Gene AqueK044 (A.queenslandica)

AqueK044

Species: A.queenslandica
Alias: AqueK044
External Links:
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: ATR

Sequence

Name Sequence Type Origin Length Description Download
AqueK044.AA Protein None 512 None Fasta, JSON

Protein domain

Protein domains of AqueK044.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

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Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK044.AA ATR 257-450 47 5e-86 292.11 In-house 76-267 (267) Show / Hide 
Range on Protein: 257-450
Range on HMM: 76-267/267
Sequence Identity: 47% (93 aa)

AVIPLSEDSGLVEWVDNTTGYRPILQTTYQEKGMYTSGVDVKKLLPKDSDKRNKKVLKDIFVNKILPRHPPVLGEWFMKAFPDPTSWYSSSQSFARTAAV
||||| ......|||.|| . ||||.  ..||..|  . ....   | | .  .|    .| . .||||||.  .|| . ||||..|||| . . |. ||
AVIPLNDQCCIIEWVNNTATLRPILDKLWKEKKQYMQFYQLRQCMDKKSREEWEKQ--KVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAV

MSIVGYMVGLGDRHGENILIDCTNGDVVHVDFSYLFNKGLTLEVPEIVPFRLTHNMVDAMGVTKYEGTFRISCEMTMKLMRQQRDPLMCVLKTL
...|||..||||||..|||||  ||..||||.  .||.| ..||||||||||||||| .||  | .| ||  || .|..||..||..| |... 
WCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase AqueK044.AA PIKK 257-450 35 4.6e-80 272.29 In-house 75-290 (290) Show / Hide 
Range on Protein: 257-450
Range on HMM: 75-290/290
Sequence Identity: 35% (78 aa)

AVIPLSEDSGLVEWVDNTTGYRPILQTTYQEKG------------------------MYTSGVDVKKLLPKDSDKRNKKVLKDIFVNKILPRHPPVLGEW
.|||.|  .||.|||||... ..|.  ..|.|.                         |. ..... . ....   .|. ..  .....   .|... .|
SVIPMSQRCGLIEWVDNCVTLKEIYKQWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNT---PPDMFKKW

FMKAFPDPTSWYSSSQSFARTAAVMSIVGYMVGLGDRHGENILIDCTNGDVVHVDFSYLFN-KGLTLEVPEIVPFRLTHNMVDAMGVTKYEGTFRISCEM
|.  ||||..|... ....|. |||..|||  ||||||.|||.|| ..|..||.|| ..|. .. .|.|||.||||||.|||.|||... || || .|| 
FWRKFPDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEH

TMKLMRQQRDPLMCVLKTL
.|..|||.|..|| |....
VMMCMRQHRETLMTVCEVF
Kinase AqueK044.AA PI3Kc 232-505 24 1.2e-64 221.97 SMART 1-336 (336) Show / Hide 
Range on Protein: 232-505
Range on HMM: 1-336/336
Sequence Identity: 24% (82 aa)

TMMCKPKDDLRKDCRLMEFNTVINK------------------AVIPLSEDSGLVEWVDNTTGYRPILQTTYQEKGMYTSGV------------------
 ...|..||||.|.| |... ..||                  ..||.....|..||| |..  ..|. . . .|.|. ..                   
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

-----DVKKLLPKDSDKRNKKVLKDIFVNKILPRHPPVLGEWFMKAFPDP-TSWYSSSQSFARTAAVMSIVGYMVGLGDRHGENILIDCTNGDVVHVDFS
     . ... .   .... . ||. |  .. | .|||| .||.. ||||  .|...   |.|  |....|.|. |.||||..||..|...| ..|.|| 
MIWHQQACHWMMMYQHMTHMEWLKY-FEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

YLFNKGLTLEVP-----EIVPFRLTHNMVDAMG----VTKYEGTFRISCEMTMKLMRQQRDPLMCVLKTLIHDPL-VEWVVKTSRSQSSDKGVKIV-SDI
..|..| .....     | |||||||.||..||    ...|.| ||  |. ....||.... .|... ....||.  .|  .  . .   .         
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSD

DERLQGKTG----KTLPLS------EATDIDNLCQMY
.|..|  .     | .. |      .. ..... ..|
EEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase AqueK044.AA PI3_PI4_kinase 258-460 29 5.7e-61 213.67 Pfam 72-300 (300) Show / Hide 
Range on Protein: 258-460
Range on HMM: 72-300/300
Sequence Identity: 29% (68 aa)

VIPLSEDSGLVEWVDNTTGYRPILQTTYQEKGMYT----SGVDVKKLLPKDSDKRNKKVLKDIFVNKILPRHPPVLGEWFMKAFPDP-TSWYSSSQSFAR
.||.....|..|||.|.|. ..|. |.. ....       .. .|. . .....| .||.  .| ..| . ..|.| .||.| .||. . | .. . |.|
CIPTGPWCGMIEWVPNCTTFHEIPRTYMVKCKHKHFNKEHKMWMKMWPDWWHLMRMQKVE--VFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVR

TAAVMSIVGYMVGLGDRHGENILI--DCTNGDVVHVDFSYLFN--KGLTLEVPEIVPFRLTH------NMVDAM------GVTKYEGTFRISCEMTMKLM
  |.|..|.|. |.||||..||..  |.|.| ..|.|| . |.  |. ....|| ||||.||      .||.||      ......|.|| .|. .. ..
SCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRAL

RQQRDPLMCVL-------KTLIHDPLVEWVV
|.. . .|..|        ...||.|..|  
RRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase AqueK044.AA ATM 327-458 44 1e-41 130.81 In-house 117-248 (304) Show / Hide 
Range on Protein: 327-458
Range on HMM: 117-248/304
Sequence Identity: 44% (59 aa)

PVLGEWFMKAFPDPTSWYSSSQSFARTAAVMSIVGYMVGLGDRHGENILIDCTNGDVVHVDFSYLFNKGLTLEVPEIVPFRLTHNMVDAMGVTKYEGTFR
||   . |  | ||  |.     . |  |  |||||..||||||  ||||     ..||.|    | .|  |  || ||||||  .|| ||.|  || ||
PVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFR

ISCEMTMKLMRQQRDPLMCVLKTLIHDPLVEW
  || ||  ||   . |. .   |. ||| .|
RCCEKTMEVMRNSQETLLTIVEVLLYDPLFDW
Kinase AqueK044.AA FRAP 350-460 41 5.9e-35 122.46 In-house 140-251 (251) Show / Hide 
Range on Protein: 350-460
Range on HMM: 140-251/251
Sequence Identity: 41% (46 aa)

FARTAAVMSIVGYMVGLGDRHGENILIDCTNGDVVHVDFSYLFNKGLTLE-VPEIVPFRLTHNMVDAMGVTKYEGTFRISCEMTMKLMRQQRDPLMCVLK
. |  |.||..||. ||||||  ||...   | .||.||   |   .. |  || .|||||  .| || ..  ||..|. ||. || .| ... .| || 
YTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLE

TLIHDPLVEWVV
  . |||  | .
AFVYDPLFYWRL
Kinase AqueK044.AA SMG1 340-402 57 6.6e-26 82.68 In-house 180-242 (242) Show / Hide 
Range on Protein: 340-402
Range on HMM: 180-242/242
Sequence Identity: 57% (36 aa)

PTSWYSSSQSFARTAAVMSIVGYMVGLGDRHGENILIDCTNGDVVHVDFSYLFNKGLTLEVPE
|  |.   ||.||  ||||.|||..|||||| .|.||| | |.|||.|.   | ||  | |||
PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase AqueK044.AA ATR 201-256 64 1.3e-24 80.39 In-house 2-57 (267) Show / Hide 
Range on Protein: 201-256
Range on HMM: 2-57/267
Sequence Identity: 64% (36 aa)

SIVSFDDRVDILNSLQRPKKVIILASDGNRYTMMCKPKDDLRKDCRLMEFNTVINK
 |  ||| |.|| |||.|||. .  |||  | ||||||||||||||.|.|| .||.
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINF
Kinase AqueK044.AA DNAPK 350-460 33 2.1e-22 78.23 In-house 190-301 (301) Show / Hide 
Range on Protein: 350-460
Range on HMM: 190-301/301
Sequence Identity: 33% (37 aa)

FARTAAVMSIVGYMVGLGDRHGENILIDCTNGDVVHVDFSYLFN-KGLTLEVPEIVPFRLTHNMVDAMGVTKYEGTFRISCEMTMKLMRQQRDPLMCVLK
|.|. ||  | ..  | |||| .| ..   |||.. .|| . |   .. | |||  |||||   .  |   |  | .. .    |. .|..|  |.    
FIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCD

TLIHDPLVEWVV
  | ||.. |. 
VFINDPSFDWKN
Kinase AqueK044.AA PIKK 201-256 35 7.4e-22 76.59 In-house 1-56 (290) Show / Hide 
Range on Protein: 201-256
Range on HMM: 1-56/290
Sequence Identity: 35% (20 aa)

SIVSFDDRVDILNSLQRPKKVIILASDGNRYTMMCKPKDDLRKDCRLMEFNTVINK
 | ..|..| .. ..|.||| .|. .||  | ..||...|||.|.|.|... ..|.
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNT
Kinase AqueK044.AA FATC 493-512 70 4.5e-11 38.5 Pfam 14-33 (33) Show / Hide 
Range on Protein: 493-512
Range on HMM: 14-33/33
Sequence Identity: 70% (14 aa)

SEATDIDNLCQMYIGWGPYL
.||||..||||||||| |..
QEATDPENLCQMYIGWCPWW
Kinase AqueK044.AA SMG1 209-255 38 7.8e-08 21.88 In-house 1-47 (242) Show / Hide 
Range on Protein: 209-255
Range on HMM: 1-47/242
Sequence Identity: 38% (18 aa)

VDILNSLQRPKKVIILASDGNRYTMMCKPKDDLRKDCRLMEFNTVIN
. ||    .|||.. | |||  |  . |  .||  | |.| |  ..|
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVN
Kinase AqueK044.AA DNAPK 201-246 41 1.7e-07 23.19 In-house 3-48 (301) Show / Hide 
Range on Protein: 201-246
Range on HMM: 3-48/301
Sequence Identity: 41% (19 aa)

SIVSFDDRVDILNSLQRPKKVIILASDGNRYTMMCKPKDDLRKDCR
 |  ||.|| .. || |||..||   |      . |   ||| | |
RIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQR
Kinase AqueK044.AA DNAPK 258-288 45 0.000583 10.09 In-house 78-108 (301) Show / Hide 
Range on Protein: 258-288
Range on HMM: 78-108/301
Sequence Identity: 45% (14 aa)

VIPLSEDSGLVEWVDNTTGYRPILQTTYQEK
.||.    ||.||||||   . ||  ..|.|
IIPMTNRLGLIEWVDNTVVLKDILNNEMQQK
Kinase AqueK044.AA PI3_PI4_kinase 230-256 21 0.000595 16.31 Pfam 1-52 (300) Show / Hide 
Range on Protein: 230-256
Range on HMM: 1-52/300
Sequence Identity: 21% (11 aa)

RYTMMCKPKDDLR--KDCRLMEFN-----------------------TVINK
 | ...| .||||  .|.|.|..                        ...||
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNK
Kinase AqueK044.AA FRAP 257-273 47 0.010778 5.9 In-house 46-62 (251) Show / Hide 
Range on Protein: 257-273
Range on HMM: 46-62/251
Sequence Identity: 47% (8 aa)

AVIPLSEDSGLVEWVDN
..|||| ..||. || .
SIIPLSMNTGLIGWVHH
Kinase AqueK044.AA FRAP 231-256 34 0.03013 4.24 In-house 2-27 (251) Show / Hide 
Range on Protein: 231-256
Range on HMM: 2-27/251
Sequence Identity: 34% (9 aa)

YTMMCKPKDDLRKDCRLMEFNTVINK
|  . | ..|.| | | |     ||.
YHFLLKGHEDIRQDERVMQLFGLINR
Kinase AqueK044.AA SMG1 257-275 52 0.234631 0.07 In-house 67-85 (242) Show / Hide 
Range on Protein: 257-275
Range on HMM: 67-85/242
Sequence Identity: 52% (10 aa)

AVIPLSEDSGLVEWVDNTT
.| ||   |||. |||  |
SVTPLGTRSGLIQWVDGAT