Gene n1191 (Tetrahymena)
n1191
Species: Tetrahymena
Alias: 1191, 32.m00161, n1191
External Links:
Annotation:
Group:
Other
Family:
Ciliate-E6
Sequence
Protein domains of n1191.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | n1191.AA | Ciliate-E6 | 84-234 | 36 | 1.3e-48 | 152.76 | In-house | 1-154 (154) | Show / Hide |
Range on Protein: 84-234 Range on HMM: 1-154/154 Sequence Identity: 36% (56 aa) AKDISESLHENIIKCISHFQIQHFYLVQMEYCGQTLQDWIL-ENRRKKIDRQ-TFIMLSKQILDAASFIHSKGLVLYNFAPRNIFLQNQ-NIKIQLFGEA .... .. |.||.| . |||. .|...|| |. .|||||. .|.|.. .|. . |.. |.. .|||..|| |....|||| .. |||| ||. IQNLKNCNHPNILKYMDSFQIENYYFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQ KEINPSNSTQFFDMQIMQNIQFYLPPEFLDNSVDAESQSIQQIWNQQADLWCIG ..|.|. |. | | ||...|.|||..| | | .| .. | | .| | .. QCIIPNQQTKEFMAQKNQNKYHYCPPEQFDYSKDQQSKHYKVNWTQEGDIWSVC |
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| Kinase | n1191.AA | Ciliate-A2 | 72-296 | 30 | 5e-25 | 83.97 | In-house | 37-272 (272) | Show / Hide |
Range on Protein: 72-296 Range on HMM: 37-272/272 Sequence Identity: 30% (72 aa) VCQNKLADAQKLAKDISESLHENIIKCISHFQIQHFYLVQMEYC-GQTLQDWIL--ENRRKKIDRQTFIMLSKQILDAASFIHSKGLVLYNFAPRNIFL- ..|.|| .... |. .. |.||.| . ||| .| |||.| . ||||| .| .|.| .. |. . .||||| .|.| || . .||| . ISQQKLQECKHEAQFLKNCNHPNIVKYHDEFQIGFYYFIQMEKCPECSLQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILID QNQN-IKIQLFGEAKEINPSNSTQFFDMQIMQNIQFYLPPEFLDN---SVDAESQSIQQIWNQQADLWCIGMCLYSMAQAK-NLLYYLK-ELSYGTMYYQ |... || || ||...|. ..|.| .. || ||| . ... . .. | . . ..| | .| |||. . |. . .|.|. . . . || QDNQIIKLCDFGLAKKYQPEINSQMFYTSCPKGVFFYYPPECHFQCFEMNGEQNKKQQIKQTFMGDIWAFGICLYQLGGADQQHCYKLTQCNQKKWWQYQ FQKSIDIDINYILLDFFQFDQIKRP-DILKQIDSFD .. |. .| |.. . | ||| |.. .. . DYPNLDEKCNQIIQQILNCDPKKRPSSIQQIRHHWH |
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| Kinase | n1191.AA | Ciliate-E2-Unclassified | 92-240 | 21 | 3.4e-16 | 52.7 | In-house | 80-263 (352) | Show / Hide |
Range on Protein: 92-240 Range on HMM: 80-263/352 Sequence Identity: 21% (42 aa) HENIIKCISHFQIQHFYLVQMEYC-GQTLQDWILE---------------NRRKKIDRQTFI-----MLSKQILDAASFIHSKG-LVLYNFAPRNIFLQN |..|.|.. .|| . |||| |..|...| . ..||... | . . .|||.. ...|.|. . .. | ||...| HPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDN Q----NIKIQLFGEAKEINPSNSTQFFD-------------MQIMQNIQF---YLPPEFLDNSVDAESQSIQQIWNQQADLWCIGMCLYSM . .||| || .|... .| . .. ........ |..|| |.. .| . ..| |. |..|| | NGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA------YKCDIWSLGVILYEM |
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| Kinase | n1191.AA | PKR | 110-178 | 39 | 5e-11 | 35.61 | In-house | 98-168 (272) | Show / Hide |
Range on Protein: 110-178 Range on HMM: 98-168/272 Sequence Identity: 39% (28 aa) VQMEYCGQ-TLQDWILENRRKKIDRQTFIMLSKQILDAASFIHSKGLVLYNFAPRNIFL-QNQNIKIQLFG .|||.| . || |. . | .|.|. . | || .||||.|. | |||| ...||| || IQMEFCDKGTLEQWMRNRRQEKVDKVLILDLYEQIVKGVDYIHSKKLIHRDLKPSNIFLVDERHIKIGDFG |
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| Kinase | n1191.AA | PEK | 111-174 | 23 | 1.8e-10 | 31.95 | In-house | 361-473 (655) | Show / Hide |
Range on Protein: 111-174 Range on HMM: 361-473/655 Sequence Identity: 23% (26 aa) QMEYCG-QTLQDWILEN------------------------------------------RRKKIDRQTFIMLSKQILDAASFIHSKGLVLYNFAPRNIFL |||||. || ||| .| .....|... .. .|||.. .|||.|.. |.|||| QMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFL -QNQN-----IKI .... .|| DCDGQHHQMQVKI |
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| S_TKc | n1191.AA | S_TKc | 32-295 | 20 | 4.2e-10 | -28.68 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 32-295
Range on HMM: 1-231/231
Sequence Identity: 20% (58 aa)
IIDSKKYEEGLSDIVYI---KQSNFQYLLKIINLQSDFEELGVVCQNKLADAQKLAKDISESLHENIIKCISHFQIQHFYLVQMEYCGQ---TLQDWILE
.| .| || | .. .. .|||. .. . | | | |.||.|.. .|| ... . ||||.. .| | | .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK
NRRKK----IDRQTFIMLSKQILDAASFIHSKGLVLYNFAPRNIFLQNQNIKIQLFGEAKEINPSNSTQFFDMQIMQNIQFYLPPEFLDNSVDAESQSIQ
..|.. .. . . .||..| ..||.| . | ||.| . .||| || |... . .|..|| |
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-----------TTFCGTPWYMAPEVL------------
QIWNQ-QADLWCIGMCLYSMAQAKNLLYYLKELSYGTMYYQFQKSIDIDINYILLDFFQFDQIKRPDILKQID---------SF
.. .| | .| .|| |. . . . . .|. . . . .. .|.| ||| . . |
-GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | n1191.AA | Ciliate-E2 | 92-240 | 23 | 6.5e-09 | 26.72 | In-house | 91-289 (365) | Show / Hide |
Range on Protein: 92-240 Range on HMM: 91-289/365 Sequence Identity: 23% (50 aa) HENIIKCISHFQ---IQHFYLVQMEYCGQ-TLQDWILENRRK---------KIDRQTFIMLSKQILD---------------AASFIHSKG-LVLYNFAP | ||||.. .|| ...||| |||| . .|.|.| .|. | ... . . ..||||. | ..|||. . . | HPNIIKMYECFQEKDDNNIYLV-MEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKP RNIFLQNQNIKIQLFGEAKEINPSNSTQFFDMQIMQNIQF----------------------------YLPPEFLD------NSVDAESQSIQQIWNQQA ||.. ||| || .|.....| .. .|......| |..|| | . . |. .. .. ENILF----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ-------QKQKGYDYKC DLWCIGMCLYSM |.|..|..|| | DIWSLGVILYEM |
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| Kinase | n1191.AA | PEK | 109-167 | 37 | 1.8e-08 | 23.1 | In-house | 415-475 (758) | Show / Hide |
Range on Protein: 109-167 Range on HMM: 415-475/758 Sequence Identity: 37% (23 aa) LVQMEYC-GQTLQDWILENRRKKIDRQTFIMLS--KQILDAASFIHSKGLVLYNFAPRNIFL . ||..| ..|| || ..||. .| . ||. .||... .|||||. . |.|||. YIQMQLCRKETLKDW-MRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFF |
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| Kinase | n1191.AA | CMGC | 81-156 | 15 | 8.6e-07 | 17.36 | In-house | 76-206 (513) | Show / Hide |
Range on Protein: 81-156
Range on HMM: 76-206/513
Sequence Identity: 15% (21 aa)
QKL--AKDISES--------LHEN-IIKCISHFQIQ------------------HFYLVQMEYCGQTLQDWILENR-------RKKIDRQT---------
..| ..|. .. |.| |.|.. .|. |.||| .||....| . | .|. ... .
KHLNKNHDP-NWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLV-FEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRP
---FIMLS------KQILDAAS--FIHSKG--LV
.. .||| . ..||.. .
PHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNII
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| Kinase | n1191.AA | TKL | 74-238 | 13 | 4e-06 | 18.17 | In-house | 59-280 (364) | Show / Hide |
Range on Protein: 74-238 Range on HMM: 59-280/364 Sequence Identity: 13% (32 aa) QNKLADAQKLAKDISESL-------HENIIKCIS-HFQIQH-------------FYLVQMEYC-GQTLQDWILENRRKKIDRQTFIMLSKQILDAASFIH |.. .|... . . | . |.||.... ..... ...| |||| | .| . .. . .. ....| . .. | QLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIV-MEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLH S--------KGLVLYNFAPRNIFLQNQN---------------IKIQLFGEAKEINPSNSTQFFDMQIM-----------QNIQF----YLPPEFLDNSV | .... . ..||.. . . .|| || ......|.. . . .| . | ...|| |... SMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQM D-------AESQSIQQIWNQQADLWCIGMCLY . .| . . ....| . |..|. NYTEKVGIDE-FCKGFEYSEKCDVYSFGIVLW |
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| Kinase | n1191.AA | HRI | 106-167 | 32 | 4e-06 | 16.65 | In-house | 391-466 (613) | Show / Hide |
Range on Protein: 106-167 Range on HMM: 391-466/613 Sequence Identity: 32% (25 aa) HFYL-VQMEYCGQTLQDWILENRRKK----IDRQT--FIMLS--------KQILDAASFIHSKGLVLYNFAPRNIFL |..| .||. | .| ||| | | |. .|. . | . ||. .|| .. | |||||| HYMLHIQMQLCELSLWDWISE-RNKRSREYVDETECPYVMANEKVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFL |
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| Kinase | n1191.AA | TPR_1 | 174-187 | 42 | 23.907059 | 1.71 | Pfam | 21-34 (34) | Show / Hide |
Range on Protein: 174-187 Range on HMM: 21-34/34 Sequence Identity: 42% (6 aa) IQLFGEAKEINPSN |. . .| |.||.| IECYQKALELNPNN |
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| Kinase | n1191.AA | TPR_2 | 174-187 | 28 | 35.936462 | 1.15 | Pfam | 21-34 (34) | Show / Hide |
Range on Protein: 174-187 Range on HMM: 21-34/34 Sequence Identity: 28% (4 aa) IQLFGEAKEINPSN |... .| ...| | IEYYEKALKLDPNN |
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| TPR_1 | n1191.AA | TPR_1 | 359-392 | 35 | 2e-05 | 22.9 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 359-392 Range on HMM: 1-34/34 Sequence Identity: 35% (12 aa) YETYSSIGYCYYIIGDTINSEESFKKSIELNKNY .|... .|.||| |. .| ..| .||| |. AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR | n1191.AA | TPR | 359-392 | 35 | 6.3e-05 | 23.62 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 359-392 Range on HMM: 1-34/34 Sequence Identity: 35% (12 aa) YETYSSIGYCYYIIGDTINSEESFKKSIELNKNY .|... .| ||| || .| ..|..||. |. AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_2 | n1191.AA | TPR_2 | 325-358 | 26 | 0.000335 | 18.95 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 325-358 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) IEDLLDEAYSFFDQKKESEAIEKFKKVIEINPNS | . . . . |.. |||| ..|.....|| AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR | n1191.AA | TPR | 325-358 | 26 | 0.00052 | 20.57 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 325-358 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) IEDLLDEAYSFFDQKKESEAIEKFKKVIEINPNS .| .. . ... ... |||| ..|..|..|| AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | n1191.AA | TPR_1 | 325-358 | 29 | 0.00113 | 16.81 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 325-358 Range on HMM: 1-34/34 Sequence Identity: 29% (10 aa) IEDLLDEAYSFFDQKKESEAIEKFKKVIEINPNS | . .. .. ... |||| ..|..|.||| AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR_2 | n1191.AA | TPR_2 | 359-392 | 32 | 0.004414 | 14.99 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 359-392 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) YETYSSIGYCYYIIGDTINSEESFKKSIELNKNY | . .| ||| || .| ..|...|. |. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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