Gene n29 (Tetrahymena)

n29

Species: Tetrahymena
Alias: n29, 72.m00167, 29
External Links:
Annotation:

Classification

Group: Atypical
Family: PI3K
Subfamily: PI4K

Sequence

Name Sequence Type Origin Length Description Download
n29.AA Protein None 2284 None Fasta, JSON
n29.NA RNA None 6855 None Fasta, JSON

Protein domain

Protein domains of n29.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PI3Kc n29.AA PI3Kc 2022-2281 27 3e-75 257.22 SMART 1-336 (336) Show / Hide 
Range on Protein: 2022-2281
Range on HMM: 1-336/336
Sequence Identity: 27% (93 aa)

SCIFKVFDDVRQDQLALQIITLFQGIFQKA----NLELYVFPYKTISNRTGNNLDIGGIIEVVKNSISRDQLGK--------------------------
. |||. || |||....|.. |.. | ||     .. |...||| |.   .     .|.||.|.|. .. |. |                          
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPK-----CGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQ

-------------------------------------TNQCSLYDYFINKFGQEDSANFQVARENFIKSQAAYSVISYILQIKDRHNGNILIN-DKGHII
                                     ... .|||.|...|....  ... ||.||..| |.|....|||.|.||||.||..  . ||..
KNMYMMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN-EDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCF

HIDFGFIFDISPANNLRF-----ESANFKLTKEMIQIMGG-SKDSEAFQYYVNLTIKGFLTMRNYFEHIYNTIRLMVASSL-PCFLKN--SMKNLVSRFV
|||||.||. .   .. |     | . |.||..|. .|||  |.|. |.|.. .  .... || . . | |....|| ... ||. ..  . |.| .|| 
HIDFGHIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFR

LD-KNDIEAAKYMRN-----IIYDAYDKFTTRWYDDIQYLQNK
|| ..| |||.|. .     .| .  . .||| |. ...... 
LDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
PI3_PI4_kinase n29.AA PI3_PI4_kinase 2020-2233 20 1.3e-44 159.28 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2020-2233
Range on HMM: 1-300/300
Sequence Identity: 20% (62 aa)

QVSCIFKVFDDVR--QDQLALQII-----------------------TLFQGIFQKANLELY----VFPYKTISNRTGNNLDIGGIIEVVKNSISRDQLG
 .. |||. || |  ||.. .|.|                       .|. .. .| .. .     ..||. |.  ...     |.||.|.|. . ... 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWC-----GMIEWVPNCTTFHEIP

KTNQ-------------------------------------------CSLYDYFINKFGQEDSANFQVARENFIKSQAAYSVISYILQIKDRHNGNILI-
.|                                             ..||..|. .....   ... ||.||..| | ..|..|||.. ||||.||.. 
RTYMVKCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDA-YEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVK

--NDKGHIIHIDFGFIFD-ISPANNLRFESANFKLTK------EMIQIMGGS---KDSEAFQYYVNLTIKGFLTMRNYFEHIYNTI-------RLMVASS
   ..||..|||||..|.         .|   |..|.      .|.  |||    ..|. .. .  .  . .. .| . . . |..        .|| . 
DDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDG

LPCFLK
||.. .
LPMWRS
Kinase n29.AA ATR 2099-2220 26 3.5e-15 47.77 In-house 148-267 (267) Show / Hide 
Range on Protein: 2099-2220
Range on HMM: 148-267/267
Sequence Identity: 26% (33 aa)

DYFINKFGQEDSANFQVARENFIKSQAAYSVISYILQIKDRHNGNILIND-KGHIIHIDFGFIFDISPANNLRFESANFKLTKEMIQIMGGSKDSEAFQY
|.|  .|   |. ..  .|||...| |..... ||. . |||  ||||.   | ..|.|.  ||      .   |   |.||. |.  ||  |    |  
DWFNRRF--PDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVP-EIVPFRLTHNMVFGMGPMKTYGLFRR

YVNLTIKGFLTMRNYFEHIYNTI
 .  ... .   |.    .... 
ACEVIMMCMRDHRDDIMSVWDCF
Kinase n29.AA PIKK 2116-2161 46 5.6e-09 29.21 In-house 185-231 (290) Show / Hide 
Range on Protein: 2116-2161
Range on HMM: 185-231/290
Sequence Identity: 46% (22 aa)

ARENFIKSQAAYSVISYILQIKDRHNGNILINDK-GHIIHIDFGFIF
.|||.. | |  ..  ||| . |||  ||.|.   | |.|||||..|
RRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCF
Kinase n29.AA FRAP 2117-2163 43 1.6e-07 23.88 In-house 137-184 (251) Show / Hide 
Range on Protein: 2117-2163
Range on HMM: 137-184/251
Sequence Identity: 43% (21 aa)

RENFIKSQAAYSVISYILQIKDRHNGNILIN-DKGHIIHIDFGFIFDI
| |. .| |  |.. ||| . |||  ||...   | |.|||||  |..
RTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEV
Kinase n29.AA ATM 2117-2162 42 4.1e-07 18.35 In-house 137-183 (304) Show / Hide 
Range on Protein: 2117-2162
Range on HMM: 137-183/304
Sequence Identity: 42% (20 aa)

RENFIKSQAAYSVISYILQIKDRHNGNILINDKG-HIIHIDFGFIFD
|  . .| |  |.. ||| . |||  |||||..   ..||| |  |.
RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFE
Kinase n29.AA DNAPK 2117-2161 45 0.000146 12.31 In-house 187-232 (301) Show / Hide 
Range on Protein: 2117-2161
Range on HMM: 187-232/301
Sequence Identity: 45% (21 aa)

RENFIKSQAAYSVISYILQIKDRHNGNILIN-DKGHIIHIDFGFIF
|| || . |   .  .|| | |||  | ..| . | || ||||. |
REHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSF