Gene AqueK119 (A.queenslandica)

AqueK119

Species: A.queenslandica
Alias: AqueK119
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
AqueK119.AA Protein None 743 None Fasta, JSON
AqueK119.kin_dom Protein Kinase Domain None 301 None Fasta, JSON

Protein domain

Protein domains of AqueK119.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK119.AA ERK1 29-329 35 2.8e-58 199.95 In-house 1-289 (289) Show / Hide 
Range on Protein: 29-329
Range on HMM: 1-289/289
Sequence Identity: 35% (109 aa)

YKDLEYLALGGNGLVCKAIDTYTDKRVVISKRDSLFSKTYCQRDLRELQVISRLQKALGDDLPIPELIDIVCEPANQPIGEGTKFYVVQEAKEGTIEIIL
| .|.|.. |  |.|| |.|| . .|| | |      .||||| |||.... | .        | .. ||.  ..   | .    |.||.  |  .  .|
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHEN-----IINIQDIIRADT---IEQMRDVYIVQCLMETDLYKLL

QADQLPSPEQVKILMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLAAVNGIESDPNFELLRFTDSYRVEHLHYWAPEVLINEE-ITPVVD
.. .| | . .   .||.|| ||  ||| ..|| ..   .|.   |||..||| || .    .||. .   |   | |    | |||...|    |  .|
KTQHL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARI----ADPEHDHTGFLTEY-VATRWYRAPEIMLNSKGYTKSID

IWSAGCIFAELLTGKKVFGSSDVRGQLDLIVDLLGAPSPEDLAFVKGDASRTALTSV-QNSSPTFEERFKNIDPVARDLLKKMLVFNPSQRITAEKALEH
||| ||| ||.|  . .|       || .|. .||.|| .||  .  .  |  | |.   .   ... | . |. | ||| ||| ||| .||| |.|| |
IWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAH

EYL
 ||
PYL
Kinase AqueK119.AA CMGC 29-329 19 9.5e-58 187.92 In-house 1-513 (513) Show / Hide 
Range on Protein: 29-329
Range on HMM: 1-513/513
Sequence Identity: 19% (102 aa)

YKDLEYLALGGNGLVCKAID--------------TYTDKRVVISKRDSLFSKTYCQ----------RDLRELQVISRLQ-----------KALGDDLP-I
|. ....  |  | |.|..|              . |...| | |  . | .. ..          | |||..   .|.           .  ... . |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

PELIDIVCEPANQPIGE---------GTKFYVVQEAKEGTIEIILQADQ---------LPSPEQ------------VKILM------YQLLRALK--LFH
  |.||.  . ... ..           ..| | |  . .   ...  |           |. .            .| .|      ||.||.||    |
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SAG--IIHRCIRSNDILIDADCDL--------------------RVCDFRLAAVNGIESDPNFELLRF-------------TDSYRVEHLHYWAPEVLIN
|..  |||| .    |||. .|.|                    ..||| ||   ...||..|.  ..             . . .|  ..| |||.|..
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

EE----------ITPVVDIWSAGCIFAELLTG--------KKVFGSSDV-----------RGQLDLIVDLLGAPS---------------PEDLAFVKG-
 .           |. .|.||.||||||..||        |  |  ..              ||..|...|| |.               .|.   ... 
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

--------------------DASRTALTS----VQNSSPTFEERFKN-----------------------------------IDPVARDLLKKMLVFNPS
                    .  |... |     .   ..... |..                                   .|| |.|||||||...|.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

QRITAEKALEHEYL
.||||| ||.|.|.
KRITAEQALQHPYF
Kinase AqueK119.AA nmo 114-329 35 1.1e-49 150.68 In-house 79-292 (292) Show / Hide 
Range on Protein: 114-329
Range on HMM: 79-292/292
Sequence Identity: 35% (79 aa)

YVVQEAKEGTIEIILQADQLPSPEQVKILMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLAAVNGIESDPNFELLRFTDSYRVEHLHYWA
||| |     .  |. . |  |.. ||. .||.|| ||  |||.|.|| |.  ..|....| |..||| || |   .   .      |  ||       |
YVVTELMQSDLHKIIVSPQHLSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYR-------A

PEVLI-NEEITPVVDIWSAGCIFAELLTGKKVFGSSDVRGQLDLIVDLLGAPSPEDLAFVKGDASRTALTSVQNSSPTFEERFKNID-----PVARDLLK
||.|.     |  ||||| ||||||||  . .|       ||..|.|||| || ||. .   .  .. .       | ..  ..          | .||.
PEILMGARHYTSAVDIWSVGCIFAELLGRRILFQAQSPIQQLQMITDLLGTPSMEDMKYA-CEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLC

KMLVFNPSQRITAEKALEHEYL
.||.|.|..|| .. ||.| ||
RMLHFDPDKRISCKDALAHPYL
Kinase AqueK119.AA ERK5 29-329 31 2.7e-47 163.45 In-house 1-295 (295) Show / Hide 
Range on Protein: 29-329
Range on HMM: 1-295/295
Sequence Identity: 31% (96 aa)

YKDLEYLALGGNGLVCKAIDTYTDKRVVISKRDSLFSK-TYCQRDLRELQVISRLQKALGDDLPIPELIDIVCEPANQPIGEGTKFYVVQEAKEGTIEII
|| .| .  |  | || |.   . ..| | |    | . |  .| .|||...   .        |  . ||.     .|..|    ||| .  |  .  |
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDN-----IIAIRDILM--PKVPYSEMKDVYVVFDLMESDLHQI

LQADQLPSPEQVKILMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLAAVNGIESDPNFELLRFTDSYRVEHLHYWAPEVLI-NEEITPVV
. ..|  . | ..  .||.|| ||  ||| .||| ..   .|.   |.|.. || .|   |.      .   |  .| |    | |||...  .. |  .
IHSNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMAR--GLCTFSPDKHQMFMTEY-VATRWYRAPELMFSSHDYTQAI

DIWSAGCIFAELLTGKKVFGSSDVRGQLDLIVDLLGAPSPEDLAFVKGDASRTALTS-VQNSSPT-FEERFKNIDPVARDLLKKMLVFNPSQRITAEKAL
|.|| |||| |... ...|       ||.||.. || |.|  .  |  |  .  . . . |  |  .|. .   |. | ||| .||.| ||.|||. |||
DVWSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKAL

EHEYL
 | .|
QHPFL
Kinase AqueK119.AA ERK7 139-329 36 8.8e-45 150.92 In-house 102-292 (292) Show / Hide 
Range on Protein: 139-329
Range on HMM: 102-292/292
Sequence Identity: 36% (71 aa)

VKILMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLAAVNGIESDPNFELLRFTDSYRVEHLHYWAPEVLIN-EEITPVVDIWSAGCIFAE
..  |||||||.|  ||. .||| ..   ||.|..| ..|||| ||   .   . . .    |. | |    | |||.|.  .. |. || || ||| .|
KQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTE-Y-VATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

LLTGKKVF-GSSDVRGQLDLIVDLLGAPSPEDLAFVKGDASRTALTSVQNSSP-TFEERFKNIDPVARDLLKKMLVFNPSQRITAEKALEHEYL
.|.|| .| |.| .  |...|..... |. ||.. .. . . . | ... . . |... ...  . | ||||..||||| .|.|||.||.| | 
MLRGKPMFPGTSTMN-QIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase AqueK119.AA MAPK 213-329 40 2.3e-44 151.23 In-house 199-328 (328) Show / Hide 
Range on Protein: 213-329
Range on HMM: 199-328/328
Sequence Identity: 40% (52 aa)

APEVLIN---EEITPVVDIWSAGCIFAELLT-GKKVFGSSDVRGQLDLIVDLLGAPSPEDLAFVK-GDASRTALTSV---QNSSP-TFEERFKN----ID
|||.. |    . |  ||.||.||||||.|| .|  |  .|   |. ||...|| ||.|.. ...  .. |. . |    ..  . ..|. |.|     .
APEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNAN

PVARDLLKKMLVFNPSQRITAEKALEHEYL
| |.|||.|||||.|..|||.| ||.|.|.
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase AqueK119.AA S_TKc 29-329 21 1.4e-34 122.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 29-329
Range on HMM: 1-231/231
Sequence Identity: 21% (69 aa)

YKDLEYLALGGNGLVCKAIDTYTDKRVVISKRDSLFSKTYCQRDLRELQVISRLQKALGDDLPIPELIDIVCEPANQPIGEGTKFYVVQEAKEG---TIE
|. |. .  |. | |.|.... |...| | . .        .. .||.|. ..      .   |  |.|.  .         ...|.| |  .|   .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK------HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLF

IILQADQLP------SPEQVKILMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLAAVNGIESDPNFELLRFTDSYRVEHLHYWAPEVLIN
 ...  . .      .. ... .|||...||.  || ||||| .    ||.|    . .||| ||..                .  .  ..| |||||  
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL--

EEITP-VVDIWSAGCIFAELLTGKKVFGSSDVRGQLDLIVDLLGAPSPEDLAFVKGDASRTALTSVQNSSPTFEERFKNIDPVARDLLKKMLVFNPSQRI
   ..  .|.|| |||..|.|.|.  |       |.... ...|                                    .| |.|...|.|...|..|.
-GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRP

TAEKALE-------HEYL
|| .||.       |...
TA-EALQDEWDIKCHPWF
Kinase AqueK119.AA ERK 226-329 41 6e-33 115.78 In-house 198-307 (307) Show / Hide 
Range on Protein: 226-329
Range on HMM: 198-307/307
Sequence Identity: 41% (46 aa)

VDIWSAGCIFAELLTGKKVFGSSDVRGQLDLIVDLLGAP-SPEDLAFVKGDASRTALTSVQN--SSPT-FEERFKN--IDPVARDLLKKMLVFNPSQRIT
.||||.||||||.| .| .|   | ..|...| ...| | | |||   . .  .  ... .|    |  .|..|.|  . | | |||.|||||.|..|||
MDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRIT

AEKALEHEYL
.| .|||.|.
VEECLEHPYF
Kinase AqueK119.AA p38 211-329 40 5.3e-32 106.47 In-house 169-289 (289) Show / Hide 
Range on Protein: 211-329
Range on HMM: 169-289/289
Sequence Identity: 40% (49 aa)

YWAPEVLINE-EITPVVDIWSAGCIFAELLTGKKVFGSSDVRGQLDLIVDLLGAPSPEDLAFVKGDASRTALTSV-QNSSPTFEERFKNIDPVARDLLKK
| |||.. |  . |  ||||| ||| |||.||.  |  .|   ||  |. ..| |..| .. .. ...|. . |  |     |.. |.. .| | ||| |
YRAPEIMLNWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEK

MLVFNPSQRITAEKALEHEYL
||.  | .||||| |..|.|.
MLELDPDKRITAEEAMQHPYF
Kinase AqueK119.AA Pkinase 209-329 26 1.2e-26 95.24 Pfam 175-293 (293) Show / Hide 
Range on Protein: 209-329
Range on HMM: 175-293/293
Sequence Identity: 26% (33 aa)

LHYWAPEVLI-NEEITPVVDIWSAGCIFAELLTGKKVFGSS----DVRGQLDLIVDLLGAPSPEDLAFVKGDASRTALTSVQNSSPTFEERFKNIDPVAR
..| ||||.  .....| ||.||.|||..|.|.|.  | ..    . . |. .|.  .|.| ..|         .. ..  . . . .... .|... ..
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECK

DLLKKMLVFNPSQRITAEKALEHEYL
|..|..| ..|..|.||| .|.|...
DFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK119.AA MAPK-Unclassified 209-329 29 4.6e-26 90.9 In-house 412-575 (575) Show / Hide 
Range on Protein: 209-329
Range on HMM: 412-575/575
Sequence Identity: 29% (49 aa)

LHYWAPEV-LINEEITPVVDIWSAGCIFAELLTG-----------KKVFGSSD--------------------VRGQLDLIVDLLGAPSPEDLAFVKGDA
. | |||  | . | .  |||||.||||||..             .  |  .|                    . .|. .|.| || |  ||. |.. | 
RWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDCNFITCDS

SRTALTSV-QNSSPTFE-ERFKNID---------PVARDLLKKMLVFNPSQRITAEKALEHEYL
 |  . |  .  .  |    | .           . ..|...|||.|||. ||||. ||||.| 
ARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase AqueK119.AA p38 29-184 34 1.6e-17 56.22 In-house 1-153 (289) Show / Hide 
Range on Protein: 29-184
Range on HMM: 1-153/289
Sequence Identity: 34% (55 aa)

YKDLEYLALGGNGLVCKAIDTYTDKR---VVISK-RDSLFSKTYCQRDLRELQVISRLQKALGDDLPIPELIDIVCEPANQPIGEGTKFYVVQEAKEGTI
|..|...  |  | ||||.|. |...   | | | .   .|  .  |  |||    || | .  .  | .|.| |  |... . . . .|.| .  .   
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYREL----RLLKHMRHENVI-CLLD-VFTPPAHSMNDFQDVYMVTHFMGADL

EIILQADQLPSPEQVKILMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLA
. |.   .| | .....| ||.||.||  ||||||||      | .  ||.||. || ||
NNIMKCQRL-SDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLA
Kinase AqueK119.AA MAPK 135-184 46 9.5e-14 43.7 In-house 113-164 (328) Show / Hide 
Range on Protein: 135-184
Range on HMM: 113-164/328
Sequence Identity: 46% (24 aa)

SPEQVKILMYQLLRA--LKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLA
| . .. .|||.||.  ||  |||..||| .    ||.. .|||..||| ||
SDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLA
Kinase AqueK119.AA ERK3 297-329 54 4.3e-13 38.07 In-house 268-300 (300) Show / Hide 
Range on Protein: 297-329
Range on HMM: 268-300/300
Sequence Identity: 54% (18 aa)

NIDPVARDLLKKMLVFNPSQRITAEKALEHEYL
|||  | |.| .|| |.|. |.||| ||.| |.
NIDCHALDFLEQMLTFDPMDRLTAEMALQHPYM
Kinase AqueK119.AA MAPK-Unclassified 127-184 38 3.1e-11 36.37 In-house 98-156 (575) Show / Hide 
Range on Protein: 127-184
Range on HMM: 98-156/575
Sequence Identity: 38% (23 aa)

ILQADQ-LPSPEQVKILMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLA
|.. .|   . .......||.|| ||  |||.||||      .||. || .|.||| ..
IIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMS
Kinase AqueK119.AA ERK 142-184 51 3e-10 34.54 In-house 113-155 (307) Show / Hide 
Range on Protein: 142-184
Range on HMM: 113-155/307
Sequence Identity: 51% (22 aa)

LMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLA
.|||.|..||  |||..||| ..   ||.  .||| .||| ||
FMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLA
Kinase AqueK119.AA ERK3 29-83 41 6.5e-10 27.68 In-house 1-54 (300) Show / Hide 
Range on Protein: 29-83
Range on HMM: 1-54/300
Sequence Identity: 41% (23 aa)

YKDLEYLALGGNGLVCKAIDTYTDKRVVISKRDSLFSKTYCQRDLRELQVISRLQ
. ||  |  |.||||  |.|   .|.| | |. .|  |  |   ||| ..| ||.
FCDLRPLGCGSNGLVFSAVDSECCKKVAI-KKIVLTDKKSCKHALREIKIIRRLD
Kinase AqueK119.AA ERK3 114-184 37 6.7e-10 27.64 In-house 88-158 (300) Show / Hide 
Range on Protein: 114-184
Range on HMM: 88-158/300
Sequence Identity: 37% (27 aa)

YVVQEAKEGTIEIILQADQLPSPEQVKILMYQLLRALKLFHSAGIIHRCIRSNDILIDA-DCDLRVCDFRLA
..|||  |     ..   .| | | ..  |||||| ||  ||| . ||  .   |.|   |  |.. || .|
CIVQEYMETDLACVMEQQRL-SEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTEDLVLKIGDFGMA
Kinase AqueK119.AA ERK3 226-245 65 3.1e-09 25.47 In-house 196-215 (300) Show / Hide 
Range on Protein: 226-245
Range on HMM: 196-215/300
Sequence Identity: 65% (13 aa)

VDIWSAGCIFAELLTGKKVF
.|.|.||||.||.||||  |
IDMWAAGCILAEMLTGKMLF
Kinase AqueK119.AA MAPK 29-76 32 2.6e-08 24.63 In-house 1-55 (328) Show / Hide 
Range on Protein: 29-76
Range on HMM: 1-55/328
Sequence Identity: 32% (18 aa)

YKDLEYLALGGNGLVCKAIDTY------TDKRVVISKR-DSLFSKTYCQRDLREL
|..|...  |  |.||.|||.       ..|.|.| |  .   ..|.|.| .||.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREI
Kinase AqueK119.AA MAPK-Unclassified 29-78 32 0.000623 9.5 In-house 1-52 (575) Show / Hide 
Range on Protein: 29-78
Range on HMM: 1-52/575
Sequence Identity: 32% (17 aa)

YKDLEYLALGGNGLVCKAIDTYT-DKRVVISKRDSLFS-KTYCQRDLRELQV
|   ...  |. | ||.|.|. .  . | | |   .|  .| | | |||. .
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRI
Kinase AqueK119.AA Pkinase 135-181 43 0.002031 13.17 Pfam 106-156 (293) Show / Hide 
Range on Protein: 135-181
Range on HMM: 106-156/293
Sequence Identity: 43% (22 aa)

SPEQVKILMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDL----RVCDF
|....|  |||.||.|.  || ||||| . .  |||| ....    ..|||
SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF
Kinase AqueK119.AA ERK 29-76 35 0.002948 8.21 In-house 1-54 (307) Show / Hide 
Range on Protein: 29-76
Range on HMM: 1-54/307
Sequence Identity: 35% (19 aa)

