Gene AqueK115 (A.queenslandica)

AqueK115

Species: A.queenslandica
Alias: AqueK115
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: PRP4

Sequence

Name Sequence Type Origin Length Description Download
AqueK115.AA Protein None 184 None Fasta, JSON
AqueK115.kin_dom Protein Kinase Domain None 174 None Fasta, JSON

Protein domain

Protein domains of AqueK115.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK115.AA PRP4 11-184 73 1.1e-133 450.41 In-house 1-176 (320) Show / Hide 
Range on Protein: 11-184
Range on HMM: 1-176/320
Sequence Identity: 73% (130 aa)

YMVYGYTGQGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMAELEILKKLNAT--DPDDKFHCIRLFSNFFHKNHLCLVFESMSMNIREVLRKYGKN
| ||||.||||||||.|.||. |  ..||||||||||.|||||. |||||.||| .  |..|||||.|.|  |.|..|.||||| |||| |||| ||||.
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

IGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKLMLKLCDFGSASFIQDNEITPYLVSRFYRAPEI
.|||.||||||.|||.||||..|.| |||||||||||||||||. ||.||||||| |..|||||||||||||||||
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEI
Kinase AqueK115.AA DYRK 11-184 42 3e-94 319.44 In-house 1-175 (320) Show / Hide 
Range on Protein: 11-184
Range on HMM: 1-175/320
Sequence Identity: 42% (75 aa)

YMVYGYTGQGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMAELEILKKLNATDPDDKFHCIRLFSNFFHKNHLCLVFESMSMNIREVLRKYGKNIG
| ...|.|.|.|..||...|. .  . |||||||||. .|.... |..||..||  |||||.||....  | |.||||.||| .||| .|.|...... .
YEILEYIGKGSFGQVVKCWDH-KTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

LHIKAVRSYSQQLLLALKLMKRC-TILHADIKPDNILVNE--SKLMLKLCDFGSASFIQDNEITPYLVSRFYRAPEI
.....||.. ||.|..||.....  |.|.|.||.||....  .|  .|..||||..|. . .|..|..||||||||.
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEV
Kinase AqueK115.AA CMGC 11-184 22 3.3e-61 199.5 In-house 1-296 (513) Show / Hide 
Range on Protein: 11-184
Range on HMM: 1-296/513
Sequence Identity: 22% (68 aa)

YMVYGYTGQGVFSNVVRARDTS-------------RSSQEVAIKIIRNNEMMHKTGM-------------AELEILKKLNAT---------DPDDKFH--
| . .. |.| ...|...||.              .. ..||||.|.|.. .. ..               |..|||.|| .         |||.| |  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

CIRLFSNFFHKN-----------------HLCLVFESMSMNIREVLRKYGK-------------------------NIGLHIKAVRSYSQQLLLALK--L
...|.  | |||                 ||.|||| | ..  ...... .                            . | ..| |..|.| .||   
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

MKRCT--ILHADIKPDNILVNESK-------------------LMLKLCDFGSASFIQDN-----------------------EITPYLVSRFYRAPEI
. .    |.| |.|| |||.|. .                     ||.||||.| .. ..                        .|.| |.|.||||||
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI
Kinase AqueK115.AA DYRK2 11-184 35 1.1e-42 136.45 In-house 1-173 (318) Show / Hide 
Range on Protein: 11-184
Range on HMM: 1-173/318
Sequence Identity: 35% (62 aa)

YMVYGYTGQGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMAELEILKKLNATDPDDKFHCIRLFSNFFHKNHLCLVFESMSMNIREVLRKYGKNIG
| .    |.| |  ||.. |     | ||||.|||    |..   |..||...   |.|  . |....  |   ||.|..|| .|||. | ..|  .. |
YEILEVIGKGSFGQVVKCYDH-KTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQ-G

LHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNES-KLMLKLCDFGSASFIQDNEITPYLVSRFYRAPEI
.  . ||   ...| .|.. ..  | |.| || ||| ..  .  .|. ||||  |     |  |  ||||||||.
FSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEV
Kinase AqueK115.AA HIPK 11-184 39 3.8e-40 123.79 In-house 1-174 (329) Show / Hide 
Range on Protein: 11-184
Range on HMM: 1-174/329
Sequence Identity: 39% (71 aa)

YMVYGYTGQGVFSNVVRARDTSRSSQE-VAIKIIRNNEMMHKTGMAELEILKKLNATDPDDKFHCIRLFSNFFHKNHLCLVFESMSMNIREVLRKYGKNI
| |  . |.| |  ||..    |. .| |||||..|.    . |  |..||..|   ..|. .| .| .  | |||| ||||| .  |. . . |  |  
YEVLEFLGRGTFGQVVKCWK--RGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADE-YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQ-KQNKFM

GLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNI-LVNESK--LMLKLCDFGSASFIQDNEITPYLVSRFYRAPEI
 | .|..|   || | ||. .|   ..|||.||.|| || ...     |  |||||| . .    .|| ||.||||||
PLPLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEI
Kinase AqueK115.AA CLK 11-152 30 1.1e-36 106.96 In-house 1-152 (350) Show / Hide 
Range on Protein: 11-152
Range on HMM: 1-152/350
Sequence Identity: 30% (46 aa)

YMVYGYTGQGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMAELE-ILKKLNAT-DPDDKFH--CIRLFSNFFH-KNHLCLVFESMSMNIREVLRKY
| ..   |.|.|. ||. .|.... . ||.||||| |       .|.. |.||.|.. ||. |.   |..... | . ..| |.||| .  .| ..... 
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

G-----KNIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKL
.     | |.. | ..|. . ||. |.| .    . | | || ||.   |..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRF
Kinase AqueK115.AA DYRK1 11-184 36 1e-32 111.92 In-house 1-174 (321) Show / Hide 
Range on Protein: 11-184
Range on HMM: 1-174/321
Sequence Identity: 36% (65 aa)

YMVYGYTGQGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMAELEILKKLNATDPDDKFHCIRLFSNFFHKNHLCLVFESMSMNIREVLRKYGKNIG
| .    |.| |  ||.| |.    ..||||||.|          |. .|  .|. |...|.. ..|   | ..|||||||| .| |. ..||   .  |
YEIDSLIGKGSFGQVVKAYDH-QEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRN-THFRG

LHIKAVRSYSQQLLLALKLMK--RCTILHADIKPDNI-LVNESKLMLKLCDFGSASFIQDNEITPYLVSRFYRAPEI
  .  .| . ||.. ||  |      |.| |.||.|| |.|  .  .|. |||| |   .. |  |. |||||.||.
VSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGS-SCQLGQRIYQYIQSRFYRSPEV
Kinase AqueK115.AA YAK 11-184 34 1.7e-26 86.68 In-house 1-176 (347) Show / Hide 
Range on Protein: 11-184
Range on HMM: 1-176/347
Sequence Identity: 34% (62 aa)

YMVYGYTGQGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMAELEILKKLNA-TDPDDKF---HCIRLFSNFFHKNHLCLVFESMSMNIREVLRKYG
|.|    ||| |  ||  .        .|.|.| |       .  |  ||. ||   ||..|    | .|.   | ||||.|||||  |.|  | | |  
YIVLDMLGQGTFGQVVKCQNC-DTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYL-KQN

KNIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNE-SKLMLKLCDFGSASFIQDNEITPYLVSRFYRAPEI
|  |. .  .| .  | | ..   .   | | | || ||.     |  .|. ||||.       .. |  .|.||.|||
KFCGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSC-QEKKMVYTYIQQRHYRSPEI
Kinase AqueK115.AA GSK 88-183 38 1.8e-25 74.29 In-house 89-188 (328) Show / Hide 
Range on Protein: 88-183
Range on HMM: 89-188/328
Sequence Identity: 38% (39 aa)

CLVFESMSMNIREVLRKY---GKNIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKLMLKLCDFGSASFIQDNE---ITPYLVSRFYRA
|||.| | ..  .|.|.|   ....   |. .. |. |.. .|.      | | ||||.||||....  ||.||||||  ...|.    ..| .||.|||
CLVMEYMPQTLYQVIRHYVKNKQQM--PIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRA

PE
||
PE
Kinase AqueK115.AA Pkinase 18-184 25 4.8e-23 82.58 Pfam 8-182 (293) Show / Hide 
Range on Protein: 18-184
Range on HMM: 8-182/293
Sequence Identity: 25% (47 aa)

GQGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMA-----ELEILKKLNATDPDDKFHC--IRLFSNFFHKNHLCLVFESMSM-----NIREVLR--
|.| |. | .... . .  .||.|||.  .  ..  ..     |..|.|.||        |.  .||.  |  |.|...|.| . .        ....  
GSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

KYGKNIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKLML----KLCDFGSASF--IQDNEITPYLVSRFYRAPEI
..|. . .  . ...|  |.| .|. . .. |.| |.||.|||.. ..  .    |.||||.| .  .  |. | . ....|.|||.
RHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEV
Kinase AqueK115.AA DyrkP 11-184 30 1.5e-22 70.52 In-house 1-176 (323) Show / Hide 
Range on Protein: 11-184
Range on HMM: 1-176/323
Sequence Identity: 30% (55 aa)

YMVYGYTGQGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMAELEILKKLNATDPDDKFHCIRLFSNFFHKNHLCLVFESMSMNIREVL---RKYGK
| .  | |   ||  .   |     | . .||| ||       . |. .|. .|     |    .| .  |.|| || .. | .  |. |     |   .
YQIMEYLGSAAFSKAIQCQDK-QTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQ

NIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVN-ESKLMLKLCDFGSASFIQDNEITPYLVSRFYRAPEI
     .  .    ||.|.||  .    ..| |.||.|||.   .|   |. ||||. || |  .  |  || |||||.
QRYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHD-HLSSYVQSRSYRAPEV
Kinase AqueK115.AA S_TKc 11-184 19 9.1e-14 24.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-184
Range on HMM: 1-231/231
Sequence Identity: 19% (50 aa)

YMVYGYTGQGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMAELEILKKLNATDPDDKFHCIRLFSNFFHKNHLCLVFESMSM---NIREVLRKYGK
| .    |.| |. | ..|... . ..||||||.      .. . |..||||       .  . ..|.  | . .||..|.| ..    . .....|.|.
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

---NIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKLMLKLCDFGSASFIQDNEITPYLVSRFYRAPE---------------------
   . ...   .|.| .|...||. . .  |.| |.||.|||..|    .|.||||.| ..     | . ....|.|||                     
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEM

------------------------------------------------------I
                                                      .
LCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK115.AA GSK 11-41 28 3e-06 14.29 In-house 1-38 (328) Show / Hide 
Range on Protein: 11-41
Range on HMM: 1-38/328
Sequence Identity: 28% (11 aa)

YMVYGYTGQGVFSNVVRARDTSR--SSQEV-----AIK
|  .   |.|.|..|..| ..|    ..|.     |||
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIK
Kinase AqueK115.AA CLK 155-184 46 0.000163 8.66 In-house 187-218 (350) Show / Hide 
Range on Protein: 155-184
Range on HMM: 187-218/350
Sequence Identity: 46% (15 aa)

KLCDFGSAS-FIQDNEITPYLVS-RFYRAPEI
.. |||||    .|.|  . .|| | |||||.
CVIDFGSATKIRFDHEHHSTIVSTRHYRAPEV
Kinase AqueK115.AA TyrKc 11-184 13 0.000257 -152.85 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-184
Range on HMM: 1-280/280
Sequence Identity: 13% (41 aa)

YMVYGYTGQGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMAELEILKKL--NATDPDDKFHCIRLFSNFFHK-------NHLCLVFESMSM-NIRE
       | | |  |.... .    ..||.| ....   ..  | |..|..||  .        . .||.    ..         |..|.| |.  . ..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHP------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

VLRKYGKNIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKLMLKLCDFGSASFIQDN-----------------EI-------------
 |||....  |  |   |.. |         .  . | |.   |.||.| .   | .||| . .| |                  .              
YLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

--------------------------TPYLV------------------SRFYRAPE-------------------------------------I
                          .||                     |  . |.                                     .
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF