Gene n808 (Tetrahymena)

n808

Species: Tetrahymena
Alias: 808, n808, 220.m00040
External Links:
Annotation:

Classification

Group: Other
Family: PLK
Subfamily: PLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
n808.AA Protein None 313 None Fasta, JSON
n808.NA RNA None 942 None Fasta, JSON
n808.kin_dom Protein Kinase Domain None 198 None Fasta, JSON

Protein domain

Protein domains of n808.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase n808.AA PLK-Unclassified 46-242 76 1.1e-160 540.14 In-house 1-205 (264) Show / Hide 
Range on Protein: 46-242
Range on HMM: 1-205/264
Sequence Identity: 76% (157 aa)

YQRGSLLGKGGFAKCFQVTNLENKKVMAAKIIPKSTLVKNRARQKLISEIKIHKSLHHNNIVKFEHVFEDHDNVYILLELCPHQTLNELIKRR-------
|.||..|||||||||.||.|.|.||..||||||||.| ||||||||||||||||||||.|||||||.||||.|||||||.||..||.|.||||       
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

KRITELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEKMEIKLGDFGLATKLEFDGEKKRTICGTPNYIAPEILDGRV-GHSYEVDIWSLGVILYT
||.||.|. |||.|||||||||||||.|||||||||.|....||.|..|||||||||.|||||.||||||||||||||||.  |||||||.||.|.||||
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

LLIGK
|||||
LLIGK
Kinase n808.AA PLK 46-242 63 2.2e-153 502.78 In-house 1-199 (258) Show / Hide 
Range on Protein: 46-242
Range on HMM: 1-199/258
Sequence Identity: 63% (127 aa)

YQRGSLLGKGGFAKCFQVTNLENKKVMAAKIIPKSTLVKNRARQKLISEIKIHKSLHHNNIVKFEHVFEDHDNVYILLELCPHQTLNELIKRR-KRITEL
|.||..|||||||||...|....|.|.|.|..|||...|...|.|...||.||..||| |||||.|.||||.||||.||.|....|....||| ||.|| 
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

ETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEKMEIKLGDFGLATKLEFDGEKKRTICGTPNYIAPEILDGRV-GHSYEVDIWSLGVILYTLLIGK
|. .|..||||.||||||.|.|||||||||||  ..|..|.|||||||.||.|||.|.|.||||||||||.|||   |||||||.||||.|.|||||||
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGK
Kinase n808.AA PLK1 46-242 58 4.3e-106 349.79 In-house 1-196 (253) Show / Hide 
Range on Protein: 46-242
Range on HMM: 1-196/253
Sequence Identity: 58% (115 aa)

YQRGSLLGKGGFAKCFQVTNLENKKVMAAKIIPKSTLVKNRARQKLISEIKIHKSLHHNNIVKFEHVFEDHDNVYILLELCPHQTLNELIKRRKRITELE
|..|  |||||||.|. ... . |.|.|.|..||| |.|. .|.|.  ||.||..|||..|||| | |||..||||.|||| .. | || |||| ||| |
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPE

TLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEKMEIKLGDFGLATKLEFDGEKKRTICGTPNYIAPEILDGRVGHSYEVDIWSLGVILYTLLIGK
.  |. |||.. .|||.|..|||||||||||. .....|.||||||||.|.|||.|.|.||||||||||.|  . |||.||||||.| |.|.||.|.
CRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLN-KKGHSFEVDIWSIGCIMYILLFGQ
Kinase n808.AA PLK2 46-241 52 5.5e-105 339.04 In-house 1-199 (257) Show / Hide 
Range on Protein: 46-241
Range on HMM: 1-199/257
Sequence Identity: 52% (105 aa)

YQRGSLLGKGGFAKCFQVTNLENKKVMAAKIIPKSTLVKNRARQKLISEIKIHKSLHHNNIVKFEHVFEDHDNVYILLELCPH----QTLNELIKRRKRI
| || ||||||||.|.  | ... .| |.||.|.|   | . | |   || .|  |.| .||.| | ||| ||.|||||.| .    . .    | |.  
YCRGKLLGKGGFARCYEMTDMDTHYVYAVKIVPHSRVAKPHQREKMEREIELHRQLRHRHIVQFHHHFEDRDNIYILLEYCSRQVPLKSMAHMWKVRHHL

TELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEKMEIKLGDFGLATKLEFDGEKKRTICGTPNYIAPEILDGRVGHSYEVDIWSLGVILYTLLIG
|| |   |  |||  |.|||| ..|||||||||.|. . ||.| |||||| .||. .. .||.||||||||||.| .| ||| | |||.|| | ||.|.|
TEPEVRYYMRQIVSGLRYLHQQCIIHRDLKLGNFFINDNMEVKIGDFGLAARLEPEEHCHRTMCGTPNYIAPEVL-NRQGHSCESDIWALGCIMYTMLCG
Kinase n808.AA Pkinase 46-242 34 2.5e-76 264.7 Pfam 1-209 (293) Show / Hide 
Range on Protein: 46-242
Range on HMM: 1-209/293
Sequence Identity: 34% (73 aa)

YQRGSLLGKGGFAKCFQVTNLENKKVMAAKIIPKSTLVKNRARQKLI-SEIKIHKSLHHNNIVKFEHVFEDHDNVYILLELCPHQ----TLNELIK--RR
|..|. .|.|.|..... ..  . |. | |||.|..  ..  ....  |||.|.|.|.| |||.. ..|||.|..|. .|.|..      | ..|.  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KRI--TELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEKMEI----KLGDFGLATKL-EFDGEKKRTICGTPNYIAPEILDGRVGHSYEVDIWSL
...  .| |  .|  ||...|.|.|....||||||. |... ....|    |..||||| .. .  ..   |.||||.|.|||.. |. .....||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVILYTLLIGK
|.||| .| |.
GCILYEMLCGR
Kinase n808.AA AGC 46-242 22 5.8e-76 195.02 In-house 1-302 (395) Show / Hide 
Range on Protein: 46-242
Range on HMM: 1-302/395
Sequence Identity: 22% (70 aa)

YQRGSLLGKGGFAKCFQVTNL------ENKKVMAAKIIPKST-LVKNR--ARQKLISE------------IKIHKSLH----------HNNIVK-FEHVF
..   ..|||.| |...|          ..|. | |.. |..  |...    .. ..|             .| . ..          | .|||   . |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EDHDN--VYILLELCP----------H-QTLNELIK--RRKRITELETLCYTVQ-------IVQALKYLHQ-NRVIHRD-LKLGNLFVGEKMEIKLGDFG
.| |.  .|...|..|             ..  | .  ...| .| ..  |. .       || || |||. . .|||| ||. |.   |.  ||| |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LATKLEFDG--------------------------------------------------EKKRTICG--TPNYIAPEILDGRVGHSYEVDIWS--LGVIL
|....  ||                                                  ..  |.||  ||.|.|||||     .....|.||  ||...
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLM

YTLLIGK
| .|.|.
YEMLTGY
Kinase n808.AA CAMK 51-242 22 4.9e-72 231.2 In-house 1-331 (425) Show / Hide 
Range on Protein: 51-242
Range on HMM: 1-331/425
Sequence Identity: 22% (75 aa)

LLGKGGFAKCFQVTNLENK------------KVMAAKIIPKSTLVK-------------------------NRARQKLISEIKIHKS-------LHHNNI
 ||.|.|.| . ... ...            .  |.|||.|. | .                          . |... .||.|.|.       |.| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKFEHVFEDHDN-------------------VYILL---ELCPHQ----TLNELIKRR---------------KRITELETLCYTVQIVQALKYLHQNRV
.|. .|.||...                   .|. .   |.|.       | . |...               .|.|| |.  |  ||..|..|.|.. .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKLGNLFVGEKM-----------------EIKLGDFGLATKLEF-----------------------DGEKKRTICGTPNYIA-PEILDG------
.|||||. |. . ...                  ||. |||.|.|..                        .|.| .| |||| |.| ||.| |      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------RVGHSYEVDIWSLGVILYTLLIGK
       . ......|.||.|||||..| |.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGY
Kinase n808.AA S_TKc 46-289 30 3.8e-68 233.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 46-289
Range on HMM: 1-231/231
Sequence Identity: 30% (81 aa)

YQRGSLLGKGGFAKCFQVTNLENKKVMAAKIIPKSTLVKNRARQKLISEIKIHKSLHHNNIVKFEHVFEDHDNVYILLELCPH--QTLNELIKRRKR---
|. . ..|||.|.|...... . ....| |||.          .....||.|.|. || ||||.  ||.| |..|. .|.|..   .| ..||.|.|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---ITELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEKMEIKLGDFGLATKLEFDGEKKRTICGTPNYIAPEILDGRVGHSY-EVDIWSLGVILY
   ..| .. .|. ||..||.|.|....||||||  |... |  .||..|||||..|       .|.||||.|.|||.|    |... ..|.||.|.|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILY

TLLIGKN---NCIQLSFRRSRKQYSRLAWPYFNKRIILITLSFDSK----KQSDRQ-------SERK
 .| |.    .  ..  .           | .   .|   | .| .         |        .  
EMLCGYPPFPQMQMMFKKIG--------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase n808.AA CAMKL 46-242 32 2.9e-67 213.64 In-house 1-233 (297) Show / Hide 
Range on Protein: 46-242
Range on HMM: 1-233/297
Sequence Identity: 32% (75 aa)

YQRGSLLGKGGFAKCFQVTN-LENKKVMAAKIIPKSTLVKNRARQK------------LISEIKIHKSLH---HNNIVKFEHVFEDHDN------VYILL
|. |  ||||.|.|    |. . ...  | ||| |. . ..   .|            .  ||.|.|.|.   | ||.|. .|.|. ..      .|. .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCPHQT--LNELIKRR----KRITELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEKM--EIKLGDFGLATKLE-F---DGEKKRTICGTPNYI
|.|.     | . |...    .|..| |.  |  ||| |..|.|.....|||.|. |. . |..   ||. |||.... .     .|.| .| ||.|.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEILDG--RVGHSYEVDIWSLGVILYTLLIGK
||||. |  .  . ..|||||.|||||... |.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGY
Kinase n808.AA ULK 46-242 30 1.1e-60 207.98 In-house 1-249 (324) Show / Hide 
Range on Protein: 46-242
Range on HMM: 1-249/324
Sequence Identity: 30% (76 aa)

YQRGSLLGKGGFA-KCFQVTNLEN---KKVMAAKIIPKSTLVKNRAR-------QKLISEIKIHKSLH---HNN--IVKFEHVFEDH--DNVYILLELCP
|.    |||| |. | .. .| ..   ... |.|.|.|. . |.  .       |.|..||.| | |.   |.|  |||. ..||.   .|.|| .|.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

HQTLNELIKRR---------KRITELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEK------------MEIKLGDFGLATKLEFDG---EKKRT
. .| ..||..         ||..| |.. .  ||....|.||.. .||||.|. |. . ..              .|..|||.| ... ..    .  |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

IC------GTPNYIAPEILD---GRVGHS-YEVDIWSLGVILYTLLIGK
..      ||| | ||.||    ..  .. |..||||||.|.| .| ||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGK
Kinase n808.AA ULK 46-242 30 1.4e-60 207.59 In-house 1-253 (329) Show / Hide 
Range on Protein: 46-242
Range on HMM: 1-253/329
Sequence Identity: 30% (78 aa)

YQRGSLLGKGGFAKCFQVTNLENK----KVMAAKIIPKSTLVKNR-------ARQKLISEIKIHKSLH----HNN----IVKFEHVFEDH--DNVYILLE
|.    |||| |.| .. .| ..|    .. |.|.|.|... ..        . | |..|||| | |.    |.|    |||. ..||.   .|.|| .|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LCPHQTLNELIKRR----------KRITELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEK------------MEIKLGDFGLATKLEFDG----
.|.. .| ..||..          ||..| |.. .  ||....|.||....||||.|. |  . ..            . .|..|||.| ... |.    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-EKKRT----ICGTPNYIAPEILD---GRVGHS-YEVDIWSLGVILYTLLIGK
 ..  .    .|||| | ||.||    ..  .. |..||||||.|.| .| ||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGK
Kinase n808.AA STE 46-242 23 9.4e-57 194.86 In-house 1-265 (359) Show / Hide 
Range on Protein: 46-242
Range on HMM: 1-265/359
Sequence Identity: 23% (63 aa)

YQRGSLLGKGGFAKCFQVTNL------ENKKV---------MAAKIIP---KSTLVKN------------RARQKLISEIKIHKSLH--HNNIVKFEHVF
... . .|||.| . ..  |       ....|         || |...   ... . .              .|... ||||.| ..  | ||||.   .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

EDH-------DNVYILLELCPHQTLNELIKRR--------------KRITELETLCYTVQIVQA-LKYLHQNRVIHRDLKLGNLFVGEKMEIKLGDFGLA
..        |...| .|...  .| ..||..              .|. | .  ....||... |.|||....||||.| .| ..     .|| |||..
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

TKLEFD----------------GEKKRTICGTPNYIAPEILDG-----RVGHSYEVDIWSLGVILYTLLIGK
..|. .                ..|  |..||| . |||....     . |... .||||||  .  .. ||
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase n808.AA Pkinase_Tyr 86-236 29 2e-21 73.2 Pfam 43-205 (270) Show / Hide 
Range on Protein: 86-236
Range on HMM: 43-205/270
Sequence Identity: 29% (49 aa)

RA--RQKLISEIKIHKSL-HHNNIVKFEHVFE-DHDN--VYILLELCPHQTLNELIKR----RKRITELETLCYTVQIVQALKYLHQNRVIHRDLKLGNL
..  |.....|.|| |.| || |||..  |   . .   .|| .|..||  | .  ..    ....|  . |.. .|| ... ||.... |||||   | 
EQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNC

FVGEKMEIKLGDFGLATKL-------EFDGEKKRTICGTPNYIAPEILDGRVGHSYEVDIWSLGVILY
 |.|.. .| .|||||  .          |. |  |  .    ||| .  ..  . . |.|| || ..
LVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGK-FTTKSDVWSFGVLMW
Kinase n808.AA TyrKc 46-296 21 6.9e-14 1.85 SMART 1-280 (280) Show / Hide 
Range on Protein: 46-296
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

YQRGSLLGKGGFAKCFQVTNLENKKVMAAKIIPKSTLVKNRARQKLISEIKIHKSL--HHNNIVKFEHVFEDH-------DNVYILLELCPHQTLNELIK
 . |  || | | . .. |        | | . ...      |. ...|..| ..|  || |||..  |  ..       . ..|..|..||  |.. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RRKR-ITELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEKMEIKLGDFGLATKLEFD---GEKKRTIC-----GTP-----NYIAPEILDGRVGH
.... ..  . | . .|| .   |||....|||||   |  |||.  .| .||||. ... |   || | ..      |.         ||| .. ..  
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK-F

SYEVDIWSLGVILY-------TLLIG----KNNCIQLSFRRSRKQYSRLAWPY--------FNKRIILITLSFDSKKQSDRQSERKTDESNKL
. . |.|| || ..       .   |    . . ... ... .. | .   |.          . .  | ..    . .|| . .      ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEV-IEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF