Gene n737 (Tetrahymena)
n737
Species: Tetrahymena
Alias: 32.m00265, 737, n737
External Links:
Annotation:
Sequence
Protein domains of n737.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3K_rbd | n737.AA | PI3K_rbd | 147-202 | 24 | 1.6e-07 | 30.29 | Pfam | 44-100 (115) | Show / Hide |
Range on Protein: 147-202 Range on HMM: 44-100/115 Sequence Identity: 24% (14 aa) ADEVIKNILRKIYKEYKIALKPKDQN-HQFILQVKGFREYLAGNHPMLNYDRVRTSL .. |.. ...| . ... .... || ...|.| |..|||.|.|| ... .| .. PFQVMHQAFCKMAMKHSVHDQNDVQNPGDYVLKVCGRDEYLHGDHPLCQFEYIRNCI |
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| PI3K_rbd | n737.AA | PI3K_rbd | 111-217 | 18 | 2.3e-05 | 18.9 | SMART | 1-116 (116) | Show / Hide |
Range on Protein: 111-217 Range on HMM: 1-116/116 Sequence Identity: 18% (21 aa) LNVNLDEYIN--QLREKKPAEVDWD------CKSLTIEAGLVTGADEVIKNILRKIYKEYKIALKPKDQNH-QFILQVKGFREYLAGNHPMLNYDRVRTS . . |.| ..| . | |. .. |.. . .|.|.. ...|. . ... .... .. ..||.| |..|||...|| ... .| . MSRKCPEHIWMKTINNKIIIVVHWEKRVCNWQQTKTMDCNPNCTPDSVMHQFFCKMMMNHSMHDQNDPTDECDYILKVCGRDEYLHPDHPLGQFEYIRNC LRGLDHLDVKLTEMPI . . ...| | . IMWGRCPHFVLMECCK |
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| PI3K_C2 | n737.AA | PI3K_C2 | 463-540 | 23 | 8.8e-12 | 44.63 | Pfam | 22-115 (168) | Show / Hide |
Range on Protein: 463-540 Range on HMM: 22-115/168 Sequence Identity: 23% (22 aa) KSV-ETKRVPYG----NTCKFNQWISFNNIKVSQLPLESRLCFNLKAYAQNSNDY---------QIIGSSTLPIFNS-QELFQQGLNAINV-WP | | |...|.. .. ..|.|| |..|....||...|||. . ... .. . . || ..||.|.. .. .| .... || KPVQSTSYKPFNNHFFPRWNWNEWITFPQIQYCDLPRDARLCITIWEIYCKKKSESNMNEQNKKCPIGWCNLPLFDHEKCMLRCGMHKLHMTWP |
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| PI3K_C2 | n737.AA | PI3K_C2 | 395-523 | 15 | 0.000171 | 15.43 | SMART | 1-133 (133) | Show / Hide |
Range on Protein: 395-523 Range on HMM: 1-133/133 Sequence Identity: 15% (23 aa) KQNKDIQ-LQQEQQKQRKDQVTPKLNTRIVNHGIKGV-----EFMKQIQGYYGMNLVPFSISIEAIIMNGSTCIKSVETKR----VPYGNT-----CKFN . . .. . ..... .| .....| . . . .. ..| |.| .| ..| |.. .. .|. |.| VKICSLWCCNRPFVFL-PHEITIYCIHDIMLNWSQDYESSCVDLYVECQLYHG---------------MGKQFCCPVRTSYHQYVKHFFNRTFHLFWKWN QWISFNNIKVSQLPLESRLCFNLKAYAQNSNDYQ-II----GSSTLPIF .|. | .|....|| ..|||. . .. .| .. .. |.|.. .| EWLTFFPIQYCDLPRMARLCITIWDVYDDSKKSEPFFSRCVGWSNFDWF |
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| PI3Ka | n737.AA | PI3Ka | 622-812 | 28 | 6.9e-38 | 133.1 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 622-812
Range on HMM: 1-232/232
Sequence Identity: 28% (67 aa)
HRNFNQTPKTEDLARLQFLLNADPLKRPEFTPEDKHILMISRNHYK-TLTQALQ-----VFLLAVDWLDPEQVKEAILMLKKW--TPLQPEDALPLLDAH
..... . |. .|. ... .|.. | | |.| . |..| . .|| ||..|.| ....||.|. ....| .|..||||| |||..
DYDLKPRWNEEERDQLEDIMKYPPTY--ELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPK
ISN---EIVRLYAVERISTFSDDEIALYMLELTQLLLYE--------------------------RNHFSPLAEMLLERSLLNPYVVGHEFFWQLKSQL-
. . || |||... .||||. .| | | | | || ..| |||...||.|.| || .|| |.|.||| .
FPDYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNP-RIGHFFYWYLKSEMY
-----NVKAFHERFSLLIEQFIMVC-GSFRKEIAN
. . ...|| .| |... .| | ... .
DHCQLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK
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| PI3Ka | n737.AA | PI3Ka | 626-812 | 30 | 1.6e-33 | 116.87 | Pfam | 1-211 (211) | Show / Hide |
Range on Protein: 626-812 Range on HMM: 1-211/211 Sequence Identity: 30% (64 aa) NQTPK--TEDLARLQFLLNADPLKRPEFTPEDKHILMISRNHYK-TLTQALQ------VFLL-AVDWLDPEQVKEAILMLKK--WTPLQPEDALPLLDAH ..... ... .|. ... ||| . | |.| . .| .. . .|| ||. | | |..||..|. ... |.|. |.||| |||. KDLKPVNNKERKQLEQIIKYDPLS--QLTAEEKCLIWKFRHYCCMNNPKALPLMCVGPKFLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCN ISN--EIVRLYAVERIST-FSDDEIALYMLELTQLLLYE----RNHFSPLAEMLLERSLLNPYVVGHEFFWQLKSQL------NVKAF-HERFSLLIEQF .. . || |||... . .||||. .|.| |.| | || . | |.|.. ||.|.. |. . || ||| .|| . |.. .||..| |.. FPDNCPMVRQYAVKCLESYMSDDELLCYLLQLVQALKYENFDEPFHDSYLSRFLLWRAWQNRQRIGHFFFWYMKSEMYKDDEGHDKDYICQRFGVLLESY IMVCGSFRKEIAN || ... . CRECGTHMQHLNK |
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| Kinase | n737.AA | PI3Kc | 939-1200 | 35 | 1.5e-114 | 387.78 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 939-1200
Range on HMM: 1-336/336
Sequence Identity: 35% (119 aa)
KILFKRGDDIRQDQLTLQLLKIMDKIWLDA----GQDFRMKPYKVITTGDQVGMIEVVVNAETTARIH--------------------------------
..|| ||| |||....|....|.||| ..|..|.|||.| ||.. ||||.| |.|| . |.
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
-----------------------KQEGGGLGALKEDTLKNYLQKHNPDK-ENLKSATENFIRSCAGYCVATYILGIGDRHPDNIMLS-QTGHLFHIDFGH
| ..| ... |...|......|.|| |. .| .||.|||||||..||||||||||.||||| .|||.|||||||
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
FLGNFKKKLGID---RERAPFVFTEEMAFVMG--GKESADFKNFTDYCTQAYNLIRKQGNFIINIFLLMLDAGI-PELQSA-KNIEYLKNKLALQ-LSEQ
..|...||.|. |||.||..| .| ||| ||.| .|..| ..| .||...||. | |.|.| .|....| |.... | |.||.... |. ||..
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE
EATNKFKK-----EIHFSLNSRFRKLDNLIHNLVKQ
||...|.. |. |..| . .. ...||. .
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| PI3_PI4_kinase | n737.AA | PI3_PI4_kinase | 937-1151 | 31 | 2.5e-88 | 304.52 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 937-1151 Range on HMM: 1-300/300 Sequence Identity: 31% (95 aa) EMKILFKRGDDIR--QDQLTLQLL-----------------------KIMDKIWLDAGQDFR----MKPYKVITTGDQVGMIEVVVNAETTARIHKQEGG .....||.||| | ||....|.. ..|.|.| | |.| | ||..| ||.. ||||.| |..| ..|.. . WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV GLGALK-----------------------------------EDTLKNYLQKHNPDK-ENLKSATENFIRSCAGYCVATYILGIGDRHPDNIML---SQTG ... . | ... ||||| |.. .| .||.|||||.||..||||.||||.||||. || KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG HLFHIDFGHFLGNFKKKLGIDRERAPFVFTE------EMAFVMGG----KESADFKNFTDYCTQAYNLIRKQGNFIINIF-------LLMLDAGIPELQS |||||||||.....| | .. .|| ||..| .| .||| ..| |. | ||| .||...|...|...| . ..|...|.|.. | HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | n737.AA | ATR | 1018-1141 | 28 | 2.2e-15 | 48.48 | In-house | 147-267 (267) | Show / Hide |
Range on Protein: 1018-1141 Range on HMM: 147-267/267 Sequence Identity: 28% (35 aa) KNYLQKHNPDKENLKSATENFIRSCAGYCVATYILGIGDRHPDNIMLSQ-TGHLFHIDFGHFLGNFKKKLGIDRERAPFVFTEEMAFVMGGKESADFKNF ... . || .. |. ||..|| | .|. ||.|.|||| |||.. . .| . |.|. . | ... . | || |. | | || .. | HDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDY-NCIFNSGEQFEVP-EIVPFRLTHNMVFGMGPMKTYGL--F TDYCTQAYNLIRKQGNFIINIFLLM | ..|.. . |. .. RRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | n737.AA | PIKK | 1033-1077 | 56 | 3.4e-15 | 52.05 | In-house | 184-229 (290) | Show / Hide |
Range on Protein: 1033-1077 Range on HMM: 184-229/290 Sequence Identity: 56% (26 aa) SATENFIRSCAGYCVATYILGIGDRHPDNIML-SQTGHLFHIDFGH ...||..|| | |.. ||||.|||||.|||. .||| . |||||. ERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGC |
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| Kinase | n737.AA | FRAP | 1037-1076 | 60 | 1e-12 | 43.18 | In-house | 139-179 (251) | Show / Hide |
Range on Protein: 1037-1076 Range on HMM: 139-179/251 Sequence Identity: 60% (25 aa) NFIRSCAGYCVATYILGIGDRHPDNIMLS-QTGHLFHIDFG |. || | .| ||||.||||| |||| .|| . ||||| NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG |
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| Kinase | n737.AA | DNAPK | 1036-1080 | 50 | 1.1e-08 | 27.59 | In-house | 188-233 (301) | Show / Hide |
Range on Protein: 1036-1080 Range on HMM: 188-233/301 Sequence Identity: 50% (23 aa) ENFIRSCAGYCVATYILGIGDRHPDNIMLS-QTGHLFHIDFGHFLG | |||. | |. .|||||||| .| | .| ||||| | EHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFG |
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| Kinase | n737.AA | ATM | 1038-1076 | 47 | 2.7e-07 | 18.93 | In-house | 140-179 (304) | Show / Hide |
Range on Protein: 1038-1076 Range on HMM: 140-179/304 Sequence Identity: 47% (19 aa) FIRSCAGYCVATYILGIGDRHPDNIMLS-QTGHLFHIDFG . || | . ||||.|||| ||.. | | ||| | YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG |
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| Kinase | n737.AA | SMG1 | 1035-1075 | 42 | 1.1e-05 | 14.69 | In-house | 187-228 (242) | Show / Hide |
Range on Protein: 1035-1075 Range on HMM: 187-228/242 Sequence Identity: 42% (18 aa) TENFIRSCAGYCVATYILGIGDRHPDNIMLS-QTGHLFHIDF | . || | . ||.|.|||| ||... || |||. TQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY |
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| Kinase | n737.AA | PIKK | 941-961 | 47 | 0.109668 | 2.37 | In-house | 34-54 (290) | Show / Hide |
Range on Protein: 941-961 Range on HMM: 34-54/290 Sequence Identity: 47% (10 aa) LFKRGDDIRQDQLTLQLLKIM |.| ..|.|||| ..||. .| LCKGHEDLRQDQRVMQLFQLM |
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| Kinase | n737.AA | FRAP | 937-957 | 47 | 0.152608 | 1.62 | In-house | 1-21 (251) | Show / Hide |
Range on Protein: 937-957 Range on HMM: 1-21/251 Sequence Identity: 47% (10 aa) EMKILFKRGDDIRQDQLTLQL | | | .||||| .|| EYHFLLKGHEDIRQDERVMQL |
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