Gene PhK_ (Fruit Fly)

PhK_

Species: Fruit Fly
Alias: DPhK-gamma, EP779, CG1830, phosphorylase kinase gamma, PhK_, anon-sts6, ESTS:194B3T
External Links: Flybase Link
Annotation:

Classification

Group: CAMK
Family: PHK

Sequence

Name Sequence Type Origin Length Description Download
PhK_.AA Protein None 560 None Fasta, JSON
PhK_.kin_dom Protein Kinase Domain None 269 None Fasta, JSON

Protein domain

Protein domains of PhK_.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PhK_.AA PHK 23-291 72 1.8e-241 808.49 In-house 1-273 (273) Show / Hide 
Range on Protein: 23-291
Range on HMM: 1-273/273
Sequence Identity: 72% (198 aa)

YEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQVM---GHPYIIDLQDVFESDAFVFLVFELCPKGELFDYL
||||||||||.||||||||.|.||.|||.||||...|....|....||.|||||||.||||||   |||.||.|.|..|...|.||||...|.|||||||
YEPKEILGRGVSSTVRRCIHKNTGQEFAVKIIDITGTEHQSENEAEHMREATRQEIHILRQVMEGEGHPNIIQLHDFYETNSFMFLVFDMMPRGELFDYL

TSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKLTNLCGTPGYLAPETLKCNMF-EGSPGYSQEVDIWA
|..|||||||||.||||.||||.|.||..||||||||||||.|.|.|.||.|||||.||||||||..|||||||||||..||.|. |..|||.||||.||
TEKVTLSEKKTRRIMRQLFEGVCYMHAHNIVHRDLKPENILCDDNMNIKISDFGFACQLQEGEKLRELCGTPGYLAPEMIKCSMYLENHPGYGQEVDMWA

CGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFF
|||||.|||.|||||||||||.|||.||||||.|.||||.|||..|||||.|||.|||.||||..|.|.||||
CGVIMYTLLAGCPPFWHRKQMMMLRMIMEGKYQFGSPEWDDISDTPKDLISKCLQVDPQQRITAEECLQHPFF
Kinase PhK_.AA CAMK 28-291 28 4.6e-126 408.46 In-house 1-425 (425) Show / Hide 
Range on Protein: 28-291
Range on HMM: 1-425/425
Sequence Identity: 28% (120 aa)

ILGRGISSTVRRCIEKETG------------KEFAAKI-------------------IDLGATTESGETNPYHMLEATRQEISILRQVMG------HPYI
.||||  ..|..||.|.|.            ...|.||                   ||   .  ...    ....  |.||.|.... |      || |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IDLQDVFES-------------------DAFVFLVF---ELCPKGEL----FDYLTSV---------------VTLSEKKTRTIMRQIFEGVEYIHAKSI
| | .|.|.                   | ....|.   |.|. |||    |||...                  ..|. .|...||| ..|.|.| . |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENILLDENH-----------------NVKITDFGFAKQLQE------------------------GEKLTNLCGTPGYLA-PETL----KCNM
|||||||||||||.|.                 |.||.|||||.....                        |.|..  ||||.| | || |    .|||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

FEG-----SPGYSQEVDIWACGVIMFTLLVGCPPFWHR-------------KQMVMLRNIMEGKYSFTSPE------------WADISED--------PK
. .      |.|....|.|.||||....|.|.|||..               .  ....||.|||.| .|.            | |||..         |
Q-NATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLIRKCLVVDPSQRITVKEVLRHPFF
|||||.|.|||..|.|....|.||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PhK_.AA CAMK1 23-291 40 1e-118 346.75 In-house 1-276 (276) Show / Hide 
Range on Protein: 23-291
Range on HMM: 1-276/276
Sequence Identity: 40% (114 aa)

YEPKEILGRGISSTVRRCIEKET---GKEFAAKIIDLGATTESGETNPY-HMLEATRQEISILRQV--MGHPYIIDLQDVFESDAFVFLVFELCPKGELF
|| ....|||  |.|..|..|||   ||..| |.||     .. ...     .|| ..||.|...|    || || .....||| .. || ||.  ||||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDK---KKFMKKKDMQK-QEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELF

DYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILL---DENHNVK--ITDFGFAKQLQEGE-KLTNLCGTPGYLAPETLKCNMFEGSPGY
|        .||. |.||.||.. |||.|.| ||||||||||.|.   ||.. .|  | ||| .|.. ..| ...  |||||| ||| |.|       .|
DRIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK---DKPY

SQEVDIWACGVIMFTLLVGCPPFWHRK-QMVMLRNIMEGKYSFTSPEWADISED-PKDLIRKCLVVDPSQRITVKEVLRHPFF
....|.| .||| ..||.|.|||.    .. ... |....| | ||.| .||.   ||.|.. |.|||..|.|....|.||..
DKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase PhK_.AA S_TKc 23-291 36 1.1e-111 378.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 23-291
Range on HMM: 1-231/231
Sequence Identity: 36% (105 aa)

YEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPK--GELFDYLT
||  ...|.|  ..|..|..|.||...| |||.                | .|.||.||..  .||.|. | |||..  ....|.|.|.   |.||||. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIK

SVVT------LSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKLTNLCGTPGYLAPETLKCNMFEGSPGYSQ-E
.  .      ..|  .| .|.||....||.| . |.|||||||||||||  ..||.|||.|.||      | .|||| |.||| |         ||.  .
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---------GYGKCK

VDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLR-------HPFF
.|.|.||.|.. .|.|.|||.   ...|...|.              |.. ||.|||||..||..|.|. |.|.       ||.|
CDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PhK_.AA Pkinase 23-291 34 2.8e-106 364.16 Pfam 1-293 (293) Show / Hide 
Range on Protein: 23-291
Range on HMM: 1-293/293
Sequence Identity: 34% (107 aa)

YEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGE-----TNPYHMLEATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKG----
|. ....|.| ...|..|..| |||..| |||..  . .. .     .          .||.|.. . .||.|. | |.||..  . .|.|.|..|    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----------SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVM

ELFDYLT--SVVTL--SEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNV----KITDFGFAKQ--LQEGEKLTNLCGTPGYLAPETLKCNM
.||||..  .  ..  ||.  . .|.||..|.||.|...|.||||||||||.|.| ..    ||.|||.|||  .  .. .| .||||.|.||| ..   
DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---

FEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHR------KQMVMLRNIMEGKYSFTSPEWADIS-----------------EDPKDLIRKCLVVDPSQRI
  |...|...||.|.||.|.. .| | |||...       ||.|...||.....| .|.| .||                 |. ||.|..|| .||..|.
--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP

TVKEVLRHPFF
| ...| ||.|
TAEQILQHPWF
Kinase PhK_.AA AGC 23-291 23 2.3e-104 270.15 In-house 1-395 (395) Show / Hide 
Range on Protein: 23-291
Range on HMM: 1-395/395
Sequence Identity: 23% (96 aa)

YEPKEILGRGISSTVRRCIEK------ETGKEFAAKIIDLGATTESGETNPYH-------MLEATRQE------------ISILRQVMG---------HP
.| . ..|.|  ..|. . .|       ||| .| |...                     |.| |  |              || .. .         ||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKH----------KIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHP

YIID-LQDVFESDAF--VFLVFELCP---------KG-ELFDYLT---SVVTLSEKKTRTIMRQ-------IFEGVEYIHA-KSIVHRD-LKPENILLDE
.|.  |   |...    ...| |..|          | ||| .|       ...|. .| .. .       |  ..||.|  . |.||| ||||||||||
FIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDE

NHNVKITDFGFAKQLQEGE--------------------------------------------------KLTN-LCG--TPGYLAPETLKCNMFEGSPGY
. ..|.||||..|..  ..                                                  ..|. .||  || |.||| |          |
DGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----------Y

SQEVDIWA--CGVIMFTLLVGCPPFWHR----------KQMVMLRNIMEGKYSFTSP------------EWADISEDPKDLIRKCLVVDPSQRIT-----
....|.|.   |..|. .|.|.||| .            .| |  .||.|.| .. .            |.  .|.. ||||.|.|..||..|..     
GKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGND

-----VKEVLRHPFF
     ..|. .||.|
FGDKGAEEIKNHPWF
Kinase PhK_.AA RSK 25-291 33 8.8e-94 317.87 In-house 1-278 (278) Show / Hide 
Range on Protein: 25-291
Range on HMM: 1-278/278
Sequence Identity: 33% (95 aa)

PKEI--LGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSV
 |.   .| |  ...|.|. . ||...| |...      .  .     .. |..|..||  . .|| |..| ..|. .  ..|. |.|. ||||. |   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKD-----TRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKE

VT---LSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDE---NHNVKITDFGFAKQ-LQE-GEKLTNLCGTPGYLAPETLKCNMFEGSPGYSQEV
..   .||.  . .|..|   ||..| . |.||||||||||.|.   .  .|.|||||.||   . ....   |.|  |.||| ||     .  |... .
KHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN--QQGGHDKAC

DIWACGVIMFTLLVGCPPFWH---RKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVVDPSQRIT-----VKEVLRHPFF
|.|  ||.|...|.||||| .     . . ...|..||.|.|.|.|. .|.. ||||||.| .||..|..     ..|...||.|
DWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PhK_.AA CAMKL 23-291 35 4.7e-93 297.3 In-house 1-297 (297) Show / Hide 
Range on Protein: 23-291
Range on HMM: 1-297/297
Sequence Identity: 35% (108 aa)

YEPKEILGRGISSTVRRCIE-KETGKEFAAKIIDLGATT-ESGETNP------YHMLEATRQEISILRQV-MG-HPYIIDLQDVFESDAF------VFLV
|.  . ||.|  ..|. ..  . ||.. | ||||   .. .   ..         ..   |.||.|....  | || || | .|.| . .      ..||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

FELCPKGE--LFDYLTSV----VTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENH--NVKITDFGFAKQLQE-----GEKLTNLCGTPGY
 |.|. ||  ||||. .       ..|. .| . ||| ..|.|.| . |||||.||||||||||.  |.||.||||. . ..     |.||.  ||.| |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

LAPETLKCNMFEG--SPGYSQEVDIWACGVIMFTLLVGCPPFWHR--------KQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVVDPSQRITVK
 |||     .|.|   | . ..||||.||||......|  ||            .  ... ||.| | .  | | ..| | .||||| |.|.|..|.|..
MAPE-----IFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYP--PIWYHVS-DCRDLIRKMLQVNPEKRPTIH

EVLRHPFF
....||..
QIMNHPWM
Kinase PhK_.AA RAD53 23-291 33 2.2e-91 272.43 In-house 1-305 (305) Show / Hide 
Range on Protein: 23-291
Range on HMM: 1-305/305
Sequence Identity: 33% (103 aa)

YEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQVMGHPYIIDLQDVFES-DAFVFLVFELCPKGELFDYLTS
|   ..||.|  .||....||.|.. .| ||||.   .  . ..   . .  . |. ||. .  || || . |.|.. .  ...| ||   ||||. . |
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFF-IRCMHTIKKMDQVMNEVEILKKLN-HPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVS

VVT----LSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENH------------------NVKITDFGFAKQLQEGEKLTNLCGTPGYLAPETL
  .    ..| . ... .|. ..| |.| . |.||||||||||....                    .|||||| .| ..||. .. .|||| |.||| .
NKRCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVI

K----CNMFEGS-----PGYSQEVDIWACGVIMFTLLVGCPPFW-HRKQ----MVMLRNIME-GKYSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKE
      . .| .      ||. .||.|  |.| ...| | |||  ...|    | .   |   |||.|..|.|..|||  ||||.. |.|||  |.|..|
TSKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDE

VLRHPFF
.|.|| .
ALNHPWM
Kinase PhK_.AA Ciliate-E2 23-291 27 4.5e-86 292.27 In-house 1-365 (365) Show / Hide 
Range on Protein: 23-291
Range on HMM: 1-365/365
Sequence Identity: 27% (104 aa)

YEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESG-------------ETNPYHMLEATRQEISILR---------------QVMGHPYIIDLQ
|.  ...|.|  ..|..|  ....|.|| ||||      ..             ...   ..|.. |||.|.|               . . ||.|| . 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

DVFE--SDAFVFLVFELCPKGELFDYLTSV-----------VTLSEKKTRTIMRQIFE---------------GVEYIHAKS-IVHRDLKPENILLDENH
..|.  .|  ..||.|.|  |.||||. .              ..||. ..||.||..               ..||.| |  |.|||.||||||.    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

NVKITDFGFAKQLQE-----------GEKLTNL----------------------CGTPGYLAPETLKCNMFEG---SPGYSQEVDIWACGVIMFTLLVG
 .||.|||..|....           ....                         ||||||.||| |.    ..   . ||. ..|||..|||.. .| |
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

CPPFWHRKQMVMLRNIMEGKYSFTSPE--------------WADISEDPKDLIRK----CLVVDPSQRIT-VKEVLRHPFF
 |||        ...|...|..| .||              | ..|.. ||||.|    .|..||..|||  ...| ||.|
KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase PhK_.AA CAMK-Unique 23-291 24 2.2e-82 271.77 In-house 1-363 (363) Show / Hide 
Range on Protein: 23-291
Range on HMM: 1-363/363
Sequence Identity: 24% (92 aa)

YEPKEILGRGISSTVRRCIEKETGKEFAAKIIDL-GATTESGETN---------PYHMLEA-TRQEISILRQVMGHPYIIDLQDV----FESDA------
|.  .|.| |  . |..|. .||||..| |.. . ..  ... ..             ..  .. |..|.. | .|| || | |.    |. .       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMV-DHPNIIKLYDWNNPIFCDRKYPLCDL

---------FVFLVFELCPKGELFDYLTS--------------------VVTLSE--KKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDEN------
           ..| |.|..|.|||.. .                       .||    |..||... . |.| | ..|||||||.|||.. ..      
IIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNH

----------HNVKITDFGFAKQLQEGEKLT---NLCGTPGYLAP--------------ETLKCNMFEGSPGYSQEV----DIWACGVIMFTLLVGCPPF
          ...|..||| ...... .. .   . |||| |.||              |...       ..|.| .    |||..||||...|.|||||
HRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVIN------MQCYDQQCSPASDIWSLGVIMYYMLCGCPPF

WHRKQM--------VMLRNIMEGKY-SFTSPEWAD---ISEDPKDLIRKCLVVDPSQRITVKEVLRHPFF
 .              ...|. |.| .| .. | .   ||.  ||.. .|..|||..|.. || | |...
DCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase PhK_.AA MARK 23-291 34 7.2e-82 267.41 In-house 1-262 (262) Show / Hide 
Range on Protein: 23-291
Range on HMM: 1-262/262
Sequence Identity: 34% (98 aa)

YEPKEILGRGISSTVRRCIEKETGKEFAAKIID---LGATTESGETNPYHMLEATRQEISILRQVMGHPYIIDLQDVFE--SDAF-VFLVFELCPKGELF
|. .  .| |  ..|. .. | ||...| ||..   |         |. . ..  . ||.|....  ||.|| | .|.|       ..|. |....|||.
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKL---------NDPQWMKNVMREIEIMKKLD-HPNIIKLFHVIEQDTEQHQIYLIMEYASGGELY

DYLTSV--VTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENH--NVKITDFGFAKQLQEGEKLTNLCGTPGYLAPETLKCNMFEGSPGYSQ
||. ..    |.|. .|.| ||| ..|.| | |.|||||.||||||.|||   |.||.||||. . ..|.||.  |||| | |||     .|.. | . .
DYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPE-----IFLKKPYDGP

EVDIWACGVIMFTLLVGCPPFWHRK--QMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFF
.||||..||.......|. ||      .  . ..|  |||.. .     .| . ..||.. |.|.|..|.|..|...||..
KVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH----VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase PhK_.AA TyrKc 23-291 23 6.6e-15 18.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 23-291
Range on HMM: 1-280/280
Sequence Identity: 23% (73 aa)

YEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQV-MGHPYIIDLQDVFESD-------AFVFLVFELCPKGE
 . ...||.|   .|.... |    . | | .  .|            .|. ..|..|....   || |. |  |  ..         ...|.|..|.| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD

LFDYL-TSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEG-----EKLTNLC----GTPG-----YLAPETL
| |||  .  .|. |.   .. || .| ||.| | ..||||   |.|..||| |||.||| .. . ..     .| .       |. .      .|||..
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

KCNMFEGSPGYSQEVDIWACGVIM---FTLLVGCPPFWH-----RKQMVMLRNIMEGKYSFTSPE-----WADISEDPKDLIRKCLVVDPSQRITVKEVL
. ..|      . . |.|. || |   ||.  | .| .       .   .......|..    |.         ...  .....|   ||..| | .|. 
NYGKF------TTKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-

RHPFF
 | .|
-HECF
Kinase PhK_.AA Pkinase_Tyr 76-182 34 5.2e-13 44.68 Pfam 52-165 (270) Show / Hide 
Range on Protein: 76-182
Range on HMM: 52-165/270
Sequence Identity: 34% (39 aa)

QEISILRQVMGHPYIIDLQDVFE-SDAF--VFLVFELCPKGELFDYLTS----VVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVK
.|..|..|   || |. |  |    .    ...|.|..|.| | ||| .       |. |    . .|| .| || ..| ..||||   |.|..||. ||
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK

ITDFGFAKQLQEGE
|.||| |. ... .
ICDFGLARDIYNDD