Gene rol-3 (Nematode worm)

rol-3

Species: Nematode worm
Alias: C16D9.2, CE30727, aSWK329, rol-3
External Links:
Annotation:

Classification

Group: TK
Family: Sev

Sequence

Name Sequence Type Origin Length Description Download
rol-3.AA Protein None 2364 None Fasta, JSON
rol-3.kin_dom Protein Kinase Domain None 270 None Fasta, JSON

Protein domain

Protein domains of rol-3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FN3 rol-3.AA FN3 1472-1571 13 1.2e-08 35.94 SMART 1-69 (69) Show / Hide 
Range on Protein: 1472-1571
Range on HMM: 1-69/69
Sequence Identity: 13% (16 aa)

PSAPRD---PHAIPVTPD------TVYLYWNLPETLNAPISEIKYKISQQAAGISVPTSIAVIALSETVSSNISSDTTSCLINPCRVKIANLRPS----N
|..|..   ... .||..      .| | |. |        .. |.                                        ... .|.|      
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR----------------------------------------YTVTGLKPGQYPWT

EYKFWVTAT----HISH
||.|.|.|     . . 
EYEFRVRAVNGNDAGEG
FN3 rol-3.AA FN3 1593-1680 17 6e-06 27.12 SMART 1-69 (69) Show / Hide 
Range on Protein: 1593-1680
Range on HMM: 1-69/69
Sequence Identity: 17% (18 aa)

LDVPGT---LRPDNVTGS------SLLLRWNGLEPEHRPSSIAVQYRESGGANNEWQFPMNVSFEPDVTTELVPITNLLSA----TSYDYRFVATYT--G
 . |.    ||  .|| .      |. |.|.  .|        |.||                         . .|.|       | | .| .| .   .
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWK--PP-------IVGYR-------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDA

TYT
 . 
GEG
FN3 rol-3.AA FN3 1706-1797 14 0.011179 14.22 SMART 1-69 (69) Show / Hide 
Range on Protein: 1706-1797
Range on HMM: 1-69/69
Sequence Identity: 14% (16 aa)

PTAPQF---VEAK-QDEE------GWIVTWKEPMSDGGSPITSYAVETRINKTAEWEIAERGLDGWKTWWRPGKSDTTSSTSTSST----EVSEFRIRAA
| .|.    ....  ..          ..||.|       |..|                                    |  .         |||.|| 
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR--------------------------------YTVTGLKPGQYPWTEYEFRVRAV

NI--EGFG
|    | |
NGNDAGEG
Kinase rol-3.AA TK-Unique 1849-2115 30 2.8e-118 399.26 In-house 1-294 (294) Show / Hide 
Range on Protein: 1849-2115
Range on HMM: 1-294/294
Sequence Identity: 30% (90 aa)

VTFNDYIDTCAYGIVHSGTAEEVPMSWEKDVRVAIKKLKPNHSFQEKMMFMKEAILLNNLD-HPNIVKELGVCITPG-QELILLEYMEGGNLLKFLQKST
....|.|...|.| |. |........|.|...||.|.|| |.....|..|.||. ....|. |||||. ||.|.... . .|..||...|||...|... 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PN-------------------EYQSSELSPRDLLSISVDIARGMNYLERLPH--VHKNLSARKCLLAGRPGVTKLEMGMSKELSN-GQVNRSDLENMEIV
|.                   ... ...||.||... ..||.||.||.....  ||..|.|| .||...  .    .||...... |...... ... ..
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMAPEVLK--DFQF-SSKSDVWAYGVLLYEVFSFGEVPYGDKDNRRIMTDVRNGSVLPIPSYCPSKRIYKVIKQCLTSDSTKRANFATILKIF
||||||.||  . .. ..|||||..|||..|.|..|. ||.. ....||...|.|. .| |..|.|...|...|.|.... ..| .|..|....
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase rol-3.AA TyrKc 1849-2115 29 5e-101 342.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 1849-2115
Range on HMM: 1-280/280
Sequence Identity: 29% (89 aa)

VTFNDYIDTCAYGIVHSGTAEEVPMSWEKDVRVAIKKLKPNHSFQEKMMFMKEAILLNNL--DHPNIVKELGVCITP-------GQELILLEYMEGGNLL
.|... .  .|.|.|. ||.          . ||.|.||...    ...||.|| .. .|  .|||||. .|||...       .. .|..|||..|.|.
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

KFLQKSTPNEYQSSELSPRDLLSISVDIARGMNYLERLPHVHKNLSARKCLLAGRPGVTKLEMGMSKELSNG-------QVNRS----DLENMEIVRWMA
..|.|. |.      |...||||....||.||.||.. . .|  | || ||.. .  |     |.|... ..       .. |.    .   |  .||||
DYLRKHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEVLKDFQFSSKSDVWAYGVLLYEVFSFGEVPYGD-----KDNRRIMTDVRNGSVLPIPSY-------CPSKRIYKVIKQCLTSDSTKRANFATILKIF
||....  |..|||||..||...|.|..|. || .     ..|.... .|..|  .|.| .       | .. .|...|||   |  .| .|..| ..|
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase rol-3.AA TK 1849-2115 17 6.6e-78 260.59 In-house 1-486 (486) Show / Hide 
Range on Protein: 1849-2115
Range on HMM: 1-486/486
Sequence Identity: 17% (83 aa)

VTFNDYIDTCAYG---IVHSGTAEEVP-------------------MSWEKDVRVAIKKLKP--NHSFQEKMM--------------FMKEAILLNN--L
.|. . .   ..|    |. |.... .                   .. .. ..||.| ||.  ..| .|...              .. |. ....  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHPNIVKELGVCITP------------GQELILLEYMEGGN----LLKFLQKSTPNEYQ-----------------------------------------
.|||||. .|||  .            .  .|..|||..|.    |...|.|. |.. .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------SSELSPRDLLS-------------------ISVDIARGMNYLERLPH------VHKNLSARKCLLAGRPG-------------VTKLEMG--
        ...|. .|||.                   ....||.|| ||....       || .| || ||.. .               ..   .   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----MSKELSNGQVNRSDL------------------------ENMEIVRWMAPEVLKDFQ---------FSSKSDVWAYGVLLYEVFSFG-EVPYGDKD
    ..... ...  ...                           .  .||||||.|.| .         |..|||||..|||..|.|..| | .||. .
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

N---------RRIMTDVRNG--------------SVLPIPSYCPS-------------KRIYKVIKQCLTSDSTKRANFATILKIF
|         . .|  .|.|                .| | .||.             . .| ...||   |  .| .|..... .
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase rol-3.AA UTK 1859-2115 28 6.3e-59 200.21 In-house 11-296 (296) Show / Hide 
Range on Protein: 1859-2115
Range on HMM: 11-296/296
Sequence Identity: 28% (82 aa)

AYGIVHSGTAEEVP--MSWEKDVRVAIKKLKPNHSFQEKMM----FMKEAI---LLNNLD-HPNIVKELGVCITPGQELILLEYMEGGNLLKFLQKSTPN
|.|.|| .......  |   ....||.|.... .. | ..     ||.||    .. ... |||... .|||   .. .|..||||.|.|...|....|.
AFGEVHKARFTQCSEHM---YEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPT

EY-QSSELSPRDLLSISVDIARGMNYLERLPHVHKNLSARKCLLAGRP------GVTKL-EMG---MSKELS-------NGQVNRSDLENMEI--VRWMA
   .   |. ...|. ..||||||.||..   || .| || ||..          | |.   |   ||....        .. . .   . ..  .||||
PPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMA

PEVLKDF-QFSSKSDVWAYGVLLYEVFSFGEVPYGDKDNRRIMTDVRNG--SVLPIPSYCPSKRIYKVIKQCLTSDSTKRANFATILKIF
||.| .  .|..|||||..||...|....| .||..  |... . |.||    .| |  ||  ..|.. ..| ..|  .| .| .... .
PEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCP-HPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase rol-3.AA Musk 1876-2115 32 1.4e-44 145.07 In-house 27-282 (282) Show / Hide 
Range on Protein: 1876-2115
Range on HMM: 27-282/282
Sequence Identity: 32% (83 aa)

EKDVRVAIKKLKPNHSFQEKMMFMKEAILLNNLDHPNIVKELGVCITPGQEL-ILLEYMEGGNLLKFLQ-------KSTPNEYQS----------SELSP
|... ||.| || . | | .| |  || ..   ||||||| ||||   |. .  |.|||  | |  ||.        | . . ..          ..|. 
EEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFV-GRPMCLLFEYMAYGDLNEFLHSCSPHRTCSRTHQDRGMRAQVSSPGPPQLKC

RDLLSISVDIARGMNYLERLPHVHKNLSARKCLLAGRPGVTKLEMGMSKELSNGQVNRSDLENMEIVRWMAPEVLKDFQFSSKSDVWAYGVLLYEVFSFG
 ..| .  .|| || ||     ||  |  | ||   .  |     |.|..       . . ..   .|||.|| . ..||.  ||||||||.| |.||..
YHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESIWYNQFTYESDVWAYGVCLWEIFSYA

EVPYGDKDNRRIMTDVRNGSVLPIPSYCPSKRIYKVIKQCLTSDSTKRANFATILKIF
. ||       ..  .|.| .|  |  || | .|.. ..|       |  |. | .. 
LQPYYGMTHEEVIYYIRQGNILSCPENCPQK-VYQLMRRCWQKNPADRPFFCQIHHCI
Kinase rol-3.AA TKL 1874-2115 21 2.3e-42 147.09 In-house 23-364 (364) Show / Hide 
Range on Protein: 1874-2115
Range on HMM: 23-364/364
Sequence Identity: 21% (77 aa)

SWEKDVRVAIKKLKPNHS------------------------FQEKMMFMKEAILL--NNLDHPNIVKELGVCITPGQE-------------LILLEYME
|  ..  ||.||.| ...                        ......| .|  ..  ..|.|||||. .|.|. |..               |  ||..
S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCP

GGNLLKFLQKSTPNEYQSSELSPRDLLSISVDIARGMNYLER--------LPHVHKNLSARKCLLAGR-------------PGVTKLE-MGMSKELSNGQ
||.|| .|.             .  ..... |||||||||           | .| .|  . .|.                ... |.  .| |...|. .
GGSLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSG

VNRSDL--------------ENMEIV---RWMAPEVLK----------------DFQFSSKSDVWAYGVLLYEVFS----FGEVPYGDKD-----NRRIM
 .                   .| ..   ||||||||.                 |..| |.||...|..|.|...    . . || . .        .|
NMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFM

TDVRNGSVLPIP---------SYCPSK--RIYKVIKQCLTSDSTKRANFATILKIF
 .. .|  .|||         . ||.   .. | ...|  .| .|| .| .|||..
MVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase rol-3.AA Pkinase_Tyr 1859-1992 35 2.3e-37 127.14 Pfam 11-145 (270) Show / Hide 
Range on Protein: 1859-1992
Range on HMM: 11-145/270
Sequence Identity: 35% (50 aa)

AYGIVHSGTAEEVPMSWEKDVRVAIKKLKPNHSFQE--KMMFMKEAILLNNL-DHPNIVKELGVCITPGQE---LILLEYMEGGNLLKFLQKSTPNEYQS
|.| |. ||.       .... ||.|.||.... ..  . .||.|| .. .| .|||||. .|||.  |.    .| .|||..|.||..|.|      . 
AFGEVYKGTWKG--DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR---EDK

SELSPRDLLSISVDIARGMNYLERLPHVHKNLSARKCLLA
  |.. |||.....||.||.|||. . .|  | || ||..
QPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT
Kinase rol-3.AA Pkinase_Tyr 2024-2115 37 2.3e-36 123.77 Pfam 178-270 (270) Show / Hide 
Range on Protein: 2024-2115
Range on HMM: 178-270/270
Sequence Identity: 37% (35 aa)

VRWMAPEVLKDFQFSSKSDVWAYGVLLYEVFSFGEVP-YGDKDNRRIMTDV-RNGSVLPIPSYCPSKRIYKVIKQCLTSDSTKRANFATILKIF
..|||||....  |..|||||..|||..|.|..|| | | . .| ...  . ..|  .|.| .|| . ||...|||   |  .|  |. |. ..
IKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCP-DEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase rol-3.AA Fer 2024-2116 26 4.7e-30 99.61 In-house 182-283 (283) Show / Hide 
Range on Protein: 2024-2116
Range on HMM: 182-283/283
Sequence Identity: 26% (27 aa)

VRWMAPEVLKDFQFSSKSDVWAYGVLLYEVFSFGEVPYGD---------KDNRRIMTDVRNGSVLPIPSYCPSKRIYKVIK-QCLTSDSTKRANFATILK
.||.|||..... .|.|.|||..||...|.|. |. ||..          ...... ....|  .|.|. .| ..|..... || . |  .|.....| .
IRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMP-PEIMQIMMKQCWQKDPEDRPTMKEICQ

IFE
...
KLK
Kinase rol-3.AA ALK 1881-1991 38 9.8e-28 92.82 In-house 32-144 (273) Show / Hide 
Range on Protein: 1881-1991
Range on HMM: 32-144/273
Sequence Identity: 38% (43 aa)

VAIKKLKPNHSFQEKMMFMKEAILLNNLDHPNIVKELGVCITPGQELILLEYMEGGNLLKFLQKSTPNEY--QSSELSPRDLLSISVDIARGMNYLERLP
||.| |.   | |.   |..||  . . .|.|.|. .|.|      .|.||||||| ...||  . |..   | | |  .||| .  |.| |  |||   
VAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHPESLQPSQLTMKDLLQCCCDVAQGCHYLEENH

HVHKNLSARKCLL
 .|    || |||
FIHRDIAARNCLL
Kinase rol-3.AA Sev 1859-1990 38 1.9e-27 88.38 In-house 11-146 (277) Show / Hide 
Range on Protein: 1859-1990
Range on HMM: 11-146/277
Sequence Identity: 38% (53 aa)

AYGIVHSGTAEEVPMSWEKDVRVAIKKLKPNHSFQEKMMFMKEAILLNNLDHPNIVKELGVCITPGQELILLEYMEGGNLLKFLQKSTPNEYQSSE----
|.| |  |.| ..    | ..||||| |.     |||  | ||| |  .  |||||. .|||       | .| |||| || .| .      | ..    
AFGEVYEGQAKDIDGVGEEEQRVAIKTLRKGSTDQEKQEFLKEAHLMSKFKHPNIVCQMGVCLDNEPQYIIMEHMEGGDLLCYLRAARMTTFQNPQPTAG

LSPRDLLSISVDIARGMNYLERLPHVHKNLSARKCL
|.  ||. . .||..|  |||..  ||  | .| ||
LTLMDLVEMCIDISKGCEYLEDMHFVHRDLACRNCL
Kinase rol-3.AA Src 2024-2115 33 5.2e-27 88.76 In-house 164-255 (255) Show / Hide 
Range on Protein: 2024-2115
Range on HMM: 164-255/255
Sequence Identity: 33% (31 aa)

VRWMAPEVLKDFQFSSKSDVWAYGVLLYEVFSFGEVPYGDKDNRRIMTDVRNGSVLPIPSYCPSKRIYK-VIKQCLTSDSTKRANFATILKIF
..|.||| .   .|. ||||| .|.||.|....| |||   .|.  .. | .|  .| |. || ...|. ...||  .|  .|  |... . .
IKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCP-DELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase rol-3.AA MLK 2024-2115 38 7.4e-25 83.23 In-house 197-291 (291) Show / Hide 
Range on Protein: 2024-2115
Range on HMM: 197-291/291
Sequence Identity: 38% (37 aa)

VRWMAPEVL---KDFQFSSKSDVWAYGVLLYEVFSFGEVPYG-DKD-NRRIMTDVRNGSVLPIPSYCPSKRIYKVIKQCLTSDSTKRANFATILKIF
..||||||.   .  ..| |.||| .||.|.|... .||||  . |  ....  . ||  .|||| || ... | .|||  .|. || .|. |....
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLT-REVPYKQHYDPMAIAWWVAYNGLRPPIPSTCP-EHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase rol-3.AA ALK 2024-2117 38 4.4e-24 80.02 In-house 181-273 (273) Show / Hide 
Range on Protein: 2024-2117
Range on HMM: 181-273/273
Sequence Identity: 38% (36 aa)

VRWMAPEVLKDFQFSSKSDVWAYGVLLYEVFSFGEVPYGDKDNRRIMTDVRNGSVLPIPSYCPSKRIYKVIKQCLTSDSTKRANFATILKIFET
| || || . |  | ||.|||..|||. |.|| | .||  . |  .|  |  |  .  |  ||  ..|..  ||       | .|.||| ... 
VKWMPPEAFMDGIFTSKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCP-QPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase rol-3.AA Src 1875-1987 31 4.1e-22 71.87 In-house 20-126 (255) Show / Hide 
Range on Protein: 1875-1987
Range on HMM: 20-126/255
Sequence Identity: 31% (36 aa)

WEKDVRVAIKKLKPNHSFQEKMMFMKEAILLNNLDHPNIVKELGVCITPGQELILLEYMEGGNLLKFLQKSTPNEYQSSELSPRDLLSISVDIARGMNYL
| . . ||.| ||| .   .  .| .|| .. .|.|...|. . || .    .|  |||. |.||..|.|    . . ..|. ..|....  .|.||.||
WNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----DGEGRHLHLPQLIDMAAQVAEGMAYL

ERLPHVHKNLSAR
|.   .|  | ||
ESMNYIHRDLAAR
Kinase rol-3.AA Fer 1849-1981 29 3.5e-19 62.07 In-house 1-134 (283) Show / Hide 
Range on Protein: 1849-1981
Range on HMM: 1-134/283
Sequence Identity: 29% (41 aa)

VTFNDYIDTCAYGIVHSG--TAEE-VPMSWE-KDVRVAIKKLKPNHSFQE-KMMFMKEAILLNN-LDHPNIVKELGVCITPGQELILLEYMEGGNLLKFL
||... .   |.|.|..|  |  .  ... .  .| |. ||.| ...  | .  ||.|| ...| .||||.||  |||      .|..|.. ||.|...|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

QKSTPNEYQSSE-LSPRDLLSISVDIARGMNYLERLPHVH
.|.      ... .| .... .. ..|.||.||.    .|
KKN------KNKTVSDNEKIRMCYQAACGMEYLHSKNCIH
Kinase rol-3.AA MLK 1881-1974 27 7.2e-19 62.18 In-house 30-140 (291) Show / Hide 
Range on Protein: 1881-1974
Range on HMM: 30-140/291
Sequence Identity: 27% (30 aa)

VAIKKLKPNH-----SFQEKMMFMKEAILLNNLDHPN----IVKELGVCITPGQE-LILLEYMEGGNLLKFLQKSTPNEY-------QSSELSPRDLLSI
||.|. . .      .  |.  | .|. .|. |.|||    |.. .|||. |... .|..||.||| |  .|   .....        .   ..  ....
VAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNW

SVDIARGMNYL
....||||.||
ALQCARGMHYL
Kinase rol-3.AA Sev 2024-2115 35 3.6e-17 53.61 In-house 187-277 (277) Show / Hide 
Range on Protein: 2024-2115
Range on HMM: 187-277/277
Sequence Identity: 35% (33 aa)

VRWMAPEVLKDFQFSSKSDVWAYGVLLYEVFSFGEVPYGDKDNRRIMTDVRNGSVLPIPSYCPSKRIYKVIKQCLTSDSTKRANFATILKIF
||||||| | |  |.. |||||.|.|  |. . |  ||  . |  .   |. |  |  |  || . ..  . ||   |   |  |  .    
VRWMAPESLMDGYFTTQSDVWAFGILCWEIMTLGHQPYPAHSNFEVLNHVQAGGRLQQPRMCPDD-LWMMMRQCWRQDPWQRPSFHMCQNML
Kinase rol-3.AA S_TKc 1849-2115 20 8.1e-16 55.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 1849-2115
Range on HMM: 1-231/231
Sequence Identity: 20% (57 aa)

VTFNDYIDTCAYGIVHSGTAEEVPMSWEKDVRVAIKKLKPNHSFQEKMMFMKEAILLNNLDHPNIVKELGVCITPGQELILLEYMEG--GNLLKFLQKST
 .. . |   |.| |. ..  .       . .||||..|         ....|  .| . .|||||| ..|. . .   . .||..|  |.|.....|  
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

PNEYQSSELSPRDLLSISVDIARGMNYLERLPHVHKNLSARKCLLAGRPGVTKL-EMGMSKELSNGQVNRSDLENMEIV---RWMAPEVLKDFQFSS-KS
.. .. . ... .  ..   |.....|. ..  .|  |     ||     . |.   |....|            . ..    .||||||   ...  |.
RHGLR-FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKC

DVWAYGVLLYEVFSFGEVPYGDKDNRRIMTDVRNGSVLPIPSYCPSKRIYKVIKQCLTSDSTKRANFATILK---------IF
|.|. |..||| .. |. |.   .  ...  ..            |.     |..||. | .||     .|.          |
DWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase rol-3.AA Pkinase 2025-2115 21 2.1e-14 52.0 Pfam 176-293 (293) Show / Hide 
Range on Protein: 2025-2115
Range on HMM: 176-293/293
Sequence Identity: 21% (26 aa)

RWMAPEVLK-DFQFSSKSDVWAYGVLLYEVFSFGEVPYGDK------DNRRIMTDVRNGSVLPIPSYCPS-------------------KRIYKVIKQCL
..|||||.. .   ..|.|.|..|..|||... |. |. ..      | . ..  .. . .    ..  |                   .   ..|| ||
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

TSDSTKRANFATILKI--F
. | .|| ... ||.   |
CKDPKKRPTAEQILQHPWF
Kinase rol-3.AA Pkinase 1880-1974 23 8.4e-10 35.74 Pfam 26-124 (293) Show / Hide 
Range on Protein: 1880-1974
Range on HMM: 26-124/293
Sequence Identity: 23% (24 aa)

RVAIKKLKPNHSFQEK-MMFMK--EAILLNNLDHPNIVKELGVCITPGQELILLEYMEGG----NLLKFLQ--KSTPNEYQSSELSPRDLLSISVDIARG
.||.|..|  |   .| .   .  |. ....|.|||||. .... ...   . .||.|||     |  ...  ....     . .|.... ..   |.||
IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCF----Y-FSEWECKFYMYQILRG

MNYL
..|.
LEYC