLTAEKALEHEYL
||.  | .|.||| |..|.|.
MLELDPDKRITAEEAMQHPYF
Kinase AqueK120.AA ERK 211-329 38 9.6e-29 101.82 In-house 182-307 (307) Show / Hide 
Range on Protein: 211-329
Range on HMM: 182-307/307
Sequence Identity: 38% (48 aa)

YWAPEVLLN-EELTPVVDLWSAGCLFAELLTGKKVFGSSDVRGQLDLLVDLLGAP-SPEDLAFVKGDASRTALTSVQN--SSPT-FEERFKN--LDPVAR
| |||..|. .. |  .| ||.|| |||.| .| .|   | ..|...  ...| | | |||   . .  .  ... .|    |  .|..|.|  . | | 
YRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAI

DLLKKMLVFNPSQRLTAEKALEHEYL
|||.|||||.|..|.|.| .|||.|.
DLLEKMLVFDPDKRITVEECLEHPYF
Kinase AqueK120.AA Pkinase 209-329 24 2.1e-24 87.35 Pfam 175-293 (293) Show / Hide 
Range on Protein: 209-329
Range on HMM: 175-293/293
Sequence Identity: 24% (31 aa)

LHYWAPEVLL-NEELTPVVDLWSAGCLFAELLTGKKVFGSS----DVRGQLDLLVDLLGAPSPEDLAFVKGDASRTALTSVQNSSPTFEERFKNLDPVAR
..| ||||.. ... .| || ||.||...|.|.|.  | ..    . . |. ...  .|.| ..|         .. ..  . . . .... .|... ..
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECK

DLLKKMLVFNPSQRLTAEKALEHEYL
|..|..| ..|..|.||| .|.|...
DFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK120.AA MAPK-Unclassified 209-329 27 4.6e-24 83.55 In-house 412-575 (575) Show / Hide 
Range on Protein: 209-329
Range on HMM: 412-575/575
Sequence Identity: 27% (45 aa)

LHYWAPEVLL-NEELTPVVDLWSAGCLFAELLTG-----------KKVFGSSD--------------------VRGQLDLLVDLLGAPSPEDLAFVKGDA
. | ||| .| . | .  ||.||.||.|||..             .  |  .|                    . .|. ...| || |  ||. |.. | 
RWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDCNFITCDS

SRTALTSV-QNSSPTFE-ERFKNLD---------PVARDLLKKMLVFNPSQRLTAEKALEHEYL
 |  . |  .  .  |    | .           . ..|...|||.|||. | ||. ||||.| 
ARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase AqueK120.AA p38 29-184 31 2.5e-15 48.56 In-house 1-153 (289) Show / Hide 
Range on Protein: 29-184
Range on HMM: 1-153/289
Sequence Identity: 31% (50 aa)

YKDLEYLALGGNGLVCKALDTYTDKR---VVLSK-RDSLFSKTYCQRDLRELQVLSRLQKALGDDLPLPELLDLVCEPANQPLGEGTKFYVVQEAKEGTL
|..|...  |  | |||| |. |...   |   | .   .|  .  |  |||  |  ..          .||| |  |... . . . .|.| .  .  |
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHE-----NVICLLD-VFTPPAHSMNDFQDVYMVTHFMGADL

ELLLQADQLPSPEQVKLLMYQLLRALKLFHSAGLLHRCLRSNDLLLDADCDLRVCDFRLA
. ..   .| | .....| ||.||.||  ||||  || |    . .  ||.||. || ||
NNIMKCQRL-SDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLA
Kinase AqueK120.AA ERK3 297-329 54 6.5e-13 37.5 In-house 268-300 (300) Show / Hide 
Range on Protein: 297-329
Range on HMM: 268-300/300
Sequence Identity: 54% (18 aa)

NLDPVARDLLKKMLVFNPSQRLTAEKALEHEYL
|.|  | |.| .|| |.|. ||||| ||.| |.
NIDCHALDFLEQMLTFDPMDRLTAEMALQHPYM
Kinase AqueK120.AA MAPK 135-184 44 1.8e-12 39.23 In-house 113-164 (328) Show / Hide 
Range on Protein: 135-184
Range on HMM: 113-164/328
Sequence Identity: 44% (23 aa)

SPEQVKLLMYQLLRA--LKLFHSAGLLHRCLRSNDLLLDADCDLRVCDFRLA
| . .. .|||.||.  ||  |||. .|| |    .|.. .|||..||| ||
SDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLA
Kinase AqueK120.AA ERK3 114-184 40 3e-11 32.06 In-house 88-158 (300) Show / Hide 
Range on Protein: 114-184
Range on HMM: 88-158/300
Sequence Identity: 40% (29 aa)

YVVQEAKEGTLELLLQADQLPSPEQVKLLMYQLLRALKLFHSAGLLHRCLRSNDLLLDA-DCDLRVCDFRLA
..|||  |  |  ..   .| | | ..| |||||| ||  |||  ||| |.   ..    |  |.. || .|
CIVQEYMETDLACVMEQQRL-SEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTEDLVLKIGDFGMA
Kinase AqueK120.AA MAPK-Unclassified 137-184 41 1.4e-09 30.27 In-house 109-156 (575) Show / Hide 
Range on Protein: 137-184
Range on HMM: 109-156/575
Sequence Identity: 41% (20 aa)

EQVKLLMYQLLRALKLFHSAGLLHRCLRSNDLLLDADCDLRVCDFRLA
.... ..||.|| ||  |||. .|| |    ||.. || .|.||| ..
QHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMS
Kinase AqueK120.AA ERK3 211-245 47 6.4e-09 24.42 In-house 180-215 (300) Show / Hide 
Range on Protein: 211-245
Range on HMM: 180-215/300
Sequence Identity: 47% (17 aa)

YWAPEVLLN-EELTPVVDLWSAGCLFAELLTGKKVF
|  |. ||   . |  .|.|.||| .||.||||  |
YRSPRLLLQPNNYTKAIDMWAAGCILAEMLTGKMLF
Kinase AqueK120.AA ERK 142-184 48 1.2e-08 28.58 In-house 113-155 (307) Show / Hide 
Range on Protein: 142-184
Range on HMM: 113-155/307
Sequence Identity: 48% (21 aa)

LMYQLLRALKLFHSAGLLHRCLRSNDLLLDADCDLRVCDFRLA
.|||.|..||  |||. .|| |.   .|.  .||| .||| ||
FMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLA
Kinase AqueK120.AA ERK3 29-83 38 3.2e-08 22.15 In-house 1-54 (300) Show / Hide 
Range on Protein: 29-83
Range on HMM: 1-54/300
Sequence Identity: 38% (21 aa)

YKDLEYLALGGNGLVCKALDTYTDKRVVLSKRDSLFSKTYCQRDLRELQVLSRLQ
. ||  |  |.||||  | |   .|.|   |. .|  |  |   ||| ... ||.
FCDLRPLGCGSNGLVFSAVDSECCKKVAI-KKIVLTDKKSCKHALREIKIIRRLD
Kinase AqueK120.AA MAPK 29-83 26 5e-07 20.11 In-house 1-63 (328) Show / Hide 
Range on Protein: 29-83
Range on HMM: 1-63/328
Sequence Identity: 26% (17 aa)

YKDLEYLALGGNGLVCKALDTY------TDKRVVLSKR-DSLFSKTYCQRDLRELQVLSRL-Q
|..|...  |  |.||.| |.       ..|.|.. |  .   ..|.|.| .||.  | .. .
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHH
Kinase AqueK120.AA Pkinase 29-181 23 0.010078 10.71 Pfam 1-156 (293) Show / Hide 
Range on Protein: 29-181
Range on HMM: 1-156/293
Sequence Identity: 23% (41 aa)

YKDLEYLALGGNGLVCKALDTYTD-----KRVVLSKRDSLFSKTYCQRDLRELQVLSRLQKALGDDLPLPELLDLVCEPANQPLGEGTKFYVVQEAKEGT
|. .. .  |. | |.|. .  |      |.. .....| . .|   .  .|.|.. ||.    .     .|.| . .        ... |.|.|  ||.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLN---HPNI--VRLYDWFED--------KDHIYMVMEYCEGG

L---ELL--LQ--ADQLP--SPEQVKLLMYQLLRALKLFHSAGLLHRCLRSNDLLLDADCDL----RVCDF
|   .|   ..  ..     |....|  |||.||.|.  || | .|| | .  .|.| ....    ..|||
LYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF
Kinase AqueK120.AA MAPK-Unclassified 29-79 32 0.021248 3.86 In-house 1-53 (575) Show / Hide 
Range on Protein: 29-79
Range on HMM: 1-53/575
Sequence Identity: 32% (17 aa)

YKDLEYLALGGNGLVCKALDTYT-DKRVVLSKRDSLFS-KTYCQRDLRELQVL
|   ...  |. | ||.| |. .  . |   |   .|  .| | | |||. .|
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRIL
Kinase AqueK120.AA CMGC 584-698 23 3.8e-35 112.26 In-house 303-513 (513) Show / Hide 
Range on Protein: 584-698
Range on HMM: 303-513/513
Sequence Identity: 23% (49 aa)

YDEQ------TTACDIWSAGCVFGEMLLG--------QPLFVSDANA----------VNIFRVIFSTLGRPK---------------DQELAFVTS----
|...      ||..|.||.||.|.||..|        .|||  . .           ..    || .|| |                ..|   ...    
YTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWY

-------------------------------RIGLQVLKELKINESPSLDSNLRK------------------------RNVDGQVIDLLKKMLAFSPAK
                               ..  . .|.|. . ..  | | .|                        .. | | |||||||| . |.|
NKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDK

RITAEEALKHPYF
|||||.||.||||
RITAEQALQHPYF
Kinase AqueK120.AA ERK7 509-698 34 1.7e-33 111.72 In-house 104-292 (292) Show / Hide 
Range on Protein: 509-698
Range on HMM: 104-292/292
Sequence Identity: 34% (67 aa)

CIMYSLLVSLKLLHSAGVVHRCIRPRHLLLTSEFDLAICD--LRRSIMNHEPCGEEYNWTGSSTEGSWQYLSPQA-VCYDEQTTACDIWSAGCVFGEMLL
.||| ||  .| .||. |.|| ..|  .|| ||  . .||  | ||| . |  .|.           | | .|   .   . | . | || ||. |||| 
YIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRW-YRAPEILLGSHRYTKGVDMWSIGCILGEMLR

GQPLFVSDANAVNIFRVIFSTLGRPKDQELAFVTSRIGLQVLKELKINESPSLDSNLRKRNVDGQVIDLLKKMLAFSPAKRITAEEALKHPYF
|.|.|      .|    |  |...|. .... . | .. ..|.... ..  .||  ...   |.  |||||..|.| | ||.|||.||.||| 
GKPMFPGTS-TMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDA--IDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase AqueK120.AA MAPK 588-698 36 2.1e-31 105.73 In-house 212-328 (328) Show / Hide 
Range on Protein: 588-698
Range on HMM: 212-328/328
Sequence Identity: 36% (43 aa)

TTACDIWSAGCVFGEMLL-GQPLFVSDANAVNIFRVIFSTLGRPKDQELAFVT-SRIGLQVLKEL---KINESPSLDSNLRKRN--VDGQVIDLLKKMLA
|.| |.||.|| |.|||  ..|||    . .. .  |...|| |... . ... |    .... |   .     .... . . |  .. | ||||.|||.
TKAVDMWSVGCIFAEMLTDRKPLFP-GKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLV

FSPAKRITAEEALKHPYF
|.| ||||.|||| ||||
FDPDKRITVEEALQHPYF
S_TKc AqueK120.AA S_TKc 397-698 21 2.6e-29 104.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 397-698
Range on HMM: 1-231/231
Sequence Identity: 21% (70 aa)

YRNLEFLTKGSNGSMCFATDTRTSSRVVISKRDGLYSQEYSKRNLREIQILTRLQRMYSDDYDPFPRIIDFICYPQNLSGPKQAELYVVQTAFDV---NL
|. |. . ||. |. . .....|  .| | . .        .. .|||||| .            | |. .. . |.       .||.|    |    .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK----------HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDL

ADILNQQR-------MTHDQIWCIMYSLLVSLKLLHSAGVVHRCIRPRHLLLTSEFDLAICD--LRRSIMNHEPCGEEYNWTGSSTEGSWQYLSPQAVCY
 |.. ...       ..  .....|| ..  |. .|| |..|| . |  .||..   . |||  | | .              ..  |.  |..|  .  
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL--

DEQTT-ACDIWSAGCVFGEMLLGQPLFVSDANAVNIFRVIFSTLGRPKDQELAFVTSRIGLQVLKELKINESPSLDSNLRKRNVDGQVIDLLKKMLAFSP
   .. .||.|| ||.. ||| |.|.|    .   .|..|                                            . ...|...|.| . |
-GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------------------------------------------SPEAKDFIRKCLQKDP

AKRITAEEALK-------HPYF
.||.|| |||.       ||.|
EKRPTA-EALQDEWDIKCHPWF
Kinase AqueK120.AA ERK5 397-698 28 1.7e-24 86.59 In-house 1-295 (295) Show / Hide 
Range on Protein: 397-698
Range on HMM: 1-295/295
Sequence Identity: 28% (86 aa)

YRNLEFLTKGSNGSMCFATDTRTSSRVVISKRDGLYSQ-EYSKRNLREIQILTRLQRMYSDDYDPFPRIIDFICYPQNLSGPKQAELYVVQTAFDVNLAD
|. .| .  |  | .| |   ..  .| | |    . .    || .||..||   .       |    | | .   . .|  |  . |||    .  |  
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFR------HDNIIAIRDILMPKVPYSEMK--DVYVVFDLMESDLHQ

IL-NQQRMTHDQIWCIMYSLLVSLKLLHSAGVVHRCIRPRHLLLTSEFDLAICD--LRRSIMNHEPCGEEYNWTGSSTEGSWQYLSPQAV-CYDEQTTAC
|.  .| .| . |   .| .|  || .||| |.|| ..|  ||     .| | |  . | .    |  ...  | .     | |  |  .   .. | | 
IIHSNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMT-EYVATRW-YRAPELMFSSHDYTQAI

DIWSAGCVFGEMLLGQPLFVSDANAVNIFRVIFSTLGRPKDQELAFVTSRIGLQVLKELKINESPSLDSNLRKRNVDGQVIDLLKKMLAFSPAKRITAEE
|.|| ||.||||.  . .|    | ..  ..|   || |  . .  | .      ...   |  |   . .  .  | | .||| .|| | |..|||. .
DVWSVGCIFGEMIARRQMFPG-KNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPK-ADRQALDLLARMLRFEPSERITVNK

ALKHPYF
||.||. 
ALQHPFL
Kinase AqueK120.AA MAPK-Unclassified 588-698 28 3.7e-24 83.92 In-house 427-575 (575) Show / Hide 
Range on Protein: 588-698
Range on HMM: 427-575/575
Sequence Identity: 28% (42 aa)

TTACDIWSAGCVFGEMLLG-----------QPLFVSDA---------NAVN-----------IFRVIFSTLGRPKDQELAFVTSRIGLQVLKELKINESP
.|. ||||.||.|.||..            .|||  .          | |.           |. .||. ||.|. . . |.|.    . .. .|   . 
DTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIK-MIFDYLGMPPEEDCNFITCDSARKYIQSFKCKTPV

SLDSNLRKRNV--------DGQVIDLLKKMLAFSPAKRITAEEALKHPYF
  ..     .         . . ||...|||.|.| |||||..||.||||
HFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase AqueK120.AA ERK 588-698 40 9.4e-24 85.24 In-house 195-307 (307) Show / Hide 
Range on Protein: 588-698
Range on HMM: 195-307/307
Sequence Identity: 40% (46 aa)

TTACDIWSAGCVFGEMLLGQPLFVSDANAVNIFRVIFSTLGRP-KDQELAFVTSRIGLQVLKELKI--NESPSLDSNLRKRNVDGQVIDLLKKMLAFSPA
|.| ||||.|| | ||| ..|||   .. |. .. ||...| |  ...|   .|   .. .|.|     .  .. .   . |.  | ||||.|||.| | 
TKAMDIWSCGCIFAEMLGRKPLFP-GKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPD

KRITAEEALKHPYF
||||.||.|.||||
KRITVEECLEHPYF
Kinase AqueK120.AA ERK1 397-548 34 1.2e-20 74.12 In-house 1-143 (289) Show / Hide 
Range on Protein: 397-548
Range on HMM: 1-143/289
Sequence Identity: 34% (53 aa)

YRNLEFLTKGSNGSMCFATDTRTSSRVVISKRDGLYSQEYSKRNLREIQILTRLQRMYSDDYDPFPRIIDFICYPQNLSGPKQAELYVVQTAFDVNLADI
| ||... .|  | .| | ||..  || | |      | | .| ||||.|||| .            ||.     .  .  .  ..|.||   .  |  .
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHE---------NIINIQDIIRADTIEQMRDVYIVQCLMETDLYKL

LNQQRMTHDQIWCIMYSLLVSLKLLHSAGVVHRCIRPRHLLLTSEFDLAICD
|  |..  | |   .| .|  || .||| |.|| ..|  |||    || |||
LKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICD
Kinase AqueK120.AA p38 588-698 33 2.8e-18 58.82 In-house 182-289 (289) Show / Hide 
Range on Protein: 588-698
Range on HMM: 182-289/289
Sequence Identity: 33% (37 aa)

TTACDIWSAGCVFGEMLLGQPLFVSDANAVNIFRVIFSTLGRPKDQELAFVTSRIGLQVLKELKINESPSLDSNLRKRNVDGQVIDLLKKMLAFSPAKRI
| . |||| ||.  |.. |..||  | . ..  . | . .| |..  .. . |     ... .   .   . . ... |.    |||| |||   | |||
TQTVDIWSVGCIMAELITGRTLFPGD-DHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQA--IDLLEKMLELDPDKRI

TAEEALKHPYF
|||||..||||
TAEEAMQHPYF
Kinase AqueK120.AA nmo 588-698 29 8.4e-18 50.74 In-house 182-292 (292) Show / Hide 
Range on Protein: 588-698
Range on HMM: 182-292/292
Sequence Identity: 29% (33 aa)

TTACDIWSAGCVFGEMLLGQPLFVSDANAVNIFRVIFSTLGRPKDQELAFVTSRIGLQVLKELKINESPSLDSNLRK-RNVDGQVIDLLKKMLAFSPAKR
| | |||| ||.|.|.|  . ||   .. ..   .|   || |   .. .        .|.. . . . .   .|    .     ..||..|| | | ||
TSAVDIWSVGCIFAELLGRRILFQA-QSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKR

ITAEEALKHPYF
| ...||.||| 
ISCKDALAHPYL
Kinase AqueK120.AA Pkinase 588-698 26 1.2e-17 63.5 Pfam 190-293 (293) Show / Hide 
Range on Protein: 588-698
Range on HMM: 190-293/293
Sequence Identity: 26% (30 aa)

TTACDIWSAGCVFGEMLLGQPLFVSDA----NAVNIFRVIFSTLGRPKDQELAFVTSRIGLQVLKELKINESPSLDSNLRKRNVDGQVIDLLKKMLAFSP
....|.||.||.. |||.|.|.|  ..    | ..   .|. ..|.| . .     |.     ..  .          ..  |..   .|..|..|.. |
GPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----F-HWTF-HNWSEECKDFIKWCLCKDP

AKRITAEEALKHPYF
.||.|||..|.||.|
KKRPTAEQILQHPWF
Kinase AqueK120.AA ERK3 666-698 51 9.7e-17 50.02 In-house 268-300 (300) Show / Hide 
Range on Protein: 666-698
Range on HMM: 268-300/300
Sequence Identity: 51% (17 aa)

NVDGQVIDLLKKMLAFSPAKRITAEEALKHPYF
|.|   .|.| .|| |.|  |.|||.||.|||.
NIDCHALDFLEQMLTFDPMDRLTAEMALQHPYM
Kinase AqueK120.AA ERK1 588-698 36 2.6e-15 53.83 In-house 182-289 (289) Show / Hide 
Range on Protein: 588-698
Range on HMM: 182-289/289
Sequence Identity: 36% (40 aa)

TTACDIWSAGCVFGEMLLGQPLFVSDANAVNIFRVIFSTLGRPKDQELAFVTSRIGLQVLKELKINESPSLDSNLRKRNVDGQVIDLLKKMLAFSPAKRI
| . |||| ||.  |||   |.|      .     | . || |  ..|  .  .   . |. |   .  ....   |   | . .||| |||.| | |||
TKSIDIWSVGCILAEMLSNRPIFPG-KHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPK--ADSKALDLLDKMLTFNPHKRI

TAEEALKHPYF
| |||| ||| 
TVEEALAHPYL
Kinase AqueK120.AA CMGC 397-548 16 2.5e-13 39.24 In-house 1-247 (513) Show / Hide 
Range on Protein: 397-548
Range on HMM: 1-247/513
Sequence Identity: 16% (41 aa)

YRNLEFLTKGSNGSMCFATDTRTSSR--------------VVISK--RDGLYSQEYSK----------RNLREIQILTRLQRM----------YSDDYDP
| ... . .|. |  . ..|.||  .              | | |  .     .|  |          | ||||.|| .|..            ... ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAI-KKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

-FPRIIDFICYPQ-NLSGPK--------QAELYVVQTAFDVNLADILNQQR----------MTHDQ------------IWCIM------YSLLVSLK--L
   ...|.. ... . ....          .|| |    | .|.... ...          ... .            | ..|      | .| .||   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHSAG--VVHRCIRPRHLLLTSE--------------------FDLAICD
.||..  ..|| . |  .|....                    . | |||
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICD
Kinase AqueK120.AA ERK3 482-541 35 6.3e-11 30.99 In-house 87-146 (300) Show / Hide 
Range on Protein: 482-541
Range on HMM: 87-146/300
Sequence Identity: 35% (21 aa)

LYVVQTAFDVNLADILNQQRMTHDQIWCIMYSLLVSLKLLHSAGVVHRCIRPRHLLLTSE
...||   .  || .. |||.. . .   || ||  || .||| | ||  .|  ..   |
VCIVQEYMETDLACVMEQQRLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTE
Kinase AqueK120.AA nmo 481-548 39 6.7e-11 29.12 In-house 77-145 (292) Show / Hide 
Range on Protein: 481-548
Range on HMM: 77-145/292
Sequence Identity: 39% (27 aa)

ELYVVQTAFDVNLADIL-NQQRMTHDQIWCIMYSLLVSLKLLHSAGVVHRCIRPRHLLLTSEFDLAICD
|.|||   .   |  |.   | .. | .   .| .|  || ||||...|| |.|  ||. |.  | |||
EIYVVTELMQSDLHKIIVSPQHLSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICD
Kinase AqueK120.AA p38 481-529 36 1e-09 29.06 In-house 82-130 (289) Show / Hide 
Range on Protein: 481-529
Range on HMM: 82-130/289
Sequence Identity: 36% (18 aa)

ELYVVQTAFDVNLADILNQQRMTHDQIWCIMYSLLVSLKLLHSAGVVHR
. |.| .  .  |  |. .||.. |.|  . | .|  ||  ||||..||
DVYMVTHFMGADLNNIMKCQRLSDDHIQFLVYQILRGLKYIHSAGIIHR
Kinase AqueK120.AA ERK3 588-610 56 2.1e-08 22.72 In-house 193-215 (300) Show / Hide 
Range on Protein: 588-610
Range on HMM: 193-215/300
Sequence Identity: 56% (13 aa)

TTACDIWSAGCVFGEMLLGQPLF
| | |.|.|||.. ||| |..||
TKAIDMWAAGCILAEMLTGKMLF
Kinase AqueK120.AA MAPK 481-548 35 2.4e-08 24.71 In-house 90-160 (328) Show / Hide 
Range on Protein: 481-548
Range on HMM: 90-160/328
Sequence Identity: 35% (25 aa)

