Gene CC1G_04741 (C.cinerea)
CC1G_04741
Species: C.cinerea
Alias: CC1G_04741
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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CC1G_04741.AA | Protein | None | 725 | None | Fasta, JSON |
CC1G_04741.NA | RNA | None | 2178 | None | Fasta, JSON |
CC1G_04741.kin_dom | Protein Kinase Domain | None | 288 | None | Fasta, JSON |
Protein domains of CC1G_04741.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | CC1G_04741.AA | TKL | 422-703 | 20 | 4.9e-47 | 162.58 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 422-703 Range on HMM: 1-364/364 Sequence Identity: 20% (75 aa) VAFGTFSDVWEGTWKDPIEKRD-----TAVAVKFLRQ--AMVKNVKER--------------------LIRRIQAEVATWHKLCHRNVSQFFGIVQSANS . |.|. |. |.|. . . . |||| ... . .. ... . .. |. ..|.| |. || |.... .. IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC -------------FGMVSPWYCNGIISEYVRKNPGVDR-LKLLIQVASGIGHLHSFS------PPIVHGDLKGGNILIDACGA--------------AII ...| .. .| .|. .. ... ...|.|. .||| |||.| ||| |||.| . . | GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI TDFGLSKVMEETLTEVCEEDGGA------VSGRGTSVFAGSTRWMAPELIMALVEDDDNGG-----PGPKITPMSDVYAFGSVCLEIATDELPYSHRRTD .|||||..|... . . .. ... |. |..||||||... .... | .| . .. .|||.|| | ||.| ..||.. . CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYM HAV---------TLDIIRGILPTRKDTCL-----VKGVDE-DRFWQLLERCWSLDVTLRPTMIEALHWL . ... .| |....... .. | ... .|...||. | . ||.. | |..| PMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | CC1G_04741.AA | S_TKc | 422-703 | 18 | 2.6e-28 | 101.31 | SMART | 7-231 (231) | Show / Hide |
Range on Protein: 422-703 Range on HMM: 7-231/231 Sequence Identity: 18% (56 aa) VAFGTFSDVWEGTWKDPIEKRDTAVAVKFLRQAMVKNVKERLIRRIQAEVATWHKLCHRNVSQFFGIVQSANSFGMVSPWYCN--GIISEYVRKN----- . |.|. |. ...|. . ||.| .. ..|. |.. .| | |. ..... |. ... || . | .| .|. IGKGAFGKVYKCRHKK----TGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ----PGVDRLKLLIQVASGIGHLHSFSPPIVHGDLKGGNILIDACGAAIITDFGLSKVMEETLTEVCEEDGGAVSGRGTSVFAGSTRWMAPELIMALVED | . ... |..... ..|| |.| ||| |||.| |.||||.... . | |. .||||.. RFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------------------TTFCGTPWYMAPEVL------ DDNGGPGPKITP-MSDVYAFGSVCLEIATDELPYSHRRTDHAVTLDIIRGILPTRKDTCLVKGVDEDRFWQLLERCWSLDVTLRPTMIEALH-------- . .. .|....| . | .. . |.. ........|. . .......|. | . ||| |||. --------GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH -WL |. PWF |
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Kinase | CC1G_04741.AA | Pkinase | 425-703 | 19 | 1e-27 | 99.08 | Pfam | 10-293 (293) | Show / Hide |
Range on Protein: 425-703 Range on HMM: 10-293/293 Sequence Identity: 19% (62 aa) GTFSDVWEGTWKDPIEKRDTAVAVKFLRQAMVKNVKERLIRRIQAEVATWHKLCHRNVSQFFGIVQSANSFGMVSPWYCNG----IISEYVR--KNPGV- |.|. |.....|. . |||| .. | |.. ||. .|.. ..|.| |. ........ .. || .. .| ..|.. .. .. GSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY ----DRLKLLIQVASGIGHLHSFSPPIVHGDLKGGNILIDACGAA----IITDFGLSKVMEETLTEVCEEDGGAVSGRGTSVFAGSTRWMAPELIMALVE . . . |...|. ..|| |.| ||| ||||| | |.||||.|... ... ...|.|. ..||||.|. FSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------------Y-NNS-MTTFCGTPWYMAPEVIR---- DDDNGGPGPKITPMSDVYAFGSVCLEIATDELPYSHR--RTDHAVTLDIIRGILPTRKDTCLVKGVDE------------------DRFWQLLERCWSLD |....| .|....| .. | .. ..|.... . . . .|. |.... . . .. . . .....|. .| ------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD VTLRPTMIEALHW--L . ||| ..|. . PKKRPTAEQILQHPWF |
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Kinase | CC1G_04741.AA | TK | 425-703 | 15 | 5.5e-26 | 83.46 | In-house | 10-486 (486) | Show / Hide |
Range on Protein: 425-703 Range on HMM: 10-486/486 Sequence Identity: 15% (76 aa) GTFS---DVWEGTWKDPIEKRD---------------------TAVAVKFLRQAMVKNVKERLIR------------RIQAEVATWH--KLCHRNVSQFF | | .|..|.|.... .. | |||| |. . .|.. . . .| . . .. | |. ... GQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLY GIVQSA------------NSFGMVSPWYCNGI----ISEYVRKNPGV----------------------------------------------------- |.. . .| . ..| .| ||... GVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHP --------------------------DRLKLLIQVASGIGHLHSFSP----PIVHGDLKGGNILIDACGA-----------AIITDFGLSKVME--ETLT ..| |.|.| .||| .||.|| |.|.. . . |.|||||.... . PPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARD EVCEEDGGAVSGRGTS-------------------VFAGSTRWMAPELIMALVEDDD--NGGPGPKITPMSDVYAFGSVCLEIATDE-LPYSHRRTD--- ..| ..|..||. |||||| .. |. .| | |. |||..|| .. || | || .. IYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYG----KFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDV ------HAVTLDIIRG--------------ILPTRKDTCLV--------KGVDEDRFWQLLERCWSLDVTLRPTMIEALHWL . | . || . . . | . .... . .|. .||..| |||. . .. | WKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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Kinase | CC1G_04741.AA | TKL-Unique | 519-645 | 33 | 3.6e-22 | 75.08 | In-house | 112-236 (290) | Show / Hide |
Range on Protein: 519-645 Range on HMM: 112-236/290 Sequence Identity: 33% (47 aa) RLKLLIQVASGIGHLHSFSPPIVHGDLKGGNILIDAC-----GAAIITDFGLSKVME-ETLTEVCEEDGGAVSGRGTSVFAGSTRWMAPELIMALVEDDD |.|. |..|.| .||. .||| |.||| |.|.| . | ||||||. .. . . | |. ... ||.||||||... . RVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR-----NQTRCGSFRWMAPEVLRMNF---- NGGPGPKITPMSDVYAFGSVCLEIATDEL------PYSH ... ||||.|| | |||| .. ||.. -----CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQG |
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Kinase | CC1G_04741.AA | CAMK | 421-577 | 13 | 1.2e-17 | 52.82 | In-house | 1-280 (425) | Show / Hide |
Range on Protein: 421-577 Range on HMM: 1-280/425 Sequence Identity: 13% (38 aa) AVAFGTFSDVWEGTWK-DPIEKR-------DTAVAVKFLRQAMVKN-----------------------VKERLIRRIQAEVATWHK-------LCHRNV |.|. | ... | .. ..| . ||.|.. .|. .... .... |.. | | |.|. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI SQFFGIVQSANS-------------------FGMVS---PWYCNG----IISEYVRKNPGV------------DRL------KLLIQVASGIGHLHSFSP ... . .... . || .| . .|...... |. .. |..|.. ..|| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN- PIVHGDLKGGNILIDAC-----------------GAAIITDFGLSKVMEE--------------------------TLTEVC ||| ||| |||.| . |.|||....... ....| -IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFC |
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Kinase | CC1G_04741.AA | STE | 425-644 | 15 | 2.9e-17 | 57.63 | In-house | 10-269 (359) | Show / Hide |
Range on Protein: 425-644 Range on HMM: 10-269/359 Sequence Identity: 15% (44 aa) GTFSDVWEGTWKDPI-----------EKRDTAVAVKFLR-------------QAMVKNVKERLIRRIQAEVATWHKLC--HRNVSQFFGIVQSA------ |.| | . .... .. . .|.| .. | ...|. . . .|. |. . .|. | |. ...| GAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQ-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKN -NSFGMVSPWYCNGIISEYVRKNPGVDR-----------------LKLLIQVASG-IGHLHSFSPPIVHGDLKGGNILIDACGAAIITDFGLSKVMEETL .. .. . .| ... .... |. . . . |. | .||| |.| |.|..|||. . ..|||... ..... DDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGVCGQLTDSM TEVCEEDGGAVS-------GRGTSVFAGSTRWMAPELIMALVEDDDNGGPGPKITPMSDVYAFGSVCLEIATDELPYS .. . . . . . |.|. ||||| |. .. .. . .|.. .| ...| || . |.. ANI-Q-S-NN-IIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R----DKGYDTKCDIWSLGCTIIEMATGKPPWH |