YKDLEYLALGGNGLVCKAIDTY-----TDKRVVISKRDSLFSKT-YCQRDLREL
|.... .  |. |.||.|||.      |...| | |    |... || | |||.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREI
Kinase AqueK119.AA Pkinase 29-57 27 3.925828 1.55 Pfam 1-29 (293) Show / Hide 
Range on Protein: 29-57
Range on HMM: 1-29/293
Sequence Identity: 27% (8 aa)

YKDLEYLALGGNGLVCKAIDTYTDKRVVI
|. .. .  |. | |.|...  | |.|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAV
Kinase AqueK119.AA ERK7 509-698 33 9.3e-33 109.13 In-house 104-292 (292) Show / Hide 
Range on Protein: 509-698
Range on HMM: 104-292/292
Sequence Identity: 33% (65 aa)

CLMYSLLVSLKLLHSAGVVHRCLRPRHLLLTSEFDLALCD--LRRSLMNHEPCGEEYNWTGSSTEGSWQYLSPQA-VCYDEQTTACDLWSAGCVFGEMLL
. || ||  .| .||. |.|| |.|  .|| ||  . .||  | ||. . |  .|.           | | .|   .   . | . |.|| ||. |||| 
YIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRW-YRAPEILLGSHRYTKGVDMWSIGCILGEMLR

GQPLFVSDANAVNLFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESPSLDSNLRKRNVDGQVLDLLKKMLAFSPAKRLTAEEALKHPYF
|.|.|        . ..|  |...|. .... . | .. ..|.... ..  .||  ...   |.  .||||..|.| | ||||||.||.||| 
GKPMFPGTSTMNQIEKIL-ETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDA--IDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase AqueK119.AA CMGC 584-698 21 5e-32 101.81 In-house 303-513 (513) Show / Hide 
Range on Protein: 584-698
Range on HMM: 303-513/513
Sequence Identity: 21% (46 aa)

YDEQ------TTACDLWSAGCVFGEMLLG--------QPLFVSDANA----------VNLFRVLFSTLGRPK---------------DQELAFVTS----
|...      ||..| ||.||.|.||..|        .|||  . .           ..     | .|| |                ..|   ...    
YTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWY

-------------------------------RLGLQVLKELKLNESPSLDSNLRK------------------------RNVDGQVLDLLKKMLAFSPAK
                               .   . .|.|. . ..  | | .|                        .. | | .||||||| . |.|
NKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDK

RLTAEEALKHPYF
|.|||.||.||||
RITAEQALQHPYF
Kinase AqueK119.AA MAPK 588-698 33 5.2e-30 100.82 In-house 212-328 (328) Show / Hide 
Range on Protein: 588-698
Range on HMM: 212-328/328
Sequence Identity: 33% (40 aa)

TTACDLWSAGCVFGEMLL-GQPLFVSDANAVNLFRVLFSTLGRPKDQELAFVT-SRLGLQVLKEL---KLNESPSLDSNLRKRN--VDGQVLDLLKKMLA
|.| | ||.|| |.|||  ..|||    . .. .   ...|| |... . ... |    .... |   .     .... . . |  .. | .|||.|||.
TKAVDMWSVGCIFAEMLTDRKPLFP-GKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLV

FSPAKRLTAEEALKHPYF
|.| ||.|.|||| ||||
FDPDKRITVEEALQHPYF
S_TKc AqueK119.AA S_TKc 397-698 20 4.1e-23 84.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 397-698
Range on HMM: 1-231/231
Sequence Identity: 20% (66 aa)

YRNLEFLTKGSNGSMCFATDTRTSSRVVLSKRDGLYSQEYSKRNLRELQLLTRLQRMYSDDYDPFPRLLDFLCYPQNLSGPKQAELYVVQTAFDV---NL
|. |. . ||. |. . .....|  .| . . .        .. .||.|.| .            | .  .. . |.       .||.|    |    .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK----------HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDL

ADLLNQQR-------MTHDQLWCLMYSLLVSLKLLHSAGVVHRCLRPRHLLLTSEFDLALCD--LRRSLMNHEPCGEEYNWTGSSTEGSWQYLSPQAVCY
 |.. ...       ..  . ...|| ..  |. .|| |..|| | |  .||..   . .||  | | |              ..  |.  |..|  .  
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL--

DEQTT-ACDLWSAGCVFGEMLLGQPLFVSDANAVNLFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESPSLDSNLRKRNVDGQVLDLLKKMLAFSP
   .. .|| || ||.. ||| |.|.|    .   .|...                                            . ...|...|.| . |
-GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------------------------------------------SPEAKDFIRKCLQKDP

AKRLTAEEALK-------HPYF
.||.|| |||.       ||.|
EKRPTA-EALQDEWDIKCHPWF
Kinase AqueK119.AA MAPK-Unclassified 588-698 24 5.2e-22 76.01 In-house 427-575 (575) Show / Hide 
Range on Protein: 588-698
Range on HMM: 427-575/575
Sequence Identity: 24% (37 aa)

TTACDLWSAGCVFGEMLLG-----------QPLFVSDA---------NAVN----------LFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESPS
.|. |.||.||.|.||..            .|||  .          | |.             ..|. ||.|. . . |.|.    . .. .|   .  
DTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDCNFITCDSARKYIQSFKCKTPVH

LDSNLRKRNV--------DGQVLDLLKKMLAFSPAKRLTAEEALKHPYF
 ..     .         . . .|...|||.|.| || ||..||.||||
FTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase AqueK119.AA ERK5 511-698 30 6.4e-22 76.97 In-house 109-295 (295) Show / Hide 
Range on Protein: 511-698
Range on HMM: 109-295/295
Sequence Identity: 30% (58 aa)

MYSLLVSLKLLHSAGVVHRCLRPRHLLLTSEFDLALCD--LRRSLMNHEPCGEEYNWTGSSTEGSWQYLSPQAV-CYDEQTTACDLWSAGCVFGEMLLGQ
.| .|  || .||| |.|| |.|  ||     .| . |  . | |    |  ...  | .     | |  |  .   .. | | |.|| ||.||||.  .
LYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMT-EYVATRW-YRAPELMFSSHDYTQAIDVWSVGCIFGEMIARR

PLFVSDANAVNLFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESPSLDSNLRKRNVDGQVLDLLKKMLAFSPAKRLTAEEALKHPYF
 .|    | ..  ...   || |  . .  | .      ...   |  |   . .  .  | | |||| .|| | |..|.|. .||.||. 
QMFPG-KNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPK-ADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase AqueK119.AA ERK 588-698 36 7.6e-21 74.46 In-house 195-307 (307) Show / Hide 
Range on Protein: 588-698
Range on HMM: 195-307/307
Sequence Identity: 36% (42 aa)

TTACDLWSAGCVFGEMLLGQPLFVSDANAVNLFRVLFSTLGRP-KDQELAFVTSRLGLQVLKELKL--NESPSLDSNLRKRNVDGQVLDLLKKMLAFSPA
|.| | ||.|| | ||| ..|||   .. |. ..  |...| |  ...|   .|   .. .|.|     .  .. .   . |.  | .|||.|||.| | 
TKAMDIWSCGCIFAEMLGRKPLFP-GKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPD

KRLTAEEALKHPYF
||.|.||.|.||||
KRITVEECLEHPYF
Kinase AqueK119.AA Pkinase 588-698 25 1.9e-17 62.74 Pfam 190-293 (293) Show / Hide 
Range on Protein: 588-698
Range on HMM: 190-293/293
Sequence Identity: 25% (29 aa)

TTACDLWSAGCVFGEMLLGQPLFVSDA----NAVNLFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESPSLDSNLRKRNVDGQVLDLLKKMLAFSP
....| ||.||.. |||.|.|.|  ..    | ..   ... ..|.| . .     |.     ..  .          ..  |..   .|..|..|.. |
GPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----F-HWTF-HNWSEECKDFIKWCLCKDP

AKRLTAEEALKHPYF
.||.|||..|.||.|
KKRPTAEQILQHPWF
Kinase AqueK119.AA ERK3 666-698 57 7.9e-17 50.32 In-house 268-300 (300) Show / Hide 
Range on Protein: 666-698
Range on HMM: 268-300/300
Sequence Identity: 57% (19 aa)

NVDGQVLDLLKKMLAFSPAKRLTAEEALKHPYF
|.|   ||.| .|| |.|  |||||.||.|||.
NIDCHALDFLEQMLTFDPMDRLTAEMALQHPYM
Kinase AqueK119.AA p38 588-698 29 7.9e-16 50.32 In-house 182-289 (289) Show / Hide 
Range on Protein: 588-698
Range on HMM: 182-289/289
Sequence Identity: 29% (33 aa)

TTACDLWSAGCVFGEMLLGQPLFVSDANAVNLFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESPSLDSNLRKRNVDGQVLDLLKKMLAFSPAKRL
| . | || ||.  |.. |..||  | . ..  . . . .| |..  .. . |     ... .   .   . . ... |.    .||| |||   | ||.
TQTVDIWSVGCIMAELITGRTLFPGD-DHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQA--IDLLEKMLELDPDKRI

TAEEALKHPYF
|||||..||||
TAEEAMQHPYF
Kinase AqueK119.AA nmo 588-698 26 4.7e-15 42.15 In-house 182-292 (292) Show / Hide 
Range on Protein: 588-698
Range on HMM: 182-292/292
Sequence Identity: 26% (30 aa)

TTACDLWSAGCVFGEMLLGQPLFVSDANAVNLFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESPSLDSNLRK-RNVDGQVLDLLKKMLAFSPAKR
| | |.|| ||.|.|.|  . ||   .. ..   ..   || |   .. .        .|.. . . . .   .|    .      .||..|| | | ||
TSAVDIWSVGCIFAELLGRRILFQA-QSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKR

LTAEEALKHPYF
. ...||.||| 
ISCKDALAHPYL
Kinase AqueK119.AA ERK1 588-698 36 1.5e-14 50.91 In-house 182-289 (289) Show / Hide 
Range on Protein: 588-698
Range on HMM: 182-289/289
Sequence Identity: 36% (40 aa)

TTACDLWSAGCVFGEMLLGQPLFVSDANAVNLFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESPSLDSNLRKRNVDGQVLDLLKKMLAFSPAKRL
| . |.|| ||.  |||   |.|        |  .| . || |  ..|  .  .   . |. |   .  ....   |   | . |||| |||.| | ||.
TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL-GVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPK--ADSKALDLLDKMLTFNPHKRI

TAEEALKHPYF
| |||| ||| 
TVEEALAHPYL
Kinase AqueK119.AA CMGC 397-548 15 1.8e-11 32.99 In-house 1-247 (513) Show / Hide 
Range on Protein: 397-548
Range on HMM: 1-247/513
Sequence Identity: 15% (38 aa)

YRNLEFLTKGSNGSMCFATDTRTSSR--------------VVLSK--RDGLYSQEYSK----------RNLRELQLLTRLQRM----------YSDDYDP
| ... . .|. |  . ..|.||  .              | . |  .     .|  |          | |||...| .|..            ... ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAI-KKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

-FPRLLDFLCYPQ-NLSGPK--------QAELYVVQTAFDVNLADLLNQQR----------MTHDQ------------LWCLM------YSLLVSLK--L
   .|.|.. ... . ....          .|| |    | .|.... ...          ... .              ..|      | .| .||   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHSAG--VVHRCLRPRHLLLTSE--------------------FDLALCD
.||..  ..|| | |  .|....                    . | .||
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICD
Kinase AqueK119.AA ERK3 482-546 38 3.4e-11 31.89 In-house 87-150 (300) Show / Hide 
Range on Protein: 482-546
Range on HMM: 87-150/300
Sequence Identity: 38% (25 aa)

LYVVQTAFDVNLADLLNQQRMTHDQLWCLMYSLLVSLKLLHSAGVVHRCLRPRHLLLTSEFDLAL
...||   .  || .. |||.. .     || ||  || .||| | || |.|  ..   | || |
VCIVQEYMETDLACVMEQQRLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTE-DLVL
Kinase AqueK119.AA ERK1 481-548 39 1.5e-10 35.78 In-house 76-143 (289) Show / Hide 
Range on Protein: 481-548
Range on HMM: 76-143/289
Sequence Identity: 39% (27 aa)

ELYVVQTAFDVNLADLLNQQRMTHDQLWCLMYSLLVSLKLLHSAGVVHRCLRPRHLLLTSEFDLALCD
..|.||   .  |  ||  |..  | .   .| .|  || .||| |.|| |.|  |||    || .||
DVYIVQCLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICD
Kinase AqueK119.AA p38 481-533 35 2.3e-09 27.84 In-house 82-134 (289) Show / Hide 
Range on Protein: 481-533
Range on HMM: 82-134/289
Sequence Identity: 35% (19 aa)

ELYVVQTAFDVNLADLLNQQRMTHDQLWCLMYSLLVSLKLLHSAGVVHRCLRP
. |.| .  .  |  .. .||.. |.   | | .|  ||  ||||..|| | |
DVYMVTHFMGADLNNIMKCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKP
Kinase AqueK119.AA ERK3 588-610 56 6.9e-09 24.33 In-house 193-215 (300) Show / Hide 
Range on Protein: 588-610
Range on HMM: 193-215/300
Sequence Identity: 56% (13 aa)

TTACDLWSAGCVFGEMLLGQPLF
| | |.|.|||.. ||| |..||
TKAIDMWAAGCILAEMLTGKMLF
Kinase AqueK119.AA nmo 500-548 38 3.6e-08 20.57 In-house 97-145 (292) Show / Hide 
Range on Protein: 500-548
Range on HMM: 97-145/292
Sequence Identity: 38% (19 aa)

QRMTHDQLWCLMYSLLVSLKLLHSAGVVHRCLRPRHLLLTSEFDLALCD
| .. | .   .| .|  || ||||...|| ..|  ||. |.  | .||
QHLSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICD
Kinase AqueK119.AA ERK1 397-451 38 4.8e-08 26.26 In-house 1-55 (289) Show / Hide 
Range on Protein: 397-451
Range on HMM: 1-55/289
Sequence Identity: 38% (21 aa)

YRNLEFLTKGSNGSMCFATDTRTSSRVVLSKRDGLYSQEYSKRNLRELQLLTRLQ
| ||... .|  | .| | ||..  || . |      | | .| |||...||| .
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFK
Kinase AqueK119.AA MAPK 481-548 32 2e-06 17.92 In-house 90-160 (328) Show / Hide 
Range on Protein: 481-548
Range on HMM: 90-160/328
Sequence Identity: 32% (23 aa)

ELYVVQTAFDVNLADLLNQQR-MTHDQLWCLMYSLLVS--LKLLHSAGVVHRCLRPRHLLLTSEFDLALCD
..|.|.   . .|  ....|. ...|    .|| .|    || .|||.|.|| | |  .|.... || .||
DIYIVMELMETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICD
Kinase AqueK119.AA p38 397-451 33 3.7e-05 13.25 In-house 1-59 (289) Show / Hide 
Range on Protein: 397-451
Range on HMM: 1-59/289
Sequence Identity: 33% (20 aa)

YRNLEFLTKGSNGSMCFATDTRTSSR---VVLSK-RDGLYSQEYSKRNLRELQLLTRLQ
|.||... .|. |. | | |.||. .   |   | .    | .. ||  ||| ||  ..
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMR
Kinase AqueK119.AA ERK 518-549 50 6.1e-05 14.55 In-house 121-152 (307) Show / Hide 
Range on Protein: 518-549
Range on HMM: 121-152/307
Sequence Identity: 50% (16 aa)

LKLLHSAGVVHRCLRPRHLLLTSEFDLALCDL
|| .|||.|.|| |.|. .|..|  ||  ||.
LKYIHSANVIHRDLKPSNILVNSNCDLKICDF
Kinase AqueK119.AA MAPK 397-451 26 0.000335 10.17 In-house 1-63 (328) Show / Hide 
Range on Protein: 397-451
Range on HMM: 1-63/328
Sequence Identity: 26% (17 aa)

YRNLEFLTKGSNGSMCFATDTRTSSR------VVLSKR-DGLYSQEYSKRNLRELQLLTRL-Q
|..|... .|. |  | |.|.||. .      |.. |  .   .. . || .||. || .. .
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHH
Kinase AqueK119.AA MAPK-Unclassified 498-548 37 0.001345 8.27 In-house 102-152 (575) Show / Hide 
Range on Protein: 498-548
Range on HMM: 102-152/575
Sequence Identity: 37% (19 aa)

NQQRMTHDQLWCLMYSLLVSLKLLHSAGVVHRCLRPRHLLLTSEFDLALCD
||    | .   ..| .|  || ||||...|| | |  ||..    .  ||
NQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICD
Kinase AqueK119.AA Pkinase 397-529 19 0.002283 12.99 Pfam 1-132 (293) Show / Hide 
Range on Protein: 397-529
Range on HMM: 1-132/293
Sequence Identity: 19% (28 aa)

YRNLEFLTKGSNGSMCFATDTRTSSRV---VLSKRDGLYSQEYSKRNLRELQLLTRLQRMYSDDYDPFPRLLDFLCYPQNLSGPKQAELYVVQTAFDV--
|. .. . .|| |. . ...  |. .|   ...||.   ......|.|.|.|.. ||.          |  . .... ..       ..|.|.   .   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---------HPNIVRLYDWFED-----KDHIYMVMEYCEGGL

---NLADLLN---QQRM--THDQLWCLMYSLLVSLKLLHSAGVVHR
    |.|..    . ..  . ... . || .|  |. .|| |..||
YVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHR
Kinase AqueK119.AA ERK5 397-447 26 0.152098 1.32 In-house 1-52 (295) Show / Hide 
Range on Protein: 397-447
Range on HMM: 1-52/295
Sequence Identity: 26% (14 aa)

YRNLEFLTKGSNGSMCFATDTRTSSRVVLSKRDGLYSQ-EYSKRNLRELQLL
|. .| .  |  | .| |   ..  .| . |    . .    || .|||..|
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKIL