Gene AqueK195 (A.queenslandica)

AqueK195

Species: A.queenslandica
Alias: AqueK195
External Links:
Annotation: Secondary Group: Other, Secondary Family: PEK, Secondary Subfamily: GCN2

Classification

Group: Other
Family: PEK
Subfamily: GCN2

Sequence

Name Sequence Type Origin Length Description Download
AqueK195.AA Protein None 1403 None Fasta, JSON
AqueK195.kin_dom Protein Kinase Domain None 431 None Fasta, JSON
AqueK195.kin_dom2 Protein Kinase Domain None 266 None Fasta, JSON

Protein domain

Protein domains of AqueK195.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RWD AqueK195.AA RWD 5-124 25 6.5e-22 82.95 Pfam 1-119 (119) Show / Hide 
Range on Protein: 5-124
Range on HMM: 1-119/119
Sequence Identity: 25% (32 aa)

SYEERQRDELEFLQFVFMSDFEDMREKDTWKIQRPPEIMIKLTPQKSISTSVQRLQISVKLHAKYSSDYP-DTPPQLD-LIEPHLLS---KDLVKELLTE
 ..|.| |||| |.  .. |||| | .  |.  .|... ||.      ..  .    ...|| ....||| |.||... . . ..|.   .. ...|...
MCQEEQEDELEALESIYPDDFEDLRGTICWTEISPWHFTIKI------DECESSHHPPLVLHFQCPEDYPSDEPPIISIISC-WNLHKLPDYQIQQLCKK

INDLAKSRI-GEVMMLEIAQHVQSFL
....... . |.||  |.....| .|
LQEYWEENCHGMVMIFEWIEWLQENL
RWD AqueK195.AA RWD 12-127 24 2.2e-20 74.93 SMART 1-128 (128) Show / Hide 
Range on Protein: 12-127
Range on HMM: 1-128/128
Sequence Identity: 24% (32 aa)

DELEFLQFVFMSDFEDMREKDTWKIQRPPEIMIKLTPQKSI---------STSVQRLQISVKLHAKYSSDYPDTPPQLDLIEPH-LLSKDLV--KELLTE
.||| |. ....|||. .|   . . ....| |...|.            .. . .  ....|| . . .|||..|...|..|.  ||.. .  .||...
MELEALESIYPDDFECIDEDRHHWV-INCCIQIHIHPHEDEMQITNYDNFYE-GEDHYWCITLHFHCPENYPDEAPPIFLENPQKWLSDEQKYYQELQKH

INDLAKSR--IGEVMMLEIAQHVQSFLHKH
......    .|..|. |..|.||.||  |
LQEIWEENWCRGMCMIFEWVQWVQEFLSEH
Kinase AqueK195.AA GCN2 318-407 29 9.7e-14 44.09 In-house 262-350 (511) Show / Hide 
Range on Protein: 318-407
Range on HMM: 262-350/511
Sequence Identity: 29% (27 aa)

HSSIVKYLLMRHNLTEHGILVEVTMEYITGGSLNSLLQGSSSSPITGKS-LQLYSKQLLEAVAYLHSQGIVHNDIRPSLVFIDPVQGVKLA
| ..|.|..|. .  . ....   |||. |..| ...  ......  .  |  |  |.||...|.||||..| |..|| .|.|  . || .
HKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYI--DNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIG
Kinase AqueK195.AA STE11 342-391 45 2.6e-12 41.09 In-house 92-142 (303) Show / Hide 
Range on Protein: 342-391
Range on HMM: 92-142/303
Sequence Identity: 45% (23 aa)

MEYITGGSLNSLLQ-GSSSSPITGKSLQLYSKQLLEAVAYLHSQGIVHNDI
|||. |||| |.|. .      . .  . | ||.||...||||.||.| ||
MEYCPGGSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDI
Kinase AqueK195.AA STE 342-407 27 2.9e-10 32.59 In-house 116-189 (359) Show / Hide 
Range on Protein: 342-407
Range on HMM: 116-189/359
Sequence Identity: 27% (22 aa)

MEYITGGSLNSLLQ---GSSS---------SPITGKSLQLYSKQLLEA-VAYLHSQGIVHNDIRPSLVFIDPVQGVKLA
|||. |||| ....   |            ...  . .  . .|.|..  .||||..|.| || |. ...     |||.
MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLC
Kinase AqueK195.AA Pkinase 342-407 26 6e-10 36.25 Pfam 79-154 (293) Show / Hide 
Range on Protein: 342-407
Range on HMM: 79-154/293
Sequence Identity: 26% (20 aa)

MEYITGG----SLNSLLQGSSSSPI--TGKSLQLYSKQLLEAVAYLHSQGIVHNDIRPSLVFIDPVQGV----KLA
|||  ||    .| ........ ..  . . .. | .|.|....|.||.||.| |. |. ..||    .    |..
MEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC
Kinase AqueK195.AA Ciliate-E2 342-407 23 1.6e-09 28.88 In-house 113-198 (365) Show / Hide 
Range on Protein: 342-407
Range on HMM: 113-198/365
Sequence Identity: 23% (22 aa)

MEYITGGSLNSLLQGS----------SSSPITGKSLQLYSKQLLE---------------AVAYLHSQG-IVHNDIRPSLVFIDPVQGVKLA
|||. ||.| .... .             ..| |  . ..||.|.               |. ||||.. |.| || |. ...     .|..
MEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKII
Kinase AqueK195.AA PEK 372-399 50 4.3e-09 27.02 In-house 434-461 (655) Show / Hide 
Range on Protein: 372-399
Range on HMM: 434-461/655
Sequence Identity: 50% (14 aa)

KQLLEAVAYLHSQGIVHNDIRPSLVFID
.|.||...|.||||..| |..|| .|.|
RQILEGLNYIHSQGMIHRDLKPSNIFLD
Kinase AqueK195.AA STE-Unique 342-407 25 9.2e-07 19.43 In-house 373-452 (616) Show / Hide 
Range on Protein: 342-407
Range on HMM: 373-452/616
Sequence Identity: 25% (21 aa)

MEYITGGSLNSLLQGSSSSP---------ITGKSLQLYSKQLLEAVAYLHSQG--IVHNDIRPSLVFIDPVQ-----GVKLA
|||  .|.|  ...  ....         .       | .|.||.  |||||.  |.| |. |. .|..  .      ||..
MEYCEHGTLQQIIK--RCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKIC
Kinase AqueK195.AA WEE 373-398 37 2e-06 17.65 In-house 119-145 (297) Show / Hide 
Range on Protein: 373-398
Range on HMM: 119-145/297
Sequence Identity: 37% (10 aa)

QLLEAVAYLHSQ-GIVHNDIRPSLVFI
.........||. |.||.|| |. .||
DICQGLHHIHSNCGMVHMDIKPENIFI
Kinase AqueK195.AA PEK 372-397 46 3e-06 15.63 In-house 449-474 (758) Show / Hide 
Range on Protein: 372-397
Range on HMM: 449-474/758
Sequence Identity: 46% (12 aa)

KQLLEAVAYLHSQGIVHNDIRPSLVF
.|..|.| |.|| |. | |  || .|
HQICEGVNYIHSKGMIHRDLKPSNIF
Kinase AqueK195.AA Pkinase_Tyr 342-388 30 0.000406 14.57 Pfam 86-134 (270) Show / Hide 
Range on Protein: 342-388
Range on HMM: 86-134/270
Sequence Identity: 30% (15 aa)

MEYITGGSLNSLLQGS--SSSPITGKSLQLYSKQLLEAVAYLHSQGIVH
|||  .|.| . |.    .  |.| | |  .. |  .. .||.|....|
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH
Kinase AqueK195.AA STE20 340-391 28 0.000917 9.98 In-house 85-143 (288) Show / Hide 
Range on Protein: 340-391
Range on HMM: 85-143/288
Sequence Identity: 28% (17 aa)

VTMEYITGGSLNSLLQGS-SSS------PITGKSLQLYSKQLLEAVAYLHSQGIVHNDI
. |||  ||||  ..... .        |.. .      ...|.. .||||..|.| ||
IVMEYCGGGSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDI
Kinase AqueK195.AA NEK 373-406 27 0.053097 3.31 In-house 122-164 (286) Show / Hide 
Range on Protein: 373-406
Range on HMM: 122-164/286
Sequence Identity: 27% (12 aa)

QLLEAVAYLHSQ-----GIVHNDIRPSLVFIDPVQG----VKL
|.. |. |.|..      |.| || |. .|..        ||.
QMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKI
Kinase AqueK195.AA STE 465-500 47 5.8e-14 45.8 In-house 322-359 (359) Show / Hide 
Range on Protein: 465-500
Range on HMM: 322-359/359
Sequence Identity: 47% (18 aa)

VPEHFSEDFKDFLNKCLNNNEYQRYPAHELLV--HPFI
.|...|..||||.||||. .  .|  |..||   ||||
YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase AqueK195.AA STE11 462-500 40 1.3e-12 42.14 In-house 259-303 (303) Show / Hide 
Range on Protein: 462-500
Range on HMM: 259-303/303
Sequence Identity: 40% (18 aa)

PPDVPEHFS------EDFKDFLNKCLNNNEYQRYPAHELLVHPFI
.|  |||.|      |. .|||..|.  . . |. |..|| ||||
HPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase AqueK195.AA GCN2 437-500 23 1.2e-10 33.06 In-house 430-511 (511) Show / Hide 
Range on Protein: 437-500
Range on HMM: 430-511/511
Sequence Identity: 23% (19 aa)

GKKTDILKL-GMVIFCMSVGRVTVSYP----------PDVPEHFS-------EDFKDFLNKCLNNNEYQRYPAHELLVHPFI
..| |.  | | ..| |. .   ....          . .|. |        .|..|....||| .. .|. | .|| |.|.
NQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLRSCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase AqueK195.AA STE20 466-500 45 2.1e-10 34.51 In-house 254-288 (288) Show / Hide 
Range on Protein: 466-500
Range on HMM: 254-288/288
Sequence Identity: 45% (16 aa)

PEHFSEDFKDFLNKCLNNNEYQRYPAHELLVHPFI
|...| .|.||..|||. .  .|  | .|| ||||
PHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase AqueK195.AA NEK 461-500 28 5.2e-10 31.84 In-house 245-286 (286) Show / Hide 
Range on Protein: 461-500
Range on HMM: 245-286/286
Sequence Identity: 28% (12 aa)

YPPDVPEH--FSEDFKDFLNKCLNNNEYQRYPAHELLVHPFI
..| .|.|  .|.| .......|. .  ||. . ..| .|||
QYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase AqueK195.AA Pkinase 461-500 23 3.6e-07 26.43 Pfam 235-293 (293) Show / Hide 
Range on Protein: 461-500
Range on HMM: 235-293/293
Sequence Identity: 23% (14 aa)

YPPDVPEHFS-------------------EDFKDFLNKCLNNNEYQRYPAHELLVHPFI
.. | |.  |                   |..|||...||. . ..|. |...| ||..
LHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK195.AA PEK 462-500 30 4.4e-07 19.89 In-house 613-655 (655) Show / Hide 
Range on Protein: 462-500
Range on HMM: 613-655/655
Sequence Identity: 30% (13 aa)

PPDVP-EHFSED---FKDFLNKCLNNNEYQRYPAHELLVHPFI
| | | ..|  .   ..||....|...  ||. | ..| |.|.
PGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase AqueK195.AA Ciliate-E2 459-500 16 2e-06 18.07 In-house 305-365 (365) Show / Hide 
Range on Protein: 459-500
Range on HMM: 305-365/365
Sequence Identity: 16% (10 aa)

VSYPPD--------------VPEHFSEDFKDFLNK----CLNNNEYQRYP-AHELLVHPFI
...|.                ... |.. ||...|    .|. .. .|.  . ..| ||..
IDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase AqueK195.AA STE-Unique 462-500 31 0.000147 11.46 In-house 573-616 (616) Show / Hide 
Range on Protein: 462-500
Range on HMM: 573-616/616
Sequence Identity: 31% (14 aa)

PP-----DVPEHFSEDFKDFLNKCLNNNEYQRYPAHELLVHPFI
||     . |. .. .. .|. |||. |  .| .||.|| |.. 
PPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase AqueK195.AA WEE 462-500 25 0.09244 1.77 In-house 258-297 (297) Show / Hide 
Range on Protein: 462-500
Range on HMM: 258-297/297
Sequence Identity: 25% (10 aa)

P-PDVPEHFSEDFKDFLNKCLNNNEYQRYPAHELLVHPFI
| |.... .|...|...   .. .  ||  . .|| || .
PFPEFDNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL
Kinase AqueK195.AA GCN2 775-938 42 1.5e-61 210.81 In-house 278-466 (511) Show / Hide 
Range on Protein: 775-938
Range on HMM: 278-466/511
Sequence Identity: 42% (82 aa)

QSQYLYIQMEYCSNQTLKVLIDSGQLVKSPGFELGWQLFREITEGLAHIHSQGMIHRDLKPVNIFLNSSGHCKIGDFGLATT------------------
...|||||||||.. ||. .||.. ..  .  || |..||.| |||..|||||||||||||.|||| ..|. |||||||||.                  
EVHYLYIQMEYCEGKTLRQYIDNHGWCMDHD-EL-WRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQA

FSKYHTGLSRQQSIPSNT-SILAGDTG----------LVGTMLYLAPELLKSVVKYTQKVDMYSL-GIILYEMSHPPPATVMERVKILTDVRKK
.|..     ..|. ..|   . .....           ||| .| .||..    .|.|||||||| |||. ||..||  | ||||.||.. | .
SSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQ--KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR-S
Kinase AqueK195.AA PEK 769-942 32 1.3e-59 204.38 In-house 348-612 (655) Show / Hide 
Range on Protein: 769-942
Range on HMM: 348-612/655
Sequence Identity: 32% (85 aa)

KQKQTGQSQYLYIQMEYCSNQTLKVLIDSGQ-----------------------------------------LVKSPGFELGWQLFREITEGLAHIHSQG
... ..| .|||||||||.  ||. .||...                                           ..   .. |..||.| |||..|||||
HNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQG

MIHRDLKPVNIFLNSSGH-----CKIGDFGLATT---------------FSKYHTGLSRQQSIPSNTSILAGD--------------------------T
||||||||.|||| ..|.      |||||||||.               .|..   .  .. .... .    .                          |
MIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHT

GLVGTMLYLAPELLKSV----VKYTQKVDMYSLGIILYEMSHPPPATVMERVKILTDVRKKEIVF
| ||| || .||.|.       .|..||||||||||. ||..|.  | |||||.|||.|.  | |
GGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQF
Kinase AqueK195.AA STE 549-917 15 2e-47 163.9 In-house 1-261 (359) Show / Hide 
Range on Protein: 549-917
Range on HMM: 1-261/359
Sequence Identity: 15% (66 aa)

FEVLEVLGKGGFGDVIKVRNYL---------------DSRLYAIKKVRLTGGS----------------KMMTKLTREVELLSQMN--HENIVRYYNAWI
.| .|..|||.|| | | .|                   ...|||...|   .                . | .. .|.......|  |.|||.|| . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EKYSEPNHHGNEEEGEEFSDSSEDEDTTEEEEEEEEEREEGLSFIEFKLDESTTLNSSDQIRDDSYSFSSDVFTDTEDRDVFKGKVDTPGTNVATLLEAD
 .  .                                                                                               
KEGHN-----------------------------------------------------------------------------------------------

LMVTTPRRGFIHSESSDSVVFQDTSLMAPPGGEGEEGSTAAAGGGGGAGGGRAKQKQTGQSQYLYIQMEYCSNQTLKVLIDSGQLVKSPG----------
                                                         ... ..|.| |||... .|  .|..   .. |           
---------------------------------------------------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRF

-FELGWQLFREITEG-LAHIHSQGMIHRDLKPVNIFLNSSGHCKIGDFGLATTFSKYHTGLSRQQSIPSNTSI---LAGDTG---LVGTMLYLAPELLKS
  ..     |.| .| |...||.. ||||.|| ||.|     .|. |||... ... .... .     .| .|   . ..     .|||  . ||| .. 
PESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANI-Q-S---NN-IIDCIETMQQKRNTFVGTP-WMAPEVIQQ

-----VVKYTQKVDMYSLGIILYEM
     . .|. |.|..|||. . ||
NGQGRDKGYDTKCDIWSLGCTIIEM
Kinase AqueK195.AA PEK 549-674 29 8.6e-37 125.23 In-house 1-159 (655) Show / Hide 
Range on Protein: 549-674
Range on HMM: 1-159/655
Sequence Identity: 29% (48 aa)

FEVLEVLGKGGF-GDVIKVRNYLDSRLYAIKKVRLTGGS----------------KMMTKLTREVELLSQMNHENIVRYYNAWIEKY-------SEPNHH
||....|||||| |.|.||.| ||...||||...|   .                | ..| .||| .|...||.|||||.||||||        ....  
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

GNEEEGEEFSD---------SSEDEDTTEEEEEEEEEREEGL--SFIEFKLDESTTLNSSD
...... .. .          .|.|. ..||..|... .|    .. ..| ... . ||..
LDSSTDWPNGKHKSKDYNFHPFEKEW-DDEEAQESNVMSE-CEDREQKGKKKCWSESNSHS
Kinase AqueK195.AA S_TKc 549-990 15 5.6e-34 120.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 549-990
Range on HMM: 1-231/231
Sequence Identity: 15% (72 aa)

FEVLEVLGKGGFGDVIKVRNYLDSRLYAIKKVRLTGGSKMMTKLTREVELLSQMNHENIVRYYNAWIEKYSEPNHHGNEEEGEEFSDSSEDEDTTEEEEE
.|.|...|||.|| | |.|.  . |..|||...                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

EEEEREEGLSFIEFKLDESTTLNSSDQIRDDSYSFSSDVFTDTEDRDVFKGKVDTPGTNVATLLEADLMVTTPRRGFIHSESSDSVVFQDTSLMAPPGGE
                                                             .. | ...              . .|    .        
-----------------------------------------------------------EHIRREIQILKK----------HHPNIVKLYDVFQD-----

GEEGSTAAAGGGGGAGGGRAKQKQTGQSQYLYIQMEYCSN--QTLKVLIDSGQLVKSP---GFELGWQLFREITEGLAHIHSQGMIHRDLKPVNIFLNSS
                            ..||. ||||..   .|. .|.. .  . .        . ....| ..|...||.| ||||||| ||.|.. 
----------------------------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-

GHCKIGDFGLATTFSKYHTGLSRQQSIPSNTSILAGDTGLVGTMLYLAPELLKSVVKYTQ-KVDMYSLGIILYEMSH---PPPATVMERVKILTDVRKKE
 | ||.|||||. .                       | ..||  |.|||.|    .|.  |.|..|.|.|||||     | | ....  |..       
-HIKICDFGLARQL-----------------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG------

IVFSERFKTSKKMSKQAVEHTLQNPNSSQYKRLMEKLFSQE------NSKLFE-------MSFF
                          |.. | ...|..  .        ....       . .|
--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK195.AA Pkinase 776-917 32 2.1e-33 119.16 Pfam 72-205 (293) Show / Hide 
Range on Protein: 776-917
Range on HMM: 72-205/293
Sequence Identity: 32% (50 aa)

SQYLYIQMEYCSN-----QTLKVLI--DSGQLVKSPGFELGWQLFREITEGLAHIHSQGMIHRDLKPVNIFLNSSGHC----KIGDFGLATTFSKYHTGL
....|. |||| .         ..   ..| .      .     ...| .||...||.| ||||||| ||.... ||.    ||.|||||  |.      
KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY--FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------

SRQQSIPSNTSILAGDTGLVGTMLYLAPELLKSVVKYTQKVDMYSLGIILYEM
         .      |...||  |.|||....  .|..||||.|.|.|||||
---------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase AqueK195.AA GCN2 549-685 28 3.3e-33 113.42 In-house 1-180 (511) Show / Hide 
Range on Protein: 549-685
Range on HMM: 1-180/511
Sequence Identity: 28% (51 aa)

FEVLEVLGKGGFGDVIK-VRNYLDSRLYAIKKVRLTGGSKMMTK---LTREVELLSQMNHENIVRYYNAWIEKYSE--------------PNHHGNEEEG
||....|||||||.|.| ||| .|.|.||||| ..   ... ..    .|||.||.  .|...||||.|||||  |                | ..|.|.
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSDDESEC

EEFSDSSEDEDTTEEEEEEEEEREEGLSFIEFKLDE----STTLNSSD-------------QIR--------DDSYSFSS
.. ........  .||  ..||  |  . .|.  ..    .    ..|             . .        ||.||. .
FSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDDHYSYCH
Kinase AqueK195.AA Ciliate-E2 777-917 23 9.1e-32 106.32 In-house 107-289 (365) Show / Hide 
Range on Protein: 777-917
Range on HMM: 107-289/365
Sequence Identity: 23% (45 aa)

QYLYIQMEYCSNQTLKVLIDSGQLVKSPG--------FELGWQLFREITE---------------GLAHIHSQG-MIHRDLKPVNIFLNSSGHCKIGDFG
...|. ||||. ..|. .| . .. .            .   .....|..               .| ..||..  ||||.|| ||..     .|| |||
NNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFG

LAT---TFSKYHTGLSRQQSIPSNTSILAGDTG-------------LVGTMLYLAPELLKSVVK--------YTQKVDMYSLGIILYEM
|..   ......|...... ..   .   . .|             ..||  |.||| |..           |. |.|..|||.|||||
LSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase AqueK195.AA STE-Unique 779-917 26 5.6e-31 106.97 In-house 369-546 (616) Show / Hide 
Range on Protein: 779-917
Range on HMM: 369-546/616
Sequence Identity: 26% (48 aa)

LYIQMEYCSNQTLKVLIDSGQLVKSPG--------FE--LGWQLFREITEGLAHIHSQG--MIHRDLKPVNIFLNSSG-----HCKIGDFGLATTFSKYH
..|.||||.. ||...|..     ...        |.  .   . ..| ||| ..|||.   ||||||| |||....|     . ||.|||.||. .  |
VWIFMEYCEHGTLQQIIKR----CGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDH

T----GLSRQQSIPSNTSI------------------LAGDTGLVGTMLYLAPELLKSV----VKYTQKVDMYSLGIILYEM
      ..   .  . .                    . . ....||. | .|| .         |  |||..|||... .|
FEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHM
Kinase AqueK195.AA WEE 779-861 33 5.2e-23 74.09 In-house 80-190 (297) Show / Hide 
Range on Protein: 779-861
Range on HMM: 80-190/297
Sequence Identity: 33% (37 aa)

LYIQMEYCSN--QTLKVLIDSGQLVKS--PGFELGWQLFREITEGLAHIHSQ-GMIHRDLKPVNIFLNSSG--------------------HCKIGDFGL
.||||||| .    |  .| .    .   |  .. ||....| .||.||||. ||.| |.|| |||... .                     |||||||.
MYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMI-WQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGH

ATTFS----KYH
.|. .    ..|
VTDMNSNNNNPH
Kinase AqueK195.AA PEK 768-855 35 5.6e-23 72.52 In-house 403-514 (758) Show / Hide 
Range on Protein: 768-855
Range on HMM: 403-514/758
Sequence Identity: 35% (40 aa)

AKQKQTGQSQYLYIQMEYCSNQTLKVLIDSGQLVKSPGFELGWQLFREITEGLAHIHSQGMIHRDLKPVNIFLNSSGH----------------------
.| . ||.  |.||||..|  .||| ..      .|   ..   .|  | ||.  ||| ||||||||| |||. . .                       
WKMHPTGNCIYMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGH

--CKIGDFGLAT
   |||||||.|
QIIKIGDFGLVT
Kinase AqueK195.AA WEE 549-617 35 4.2e-22 71.0 In-house 1-77 (297) Show / Hide 
Range on Protein: 549-617
Range on HMM: 1-77/297
Sequence Identity: 35% (27 aa)

FEVLEVLGKGGFGDVIKVRNYLDSRLYAIKKV-RLTGGSKMMTKLTREVELLSQMN-------HENIVRYYNAWIEK
|......|.| ||.| |.|. .|...|||||  .   |..      |||. ...         |..|||||.||.|.
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEED
Kinase AqueK195.AA NEK 549-620 32 9.7e-22 73.62 In-house 1-79 (286) Show / Hide 
Range on Protein: 549-620
Range on HMM: 1-79/286
Sequence Identity: 32% (26 aa)

FEVLEVLGKGGFGDVIKVRNYLDSRL-----YAIKKVRLTGGSKMMTKLTR--EVELLSQMNHENIVRYYNAWIEKYSE
.|.....|.| || | |||   |..      |..||. ... |   .. .   || .|.|..|.|||.||...||. ..
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNN
Kinase AqueK195.AA PEK 549-652 29 2.6e-21 66.85 In-house 1-131 (758) Show / Hide 
Range on Protein: 549-652
Range on HMM: 1-131/758
Sequence Identity: 29% (39 aa)

FEVLEVLGKGGFGDVIKVRNYLDSRLYAIKKVRLTG--------GSKMMTKLTREVELLSQMNHENIVRYYNAWIEKY------------SEPNHHGNEE
||. ..||.|||| | .. | .|  .||||....           ..   |  |||  |   .| |||||.||| |              |     |   
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLETPELLPPNNKMRSTSFSTVNGKQI

EGEEFSDSSED---ED----TTEEEEEEEEE
...   | ...   .|    ..|.|.| |.|
DSNNDNDIYNNHFFFDGNWGQDEDEDEYENE
Kinase AqueK195.AA STE20 814-917 34 3.4e-21 74.42 In-house 124-220 (288) Show / Hide 
Range on Protein: 814-917
Range on HMM: 124-220/288
Sequence Identity: 34% (37 aa)

REITEGLAHIHSQGMIHRDLKPVNIFLNSSGHCKIGDFGLATTFSKYHTGLSRQQSIPSNTSILAGDTGLVGTMLYLAPELLKSV----VKYTQKVDMYS
||. .||...||...||||.|  || |...| .|. |||..  ..|   .    .. . ||        .|||  ..|||... .     .|..|.| .|
REVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHG-R-D-TMQFKRNT--------FVGTPYWMAPEVIQCMEGPDKGYDYKCDIWS

LGIILYEM
||| . ||
LGITAIEM
Kinase AqueK195.AA STE20 549-617 27 9.2e-17 58.04 In-house 1-76 (288) Show / Hide 
Range on Protein: 549-617
Range on HMM: 1-76/288
Sequence Identity: 27% (21 aa)

FEVLEVLGKGGFGDVIKVRNYLDSRL----YAIKKVRLTGGS---KMMTKLTREVELLSQMNHENIVRYYNAWIEK
.| ||..|.|..|.| |...    ..    .||||. |   .   ...  .  |.  ..| .|.|||.||.. . .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKD
Kinase AqueK195.AA STE-Unique 550-617 27 2.8e-16 53.82 In-house 1-73 (616) Show / Hide 
Range on Protein: 550-617
Range on HMM: 1-73/616
Sequence Identity: 27% (20 aa)

EVLEVLGKGGFGDVIKVRNYLDSRLYAIKKVRLTGGS--K---MMTKLTREVELLSQMNHENIVRYYNAWIEK
.  . .|.|.|| | . .|  |.. .|||...| . .  .   .  .. .|.|...  .|.|||.|| .|...
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWG
Kinase AqueK195.AA Pkinase 549-617 25 8.4e-16 56.96 Pfam 1-72 (293) Show / Hide 
Range on Protein: 549-617
Range on HMM: 1-72/293
Sequence Identity: 25% (18 aa)

FEVLEVLGKGGFGDVIKVRNYLDSRLYAIKKVRLTGGSKMMTKLTR---EVELLSQMNHENIVRYYNAWIEK
.......|.|.|| | | ..  .....|.|.... . .. . .  |   |....  .||.||||.| .. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDK
Kinase AqueK195.AA NEK 775-859 27 3.5e-15 50.25 In-house 77-175 (286) Show / Hide 
Range on Protein: 775-859
Range on HMM: 77-175/286
Sequence Identity: 27% (30 aa)

QSQYLYIQMEYCS-NQTLKVLIDSGQLVKSPGFELGWQ-----LFRE---------ITEGLAHIHSQ-----GMIHRDLKPVNIFLNSSGH----CKIGD
|...|.| ||||  . .|  .| |          .  |     .| |         .  .| ..|..       .|||.|| ||||....      ||||
QNNCLCIVMEYCEGGGDLYQKIKS----------IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGD

FGLATTFSK
||..  ...
FGISKVLNH
Kinase AqueK195.AA STE11 814-917 32 5.2e-15 50.96 In-house 123-231 (303) Show / Hide 
Range on Protein: 814-917
Range on HMM: 123-231/303
Sequence Identity: 32% (38 aa)

REITEGLAHIHSQGMIHRDLKPVNIFLNSSGH-CKIGDFGLATTFSKYHTGLSR-----------QQSIPSNTSILAGDTGLVGTMLYLAPELLKSVVK-
. | |||.  ||.| ||||.|. ||.|.| |. ||..||| |. ... .|  .            . .. .         . .||  . ||| .|   . 
KQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYN---------SMMGTPMWMAPEVIKQEGRD

-YTQKVDMYSLGIILYEM
 |. |.|  ||| . .||
GYGRKADIWSLGCTVIEM
Kinase AqueK195.AA PEK 881-937 36 7.4e-15 44.87 In-house 646-717 (758) Show / Hide 
Range on Protein: 881-937
Range on HMM: 646-717/758
Sequence Identity: 36% (26 aa)

TGLVGTMLYLAPELLKSV---------------VKYTQKVDMYSLGIILYEMSHPPPATVMERVKILTDVRK
|. ||| || .|| ..                   |. ||| ||||.|. |. ||   | |||.....|.|.
TVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLRN
Kinase AqueK195.AA STE11 549-611 30 5e-14 47.36 In-house 1-76 (303) Show / Hide 
Range on Protein: 549-611
Range on HMM: 1-76/303
Sequence Identity: 30% (23 aa)

FEVLEVLGKGGFGDVIKVRNYLDSRLYAIKKVRLTGGS-------KMMTK------LTREVELLSQMNHENIVRYY
.   |..||| || | | .|    .|.|.|.... . .       |.. .      .  |..|....||.||||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYY
Kinase AqueK195.AA Ciliate-E2 549-617 19 1.5e-12 39.42 In-house 1-104 (365) Show / Hide 
Range on Protein: 549-617
Range on HMM: 1-104/365
Sequence Identity: 19% (20 aa)

