Gene n1168 (Tetrahymena)

n1168

Species: Tetrahymena
Alias: n.28253, 1168, n1168
External Links:
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
n1168.AA Protein None 695 None Fasta, JSON
n1168.NA RNA None 1864 None Fasta, JSON
n1168.kin_dom Protein Kinase Domain None 170 None Fasta, JSON

Protein domain

Protein domains of n1168.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase n1168.AA Ciliate-C7 120-288 57 1.3e-89 287.51 In-house 1-142 (164) Show / Hide 
Range on Protein: 120-288
Range on HMM: 1-142/164
Sequence Identity: 57% (97 aa)

FRFLGLGAHGLVVLAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQCKGSPYVANLLHKIEGNDYIFLVLTECLGIYHSLPSKFYSIHLLM
||||| |. |||.|||...|| ||||||. ..|...|.|| |..||||||..|.|||.|||| .|||..||...|.|||.||.|                
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQG----------------

HKLNGISRQKIGTLSDIIKNTQNQRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNAV
           |||..||...||.||||.||||| ||||.|||.||||.|.||||||||||||||||||
-----------GTLNQIIERNQNKRLNEISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAV
Kinase n1168.AA AGC 117-198 19 7.9e-13 28.0 In-house 1-112 (395) Show / Hide 
Range on Protein: 117-198
Range on HMM: 1-112/395
Sequence Identity: 19% (22 aa)

YDEFRFLGLGAHGLVVLAKEK------STNKRYAIKGIPIKD---SKD--NVDQVILGQ-------VQQEIQMLNQCKG---------SPYVAN-LLHKI
..  . .| |. | | |...|      .|.| ||.| .  |.    |.   |....  .       |..| ..| .|..         .|.. . | .  
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EGNDY--IFLVL
. .|.  ...|.
QDKDHTYLYFVM
Kinase n1168.AA CAMK 122-200 17 1.1e-12 36.47 In-house 1-140 (425) Show / Hide 
Range on Protein: 122-200
Range on HMM: 1-140/425
Sequence Identity: 17% (24 aa)

FLGLGAHGLVVLAKEKSTN------------KRYAIKGIPIKDSKDNV----------------------DQVILGQVQQEIQMLNQCKG------SPYV
 || |. | | |...|.|.            ...||| |. |  ||..                      ... . .|..||.......|       | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ANLLHKIEG-------------------NDYIFLVL--TE
 .|.. .|                    ......|.  .|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIME
Kinase n1168.AA S_TKc 117-414 19 2.7e-11 -11.17 SMART 1-231 (231) Show / Hide 
Range on Protein: 117-414
Range on HMM: 1-231/231
Sequence Identity: 19% (62 aa)

YDEFRFLGLGAHGLVVLAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQCKGSPYVANLLHKIEGNDYIFLVLTECLGIYHSLPSKFYSIH
|.  | .| || | | ....|.|....||| |.              ....|||.| .  . |.. .|.  ..  |....|.  | |             
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDG-------------

LLMHKLNGISRQKIGTLSDIIKNTQNQR----LNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNAVK--------------GNVIFQAPE
              |.| |.||. . ..    ..|  | .|.. |...| ..||.. .  ||| .|||.|     .|              |   . |||
------------DLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQLTTFCGTPWYMAPE

CYDPSKFDIYSQEYMNLGVPVQQNPSQRVFYRQNLINIQKIYYINL-KSEACSLGYLLYTMISGFQANLVFSKHQPLQYNADFQNLAYEKQLRYIIDGLT
                                            .  |.   |.| .|| |..|             |... |...   .... .|... 
VL----------------------------------------GYGKCKCDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG-SPEAKDFIRKCL

KFIPRERLKVKEALI---------VL
.. |..|. . |||           .
QKDPEKRPTA-EALQDEWDIKCHPWF
Kinase n1168.AA Ciliate-A2 124-176 32 3.3e-11 35.43 In-house 1-56 (272) Show / Hide 
Range on Protein: 124-176
Range on HMM: 1-56/272
Sequence Identity: 32% (18 aa)

GLGAHGLVVLAKEK--STNKRYAIKGIPIKDSKDN-VDQVILGQVQQEIQMLNQCK
| |. |.|......    |. |||| ..| |..|  ..|  | . . |.| |  |.
GQGCFGCVIFVEHMDNHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNCN
Kinase n1168.AA STE 117-185 16 3.7e-11 35.76 In-house 1-96 (359) Show / Hide 
Range on Protein: 117-185
Range on HMM: 1-96/359
Sequence Identity: 16% (16 aa)

YDEFRFLGLGAHGLVVLAKEK------STNKR---------YAIKGIPIKDSK-----------DNVDQVILGQVQQEIQMLNQCKG-SPYVANLL
..  ...| || | |..|. .      .|..          .||| .......           .|... .. |...||.....|.  .|.. . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYY
Kinase n1168.AA STE-Unique 231-288 31 6.2e-10 30.88 In-house 379-450 (616) Show / Hide 
Range on Protein: 231-288
Range on HMM: 379-450/616
Sequence Identity: 31% (23 aa)

GTLSDIIKNTQN-------QRLNELSAIKYTKDIAEGLYFIHSKK--CLVNDLKMDNILIDYNG-----NAV
|||..|||..         | . |  .|.||. |.||| ..||..   .  ||| .||...  |     ...
GTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVK
Kinase n1168.AA CAMKL 117-198 24 5.5e-09 24.65 In-house 1-100 (297) Show / Hide 
Range on Protein: 117-198
Range on HMM: 1-100/297
Sequence Identity: 24% (24 aa)

YDEFRFLGLGAHGLVVLAKE-KSTNKRYAIKGIP--IKDSKDNVDQVILG-------QVQQEIQMLNQCK--GSPYVANLLHKIEGNDY------IFLVL
|.  . || |. | | ||.  . |....||| |    .  ......  .|        ...||| . . .  . | .  |.. ||  ..      |.||.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM
Kinase n1168.AA ULK 117-198 22 8.1e-09 27.49 In-house 1-96 (324) Show / Hide 
Range on Protein: 117-198
Range on HMM: 1-96/324
Sequence Identity: 22% (22 aa)

YDEFRFLGLGAHG-LVVLAKEKST---NKRYAIKGIP---IKDSKDNVD-QVILGQVQQEIQMLNQCK--GSPY--VANLLHKIEGN--DYIFLVL
|   . || |. |  |  .. | |   |. .|.| |.   ....| . . |... . ..||| . . |   .|.  .  |..  |    ..|....
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM
Kinase n1168.AA ULK 117-198 20 8.3e-09 26.96 In-house 1-99 (329) Show / Hide 
Range on Protein: 117-198
Range on HMM: 1-99/329
Sequence Identity: 20% (20 aa)

YDEFRFLGLGAHGLVVLAKEKST----NKRYAIKGIPIK-DSKDNVD---QVILGQVQQEIQMLNQCK---GSPY----VANLLHKIEGN--DYIFLVL
|   . || |. | |  .. | |    |. .|.| |...  ...| .   |... ....||. . . |   ....    .  |..  |    ..|....
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM
Kinase n1168.AA Ciliate-E2 231-289 22 1.4e-08 25.59 In-house 119-196 (365) Show / Hide 
Range on Protein: 231-289
Range on HMM: 119-196/365
Sequence Identity: 22% (19 aa)

GTLSDIIKNT----------QNQRLNELSAIKYTKDIAE---------------GLYFIHSKK-CLVNDLKMDNILIDYNGNAVK
|.| |.|||           . ....|  .....| |..               .| ..|||. ..  |.| .|||.      .|
GDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IK
Kinase n1168.AA Pkinase 117-198 29 4.6e-08 29.59 Pfam 1-79 (293) Show / Hide 
Range on Protein: 117-198
Range on HMM: 1-79/293
Sequence Identity: 29% (25 aa)

YDEFRFLGLGAHGLVVLAKEKSTNKRYAIKGIPIKDSKDNVDQVI--LGQVQQEIQMLNQCKGSPYVANLLHKIEGNDYIFLVL
|   | .| |. | | ....|.|.|..|.| |. .. |...||    |    .|||... . ..|..  |..  | .|.| .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVM
Kinase n1168.AA ULK 231-284 30 5.4e-08 24.1 In-house 105-166 (329) Show / Hide 
Range on Protein: 231-284
Range on HMM: 105-166/329
Sequence Identity: 30% (19 aa)

GTLSDIIKNTQN--------QRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYN
|.|...||. ..        .||.|  ||.. |.|..|. ..|....   |.| .||||. .
GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNG
Kinase n1168.AA Pkinase 231-289 33 7.1e-08 28.92 Pfam 85-152 (293) Show / Hide 
Range on Protein: 231-289
Range on HMM: 85-152/293
Sequence Identity: 33% (23 aa)

G----TLSDIIKNTQNQRL--NELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNA---VK
|     |.|.|.  .. ..   |  ...| . |..||...||....  ||| .||||| ||.    ||
GLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVK
Kinase n1168.AA STE-Unique 118-185 22 4.5e-07 20.56 In-house 1-67 (616) Show / Hide 
Range on Protein: 118-185
Range on HMM: 1-67/616
Sequence Identity: 22% (15 aa)

DEFRFLGLGAHGLVVLAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQCKGSPYVANLL
 .  ..| |. | |.... |....|.||| |..|  ||        . . ||. .  .. ........
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLH-HQNIVKYY
Kinase n1168.AA STE 231-289 29 8.6e-07 20.14 In-house 122-187 (359) Show / Hide 
Range on Protein: 231-289
Range on HMM: 122-187/359
Sequence Identity: 29% (21 aa)

GTLSDIIK---NTQN---------QRLNELSAIKYTKDIAEG-LYFIHSKKCLVNDLKMDNILIDYNGNAVK
|.|.||||    ...         .|..|   ......| .| ||..||..    |.| .|||.      ||
GSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VK
Kinase n1168.AA ULK 231-284 31 2e-06 19.26 In-house 102-162 (324) Show / Hide 
Range on Protein: 231-284
Range on HMM: 102-162/324
Sequence Identity: 31% (19 aa)

GTLSDIIKNTQN-------QRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYN
|.|...||. ..       .||.|  ||.. |.|..|. ..|....   |.| .||||  .
GDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNG
Kinase n1168.AA CAMKL 231-289 32 2e-06 16.73 In-house 106-169 (297) Show / Hide 
Range on Protein: 231-289
Range on HMM: 106-169/297
Sequence Identity: 32% (21 aa)

GT--LSDIIKNTQN--QRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGN-AVK
|   | | |..  .  .|. |  | .| . | ......||..    |.| .|||.|.|||  .|
GEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIK
Kinase n1168.AA Ciliate-E2 117-146 33 3e-05 13.94 In-house 1-30 (365) Show / Hide 
Range on Protein: 117-146
Range on HMM: 1-30/365
Sequence Identity: 33% (10 aa)

YDEFRFLGLGAHGLVVLAKEKSTNKRYAIK
|.  . .| |..| | ..| ....|..|||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIK
Kinase n1168.AA CAMK 236-289 21 0.000685 7.63 In-house 155-236 (425) Show / Hide 
Range on Protein: 236-289
Range on HMM: 155-236/425
Sequence Identity: 21% (18 aa)

IIKNTQN------------QRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNG----------------NAVK
|......             |..|  | .| . |.... ..||..    ||| .|||.|.|.                | .|
IVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIK
Kinase n1168.AA Ciliate-A2 233-286 28 0.000895 9.33 In-house 85-140 (272) Show / Hide 
Range on Protein: 233-286
Range on HMM: 85-140/272
Sequence Identity: 28% (16 aa)

LSDIIKNTQNQR--LNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGN
|.| |.  |||.  ...  ...... | ...  .|.|   . ||.  ||||| ...
LQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQ
Kinase n1168.AA TyrKc 117-374 12 0.000984 -162.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 117-374
Range on HMM: 1-280/280
Sequence Identity: 12% (43 aa)

YDEFRFLGLGAHGLVVLAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQC-KGSPYVANLLHKIEGN-------DYIFLV--------LTE
    . || || | |.... |      |.| .             .    .|.... .  .  | . .|.  .          . ...|        | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

CLGIYHSLPSKFYSIHLLMHKLNGISRQKIGTLSDIIKNTQNQRLNELSAIKYTKDIAEGLYFIHSKK----------CLVNDLK---------MDNILI
 |  ..                                      |.    ...  .||.|  ..|||.          |||.. .         . .|  
YLRKHRPK------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYD

D--------YNGN----AVK--GNVIFQAPECYDPSKFDIYSQ------------EYMNLGVPVQQNPSQRVFYRQNLINIQKIYYINLKSEA-------
|        |         |    .   ||||    .. ...             | . .| .   .. |..   | .|.  |  |   . .        
DDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFV

-CSLGYLLYTMISGFQA---------NLVFSKHQPL
 |.       | .  ..         ..    |. .
CCPDEMYQ-IMKQCWHEDPEDRPTFSEI----HECF
Kinase n1168.AA AGC 273-286 53 0.002979 2.67 In-house 179-193 (395) Show / Hide 
Range on Protein: 273-286
Range on HMM: 179-193/395
Sequence Identity: 53% (8 aa)

D-LKMDNILIDYNGN
| || .|||.| .|.
DYLKPENILLDEDGH