Gene n502 (Tetrahymena)
n502
Species: Tetrahymena
Alias: n502, 3701.m01490, 502
External Links:
Annotation:
Sequence
Protein domains of n502.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Zf-C3HC4 | n502.AA | zf-C3HC4 | 264-304 | 25 | 1.9e-09 | 28.39 | Pfam | 1-48 (48) | Show / Hide |
Range on Protein: 264-304 Range on HMM: 1-48/48 Sequence Identity: 25% (12 aa) CSVCLIEFQESDQIRITICDHI-----FHSECLLQWLK--SQENCPNC | .|. |. . . |. | | |...|...|.. . .|| | CWICHCEWKDPNNPLIHPCGHRGSLKWFCHSCIKRWWNHSGNTQCPIC |
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| RING | n502.AA | RING | 264-304 | 24 | 7e-06 | 26.72 | SMART | 1-23 (23) | Show / Hide |
Range on Protein: 264-304 Range on HMM: 1-23/23 Sequence Identity: 24% (10 aa) CSVCLIEFQESDQIRITICDHIFHSECLLQWLKSQENCPNC |..|| .... | | |. |. || | CPICLE-------PVVLPCGH-FCY-CI---------CPIC |
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| PI3Kc | n502.AA | PI3Kc | 1493-1744 | 27 | 3.3e-86 | 293.62 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 1493-1744
Range on HMM: 1-336/336
Sequence Identity: 27% (92 aa)
AVIFKGGDDLRQELLAMQLIYKFQSIFQKA----NLQLWLRPYEIIVTSASSGIIEFLPNTYSIDGLKK-------------------------------
|||||.||||||. ..||.. .. | || .. |..||| .|.|. .|.||. ||. .. ..|
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
------------------------------KVPKFTCLYDFYKDYFGKQ---FQQAQSNFIESLAGYSIVCYLLQFKDRHNGNILID-NSGHLIHIDYGF
.. |. .|||. ...|. ...|..||. |.|||..|.|.|. .||||.||..| ..||..|||.|.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
MFCISPGGINF-----ENAPFKLTKEYAQLMG--GKESEGFERYKNLVFQGFKELQKYVDEIIFLVQIMQEESDLPCFRGF--DIKVFRERFQEH-LDEK
.| .|. . | | .||.||... .|| ||.|. | ... .. .... . |. ..|. |...|. . .||.|.. |||. |.||.. | ..
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE
NLLLYVNK-----LINDSYDNWRTKQYDNFQKMTNG
. . |. . ||..| . | |. |. |......
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| PI3_PI4_kinase | n502.AA | PI3_PI4_kinase | 1491-1696 | 20 | 5e-41 | 147.42 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 1491-1696
Range on HMM: 1-300/300
Sequence Identity: 20% (63 aa)
LRAVIFKGGDDLR--QELLAMQLI-----------------------YKFQSIFQKANLQLW----LRPYEIIVTSASSGIIEFLPNTYSIDGLKKKV--
..||||||||| |. . ||.| . . .| .. . ..|| .| |. .|.||..||....... ..
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV
---PKF------------------------------------TCLYDFYKDYFGKQ---FQQAQSNFIESLAGYSIVCYLLQFKDRHNGNILI---DNSG
|. ||.. ..... ...| .||..|.||...| |.|. ||||.||.. . .|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG
HLIHIDYGFMFC--ISPGGINFENAPFKLTK------EYAQLMGG----KESEGFERYKNLVFQGFKELQKYVDEIIFLV-------QIMQEESDLPCFR
||.|||.|..| .......| ||..|. .. .||| ..|. ..... . .. . | .. . .. | ..| .. ||..|
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMV-HDGLPMWR
G
S
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| Kinase | n502.AA | ATR | 1575-1685 | 27 | 1.3e-12 | 38.82 | In-house | 158-267 (267) | Show / Hide |
Range on Protein: 1575-1685 Range on HMM: 158-267/267 Sequence Identity: 27% (31 aa) KQFQQAQSNFIESLAGYSIVCYLLQFKDRHNGNILIDN-SGHLIHIDYGFMFCISPGGINFENAPFKLTKEYAQLMGGKESEGFERYKNLVFQGFKELQK .|. ...|.. | | ...| |.. ||| ||||| | ..|.|| .| | ||.||. || ...| | | . ... QQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVI--MMCMRD YVDEIIFLVQIM |.|. ... HRDDIMSVWDCF |
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| Kinase | n502.AA | ATM | 1587-1650 | 43 | 1.6e-07 | 19.7 | In-house | 143-207 (304) | Show / Hide |
Range on Protein: 1587-1650 Range on HMM: 143-207/304 Sequence Identity: 43% (28 aa) SLAGYSIVCYLLQFKDRHNGNILI-DNSGHLIHIDYGFMFCISPGGINFENAPFKLTKEYAQLMG | | ||| |.| ||| |||| . | |.||| | | | ||.||.. || SVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMG |
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| Kinase | n502.AA | FRAP | 1583-1622 | 41 | 1e-06 | 20.76 | In-house | 139-179 (251) | Show / Hide |
Range on Protein: 1583-1622 Range on HMM: 139-179/251 Sequence Identity: 41% (17 aa) NFIESLAGYSIVCYLLQFKDRHNGNILID-NSGHLIHIDYG |. ||| |.. |.| ||| ||... .| ..|||.| NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG |
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| Kinase | n502.AA | PIKK | 1582-1625 | 42 | 4e-06 | 18.59 | In-house | 187-231 (290) | Show / Hide |
Range on Protein: 1582-1625 Range on HMM: 187-231/290 Sequence Identity: 42% (19 aa) SNFIESLAGYSIVCYLLQFKDRHNGNILIDN-SGHLIHIDYGFMF .|.. |.| ..| | | ||| ||.|| .| ..|||.|. | ENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCF |
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| Kinase | n502.AA | SMG1 | 1587-1621 | 47 | 0.000547 | 8.93 | In-house | 193-228 (242) | Show / Hide |
Range on Protein: 1587-1621 Range on HMM: 193-228/242 Sequence Identity: 47% (17 aa) SLAGYSIVCYLLQFKDRHNGNILID-NSGHLIHIDY | | |.| |.. ||| |.||| | .|||| STAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY |
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| Kinase | n502.AA | PIKK | 1496-1555 | 31 | 0.018779 | 5.19 | In-house | 35-98 (290) | Show / Hide |
Range on Protein: 1496-1555 Range on HMM: 35-98/290 Sequence Identity: 31% (20 aa) FKGGDDLRQELLAMQLIYKFQSIFQKA----NLQLWLRPYEIIVTSASSGIIEFLPNTYSIDGL .||..||||. |||. ..|| | .| | .| | .|.|| ..|. .. .. CKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEI |
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