Gene n8 (Tetrahymena)
n8
Species: Tetrahymena
Alias: n8, 96.m00094, 8
External Links:
Annotation:
Sequence
Protein domains of n8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3K_rbd | n8.AA | PI3K_rbd | 251-359 | 14 | 0.000428 | 5.75 | SMART | 1-116 (116) | Show / Hide |
Range on Protein: 251-359 Range on HMM: 1-116/116 Sequence Identity: 14% (17 aa) NKEKTTNNQP-LEDQYSVKIKAELV-----TAFLYKLYFNKNKNRADEVLKKTLREVYYKYKIKLQPQDNK--TFILKIEGYREYLSGHYPMLSYDRVRT . .|. . . .. ...| .. . . . .| | . .|.|.. .... .... .|. . .|||. | .|||.. .| ... .| MSRKCPEHIWMKTINNKIIIVVHWEKRVCNWQQTKTMDCNPNCT-PDSVMHQFFCKMMMNHSMHDQNDPTDECDYILKVCGRDEYLHPDHPLGQFEYIRN NLRIKKSLKVILDQKQN . .. ...|... CIMWGRCPHFVLMECCK |
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| PI3K_C2 | n8.AA | PI3K_C2 | 850-942 | 25 | 3.6e-13 | 49.64 | Pfam | 5-115 (168) | Show / Hide |
Range on Protein: 850-942 Range on HMM: 5-115/168 Sequence Identity: 25% (28 aa) IQVQVKLM--YGNRALAVKK-ETQKIPFS----RSPRWDEWIKFPLIKISQLPLESRICFDIIVYSVTGLDS---------QIIGSTNFYIFDQ-FCKFT . |.. . .|.. |. |. ||. ...|.|||.|| |....||...|.|. | .. . .. . || .|...||. | .. FYVECQVYDGHGGKPLCKPVQSTSYKPFNNHFFPRWNWNEWITFPQIQYCDLPRDARLCITIWEIYCKKKSESNMNEQNKKCPIGWCNLPLFDHEKCMLR QGISPLNI-WP .| |. || CGMHKLHMTWP |
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| PI3K_C2 | n8.AA | PI3K_C2 | 822-925 | 17 | 2.2e-05 | 24.71 | SMART | 1-133 (133) | Show / Hide |
Range on Protein: 822-925 Range on HMM: 1-133/133 Sequence Identity: 17% (23 aa) FATDHGDKGCSYFQ--------QLCQKYDINFAP-Y-----LIQVQVKLMYG-NRALAVKKETQK----IPFSRS-----PRWDEWIKFPLIKISQLPLE . . . .. .|. . . ..|. . | . |.. | .| .. .. . |.. .|. . ..|.||..| |....|| . VKICSLWCCNRPFVFLPHEITIYCIHDIMLNWSQDYESSCVDLYVECQLYHGMGKQFCCPVRTSYHQYVKHFFNRTFHLFWKWNEWLTFFPIQYCDLPRM SRICFDIIVYSVTGLDSQ-II----GSTNFYIF .|.|. | .. .. .| .. |..|| .| ARLCITIWDVYDDSKKSEPFFSRCVGWSNFDWF |
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| PI3Ka | n8.AA | PI3Ka | 1075-1211 | 28 | 2.9e-24 | 85.03 | Pfam | 58-211 (211) | Show / Hide |
Range on Protein: 1075-1211 Range on HMM: 58-211/211 Sequence Identity: 28% (44 aa) FLC-AVDWSNPEHIRETYNLLKQ--WKSPPCEECITFLDAHHAD--EVIRLYGVERISK-MADDEIKLYMIELVQALMFE----NNHYSPIQELLLERSL || | |.... ..| |.. | . .. . ||. ..| . .| |.|... . | |||. .|.. ||||| .| . | |. ..||.|.. FLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCNFPDNCPMVRQYAVKCLESYMSDDELLCYLLQLVQALKYENFDEPFHDSYLSRFLLWRAW LNPFVVGHELFWSLKSQL------HLKQS-YERYALVLEQLLMLSGEYRSELLK |. . || .|| .|| . | | .|....||... | ....|.| QNRQRIGHFFFWYMKSEMYKDDEGHDKDYICQRFGVLLESYCRECGTHMQHLNK |
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| PI3Ka | n8.AA | PI3Ka | 1029-1211 | 25 | 9e-20 | 72.93 | SMART | 6-232 (232) | Show / Hide |
Range on Protein: 1029-1211 Range on HMM: 6-232/232 Sequence Identity: 25% (58 aa) P--QNQYLAELKELLKRDPINRNFDMRQKLILLICRNHFK-SIHQALD-----IFLCAVDWSNPEHIRETYNLLKQW--KSPPCEECITFLDAHHAD--- | ... .|....|..| . . ..|| |... . .|| || .|.||... ..| |..|| . . |. . .||....| PRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKF-RHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPKFPDYNC EVIRLYGVERISKMADDEIKLYMIELVQALMFE--------------------------NNHYSPIQELLLERSLLNPFVVGHELFWSLKSQL------H ...| | |... .| |||. .| ||||| .| ..| || . ||.|.| || .|| ..| ||| . | PHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNP-RIGHFFYWYLKSEMYDHCQLH LKQSYERYALVLEQLLMLS-GEYRSELLK .. ..|....||... . |.. .|.| DPHYCQRFGMLLEMYCRGCCGHHMRHLFK |
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| Kinase | n8.AA | PI3Kc | 1302-1559 | 32 | 9.2e-96 | 325.37 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 1302-1559
Range on HMM: 1-336/336
Sequence Identity: 32% (108 aa)
SIMFKDGDDLRQDILTLQLIRIMDKIWLDN----NLDLRMKPYNVVATLDQVGMLEIVQNSQTTAAIHK-------------------------------
...|| ||||||| ...|..|.|.||| . ..||.|.||....| .. ||.| | |. | . |.|
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
-----------------------QNNQRFGC-LMKESIQKYLKKHNKNYE----QARANFRTSCAGYCVATYILGIGDRHSDNIMIT-KEGHFFHIDFGH
. . | ..........|..... .|| || ||||||..||||||||||.||||.. |.|| |||||||
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
FLGNFKKKFGIN---RERSPFVFTRVMEYVML---EKQEDYEAFEKYCCQAYNLIRKHGNFFINIFRMMLSAGM-PELQRE-SDIEYLVETLQLN-LSDQ
..|...||.|.. ||| ||..|. | ||| . ... | ..||.||...||| | ..|.|.||..... |... . ||.|| ....|. |||.
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE
EAEQHFKK-----QIRIAREDKFKLFDNFIHEIVKK
|| |.|.. |. .| ... . ...| . .
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | n8.AA | PI3_PI4_kinase | 1300-1510 | 29 | 4e-76 | 263.99 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 1300-1510
Range on HMM: 1-300/300
Sequence Identity: 29% (89 aa)
EFSIMFKDGDDLR--QDILTLQLI-----------------------RIMDKIWLDNNLDLR----MKPYNVVATLDQVGMLEIVQNSQTTAAIHKQN--
. ...|| ||||| || ...|.| |.|.|.| ...|.| | || ...| .. ||.| | |. | . |..
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV
---------NQRFGCLM------------------------KESIQKYLKKHNKNY--EQ--ARANFRTSCAGYCVATYILGIGDRHSDNIMI---TKEG
. .. .| |... ....|||.. | || || .||||.||..||||.||||.||||. .. |
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG
HFFHIDFGHFLGNFKKKFGINRERSPFVFTR------VMEYVM-----LEKQEDYEAFEKYCCQAYNLIRKHGNFFINIF-------RMMLSAGMPELQR
| |||||||.....| |.....|| ||..|. | ..| |. .||. |..||..||...|.|.|...| . .|. .|.|.. .
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
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| Kinase | n8.AA | ATR | 1394-1500 | 30 | 1.8e-11 | 34.94 | In-house | 163-267 (267) | Show / Hide |
Range on Protein: 1394-1500 Range on HMM: 163-267/267 Sequence Identity: 30% (33 aa) ARANFRTSCAGYCVATYILGIGDRHSDNIMITK-EGHFFHIDFGHFLGNFKKKFGINRERSPFVFTRVMEYVMLEKQEDYEAFEKYCCQAYNLIRKHGNF .| |. | | .|. ||.|.||||.|||.| | | |.|. . | ..| . | || |. |.. | . | | . | ..|.| . SRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDY-NCIFNSGEQFEVP-EIVPFRLTHNMVFGM-GPMKTYGLFRRACEVIMMCMRDHRDD FINIFRMM . .. IMSVWDCF |
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| Kinase | n8.AA | PIKK | 1394-1437 | 51 | 5.7e-10 | 32.84 | In-house | 185-229 (290) | Show / Hide |
Range on Protein: 1394-1437 Range on HMM: 185-229/290 Sequence Identity: 51% (23 aa) ARANFRTSCAGYCVATYILGIGDRHSDNIMITKE-GHFFHIDFGH .| |. | | |.. ||||.|||| .|||| .. | |||||. RRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGC |
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| Kinase | n8.AA | FRAP | 1395-1436 | 51 | 3.6e-09 | 29.99 | In-house | 137-179 (251) | Show / Hide |
Range on Protein: 1395-1436 Range on HMM: 137-179/251 Sequence Identity: 51% (22 aa) RANFRTSCAGYCVATYILGIGDRHSDNIMITKE-GHFFHIDFG | |. | | .| ||||.|||| |||. . | ||||| RTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG |
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| Kinase | n8.AA | DNAPK | 1406-1440 | 52 | 1e-06 | 19.98 | In-house | 198-233 (301) | Show / Hide |
Range on Protein: 1406-1440 Range on HMM: 198-233/301 Sequence Identity: 52% (19 aa) CVATYILGIGDRHSDNIMITKE-GHFFHIDFGHFLG |. .|||||||| .| |. | | ||||| | CISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFG |
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| Kinase | n8.AA | ATM | 1401-1436 | 45 | 3.2e-05 | 12.18 | In-house | 143-179 (304) | Show / Hide |
Range on Protein: 1401-1436 Range on HMM: 143-179/304 Sequence Identity: 45% (17 aa) SCAGYCVATYILGIGDRHSDNIMITKEG-HFFHIDFG | | . ||||.|||| ||.| ||| | SVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG |
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| Kinase | n8.AA | PIKK | 1297-1386 | 25 | 0.002715 | 8.28 | In-house | 27-129 (290) | Show / Hide |
Range on Protein: 1297-1386 Range on HMM: 27-129/290 Sequence Identity: 25% (26 aa) NQKEFSIMFKDGDDLRQDILTLQLIRIMDKIWLDN----NLDLRMKPYNVVATLDQVGMLEIVQNSQTTAAIHKQNNQRFGCLMKESIQK---------Y . ||. ..| ..||||| ..||...| .. . .| . |.|.. .. | .| |.|. | .| ||. |... . .| . DGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYKQWCQKKHIRHEQEAQMNYQTCMYRDW LKK ||. LKQ |
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| Kinase | n8.AA | FRAP | 1300-1320 | 38 | 0.136514 | 1.8 | In-house | 1-21 (251) | Show / Hide |
Range on Protein: 1300-1320 Range on HMM: 1-21/251 Sequence Identity: 38% (8 aa) EFSIMFKDGDDLRQDILTLQL |. . | .|.||| .|| EYHFLLKGHEDIRQDERVMQL |
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