Gene n1185 (Tetrahymena)
n1185
Species: Tetrahymena
Alias: n1185, 1185, 3710.m00060
External Links:
Annotation:
Group:
Other
Family:
Ciliate-A2
Sequence
Protein domains of n1185.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | n1185.AA | Ciliate-E6 | 81-223 | 25 | 1.2e-22 | 69.14 | In-house | 1-154 (154) | Show / Hide |
Range on Protein: 81-223 Range on HMM: 1-154/154 Sequence Identity: 25% (40 aa) VDLVRGCDNLYISKIYDAFKINKFFVILFKDCDFSL-------SSYKCFDRN-QLIQLAEQMIEAIIYLHSKNIFLKTFQIQKIFVDNNFNLKITEISFP .. . |.. | | .| | | ... |.. .|...| . | ...| |... . |. .|. ||||||..| . . ||.|.|.|.|| |. IQNLKNCNHPNILKYMDSFQIENYYFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQ KLINCQTEYGKYQQ--YGQPGIYLPPEILN-QFRSNQFQKLIYKTIEQDIWSFG . |. ... ... . .|.||| .. . .... . | | |||| . QCIIPNQQTKEFMAQKNQNKYHYCPPEQFDYSKDQQSKHYKVNWTQEGDIWSVC |
|||||||||
| Kinase | n1185.AA | Ciliate-A2 | 124-283 | 26 | 3e-17 | 56.64 | In-house | 101-272 (272) | Show / Hide |
Range on Protein: 124-283 Range on HMM: 101-272/272 Sequence Identity: 26% (45 aa) RNQLIQLAEQMIEAIIYLHSKNIFLKTFQIQKIFVDNNFN-LKITEISFPKLINCQTEYGKYQQYGQPG--IYLPPEILNQ-FRS---NQFQKLIYKTIE . |.. .|.|...|| |||.||. | .. | |.... .| . | .. . .. ... . | .| |||...| | . .. .. |. | . DHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLAKKYQPEINSQMFYTSCPKGVFFYYPPECHFQCFEMNGEQNKKQQIKQTFM QDIWSFGVWLLILSGSSESSIKNLT----EGLEMYPLNIDIDFDINYLISLILQKEADQRP-SLKQIKDYFQ ||| ||..|..|.| . . ..|| .. . |. | .| .|. ||... ..|| | .||.. .. GDIWAFGICLYQLGGADQQHCYKLTQCNQKKWWQYQDYPNLDEKCNQIIQQILNCDPKKRPSSIQQIRHHWH |
|||||||||
| S_TKc | n1185.AA | S_TKc | 31-282 | 14 | 9.8e-08 | -63.51 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 31-282
Range on HMM: 1-231/231
Sequence Identity: 14% (41 aa)
NEYFQVIKNEKYGKYYAVNNRKESYLIYLISIDDGNNSYCFDKLQQAQNYVDLVRGCDNLYISKIYDAFKINKFFVILF----K---DCDFSLSSYKC--
| ..| .|| | . ..| . . |. ..... ... . . .| |.||.| ... . . | . ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG
----FDRNQLIQLAEQMIEAIIYLHSK----------NIFLKTFQIQKIFVDNNFNLKITEISFPKLINCQTEYGKYQQYGQPGIYLPPEILNQFRSNQF
|. . .. |...|. |.||. ||.| . ..||. . ... . |..||.|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------
QKLIYKTI-EQDIWSFGVWLLILSGSSESSIKNLTEGLEMYPLNIDIDFDINYLISLILQKEADQRPSLKQIKD---------YF
. . |.||.|. | .. . . .|. . . . .|. .|||. ..||. .. .|
----GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | n1185.AA | NEK | 256-284 | 44 | 1e-05 | 16.57 | In-house | 258-286 (286) | Show / Hide |
Range on Protein: 256-284 Range on HMM: 258-286/286 Sequence Identity: 44% (13 aa) DINYLISLILQKEADQRPSLKQIKDYFQC | . |||. |||. .|||| .|| .. DLQNLISQMLQKDPEQRPSCNQILEMPFI |
|||||||||
| Kinase | n1185.AA | Aur | 133-146 | 57 | 1.1e-05 | 10.42 | In-house | 109-122 (257) | Show / Hide |
Range on Protein: 133-146 Range on HMM: 109-122/257 Sequence Identity: 57% (8 aa) QMIEAIIYLHSKNI |...|..|.||||| QICNALDYCHSKNI |
|||||||||
| Kinase | n1185.AA | RAF | 122-167 | 32 | 4.5e-05 | 12.05 | In-house | 100-145 (282) | Show / Hide |
Range on Protein: 122-167 Range on HMM: 100-145/282 Sequence Identity: 32% (15 aa) FDRNQLIQLAEQMIEAIIYLHSKNIFLKTFQIQKIFVDNNFNLKIT || ..||. . |. . |||.||| . . || .. ||. FDMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIG |
|||||||||
| Kinase | n1185.AA | LKB | 248-279 | 37 | 4.7e-05 | 11.0 | In-house | 229-260 (265) | Show / Hide |
Range on Protein: 248-279 Range on HMM: 229-260/265 Sequence Identity: 37% (12 aa) PLNIDIDFDINYLISLILQKEADQRPSLKQIK | ..|.| | || .||.. ..|.|..||. PCWYDCDKDLQNLIKGMLQYDHNKRFSCHQIM |
|||||||||
| Kinase | n1185.AA | Ciliate-C4 | 193-229 | 24 | 0.000168 | 9.96 | In-house | 213-265 (361) | Show / Hide |
Range on Protein: 193-229 Range on HMM: 213-265/361 Sequence Identity: 24% (13 aa) YLPPEILNQFRSNQF------QKLIYKTIE------Q----DIWSFGVWLLIL |.|||.||.. |. | .. .. ||||.|. .... YMPPEMLNFIIQEQNEDEQLQQNHQHDMFQYLQNYECPWSIDIWSMGCVMMEI |
|||||||||
| Kinase | n1185.AA | Ciliate-B2 | 120-146 | 37 | 0.000219 | 6.11 | In-house | 99-125 (197) | Show / Hide |
Range on Protein: 120-146 Range on HMM: 99-125/197 Sequence Identity: 37% (10 aa) KCFDRNQLIQLAEQMIEAIIYLHSKNI ||| .. |.|. |.|.. | ....|| KCFNNQKLYQMIFQLIDGLIQFRMYNI |
|||||||||
| Kinase | n1185.AA | CAMKL | 242-279 | 28 | 0.000237 | 9.63 | In-house | 257-292 (297) | Show / Hide |
Range on Protein: 242-279 Range on HMM: 257-292/297 Sequence Identity: 28% (11 aa) EGLEMYPLNIDIDFDINYLISLILQKEADQRPSLKQIK .| ...| .... | ||. .||. ..||...||. CG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM |
|||||||||
| Kinase | n1185.AA | CK1-Unclassified | 130-146 | 58 | 0.00033 | 8.34 | In-house | 109-125 (244) | Show / Hide |
Range on Protein: 130-146 Range on HMM: 109-125/244 Sequence Identity: 58% (10 aa) LAEQMIEAIIYLHSKNI .|.|||. | |||.||. IADQMIQRIEYLHNKNF |
|||||||||
| Kinase | n1185.AA | Aur | 260-279 | 55 | 0.006132 | 3.03 | In-house | 233-252 (257) | Show / Hide |
Range on Protein: 260-279 Range on HMM: 233-252/257 Sequence Identity: 55% (11 aa) LISLILQKEADQRPSLKQIK ||| |||.. || .|.||. LISKILQHDPKQRMTLDQIM |
|||||||||
| Kinase | n1185.AA | CAMKL | 133-146 | 42 | 0.020177 | 3.37 | In-house | 135-148 (297) | Show / Hide |
Range on Protein: 133-146 Range on HMM: 135-148/297 Sequence Identity: 42% (6 aa) QMIEAIIYLHSKNI |...|. |.||..| QIVSAVNYCHSHGI |
|||||||||
| Kinase | n1185.AA | NEK | 122-146 | 26 | 0.075762 | 2.76 | In-house | 111-140 (286) | Show / Hide |
Range on Protein: 122-146 Range on HMM: 111-140/286 Sequence Identity: 26% (8 aa) FDRNQLIQLAEQMIEAIIYLHSK-----NI |. .| ||. |. |.|.. .| FEEEQIWDWFIQMCLALKYMHDRKGPQRKI |
|||||||||
| TPR_1 | n1185.AA | TPR_1 | 436-469 | 35 | 1.9e-10 | 40.49 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 436-469 Range on HMM: 1-34/34 Sequence Identity: 35% (12 aa) IDILNNQGTLFYKLGQYEKAIASFKKALRINSEH ....| | ..||.|.|..||. ..|||..| .. AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
|||||||||
| TPR | n1185.AA | TPR | 436-469 | 32 | 2.4e-10 | 41.62 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 436-469 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) IDILNNQGTLFYKLGQYEKAIASFKKALRINSEH .....|.| ..||.|.|..||. ..|||... .. AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
|||||||||
| TPR_2 | n1185.AA | TPR_2 | 436-469 | 32 | 3.2e-08 | 33.19 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 436-469 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) IDILNNQGTLFYKLGQYEKAIASFKKALRINSEH ....|.| . ||.|.|..||. ..|||... .. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR_1 | n1185.AA | TPR_1 | 402-435 | 29 | 6.2e-07 | 28.18 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 402-435 Range on HMM: 1-34/34 Sequence Identity: 29% (10 aa) ILALNNLGLAFQHSNQFEFSLQTYQNALKISPND |..|||... . .... .. || ||.. ||. AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
|||||||||
| TPR | n1185.AA | TPR | 402-435 | 29 | 2e-06 | 28.54 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 402-435 Range on HMM: 1-34/34 Sequence Identity: 29% (10 aa) ILALNNLGLAFQHSNQFEFSLQTYQNALKISPND . |..|||... . .... .. || ||.. ||. AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
|||||||||
| TPR_1 | n1185.AA | TPR_1 | 504-537 | 26 | 9e-06 | 24.08 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 504-537 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) NEALFHLGFSYKQVQNHQKSLKYFYQALKIAPQK ||.. || | . .|... .... .||.. |. AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
|||||||||
| TPR_2 | n1185.AA | TPR_2 | 402-435 | 29 | 2.8e-05 | 22.78 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 402-435 Range on HMM: 1-34/34 Sequence Identity: 29% (10 aa) ILALNNLGLAFQHSNQFEFSLQTYQNALKISPND |..|||.. . .... .. |. |||. ||. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR | n1185.AA | TPR | 504-537 | 23 | 2.8e-05 | 24.78 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 504-537 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) NEALFHLGFSYKQVQNHQKSLKYFYQALKIAPQK ||.. || .| . .... .... .||...|. AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
|||||||||
| TPR_2 | n1185.AA | TPR_2 | 470-503 | 32 | 7.4e-05 | 21.27 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 470-503 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) NSSYFNLGMLYLKMQKYNKSIKYFESLVKMTPLD ..|||..|.|...| . |.|.| ..| | . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR | n1185.AA | TPR | 470-503 | 26 | 0.00014 | 22.46 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 470-503 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) NSSYFNLGMLYLKMQKYNKSIKYFESLVKMTPLD ..|||..|.|| .|.. |.... ... | . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
|||||||||
| TPR_2 | n1185.AA | TPR_2 | 504-537 | 29 | 0.000164 | 20.05 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 504-537 Range on HMM: 1-34/34 Sequence Identity: 29% (10 aa) NEALFHLGFSYKQVQNHQKSLKYFYQALKIAPQK ||.. || .| . ..... ..|. .|||..|. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR_1 | n1185.AA | TPR_1 | 470-494 | 32 | 0.000505 | 18.03 | Pfam | 1-25 (34) | Show / Hide |
Range on Protein: 470-494 Range on HMM: 1-25/34 Sequence Identity: 32% (8 aa) NSSYFNLGMLYLKMQKYNKSIKYFE ..|||..|.||..|.. |.... AEAWYNLGNCYYKMGNYDEAIECYQ |
|||||||||
| TPR_1 | n1185.AA | TPR_1 | 384-401 | 50 | 0.000823 | 17.29 | Pfam | 17-34 (34) | Show / Hide |
Range on Protein: 384-401 Range on HMM: 17-34/34 Sequence Identity: 50% (9 aa) LELAKVYYQKAIQINPNN .. | .||||...|||| YDEAIECYQKALELNPNN |
|||||||||
| TPR_2 | n1185.AA | TPR_2 | 538-571 | 26 | 0.002799 | 15.69 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 538-571 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) AKYLFNIGQVYMEKLLKQKSYTYLQRSLQLKPLS |....|.||.|... .. |....|.| | AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR_2 | n1185.AA | TPR_2 | 368-401 | 32 | 0.003751 | 15.24 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 368-401 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) DLAYFILGINNTHYEFLELAKVYYQKAIQINPNN |.. || . . .. |. ||.||....||| AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR_1 | n1185.AA | TPR_1 | 538-571 | 23 | 0.008013 | 13.84 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 538-571 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) AKYLFNIGQVYMEKLLKQKSYTYLQRSLQLKPLS |. ..|.|..|... .. ..|. |.| | AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
|||||||||
| TPR | n1185.AA | TPR | 538-571 | 23 | 0.019236 | 15.36 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 538-571 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) AKYLFNIGQVYMEKLLKQKSYTYLQRSLQLKPLS |....|.|..|. . .. ..|..|.| | AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
|||||||||
| TPR | n1185.AA | TPR | 368-401 | 32 | 0.124098 | 8.55 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 368-401 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) DLAYFILGINNTHYEFLELAKVYYQKAIQINPNN |.. || . . .. | .||||....||| AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
|||||||||
| TPR_2 | n1185.AA | TPR_2 | 334-367 | 23 | 0.301279 | 8.5 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 334-367 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) DEYLAWMGRICYALEKYEISEYFCYQTLKLNKEN |.. ..|...|....|. . .. . |||. .| AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR_1 | n1185.AA | TPR_1 | 334-367 | 23 | 0.460116 | 7.7 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 334-367 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) DEYLAWMGRICYALEKYEISEYFCYQTLKLNKEN | . .| ..|....|. . .. . |.|| .| AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
|||||||||
| TPR | n1185.AA | TPR | 334-367 | 20 | 0.536822 | 2.96 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 334-367 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) DEYLAWMGRICYALEKYEISEYFCYQTLKLNKEN |.. .| ..|....|. . .. . |.|. .| AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
|||||||||
| TPR_1 | n1185.AA | TPR_1 | 605-638 | 35 | 7.4e-07 | 27.92 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 605-638 Range on HMM: 1-34/34 Sequence Identity: 35% (12 aa) EKICNYLGICYSNQNQLESAFECYKKAYSLDQKN .... || || ...... | |||.|| .|. .| AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
|||||||||
| TPR | n1185.AA | TPR | 605-638 | 38 | 2e-06 | 28.33 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 605-638 Range on HMM: 1-34/34 Sequence Identity: 38% (13 aa) EKICNYLGICYSNQNQLESAFECYKKAYSLDQKN .... || || ...... | |||.|| .|| .| AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
|||||||||
| TPR_2 | n1185.AA | TPR_2 | 605-638 | 38 | 4e-06 | 25.71 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 605-638 Range on HMM: 1-34/34 Sequence Identity: 38% (13 aa) EKICNYLGICYSNQNQLESAFECYKKAYSLDQKN .....|| || .|.... | |.|.|| .|| .| AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||