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Kinase | CC1G_04741.AA | RIPK | 522-703 | 28 | 2.9e-15 | 48.45 | In-house | 112-290 (290) | Show / Hide |
Range on Protein: 522-703 Range on HMM: 112-290/290 Sequence Identity: 28% (54 aa) LLIQVASGIGHLHSFSPPIVHGDLKGGNILIDACGAAIITDFGLSKVMEET--LTEVCEEDGGAVSGRGTSVFAGSTRWMAPELIMALVEDDDNGGPGPK .. ....| ||| ||| | ||| .|||.|. . | ||||.. |. .. | |.. . | |.||.. .|| | MIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCN--QREVYSMKSKNRWGTLSYMPPEHFR-----TDNKKPIKV ITPMSDVYAFGSVCLEIATDELPYSHRRTDHAVTLDIIRGILPTRKDTCLVKGVDED----RFWQLLERCWSLDVTLRPTMIEALHWL .|| .||| |. | |. | ||. | .. . . .| | .. . .|. . .|..|||. | ||. .| | VTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPE--YWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT |
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Kinase | CC1G_04741.AA | TyrKc | 425-703 | 23 | 3e-14 | 7.64 | SMART | 10-280 (280) | Show / Hide |
Range on Protein: 425-703 Range on HMM: 10-280/280 Sequence Identity: 23% (71 aa) GTFSDVWEGTWKDPIEKRDTAVAVKFLRQAMVKNVKERLIRRIQAEVATWHKL--CHRNVSQFFGIVQSA-------NSFGMVSPWYCNGIISEYVRKNP | | |..|||| . |||| |. .. . | .|| | |. ...|.. . .| ..| .| ||. GAFGEVYKGTWK-------IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR G----VDRLKLLIQVASGIGHLHSFSPPIVHGDLKGGNILIDACGAAIITDFGLSKVMEET-LTEVCEEDGGAVSGRGTSVFAGSTRWMAPELIMALVED . | |. .|.|.| .||| ...| || |.|... . . |.|||||. .. . ..| ..... . . |||||| |. PKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECINYG--- DDNGGPGPKITPMSDVYAFGSVCLEIATDELPYSHR-----RTDHAVTLDIIRGILPTRKDTCLVKGV----DEDRFWQLLERCWSLDVTLRPTMIEALH | |. |||..|| .. || |. . .. | .. .| . . . . . | |. ..|| | |||. | . --------KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE WL . CF |
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Kinase | CC1G_04741.AA | Src-Echino1 | 416-703 | 23 | 7.9e-14 | 43.89 | In-house | 1-252 (252) | Show / Hide |
Range on Protein: 416-703 Range on HMM: 1-252/252 Sequence Identity: 23% (70 aa) LKGNWAVAFGTFSDVWEGTWKDPIEKRDTAVAVKFLRQAMVKNVKERLIRRIQAEVATWHKLCHRNVSQFFGIVQSANSFGMVSPWYCNGIISEYVRKNP |. . . | ...||.| |. .| |||| |.. . . . || |. |... |.. . . .| || . .|.... LRMDKKIGKGHCGEVWKGVWNG-----NTPVAVKTLKEKTMSPAD------FLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGK GV-DRLKLLI----QVASGIGHLHSFSPPIVHGDLKGGNILIDACGAAIITDFGLSKVMEETLTEVCEEDGGAVSGRGTSVFAGSTRWMAPELIMALVED . .. || ..|||...| | .|| || |.|.. | |||| ..|.. . | . | . .| ||| .. CKHVKMTTLIDMGAHIASGMDYLGSKN--VVHRDLAARNVLVGKGNVCKIADFGLARMMQK--DVYCGKQGAKL----------PIKWTAPEAALY---- DDNGGPGPKITPMSDVYAFGSVCLEIAT-DELPYSHRRTDHAVTLDIIRGILPTRKDTCLVKGVDEDRFWQL-LERCWSLDVTLRPTMIEALH-WL . | |||..|| . |. | .|| .. . |. . || . . | | ... . .|| | |||. | || .. -------GRFTIKSDVWSFGILMTEMVTFGRYPYPGMMN-REVLDQVDRGYRMPKMHHC------PDSLYMMCMMKCWHKDPQQRPTF-EFLHDFF |
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Kinase | CC1G_04741.AA | RAF | 525-705 | 25 | 8.7e-14 | 40.79 | In-house | 111-282 (282) | Show / Hide |
Range on Protein: 525-705 Range on HMM: 111-282/282 Sequence Identity: 25% (49 aa) QVASGIGHLHSFSPPIVHGDLKGGNILIDACGAAIITDFGLSKVMEETLTEVCEEDGGAVSGRGTSVFAGSTRWMAPELIM--------ALVEDDDNGGP ||. | ||. . |.| ||| ||. . |.|||| .| .|. . . . .. ||||| | .. |.| QVCQGMDYLHAKN--IIHRDLKSNNIFLHEDMTVKIGDFGLMTV--KTRWSPRGN-------QQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENP-- GPKITPMSDVYAFGSVCLEIATDELPY-SHRRTDHAVTLDIIRGILPTRKDTCLVKGVDEDRFWQLLERCWSLDVTLRPTMIEALHWLDG .. ||||.|| | |. | ..|| .| . . || | . . . . .|.| ||... || . |. .. ---YSFQSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDC--PKAMHRLMEDCWKFQREERPLFQQILKRITV |
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Kinase | CC1G_04741.AA | RAF | 594-645 | 39 | 7.3e-11 | 33.43 | In-house | 167-219 (275) | Show / Hide |
Range on Protein: 594-645 Range on HMM: 167-219/275 Sequence Identity: 39% (21 aa) GSTRWMAPELIMAL-VEDDDNGGPGPKITPMSDVYAFGSVCLEIATDELPYSH |.. |||||.|... .. | . . .. ||||||| | |. . |.||.| GWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDVYAFGTVWYELMAGEWPYQH |
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Kinase | CC1G_04741.AA | Pkinase_Tyr | 425-572 | 24 | 6.8e-10 | 34.14 | Pfam | 10-164 (270) | Show / Hide |
Range on Protein: 425-572 Range on HMM: 10-164/270 Sequence Identity: 24% (39 aa) GTFSDVWEGTWKDPIEKRDTAVAVKFLRQAMVKNVKERL--IRRIQAEVATWHKL-CHRNVSQFFGIVQ-SANS--FGMVSPWYCNGIISEYVRKN---- | | .|..||||. .. .. |||| |.. . .. .. .|... ..| | |. .. |.. . .| . ..| .| ||. GAFGEVYKGTWKGDPDNTKIPVAVKMLKE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDK ---PGVDRLKLLIQVASGIGHLHSFSPPIVHGDLKGGNILIDACGAAIITDFGLSKVMEET . | |. .|.|.| .|.| ..| || |.|.. . . |.||||.. .... QPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDIYND |
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Kinase | CC1G_04741.AA | DRK | 519-566 | 37 | 8.3e-07 | 19.12 | In-house | 100-147 (258) | Show / Hide |
Range on Protein: 519-566 Range on HMM: 100-147/258 Sequence Identity: 37% (18 aa) RLKLLIQVASGIGHLHSFSPPIVHGDLKGGNILIDACGAAIITDFGLS .... . .| |. ||. | |.| ||| | |.| . ||||| MKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLS |
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Kinase | CC1G_04741.AA | RAF | 525-568 | 40 | 1.9e-05 | 14.63 | In-house | 108-149 (275) | Show / Hide |
Range on Protein: 525-568 Range on HMM: 108-149/275 Sequence Identity: 40% (18 aa) QVASGIGHLHSFSPPIVHGDLKGGNILIDACGAAIITDFGLSKV |.. | . ||. |.|.||| ||... .||||||..| QICQGMDYLHAKN--IIHRDLKSKNIFLHNGKVVVITDFGLFTV |
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Kinase | CC1G_04741.AA | DRK | 678-705 | 39 | 2.4e-05 | 14.08 | In-house | 231-258 (258) | Show / Hide |
Range on Protein: 678-705 Range on HMM: 231-258/258 Sequence Identity: 39% (11 aa) FWQLLERCWSLDVTLRPTMIEALHWLDG . ||. .||. | . ||.| | | |. YIQLMNDCWNEDPQHRPSMQECLERLEA |
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Kinase | CC1G_04741.AA | DRK | 425-487 | 31 | 0.002249 | 7.33 | In-house | 10-64 (258) | Show / Hide |
Range on Protein: 425-487 Range on HMM: 10-64/258 Sequence Identity: 31% (20 aa) GTFSDVWEGTWKDPIEKRDTAVAVKFLRQAMVKNVK-ERLIRRIQAEVATWHKLCHRNVSQFFG | . .|. ||| | | |||| . |. | .. . |. .| | |. || | GNYGEVFRGTW------RGTQVAVK---MLFNHNINDENFLNEFHREINLMCQLRHPNICQFMG |
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Kinase | CC1G_04741.AA | TKL-Unique | 681-703 | 39 | 0.010448 | 5.59 | In-house | 268-290 (290) | Show / Hide |
Range on Protein: 681-703 Range on HMM: 268-290/290 Sequence Identity: 39% (9 aa) LLERCWSLDVTLRPTMIEALHWL |...|| | . ||. .| .| | LIQQCWHHDPSQRPSFDEIIHRL |
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Kinase | CC1G_04741.AA | Pkinase_Tyr | 597-638 | 35 | 0.013834 | 9.38 | Pfam | 179-209 (270) | Show / Hide |
Range on Protein: 597-638 Range on HMM: 179-209/270 Sequence Identity: 35% (15 aa) RWMAPELIMALVEDDDNGGPGPKITPMSDVYAFGSVCLEIAT .||||| |. . | |||..|| .. || | KWMAPECINYGK-----------FTTKSDVWSFGVLMWEIFT |