Gene n858 (Tetrahymena)
n858
Species: Tetrahymena
Alias: 858, 175.m00071, n858
External Links:
Annotation:
Sequence
Protein domains of n858.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3K_rbd | n858.AA | PI3K_rbd | 147-244 | 13 | 0.000165 | 10.01 | SMART | 1-116 (116) | Show / Hide |
Range on Protein: 147-244 Range on HMM: 1-116/116 Sequence Identity: 13% (16 aa) QEEKMIKDDK-PIKYEK---RIEIE---------AGLVTGADEVIKNILREIFKQ---AKVKLEPNNPDH--QFILQIKGFREYLTGNYPMLSYDRVRIN ..|..... .. .| ....| .. ..... .. ..|.. .. .. .| | ..||.. |..|||....| ... .| MSRKCPEHIWMKTINNKIIIVVHWEKRVCNWQQTKTMDCNPNCTPDSVMHQFFCKMMMNHSMHDQNDPTDECDYILKVCGRDEYLHPDHPLGQFEYIRNC LRGHEHLDVRLTEIPI . . .. | | . IMWGRCPHFVLMECCK |
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| PI3K_rbd | n858.AA | PI3K_rbd | 174-226 | 17 | 0.000194 | 19.05 | Pfam | 40-97 (115) | Show / Hide |
Range on Protein: 174-226 Range on HMM: 40-97/115 Sequence Identity: 17% (10 aa) ADEVIKNILREIFKQ---AKVKLEPNNPDH--QFILQIKGFREYLTGNYPMLSYDRVR .... . .. ..|. . .. .| . ...|.. |..|||.|..| ... .| PNDTPFQVMHQAFCKMAMKHSVHDQNDVQNPGDYVLKVCGRDEYLHGDHPLCQFEYIR |
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| PI3K_C2 | n858.AA | PI3K_C2 | 550-635 | 25 | 7.9e-15 | 55.62 | Pfam | 11-115 (168) | Show / Hide |
Range on Protein: 550-635 Range on HMM: 11-115/168 Sequence Identity: 25% (27 aa) LF--HGSNCL-RTV-ETKKQPFC----KSIRFNEWVTFDNLKISQIPLEARICMNIILHSDDQNEH---------QIIGSTSFSLFDQ-DDKYRQGLNAL .. || ..| | |. ||. .....|||.||........|..||.| | ... . . || ....|||. .. |.| .| VYDGHGGKPLCKPVQSTSYKPFNNHFFPRWNWNEWITFPQIQYCDLPRDARLCITIWEIYCKKKSESNMNEQNKKCPIGWCNLPLFDHEKCMLRCGMHKL NV-WP .. || HMTWP |
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| PI3K_C2 | n858.AA | PI3K_C2 | 497-618 | 19 | 6.1e-05 | 20.08 | SMART | 1-133 (133) | Show / Hide |
Range on Protein: 497-618 Range on HMM: 1-133/133 Sequence Identity: 19% (28 aa) LKLCKIRKEKLLKDAQMDTSITNHGIDGVAFMGGLEKKFGLNCTP-Y-----LVSLKVMLFHG--SNCLRTVETKK----QPFCKS-----IRFNEWVTF .| |.... .. . . ||...|... ||. . | . . . |.|| . . .| |.. ..| .. ...|||.|| VKICSLWCCNRPFVFL-PHEITIYCIHDIM----------LNWSQDYESSCVDLYVECQLYHGMGKQFCCPVRTSYHQYVKHFFNRTFHLFWKWNEWLTF DNLKISQIPLEARICMNIILHSD-DQNEHQII----GSTSFSLF ........| .||.| | ..| . . .. |.. |..| FPIQYCDLPRMARLCITIWDVYDDSKKSEPFFSRCVGWSNFDWF |
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| PI3Ka | n858.AA | PI3Ka | 713-902 | 25 | 2.3e-33 | 118.09 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 713-902 Range on HMM: 1-232/232 Sequence Identity: 25% (61 aa) NWNSTP--KTDDLARLQQLLSIDPLRRLSEQSEEDKHVLMICRNHYK-TLTHTL------QIFLFAIDWLDPEQVKEAILMLKQW--TLLSPEDALPLLD . .. | .. .|..... .|. | .||.| . |..| . | ... ...| ....||.|. ...|| ....||||| ||| DYDLKPRWNEEERDQLEDIMKYPPTYEL---TEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLR-CVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLD ANMAN---ESVRLYAVERVSTFSDDEIALYMLELTQSILYE--------------------------SKHFSPLVDMLLERSLQNPFVVGHELFWQLKSQ .. .. . || |||.. .||||. .| | | | . || . | |||...||.|.|.|| .|| ..|.||| PKFPDYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNP-RIGHFFYWYLKSE L------HIKAFYERYFLIIEQMLMLC-GSFRNELVV . | . ...|. .. |... | | .| MYDHCQLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK |
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| PI3Ka | n858.AA | PI3Ka | 766-902 | 33 | 2e-30 | 106.23 | Pfam | 58-211 (211) | Show / Hide |
Range on Protein: 766-902 Range on HMM: 58-211/211 Sequence Identity: 33% (52 aa) FLF-AIDWLDPEQVKEAILMLKQ--WTLLSPEDALPLLDANMAN--ESVRLYAVERVST-FSDDEIALYMLELTQSILYE----SKHFSPLVDMLLERSL || . | |..||..|. .. |. ..|.||| |||.| .. ..|| |||.. . .||||. .|.| |.| . || | |.|. ||.|.. FLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCNFPDNCPMVRQYAVKCLESYMSDDELLCYLLQLVQALKYENFDEPFHDSYLSRFLLWRAW QNPFVVGHELFWQLKSQL------HIKAF-YERYFLIIEQMLMLCGSFRNELVV ||. . || .|| .|| . |.|.. .|. .. |... || . .| QNRQRIGHFFFWYMKSEMYKDDEGHDKDYICQRFGVLLESYCRECGTHMQHLNK |
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| PI3Kc | n858.AA | PI3Kc | 987-1248 | 34 | 1.9e-106 | 360.84 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 987-1248
Range on HMM: 1-336/336
Sequence Identity: 34% (117 aa)
NILFKCGDDIRQDQLTLQLLKIMDKIWLDA----GHDFRMKPYKVITTDDQVGMIEIVNNSETTAKIHSKY-----------------------------
..|||||| |||....|....|.||| . |..|.|||.| | .. |||| |.|.|| ..|..||
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
--------------------------GGVLGAFRNNTIWQYLKDKNMDP-HSFEIATDNFLRSCAGYCVATYILGIGDRHADNIMLS-QTGHLFHIDFGH
.|....| ... ....... || ... | ||| |||||||..|||||||||| ||||| .|||.|||||||
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
FLGNFKTKFGIK---RERAPFVLTKEMAFVMG--GKDGNLFRKFEEYCTQAYNLVRKSGNFIINIFLLMLEAGM-PELQSP-QDIEYLRNQLSIN-LTEQ
..|....|.|.| |||.||.||..| ||| ||. .| .| ..| .||...||. | |.|.| .|. ... |.... ||.|||... . |...
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE
EATNKFKK-----EITDSLNSLFRRIDNFFHGLRRR
||...|.. | .|..|.. |. ..|| ..
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| PI3_PI4_kinase | n858.AA | PI3_PI4_kinase | 985-1199 | 30 | 7.7e-84 | 289.63 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 985-1199 Range on HMM: 1-300/300 Sequence Identity: 30% (91 aa) NINILFKCGDDIR--QDQLTLQLL-----------------------KIMDKIWLDAGHDFR----MKPYKVITTDDQVGMIEIVNNSETTAKIHSKYGG .. ..||.||| | ||....|.. ..|.|.| | |.| | ||..| | .. |||| |.|..| ..|...|. WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV VLG-AFRN----------------------------------NTIWQYLKDKNMDP-HSFEIATDNFLRSCAGYCVATYILGIGDRHADNIML---SQTG .. ...| . . |.....| |. . | ||| |||||.||..||||.||||.||||. || KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG HLFHIDFGHFLGNFKTKFGIKRERAPFVLTK------EMAFVMGG----KDGNLFRKFEEYCTQAYNLVRKSGNFIINIF-------LLMLEAGMPELQS |||||||||.....|.|...|.|| ||..|. .| .||| .. . .|..|| .||...|. .|...| . ..|...|.|.. | HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | n858.AA | ATR | 1074-1189 | 31 | 2.9e-16 | 51.5 | In-house | 155-267 (267) | Show / Hide |
Range on Protein: 1074-1189 Range on HMM: 155-267/267 Sequence Identity: 31% (37 aa) MDPHSFEIATDNFLRSCAGYCVATYILGIGDRHADNIMLSQ-TGHLFHIDFGHFLGNFKTKFGIKRERAPFVLTKEMAFVMGG-KDGNLFRKFEEYCTQA .|| .. . .|..|| | .|. ||.|.||||.|||.. . .| . |.|. . .. | . | || ||. | | || | |||. | PDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQ-FEV-PEIVPFRLTHNMVFGMGPMKTYGLFRRA---CEVI YNLVRKSGNFIINIFLLM ..|. . |. .. MMCMRDHRDDIMSVWDCF |
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| Kinase | n858.AA | PIKK | 1082-1154 | 43 | 1.2e-13 | 46.39 | In-house | 185-257 (290) | Show / Hide |
Range on Protein: 1082-1154 Range on HMM: 185-257/290 Sequence Identity: 43% (32 aa) ATDNFLRSCAGYCVATYILGIGDRHADNIML-SQTGHLFHIDFGHFLGNFKTKFGIKRERAPFVLTKEMAFVMG .. |..|| | |.. ||||.|||| .|||. .||| . |||||. . .. . | || ||. | . || RRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVP-EKVPFRLTRNMVNAMG |
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| Kinase | n858.AA | FRAP | 1085-1124 | 58 | 1.1e-11 | 39.31 | In-house | 139-179 (251) | Show / Hide |
Range on Protein: 1085-1124 Range on HMM: 139-179/251 Sequence Identity: 58% (24 aa) NFLRSCAGYCVATYILGIGDRHADNIMLS-QTGHLFHIDFG |. || | .| ||||.|||| |||| .|| . ||||| NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG |
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| Kinase | n858.AA | ATM | 1088-1124 | 50 | 1.1e-07 | 20.21 | In-house | 142-179 (304) | Show / Hide |
Range on Protein: 1088-1124 Range on HMM: 142-179/304 Sequence Identity: 50% (19 aa) RSCAGYCVATYILGIGDRHADNIMLS-QTGHLFHIDFG || | . ||||.|||| ||.. | | ||| | RSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG |
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| Kinase | n858.AA | DNAPK | 1086-1128 | 47 | 1.8e-07 | 23.04 | In-house | 190-233 (301) | Show / Hide |
Range on Protein: 1086-1128 Range on HMM: 190-233/301 Sequence Identity: 47% (21 aa) FLRSCAGYCVATYILGIGDRHADNIMLS-QTGHLFHIDFGHFLG | |. | |. .|||||||| .| | .| ||||| | FIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFG |
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| Kinase | n858.AA | SMG1 | 1083-1123 | 42 | 7e-06 | 15.2 | In-house | 187-228 (242) | Show / Hide |
Range on Protein: 1083-1123 Range on HMM: 187-228/242 Sequence Identity: 42% (18 aa) TDNFLRSCAGYCVATYILGIGDRHADNIMLS-QTGHLFHIDF | . || | . ||.|.|||| ||... || |||. TQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY |
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| Kinase | n858.AA | PIKK | 989-1009 | 47 | 0.001062 | 9.78 | In-house | 34-54 (290) | Show / Hide |
Range on Protein: 989-1009 Range on HMM: 34-54/290 Sequence Identity: 47% (10 aa) LFKCGDDIRQDQLTLQLLKIM |.|...|.|||| ..||. .| LCKGHEDLRQDQRVMQLFQLM |
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