Gene n679 (Tetrahymena)
n679
Species: Tetrahymena
Alias: 3677.m00078, n679, 679
External Links:
Annotation:
Sequence
Protein domains of n679.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3K_C2 | n679.AA | PI3K_C2 | 47-153 | 24 | 2.7e-11 | 42.86 | Pfam | 1-129 (168) | Show / Hide |
Range on Protein: 47-153 Range on HMM: 1-129/168 Sequence Identity: 24% (32 aa) ENLEAMVTAQLV--VNEKKI-QPAQQT--LFID-----RMLFEQNIIFN-YKYKDLSYNSIIAITLWCSQKNKDE--------KK-PLGCTTISLFDD-Q .. . |..|. . |.. .| |.| . | . . |.|. .|.||. .. . ||.| . .| . || |.|.....||| PYMDFYVECQVYDGHGGKPLCKPVQSTSYKPFNNHFFPRWNWNEWITFPQIQYCDLPRDARLCITIWEIYCKKKSESNMNEQNKKCPIGWCNLPLFDHEK FRLRQGKYHLYI-WPDTLPDTSYTSITPG ||.|.. |. ||.. |. . . ||. CMLRCGMHKLHMTWPSKPPCPMFPTHTPW |
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| PI3Ka | n679.AA | PI3Ka | 306-515 | 27 | 1e-39 | 139.18 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 306-515 Range on HMM: 1-232/232 Sequence Identity: 27% (67 aa) PQQLKP--SKNELQIIENSIKKPILGELKQDEKLLFYRFR-YSLVQNPEALV-----KFLHSINWDNQKELNEAKKLLKIW--AKCSYGDALHLLSSSFC ..||| ...| . |. .|.| . || ..|| |...|| |.| ..|.|| |||...||... |...| |...| .. . .||| ||...| DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPKFP ANEFYNKKYKKPQDTAIYIRKYACEQLEKEQTSTICSILLQLTQALRYEPFD------------------------YQKSHLAQFLVKKACENTEIATLF . ..|.|| . ||. . |||| |||.|| || |..| |..||...|..| |. | DY------------NCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNPRIGHFF YWYLLVECDKEMDLKEKAKLSSTNQKVQEWFNQVF-ERMNEELEE |||| .|. .. |... .. . ..| . ... ... ..| . YWYLKSEMYDHCQLHDPHY-CQRFGMLLEMYCRGCCGHHMRHLFK |
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| PI3Ka | n679.AA | PI3Ka | 307-482 | 31 | 2.6e-34 | 119.6 | Pfam | 1-180 (211) | Show / Hide |
Range on Protein: 307-482
Range on HMM: 1-180/211
Sequence Identity: 31% (62 aa)
QQLKP-SKNELQIIENSIKKPILGELKQDEKLLFYRFR-YSLVQNPEALV------KFLH-SINWDNQKELNEAKKLLKI--WAKCSYGDALHLLSSSFC
.||| ...|. ..| ||.. | .|...||.| ..|| |.. ||.|| ||| ...| .... ..| |... |.. . ||| ||...|
KDLKPVNNKERKQLEQIIKYDPLSQLTAEEKCLIWKFRHYCCMNNPKALPLMCVGPKFLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCNF-
ANEFYNKKYKKPQDTAIYIRKYACEQLEK-EQTSTICSILLQLTQALRYE----PFDYQKSHLAQFLVKKACENT-EIATLFYWYLLVEC--DKE
.| ...| || . ||. . .||||.|||.|| || ..| |..||...| | .|. |.||. .|. | |
------------PDNCPMVRQYAVKCLESYMSDDELLCYLLQLVQALKYENFDEPF--HDSYLSRFLLWRAWQNRQRIGHFFFWYMKSEMYKDDE
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| Kinase | n679.AA | PI3Kc | 617-888 | 25 | 2.5e-85 | 290.7 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 617-888
Range on HMM: 1-336/336
Sequence Identity: 25% (91 aa)
EMIYKNGDDLRQDQLVMQIFNLMDGLLKGV----GQDFRLMPYKVLACSKNDGFMEFVPNSTTIQDLL--------------------------------
.|.|.|||||||...||.|.||. ... ..|... |||... ....|..|.|||..|. ..
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
--------------------------------KGGKQFSQYLQNLAANPENPIYEEYKRLRMQNDEQGKLSNIEYVSQKIMENYMLSCAGYSVMTYFLGV
. . . ..... .|. . .. ..|. .|||||...|| ||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN------------------------EDWWEARDNFTRSCAGYCMVTYILGI
GDRHLENLMVD-ITGKFFHIDFGFILGQDPKPYPP--------PLKLCRQMIEGMG--GKDSKVYAEFRKKCVHAYIYLRKYAKLIVNLFHLMIDSGI-K
||||..|.|.| ||. ||||||.|.|..||. .. | .|...|...|| ||.|... .||. |..|| .||.. ||.||| .|....|
GDRHNDNIMLDMKTGHCFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMP
DMSIE--ALEKLAEKFYLD-FNDTQAELHFLN----ILDESE-TALFARVTDMIHKWATY
. . . ....| ..| || .| .| .| . |.|.. ... |. .|.|.|| |
CWRMMEKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | n679.AA | PI3_PI4_kinase | 615-840 | 23 | 8e-69 | 239.75 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 615-840
Range on HMM: 1-300/300
Sequence Identity: 23% (76 aa)
KVEMIYKNGDDLR--QDQLVMQIF-----------------------NLMDGLLKGVGQDFR----LMPYKVLACSKNDGFMEFVPNSTTIQDLLKGG--
. .| |.||||| ||...||.. .||....|. | |.| . ||........ |..|.|||.||.. ...
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV
------------------------------------------KQFSQYLQNLAANPENPIYEEYKRLRMQNDEQGKLSNIEYVSQKIMENYMLSCAGYSV
. |.. .. |||. . ..|. .||||..|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDA----YEEWWE--------------------ARDNFVRSCAGMCV
MTYFLGVGDRHLENLMV---DITGKFFHIDFGFILG-----QDPKPYPPPLKLCR------QMIEGMGG----KDSKVYAEFRKKCVHAYIYLRKYAKLI
..| ||.||||..|.|| . ||. ||||||.... ..|| ..| .... .|...||| ..|. | .||. |.||| ||... |.
VDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLC
VNLF-------HLMIDSGIKDMSI
.||. ..|...|. . .
MNLLKKAVMRGECMVHDGLPMWRS
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| Kinase | n679.AA | ATR | 730-830 | 30 | 1.1e-13 | 42.58 | In-house | 165-267 (267) | Show / Hide |
Range on Protein: 730-830 Range on HMM: 165-267/267 Sequence Identity: 30% (32 aa) ENYMLSCAGYSVMTYFLGVGDRHLENLMVD-ITGKFFHIDFGFILGQ---DPKPYPPPLKLCRQMIEGMGGKDSKVYAEFRKKCVHAYIYLRKYAKLIVN |||. | | .... | .| |||| .|...| |.| |.|. | .. | | .| . |. ||| | | ||. |. .|. |. ENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMG--PMKTYGLFRRACEVIMMCMRDHRDDIMS LFHLM ... VWDCF |
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| Kinase | n679.AA | FRAP | 731-770 | 53 | 1.1e-10 | 35.63 | In-house | 139-179 (251) | Show / Hide |
Range on Protein: 731-770 Range on HMM: 139-179/251 Sequence Identity: 53% (22 aa) NYMLSCAGYSVMTYFLGVGDRHLENLMVD-ITGKFFHIDFG || | | |. | || ||||. |.| . ||| ||||| NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG |
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| Kinase | n679.AA | PIKK | 730-774 | 50 | 2.9e-09 | 30.26 | In-house | 187-232 (290) | Show / Hide |
Range on Protein: 730-774 Range on HMM: 187-232/290 Sequence Identity: 50% (23 aa) ENYMLSCAGYSVMTYFLGVGDRHLENLMVD-ITGKFFHIDFGFILG ||| | | .. | || ||||.||.|.| .||. |||||.. . ENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFE |
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| Kinase | n679.AA | ATM | 732-795 | 36 | 7.4e-08 | 20.76 | In-house | 140-207 (304) | Show / Hide |
Range on Protein: 732-795 Range on HMM: 140-207/304 Sequence Identity: 36% (25 aa) YMLSCAGYSVMTYFLGVGDRHLENLMV-DITGKFFHIDFGFILGQD---PKPYPPPLKLCRQMIEGMG | | | |.. | ||.|||| |... . ||| | | | | | .| | ...||| YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMG |
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| Kinase | n679.AA | PIKK | 580-681 | 28 | 8.9e-08 | 24.78 | In-house | 1-100 (290) | Show / Hide |
Range on Protein: 580-681 Range on HMM: 1-100/290 Sequence Identity: 28% (30 aa) IVESIHQQSTVFKSAMAPIKMTFTSYPIGQKEKEGKVEMIYKNGDDLRQDQLVMQIFNLMDGLLKGV----GQDFRLMPYKVLACSKNDGFMEFVPNSTT .. .. . || .. .| |... | .|| . .| ..|||||| ||| | || ..| .. . |.| . | . | | |.|..| RIRFMDRMVTVMAHKQKPKKIYI----RGHDGKE--YPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVT IQDLLK .....| LKEIYK |
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| Kinase | n679.AA | SMG1 | 732-769 | 46 | 3e-06 | 16.61 | In-house | 190-228 (242) | Show / Hide |
Range on Protein: 732-769 Range on HMM: 190-228/242 Sequence Identity: 46% (18 aa) YMLSCAGYSVMTYFLGVGDRHLENLMVDI-TGKFFHIDF | | | |.. | .|.|||||.| ..|. || |||. YARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY |
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| Kinase | n679.AA | DNAPK | 744-774 | 50 | 2.7e-05 | 14.99 | In-house | 202-233 (301) | Show / Hide |
Range on Protein: 744-774 Range on HMM: 202-233/301 Sequence Identity: 50% (16 aa) YFLGVGDRHLENLMVDI-TGKFFHIDFGFILG . ||.|||||.| || .| ||||. | WILGIGDRHLNNFMVNMENGDIISIDFGHSFG |
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| Kinase | n679.AA | FRAP | 615-681 | 26 | 0.000605 | 10.55 | In-house | 1-71 (251) | Show / Hide |
Range on Protein: 615-681
Range on HMM: 1-71/251
Sequence Identity: 26% (19 aa)
KVEMIYKNGDDLRQDQLVMQIFNLMDGLLK----GVGQDFRLMPYKVLACSKNDGFMEFVPNSTTIQDLLK
. | .|.||| |||.| |. ||. . . | .. | | | . |.. |.. |..
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIR
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| Kinase | n679.AA | DNAPK | 619-643 | 44 | 0.005709 | 6.43 | In-house | 36-60 (301) | Show / Hide |
Range on Protein: 619-643 Range on HMM: 36-60/301 Sequence Identity: 44% (11 aa) IYKNGDDLRQDQLVMQIFNLMDGLL .|| . |||||| . | | | . . CYKGIEDLRQDQRIEQLFQVMNNIF |
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| Kinase | n679.AA | ATM | 618-644 | 40 | 0.011371 | 3.9 | In-house | 2-28 (304) | Show / Hide |
Range on Protein: 618-644 Range on HMM: 2-28/304 Sequence Identity: 40% (11 aa) MIYKNGDDLRQDQLVMQIFNLMDGLLK . | |||||| . |.| . ||. QLVKGRDDLRQDAVMQQVFQMCNTLLQ |
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