Gene n235 (Tetrahymena)

n235

Species: Tetrahymena
Alias: n235, 3811.m00987, 235
External Links:
Annotation:

Classification

Group: Other
Family: Ciliate-C6

Sequence

Name Sequence Type Origin Length Description Download
n235.AA Protein None 178 None Fasta, JSON
n235.NA RNA None 540 None Fasta, JSON
n235.kin_dom Protein Kinase Domain None 160 None Fasta, JSON

Protein domain

Protein domains of n235.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase n235.AA Ciliate-C6 5-168 67 2.1e-115 389.73 In-house 129-306 (306) Show / Hide 
Range on Protein: 5-168
Range on HMM: 129-306/306
Sequence Identity: 67% (121 aa)

SEIYEESEIVKFLSQIGKTLAIIYVEERIAHRDIKPSNILIIDN--NYYLSDFGCAENLFDSEGAKYN-LVMGTLKWMSPELKEKKK----------IEA
.| ..|.|||.|..|||||||.||.|..|||||||||||||.|.  ||||||||||..||.||... | ..|||||||||||.|.||           ..
YEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLFQSEFTRNNDIHMGTLKWMSPELREMKKQYNQHQDDNSNQQ

IDYFKSDIFSLGMVLLYMLTLSDISAVNSDEFSKNQKLRIMRNSCKYVS-KEIILLVSKMLETNPDFRPDAPILIQAI
|||||.|||||||.||||||||||| ||.|||.||||.|||.|.||..| ||||.|||||||||||.|||..||||.|
IDYFKCDIFSLGMILLYMLTLSDISQVNCDEFMKNQKIRIMKNMCKDISYKEIIKLVSKMLETNPDHRPDMSILIQTI
Kinase n235.AA Pkinase 8-168 20 7.3e-18 64.25 Pfam 103-293 (293) Show / Hide 
Range on Protein: 8-168
Range on HMM: 103-293/293
Sequence Identity: 20% (40 aa)

Y--EESEIVKFLSQIGKTLAIIYVEERIAHRDIKPSNILII-DNNY----YLSDFGCAENLFDSEGAKYNLVMGTLKWMSPELKEKKKIE-AIDY-FKSD
.  .| |. ... || . |. ..  ..| |||.||.||||  ...      ..|||.|. .    .  .. . ||. .|.||.     |  . .|  |.|
FYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV-----IRGGQYYGPKVD

IFSLGMVLLYMLT----LSDI----SAVNSDEFSKNQKLRIMRNSCKYVS--------------------KEIILLVSKMLETNPDFRPDAPILIQA--I
..|.| .| .||.     ..     . .. ..  .. . .. . .. . .                    .| . .....|. .|  || |. . |   .
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase n235.AA Ciliate-E2 8-161 21 3e-17 55.77 In-house 142-356 (365) Show / Hide 
Range on Protein: 8-161
Range on HMM: 142-356/365
Sequence Identity: 21% (49 aa)

YEESEIVKFLSQIGKTL-------------AIIYVEER--IAHRDIKPSNILIIDNNYYLSDFGCAE---------------NLFDSEG-----------
. | || ..  || .               |. |  ..  | ||||||.|||.      ..||| .                ...   .           
FTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD

-----AKYNLVMGTLKWMSPELKEKKK-----IEAIDYFKSDIFSLGMVLLYMLTL-SDISAVNSDEFSKNQKLRIMRN--------------SCKYVSK
       .| . ||.  |.||  ..||      .    .|.||.|||..| .||.           .  |..|...  .              | |..|.
QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQ

EIILLVSK----MLETNPDFRPD-A
| . | .|    ||. .|. |.. .
ECKDLIKKFGKRMLQKDPEKRITGW
Kinase n235.AA STE 30-161 22 3.8e-17 57.19 In-house 170-348 (359) Show / Hide 
Range on Protein: 30-161
Range on HMM: 170-348/359
Sequence Identity: 22% (42 aa)

EERIAHRDIKPSNILIIDNNYYLSDFGCAENLFDS--------------EGA-KYNLVMGTLKWMSPELKEKKKIE-AIDY-FKSDIFSLGMVL------
. .| ||||||.|||.      |.|||.. .| ||               .. | | . ||  ||.||  .. .     .| .|.|| ||| ..      
SHHIIHRDIKPANILL----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG

-LYMLTLSDISAVNSDEFSK-------------NQKLRIMRNSC---------------KYVSKEIILLVSKMLETNPDFRPDA
   . .... .|     |..             ..  ..  . .               . .|.| .  ..| |. .|. ||.|
KPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTA
Kinase n235.AA Ciliate-E2-Unclassified 5-111 24 4.7e-16 52.21 In-house 132-265 (352) Show / Hide 
Range on Protein: 5-111
Range on HMM: 132-265/352
Sequence Identity: 24% (33 aa)

SEIYEESEIV-----KFLSQIGKTLAIIYVEERIAHRDIKPSNILIIDN----NYYLSDFGCAENLFDSEGAK--------------YNLVMGTLKWM--
..| .| ...     ... || . |  .  .  | ||||||.|||. .|    .  ..||| . .. .... .              .. ..||.  |  
RKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQ

--SPELKEKKKIEAIDYFKSDIFSLGMVLLYMLT
  .||. .... .    .|.||.|||..| .||.
YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF
Kinase n235.AA ULK 29-111 26 7.4e-16 51.92 In-house 147-251 (329) Show / Hide 
Range on Protein: 29-111
Range on HMM: 147-251/329
Sequence Identity: 26% (28 aa)

VEERIAHRDIKPSNILIIDNNYY-------------LSDFGCAENLFDS--EGAKYNLVM------GTLKWMSPELKEKK-KIEAIDYFKSDIFSLGMVL
....| ||||||.|||| ... .             ..||| |  . ..  | . .          ||   |.|.. ... . .  . .|.||.|||...
HKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF

LYMLT
 .||.
YEMLY
Kinase n235.AA Ciliate-B2 33-103 38 5.5e-15 31.59 In-house 125-197 (197) Show / Hide 
Range on Protein: 33-103
Range on HMM: 125-197/197
Sequence Identity: 38% (29 aa)

IAHRDIKPSNILIIDN-NYYLSDFGCAENLFDSEGAKYNLVMGTLKWMSPELKEKK----KIEAIDYFKSDIFSLG
| | ||||.|||.  | || ..|||    .   . .. .    | |. |||  |.         || |.|||.|.|
ILHLDIKPQNILFMQNGNYVYCDFGIS-SIKK-DNQQIKIKGFTKKYASPEQMECDHNQTFVTNID-FQSDIYSMG
Kinase n235.AA Ciliate-A1 10-107 28 1.2e-14 46.26 In-house 100-219 (301) Show / Hide 
Range on Protein: 10-107
Range on HMM: 100-219/301
Sequence Identity: 28% (35 aa)

ESEIVKFLSQIGKTLAIIYVEERIAHRDIKPSNILII-DNNYYLSDFGCAENLFDSE---------------GAKYNLVM--GTLKWMSPEL-----KEK
. ||. ...|| . .| |  .  | |||.|| ||||  |. . . |.|    |  .                   |. .   |.|  ||||.     ...
KEEIYEICYQIIEGYADIH-DHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQ

KKIEAIDYFKSDIFSLGMVLL
. ||. .| .||..|||....
MFIENKIYKQSDMYSLGCIIC
Kinase n235.AA C8 33-106 37 1.5e-14 47.0 In-house 144-226 (226) Show / Hide 
Range on Protein: 33-106
Range on HMM: 144-226/226
Sequence Identity: 37% (31 aa)

IAHRDIKPSNIL-IIDNNYY----LSDFGCAENLFDSEGAKYNLVM---GTLKWMSPELKEKKKIEAIDY-FKSDIFSLGMVL
| ||||||.|.|   |.||     |.||| |  . ...   .   |   ||.... ||  .|.. .  .|  .||.||.|.||
IMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase n235.AA TKL 33-168 18 2.3e-14 48.16 In-house 161-364 (364) Show / Hide 
Range on Protein: 33-168
Range on HMM: 161-364/364
Sequence Identity: 18% (37 aa)

IAHRDIKPSNILIIDNN---------------YYLSDFGCAENLFDSEGAKYNL------------------VMGTLKWMSPEL---------K---EKK
|.|||.|..|||. .|.                 ..||| . ... |.. . .                   . ||. ||.||.         |   .. 
IIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE-

KIEAIDYF-KSDIFSLGMVLLYMLTLSDISAVNS-----------DEFSKNQ--KLRIMRN----------SCKYVSKEIILLVSKMLETNPDFRPDAPI
...  .|. |.|..| |.||  .||     . .            ..|...   .||  .            |... .... |  .  ...|. || .  
FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQE

LIQAI
... .
ILKRL
Kinase n235.AA CAMK 33-111 26 1.5e-13 39.29 In-house 200-329 (425) Show / Hide 
Range on Protein: 33-111
Range on HMM: 200-329/425
Sequence Identity: 26% (34 aa)

IAHRDIKPSNILIIDN------------------NYYLSDFGCAENLFDSE----------------------GAKYNLVMGTLKWMS-PELKEKKK---
|.|||.|| |||. ||                  |  ..||| |  ....|                      | |.. . ||.  |. ||. ..|.   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----IEAIDY--FKSDIFSLGMVLLYMLT
      | ..|  .|.|. |.| .|  ||.
MQNATDEEKPYYGPKCDMWSCGVILYIMLC
S_TKc n235.AA S_TKc 1-168 15 3.6e-08 -57.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-168
Range on HMM: 1-231/231
Sequence Identity: 15% (42 aa)

YKNISEI------------------------------------------------------------------------------------YEESEIVKF
|. . .|                                                                                    . | .. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

LSQIGKTLAIIYVEERIAHRDIKPSNILIIDNNYYLSDFGCAENLFDSEGAKYNLVMGTLKWMSPELKEKKKIEAIDYFKSDIFSLGMVLLYMLT----L
. || . |. .    .| |||.||.|||. . .  ..||| |  |        . . ||. .|.||.         ...|.|. |.| .|  ||.     
MYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYEMLCGYPPF

SDISAVNSDEFSKNQKLRIMRNSCKYVSKEIILLVSKMLETNPDFRPDAPILIQ---------AI
.             |  ..... .   |.| . ...|.|. .|. || |  . |          .
P-------------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc n235.AA TyrKc 1-168 12 0.000933 -161.89 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-168
Range on HMM: 1-280/280
Sequence Identity: 12% (35 aa)

YKN------------------------------ISEIYEESEIVKFL-------------SQIG-------KTLAII-----------YVEERIA-----
 .                               . ....| .| . |                .       . | |.           |  ..       
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

----------------------HRDIKPSNILIIDNN-YYLSDFGCAENLFDS-----EGAKYN-----LVM--GTLKWMSPELKEKKKIEAIDYF----
                      |||.   |.|. .|.    |||| . .. |      ..  |             ..||.|        |.|.|     
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP--------ECINYGKFTT

KSDIFSLGMVL--LYMLTLSDISA-----VNSDEFSKNQKLRIMRNSCKY--------VSKEIILLVSKMLETNPDFRPDAPILIQAI
|||..| | ..  .. .  .  .      .. .|  .. | . ..   ..         ..|.  . ..  . .|. ||    ... .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase n235.AA CAMK 138-161 37 0.023871 2.57 In-house 393-416 (425) Show / Hide 
Range on Protein: 138-161
Range on HMM: 393-416/425
Sequence Identity: 37% (9 aa)

YVSKEIILLVSKMLETNPDFRPDA
.||.| . |..|||...|. |. .
FVSQECKDLIRKMLQVDPEKRMTI