FEVLEVLGKGGFGDVIKVRNYLDSR-----------------------LYAIKKVRLTGGSKMMTKLT--REVE----------LLSQMNHENIVRYYNA
.......|.|.||.| |...... .                       .||.| ..  .   .. ..   ||..          .|.|.|| ||...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WIEK
..||
FQEK
Kinase AqueK195.AA TyrKc 549-961 11 3.9e-10 -58.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 549-961
Range on HMM: 1-280/280
Sequence Identity: 11% (55 aa)

FEVLEVLGKGGFGDVIKVRNYLDSRLYAIKKVRLTGGSKMMTKLTREVELLSQM--NHENIVRYYNAWIEK-----YSEP------------------NH
 . ...|| | || | | . .   .  |.|...       .  . || .....   .|.|||| | . ...     |.||                  .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

HGNEEEGEEFSDSSEDEDTTEEEEEEEEEREEGLSFIEFKLDESTTLNSSDQIRDDSYSFSSDVFTDTEDRDVFKGKVDTPGTNVATLLEADLMVTTPRR
...                                                                                                 
RPK-------------------------------------------------------------------------------------------------

GFIHSESSDSVVFQDTSLMAPPGGEGEEGSTAAAGGGGGAGGGRAKQKQTGQSQYLYIQMEYCSNQTLKVLIDSGQLVKSPGFELGWQLF----REITEG
                                                                                    | .. .      | .|
------------------------------------------------------------------------------------LCMKDLLSFCWQIACG

LAHIHSQGMIHRDLKPVNIFLNSSGHCKIGDFGLATTFSKY-HTGLSRQQSIPSNTSILAGDTGLV----GTM--L---YLAPELLKSVVKYTQKVDMYS
 ...||.. |||||   |. ... ...||.||||.     . ..|              ..|.  .    |.   |    .||| .    |.| | | .|
MEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-------------ESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVWS

LGIILYEM----SHPPPA-----TVMERVKILTDVRKKEIVFSE---------------------RFKTSKKMSKQAVEHTL
 |. ..|.      |.|         ..|  . . ..      .                     ... ..  . ... . .
FGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK195.AA NEK 883-917 45 4.6e-09 28.47 In-house 184-217 (286) Show / Hide 
Range on Protein: 883-917
Range on HMM: 184-217/286
Sequence Identity: 45% (16 aa)

LVGTMLYLAPELLKSVVKYTQKVDMYSLGIILYEM
.|||  |..||...   .|..|.|. ||| .||||
QVGTPYYMSPEVCQ-NKPYNNKSDIWSLGCVLYEM
Kinase AqueK195.AA Pkinase_Tyr 814-854 39 1.1e-07 26.61 Pfam 118-158 (270) Show / Hide 
Range on Protein: 814-854
Range on HMM: 118-158/270
Sequence Identity: 39% (16 aa)

REITEGLAHIHSQGMIHRDLKPVNIFLNSSGHCKIGDFGLA
..| .|... .|...|||||   |. .......||.|||||
WQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase AqueK195.AA Pkinase_Tyr 549-611 25 2.9e-05 18.44 Pfam 1-70 (270) Show / Hide 
Range on Protein: 549-611
Range on HMM: 1-70/270
Sequence Identity: 25% (18 aa)

FEVLEVLGKGGFGDVIKVRNY----LDSRLYAIKKVRLTGGSKM--MTKLTREVELLSQM-NHENIVRYY
 . ...||.| ||.| | . .     .    |.|... .  ..   . .. ||.....|. .|.||||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase AqueK195.AA WEE 889-917 41 0.008895 5.23 In-house 199-229 (297) Show / Hide 
Range on Protein: 889-917
Range on HMM: 199-229/297
Sequence Identity: 41% (13 aa)

YLAPELLKS--VVKYTQKVDMYSLGIILYEM
|.|||.|       .  | | .|||| .||.
YMAPEILQGYYHYTHLYKADIFSLGITIYEL
Kinase AqueK195.AA Pkinase_Tyr 890-917 32 0.614508 3.8 Pfam 181-207 (270) Show / Hide 
Range on Protein: 890-917
Range on HMM: 181-207/270
Sequence Identity: 32% (9 aa)

LAPELLKSVVKYTQKVDMYSLGIILYEM
.||| ..  . .| | | .| |. ..|.
MAPECINYGK-FTTKSDVWSFGVLMWEI