ELYVVQTAFDVNLADILNQQR-MTHDQIWCIMYSLLVS--LKLLHSAGVVHRCIRPRHLLLTSEFDLAICD
..|.|.   . .|  |...|. ...| |  .|| .|    || .|||.|.|| . |  .|.... || |||
DIYIVMELMETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICD
Kinase AqueK120.AA Pkinase 397-529 21 1.5e-07 27.74 Pfam 1-132 (293) Show / Hide 
Range on Protein: 397-529
Range on HMM: 1-132/293
Sequence Identity: 21% (32 aa)

YRNLEFLTKGSNGSMCFATDTRTSSRV---VISKRDGLYSQEYSKRNLREIQILTRLQRMYSDDYDPFPRIIDFICYPQNLSGPKQAELYVVQTAFDV--
|. .. . .|| |. . ...  |. .|   .|.||.   ......|.|.||||. ||.          | |. .... ..       ..|.|.   .   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---------HPNIVRLYDWFED-----KDHIYMVMEYCEGGL

---NLADILN---QQRM--THDQIWCIMYSLLVSLKLLHSAGVVHR
    |.|..    . ..  . ... ..|| .|  |. .|| |..||
YVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHR
Kinase AqueK120.AA ERK 518-549 50 1.9e-05 16.5 In-house 121-152 (307) Show / Hide 
Range on Protein: 518-549
Range on HMM: 121-152/307
Sequence Identity: 50% (16 aa)

LKLLHSAGVVHRCIRPRHLLLTSEFDLAICDL
|| .|||.|.|| ..|. .|..|  || |||.
LKYIHSANVIHRDLKPSNILVNSNCDLKICDF
Kinase AqueK120.AA MAPK 397-451 28 2.5e-05 14.12 In-house 1-63 (328) Show / Hide 
Range on Protein: 397-451
Range on HMM: 1-63/328
Sequence Identity: 28% (18 aa)

YRNLEFLTKGSNGSMCFATDTRTSSR------VVISKR-DGLYSQEYSKRNLREIQILTRL-Q
|..|... .|. |  | |.|.||. .      |.| |  .   .. . || .||| .| .. .
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHH
Kinase AqueK120.AA p38 397-451 32 0.000102 11.73 In-house 1-59 (289) Show / Hide 
Range on Protein: 397-451
Range on HMM: 1-59/289
Sequence Identity: 32% (19 aa)

YRNLEFLTKGSNGSMCFATDTRTSSR---VVISK-RDGLYSQEYSKRNLREIQILTRLQ
|.||... .|. |. | | |.||. .   | | | .    | .. ||  ||.  |  ..
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMR
Kinase AqueK120.AA ERK3 397-451 36 0.000118 10.47 In-house 1-54 (300) Show / Hide 
Range on Protein: 397-451
Range on HMM: 1-54/300
Sequence Identity: 36% (20 aa)

YRNLEFLTKGSNGSMCFATDTRTSSRVVISKRDGLYSQEYSKRNLREIQILTRLQ
.  |  |  ||||    |.| .   .| | |.  |  .   |  ||||.|. ||.
FCDLRPLGCGSNGLVFSAVDSECCKKVAI-KKIVLTDKKSCKHALREIKIIRRLD
Kinase AqueK120.AA MAPK-Unclassified 498-548 39 0.000177 11.51 In-house 102-152 (575) Show / Hide 
Range on Protein: 498-548
Range on HMM: 102-152/575
Sequence Identity: 39% (20 aa)

NQQRMTHDQIWCIMYSLLVSLKLLHSAGVVHRCIRPRHLLLTSEFDLAICD
||    | .|  ..| .|  || ||||...||   |  ||..    . |||
NQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICD
Kinase AqueK120.AA MAPK-Unclassified 397-447 32 0.113705 1.18 In-house 1-53 (575) Show / Hide 
Range on Protein: 397-447
Range on HMM: 1-53/575
Sequence Identity: 32% (17 aa)

YRNLEFLTKGSNGSMCFATDTRT-SSRVVISKRDGLYSQEY-SKRNLREIQIL
|   . .  |. |. | |.|...    | | |  ..   .   || |||| ||
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRIL