Gene AqueK071 (A.queenslandica)

AqueK071

Species: A.queenslandica
Alias: AqueK071
External Links:
Annotation:

Classification

Group: CAMK
Family: DAPK
Subfamily: DAPK

Sequence

Name Sequence Type Origin Length Description Download
AqueK071.AA Protein None 1031 None Fasta, JSON
AqueK071.kin_dom Protein Kinase Domain None 257 None Fasta, JSON

Protein domain

Protein domains of AqueK071.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK071.AA DAPK 21-275 48 6.00000000001e-167 464.05 In-house 1-264 (264) Show / Hide 
Range on Protein: 21-275
Range on HMM: 1-264/264
Sequence Identity: 48% (127 aa)

VGAELGRGKFAIVKRVTEKASGEQFAAKFLRKRRGGKA----CRDDIIVEVDIMRQSMGHHRIIKLREVFESPREMIIIIELATGGELFRMIAV---DPL
 | |||||.||.|.....| .|...||||..||| |.     || .|. |. | ... ||...| | ||.|   ..|.| |...|||||  ..    . |
MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREECL

PEDKARGVVLQLLEGVEHLHSLSIVHLDLKPENILLYRKGQLD--IRIADFGLALQIAPGEQVKTLVGTAEYVAPEILNYEPLSVAADMWSIGALTYALL
 |. |.  . | |||| .|||..|.||||||.||.|  ..  .  | | ||||.  | .|| ..  .||.|||||||.|||||| |.|||||| .|| .|
CEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIML

TGYSPFQGETHSDTFCNVSMCEYDFEDEVFDEVSQEAKDFIEELLQKKPSDRLTATKCLSHPWM
.| ||| |.|   || |.| . |||..| |. .|..|||||  || |.| .|.||..||.|||.
SGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI
Kinase AqueK071.AA MLCK 19-275 45 4.6e-146 387.97 In-house 1-257 (257) Show / Hide 
Range on Protein: 19-275
Range on HMM: 1-257/257
Sequence Identity: 45% (119 aa)

YDVGAELGRGKFAIVKRVTEKASGEQFAAKFLRKRRGGKACRDDIIVEVDIMRQSMGHHRIIKLREVFESPREMIIIIELATGGELFRMIAVDP--LPED
|... ||||||| || |..||..| ..|||| . |.. .  ....  |..||.|   |...|.. . ||...||. | |. .|||||. |  .   | | 
YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKD--KENVKNEIEIMNQ-LHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTER

KARGVVLQLLEGVEHLHSLSIVHLDLKPENILLYRKGQLDIRIADFGLALQIAPGEQ-VKTLVGTAEYVAPEILNYEPLSVAADMWSIGALTYALLTGYS
  . .. |..|||.|.|.  |||||||||||..  .   .| | ||||| .. |.|  ||.. || |.||||. ||.|.... ||||.| ..| ||.|.|
EVIHYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTSHQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLS

PFQGETHSDTFCNVSMCEYDFEDEVFDEVSQEAKDFIEELLQKKPSDRLTATKCLSHPWM
|| |..  .|..||..||.||.||.||..|.||||||. || |....|.||. || ||| 
PFMGDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL
Kinase AqueK071.AA DAPK 19-275 47 4.3e-132 383.32 In-house 1-264 (264) Show / Hide 
Range on Protein: 19-275
Range on HMM: 1-264/264
Sequence Identity: 47% (125 aa)

YDVGAELGRGKFAIVKRVTEKASGEQFAAKFLRKRRGGKA----CRDDIIVEVDIMRQSMGHHRIIKLREVFESPREMIIIIELATGGELFRMIAV-DPL
||.| |.| | ||.||...||  |...|||| .|||        .|.||  || | |.  ||. || | .|.|   . ..| || .|||||  ..  . |
YDMGEEIGSGQFAVVKKCREKSTGKEYAAKFIKKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKECL

PEDKARGVVLQLLEGVEHLHSLSIVHLDLKPENILLYRKGQLD--IRIADFGLALQIAPGEQVKTLVGTAEYVAPEILNYEPLSVAADMWSIGALTYALL
 |. |   . | |.|| |.||. |.|.||||||| |  ..     |.| ||||| .| ||. .| ..||.|.||||| |||||. ..||||||  || ||
NEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYILL

TGYSPFQGETHSDTFCNVSMCEYDFEDEVFDEVSQEAKDFIEELLQKKPSDRLTATKCLSHPWM
 | ||| |.|   |. |..  .|.|..| | . |. |||||  || | |  |.|   || ||| 
SGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI
Kinase AqueK071.AA DRAK 21-275 46 1.4e-122 382.9 In-house 1-259 (259) Show / Hide 
Range on Protein: 21-275
Range on HMM: 1-259/259
Sequence Identity: 46% (120 aa)

VGAELGRGKFAIVKRVTEKASGEQFAAKFLRKRRGGKACRDDIIVEVDIMRQSMGHHRIIKLREVFESPREMIIIIELATGGELFR---MIAVDPLPEDK
 . |.||||||.| .  .| .|. |||||..||| |. || .|. |. ..  . .  ..| | ||.|   ||| . |.|.|||.|        . . |  
TAKERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKD

ARGVVLQLLEGVEHLHSLSIVHLDLKPENILLYRKGQL-DIRIADFGLALQIAPGEQVKTLVGTAEYVAPEILNYEPLSVAADMWSIGALTYALLTGYSP
.. .. | ||||  ||. .|||||||| ||||     . ||.| |||..  |  || |  . || .|||||||||.|...| |||||| ||| .||. ||
VQRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHISP

FQGETHSDTFCNVSMCEYDFEDEVFDEVSQEAKDFIEELLQKKPSDRLTATKCLSHPWM
| |..   || |.| |  |. .| |. .|..| |||  |. .|| ||.||..||.|||.
FVGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL
Kinase AqueK071.AA CAMK 24-275 24 2e-109 353.87 In-house 1-425 (425) Show / Hide 
Range on Protein: 24-275
Range on HMM: 1-425/425
Sequence Identity: 24% (105 aa)

ELGRGKFAIVKRVTEKASG------------EQFAAKFLRKRRGG--------------------------KACRDDIIVEVDIMRQSMG------HHRI
.|||| |..||....| ..            ...|.|.. |..                               |. .  |..||..  |      |  |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLREVFESPR-------------------EMIIII---ELATGGEL----FRMIAV----------------DPLPEDKARGVVLQLLEGVEHLHSLSI
||| ||.|.|.                   .|...    |...||||    | .|                    ..|. || .. |....|...||. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHLDLKPENILLYRKGQ---------------LDIRIADFGLALQIAP------------------------GEQVKTLVGTAEYVA-PEILNY------
||.|||||||||  ..                 .| |.|||.| .. |                        |.  || .|| ||.| ||.||.      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------EPLSVAADMWSIGALTYALLTGYSPFQGE-------------THSDTFCNVSMCEYDFEDEVFDEVS--------------------QEAKD
        .. . ..||||.| ..|..|.||.||.|.             . ...| ..  ..|||... |...|                    ||.||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FIEELLQKKPSDRLTATKCLSHPWM
.|  .||. |..|.|.. ||.||||
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase AqueK071.AA CAMK1 19-275 40 5.3e-106 309.14 In-house 1-276 (276) Show / Hide 
Range on Protein: 19-275
Range on HMM: 1-276/276
Sequence Identity: 40% (112 aa)

YDVGAELGRGKFAIVKRVTEKAS---GEQFAAKFLR-KRRGGKACR---DDIIVEVDIMRQS--MGHHRIIKLREVFESPREMIIIIELATGGELF-RMI
| .| |.||| |..|...|.| .   |.|.| | .  |.   |  .   . .  |..||...    |  |||. |..||...  .. || |||||| | .
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

AVDPLPEDKARGVVLQLLEGVEHLHSLSIVHLDLKPENILLYRK-GQLDIR--IADFGLALQIAPGE-QVKTLVGTAEYVAPEILNY---EPLSVAADMW
  .   |..|| .. |.|. ||..||. ||| ||||||.|.| |  . .|.  ||||||. .. ..|   || .|| .|||||.|..   .| . | |||
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMW

SIGALTYALLTGYSPFQGET-HSDTFCNVSMCEYDFEDEVFDEVSQE-AKDFIEELLQKKPSDRLTATKCLSHPWM
|||  || ||.||.||..|. ..  |  .. |||.|    .|..| . |||||  .| . |. |.|...|| ||| 
SIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase AqueK071.AA Trio 19-275 37 2.3e-105 271.01 In-house 1-258 (258) Show / Hide 
Range on Protein: 19-275
Range on HMM: 1-258/258
Sequence Identity: 37% (98 aa)

YDVGAELGRGKFAIVKRVTEKASGEQFAAKFLRKRRGGKACRDDIIVEVDIMRQSMGHHRIIKLREVFESPREMIIIIELATGGELF-RMIAVDPLPEDK
|.. .|.||| |..|.|...||.|  .||||  .|  .|.       | ... |.  | ... | . .|.||  |.| ||...|||  ..   . . |..
YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFIPYRMMDKE---QVYHEYEML-QHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRWGSYCESE

ARGVVLQLLEGVEHLHSLSIVHLDLKPENILLYRKGQ--LDIRIADFGLALQIAPG--EQVKTLVGTAEYVAPEILNYEPLSVAADMWSIGALTYALLTG
 .. . |.||.|  ||.  | |||.||||...        .|.|.||| | |. |.  |    . |. | .||||.. .| | ..| ||||.||| .|.|
VKTYMWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSG

YSPFQGETHSDTFCNVSMCEYDFEDEVFDEVSQEAKDFIEELLQKKPSDRLTATKCLSHPWM
.||| .|   .|  |.    ..|... |  |||.||.||  .||  |. | .|  ||.||| 
ISPFYDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF
Kinase AqueK071.AA S_TKc 19-275 32 3.4e-90 306.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-275
Range on HMM: 1-231/231
Sequence Identity: 32% (88 aa)

YDVGAELGRGKFAIVKRVTEKASGEQFAAKFLRKRRGGKACRDDIIVEVDIMRQSMGHHRIIKLREVFESPREMIIIIELATG--GELFRMIAVDP----
|... ..|.| |. |.....| .|...| | ..         ..|. |..|...  .|  |.|| .||..  .. .. |.. |  |.||..|   .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPEDKARGVVLQLLEGVEHLHSLSIVHLDLKPENILLYRKGQLDIRIADFGLALQIAPGEQVKTLVGTAEYVAPEILNYEPLSV-AADMWSIGALTY
   .||  || .. |.....|..||. |.| ||||||||| .     | |.||||| |.      .|..|| .|.|||.|   . .  ..|.||.| . |
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ALLTGYSPFQGETHSDTFCNVSMCEYDFEDEVFDEVSQEAKDFIEELLQKKPSDRLTATKCLS-------HPWM
 .|.|| ||.  ..  .| ..               |.||||||. .||| |..|.|| ..|        |||.
EMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK071.AA Pkinase 19-275 29 2.2e-88 304.74 Pfam 1-293 (293) Show / Hide 
Range on Protein: 19-275
Range on HMM: 1-293/293
Sequence Identity: 29% (87 aa)

YDVGAELGRGKFAIVKRVTEKASGEQFAAKFLRKRRGGKACRDDIIV--EVDIMRQSMGHHRIIKLREVFESPREMIIIIELATGG----ELFRMIA---
| .|  .|.| |. |.. ..| .|...| | ..||.  . ..   .   |. ||.   .|  |..|...||..... .. |.. ||    .||..|    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

VDPL--PEDKARGVVLQLLEGVEHLHSLSIVHLDLKPENILLYRKGQL--DIRIADFGLALQ--IAPGEQVKTLVGTAEYVAPEILN-YEPLSVAADMWS
  ..  .|. .. ...|.|.|.|..|| .|.| ||||||||. ..|..  ...|.||||| |  . ...  .|..|| .|.|||... ... . ..||||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

IGALTYALLTGYSPFQGE------THSDTFCNVSMCEYDFEDEVFDEVS-----------------QEAKDFIEELLQKKPSDRLTATKCLSHPWM
.| . | .|.|. ||.|.      ..   .|.. .....|. .  ...|                 .|.||||. .|.|.|..|.||. .| |||.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK071.AA Ciliate-E2a 19-275 34 3.6e-81 238.66 In-house 1-275 (275) Show / Hide 
Range on Protein: 19-275
Range on HMM: 1-275/275
Sequence Identity: 34% (96 aa)

YDVGAELGRGKFAIVKRVTEKASGEQFAAK-FLRKRRGGKACRDDIIVEVDIMRQSMGHHRIIKLREVFESPREMIIIIELATGGELF-RMIAVDPLPED
|..  ..| |.|. |. .. |  |.|||.| | .| .  |  .  .. |..|||| . |  |||| ||.|. .   .. |.  ||||. ...  . . | 
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQ-LDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE

--KARGVVLQLL-EGVEHLHSLSIVHLDLKPENILLY---RKG--QLDIRIADFGLALQI--APGEQVKTLVGTAEYVAPEILNYEP------LSVAADM
  ... .  ||| .|....|.. |.| ||||||||.     ..  ..|| |.||||| .|    ...... .||. |||||.||..        ..  ||
IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDM

WSIGALTYALLTGYSPFQGETHSDTFCNVSMCEYDFEDEV-FDEVSQEAKDFIEELLQKKPSDRLTATKCLSHPWM
||.|.  | ||.|..||.|.|..... ..  |..||.. . . ..|.|.||..  .|.| |. |.||. .| |||.
WSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase AqueK071.AA RSK 19-275 30 1.5e-70 240.71 In-house 1-278 (278) Show / Hide 
Range on Protein: 19-275
Range on HMM: 1-278/278
Sequence Identity: 30% (84 aa)

YDVGAELGRGKFAIVKRVTEKASGEQFAAKFLRKRRGGKACRD--DIIVEVDIMRQSMGHHRIIKLREVFESPREMIIIIELATGGELFRMIAVDPL---
  |  ..| ||. .....| ...| ..| | |.|.   .. .|  .   |..|.  . .|  |..| ..|. . .  .| |.  |||||. .        
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

-PEDKARGVVLQLLEGVEHLHSLSIVHLDLKPENILLYRKG-QLDIRIADFGLALQ-IAP-GEQVKTLVGTAEYVAPEILN---YEP-LSVAADMWSIGA
  || |. .  ..   |||||.. |.| ||||||||.  .  .  |.. |||.. |  .  ... .| ..|.||.|||.|.    .   . |.| || |.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LTYALLTGYSPFQG---ETHSDTFCNVSMCEYDFEDEVFDEVSQEAKDFIEELLQKKPSDRLT-----ATKCLSHPWM
| | .|||..||||   ..........  ...... .  ...||||||.|  .|.. |..||.     |   ..|||.
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase AqueK071.AA CAMK-Unique 19-275 22 2.2e-69 228.14 In-house 1-363 (363) Show / Hide 
Range on Protein: 19-275
Range on HMM: 1-363/363
Sequence Identity: 22% (82 aa)

YDVGAELGRGKFAIVKRVTEKASGEQFAAKFLRKRRGGKACRDD------------------IIVEVDIMRQSMGHHRIIKLREV----FESPR------
|. .  .| | | .|.... .. |  .| | ..| . |   ..                      |..|. .. .|..|||| ..    |. ..      
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIW-KMVDHPNIIKLYDWNNPIFCDRKYPLCDL

---------EMIIIIELATGGELFRMIAV---------------------DPLPE--DKARGVVLQLLEGVEHLHSLSIVHLDLKPENILLYRKGQ----
         .| |. |...||.||  |.                       .. |    .. ....||. |...||..||| |||.|||...  ..    
IIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNH

----------LDIRIADFGLALQIA-PGEQ--VKTLVGTAEYVAP--------------EILN----YEPLSVAADMWSIGALTYALLTGYSPFQGETHS
          ..| ..||||. ..    .    .| .|| .|.||              |..|     ...| |.| ||.|...| .|.|..|| .|.  
HRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECED

--------DTFCNVSMCEY-DFEDEVFDE---VSQEAKDFIEELLQKKPSDRLTATKCLSHPWM
         .| . . ..| .|. ....    .|||||||.. ... .|. |..|   |.|.| 
RDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase AqueK071.AA TyrKc 19-275 21 1.8e-11 -37.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-275
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

YDVGAELGRGKFAIVKRVTEKASGEQFAAKFLRKRRGGKACRDDIIVEVDIMRQS-MGHHRIIKLREVFESP-------REMIIIIELATGGEL--FRMI
   | .||.| | .| . | |   .| | | |..       | |.. |  ||..    |  |..|  |  ..         . |. |.. .| |  .   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

AVDPLPEDKARGVVLQLLEGVEHLHSLSIVHLDLKPENILLYRKGQLDIRIADFGLALQIAPG------EQVKTLVG--TAE------YVAPEILNYEPL
  . |. ..     .|  .| |.|||  ..| ||   |.|. ...   ..|.||||.  |  .      .....  .   .         ||| .||   
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SVAADMWSIGALTYALLT-GYSPFQG-----ETHSDTFCNVSMCEYDFEDEV-----FDEVSQEAKDFIEELLQKKPSDRLTATKCLSHPWM
. . | || | . . ..| | .|  |      . .. . .|   ..    .      | . ..|  . ...  . .|.|| | . .  |  .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF