Gene CG11489 (Fruit Fly)
CG11489
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| CG11489.AA | Protein | None | 880 | None | Fasta, JSON |
| CG11489.kin_dom | Protein Kinase Domain | None | 308 | None | Fasta, JSON |
Protein domains of CG11489.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | CG11489.AA | SRPK | 382-874 | 24 | 3.3e-174 | 453.4 | In-house | 303-554 (554) | Show / Hide |
Range on Protein: 382-874
Range on HMM: 303-554/554
Sequence Identity: 24% (121 aa)
NQQIDDEINSLRVKGVDFPDSYISSIEKQTKSRAKWPLIEPNGSTNTNTNTSNSTATNSNSSTPLAAVIMSTLDKEDTTTTTSSTLNSNTTSSLASKYSS
..|. |
QKQNND----------------------------------------------------------------------------------------------
LLGDSECNGGLGGSANINNRYRTEKKITAKSSGDCDEDAESDTLGEQSTLASTMDSPTDLDPEPELDSKPNTVPEPTTIAKSKINSNILSTCTSLTSTNE
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YCFTNTNTTTASTPSAPPSATPSSAPALASATPPSTCTPSFTQIAPSATAPATSTTCTTSAEFYDGDHKTTSTSTTTTSNAISSATTTTATTTTAIAKLN
|.. |.. .. . . ||. | . |. ...... ....... .
---------------------------------------------PNFESQNDSQMEQETNSCNNQEHKQEKTMQCQDSTKQQNKQDQQKEGQKQSEESE
VHANAIPSQNQSQSSQNNTYTIQS----LID-NSNVRVKIADLGNACYDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHA
. ...| . .. ..| . ....|||||||||. .||||||||||||||.||..||.||..||||||||.|||||||||||.||.
CESEDMQEQ-------AGKFLVWWKNPRNADLDHKIKIKIADLGNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFEPHS
GESYSRDEDHLAHIVELLGSIPQSVIFRGKHGLKYFTSYGSLRNITKLKPWSLMNVLVEKYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWL
||.||||.||.|||.||.|.||......||.. ..|...|.||.|.|||||.|||||.|||.|.. |||.|.|||.|||.||| ||.|.||||||||
GEDYSRDDDHIAHIIELCGKIPWHFALSGKYSREFFNKKGELRHIPKLKPWPLMNVLIEKYEWSHEEAKQFEDFLMPMLHYNPEKRATAKECLQHPWL
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| Kinase | CG11489.AA | SRPK | 232-378 | 52 | 5.9e-140 | 363.06 | In-house | 1-168 (554) | Show / Hide |
Range on Protein: 232-378 Range on HMM: 1-168/554 Sequence Identity: 52% (88 aa) FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPM---------------------DVKRERIVRLMNHFTVRGVNG ..|.||||||||||||||.|.....|||.|.|||||||.|||.|||.||...|..||. | .|...|.|..||..||.|| YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG MHTCLVFEALGCSLYKLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLVIDNA .|.|.||| ||..|.|.| ..||||.....|..|.||||.||||||.||.||||||||||.|| .... NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCVNQD |
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| Kinase | CG11489.AA | CMGC | 232-874 | 13 | 6.8e-115 | 379.19 | In-house | 1-513 (513) | Show / Hide |
Range on Protein: 232-874
Range on HMM: 1-513/513
Sequence Identity: 13% (110 aa)
FRVVRKLGWGHFSTVWLCRD--------------LKDEKYVALKVVKSAPHYIETAA-------------DEIRLLEAIR----------DADPMDVKRE
. ...|.|.|....|. ||| .....||.| .|... | |.| .||..|. .. | ||.. ...
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN
RIVRLMNHFTVRGVNGM-------------HTCLVFEALGCSLYKLIVKNN--YQG------------------------LAIAQVRNIIRQVLEGLD--
||.| ..|. .. .| | .|||| ....||..| .|. ||| . | ..| ...|.|.||.
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK
YLHSKC-SIIHTDIKPENILLVID-----------NAAAMNQQIDDEINSLRVKGVDFPDSYISSIEKQTKSRAKWPLIEPNGSTNTNTNTSNSTATNSN
|.||.. .|||.|.||||||. . .
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSE----------------------------------------------------------------
SSTPLAAVIMSTLDKEDTTTTTSSTLNSNTTSSLASKYSSLLGDSECNGGLGGSANINNRYRTEKKITAKSSGDCDEDAESDTLGEQSTLASTMDSPTDL
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DPEPELDSKPNTVPEPTTIAKSKINSNILSTCTSLTSTNEYCFTNTNTTTASTPSAPPSATPSSAPALASATPPSTCTPSFTQIAPSATAPATSTTCTTS
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AEFYDGDHKTTSTSTTTTSNAISSATTTTATTTTAIAKLNVHANAIPSQNQSQSSQNNTYTIQSLIDNSNVRVKIADLGNACYDYHH-------------
. .. ..| |.||.| |.|.. .|
----------------------------------------------------------D-W-NPC--QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFK
-----------FTEDIQTRQYRSIEVLLGAP----------YNYTADIWSTACLAFELATG--------DYLFDPHAGE-----SYSRDEDHLAHIVELL
.|....|| ||. |.|||.. |... |.|| .| .|. || ..|| .| .. ..... |.|..|...|
NVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVL
GSIPQSVIFRGK-------HGLKYFTSYGSLRNITKLK-------------------------PWSLMNVLVEKYDWDPV--------------------
|... ..| .|| | .... . .......| || . . ... |.|
GTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFK
------------EAKKFSDFLLPMLEYNPVIRASAAECLQHPWL
. ... |.| ||.|.| | .|...||||..
SHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
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| Kinase | CG11489.AA | CLK | 232-874 | 16 | 2e-75 | 225.41 | In-house | 1-350 (350) | Show / Hide |
Range on Protein: 232-874
Range on HMM: 1-350/350
Sequence Identity: 16% (110 aa)
FRVVRKLGWGHFSTVWLCRDLKDEK-YVALKVVKSAPHYIETAADEIR-LLEAIRDA-DPMDVKRERIVRLMNHFTV-RGVNGMHTCLVFEALGCSLYKL
. .| .|| | |..| |.| | .| |||||..... | | | ||. ...| . || ..| .... | | | |.||| .| |.| .
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHG----HICIVFELYGLSIYDF
IVKNN------YQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLVID----NAAAMNQQIDDEINSLRVKGVDFPDSYISSIEKQTKSRAKW
. .|| |... |...|.. .| .| . || . ...||| |||||..| . . .. . ||
MKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH-DMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKIN---------------------------
PLIEPNGSTNTNTNTSNSTATNSNSSTPLAAVIMSTLDKEDTTTTTSSTLNSNTTSSLASKYSSLLGDSECNGGLGGSANINNRYRTEKKITAKSSGDCD
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EDAESDTLGEQSTLASTMDSPTDLDPEPELDSKPNTVPEPTTIAKSKINSNILSTCTSLTSTNEYCFTNTNTTTASTPSAPPSATPSSAPALASATPPST
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CTPSFTQIAPSATAPATSTTCTTSAEFYDGDHKTTSTSTTTTSNAISSATTTTATTTTAIAKLNVHANAIPSQNQSQSSQNNTYTIQSLIDNSNVRVKIA
.| .|. .... | ...
---------------------------------------------------------------------------KKS-NNCVCHYWHVK---NTHICVI
DLGNAC---YDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLG-SIPQSVIFRG---KHGLK
| |.| .|. | .. ..||.|| || || .... |.|| .| ||| ||. ||. | .||| . ...| |||. | | | |
DFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHD------NREHLAMMERIMGMPIPQWMIQRTRRFKVKQK
YFTSYGSLRNITKLKPWSLMNV---LVEKYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWL
|| .. . . .. . . | | . | . |. .. | . |||| | | .... ||||.
YFYHNRLDWDWHNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
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| Kinase | CG11489.AA | S_TKc | 232-874 | 11 | 4.7e-47 | 163.57 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 232-874
Range on HMM: 1-231/231
Sequence Identity: 11% (75 aa)
FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGC---SLYKLI
....||.| | |..|..||. |. ..||.|..| |.. ||..|. . . ||.| .| | ..|.| .. .|...|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK---------HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYI
VKNNYQG----LAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLVIDNAAAMNQQIDDEINSLRVKGVDFPDSYISSIEKQTKSRAKWPLIEPNG
.|....| . ..| ...|....|.|.||. ||| |.||||||| ..| || . .
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-----------------HIKICDFGLARQL-------------------
STNTNTNTSNSTATNSNSSTPLAAVIMSTLDKEDTTTTTSSTLNSNTTSSLASKYSSLLGDSECNGGLGGSANINNRYRTEKKITAKSSGDCDEDAESDT
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LGEQSTLASTMDSPTDLDPEPELDSKPNTVPEPTTIAKSKINSNILSTCTSLTSTNEYCFTNTNTTTASTPSAPPSATPSSAPALASATPPSTCTPSFTQ
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IAPSATAPATSTTCTTSAEFYDGDHKTTSTSTTTTSNAISSATTTTATTTTAIAKLNVHANAIPSQNQSQSSQNNTYTIQSLIDNSNVRVKIADLGNACY
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DYHHFTEDIQTRQYRSIEVLLGAPYNY-TADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLGSIPQSVIFRGKHGLKYFTSYGSLRNITK
| . |. |.. ||| .|.. .|.|| |. .|...| .|. ... . ...|
-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------------QMQMMFKKIG----------------------------
LKPWSLMNVLVEKYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQ-------HPWL
. . ||. .|...| | .| |.|| |||.
--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | CG11489.AA | DYRK | 232-374 | 34 | 6.3e-41 | 142.28 | In-house | 1-138 (320) | Show / Hide |
Range on Protein: 232-374 Range on HMM: 1-138/320 Sequence Identity: 34% (49 aa) FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGCSLYKLIVKN .... .| | |. | |.| | ..||.|.... . . .| .||..|| ....|| | . ..|.. ..|. | .|.|.||| | .|| .. .| YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDD--KYHCVHMYDYFYHR----NHLCIVFELLSMNLYEFLKNN NYQGL-AIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLV . ||. . || ...|.|..|..||.. .||| |.|||||.|. HFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLK |
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| Kinase | CG11489.AA | DYRK2 | 232-373 | 35 | 4e-36 | 114.73 | In-house | 1-135 (318) | Show / Hide |
Range on Protein: 232-373 Range on HMM: 1-135/318 Sequence Identity: 35% (51 aa) FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGCSLYKLIVKN . .. .| | | | | | | ...||.|.. . ..|. ||| |..|| |. .|.. . |. |. |.|..|| |. .||..| || YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDN--TMNCVHMLDYFYFRN----HHCITFELLSMNLYEYIKKN NYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILL ..||.. . || ....|..|. || | ||| | ||||||| HFQGFSLQLVRRFAHSILQCLRFLH-KNNIIHCDLKPENILL |
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| Kinase | CG11489.AA | Pkinase | 232-374 | 26 | 1.9e-27 | 98.11 | Pfam | 1-142 (293) | Show / Hide |
Range on Protein: 232-374 Range on HMM: 1-142/293 Sequence Identity: 26% (42 aa) FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAAD------EIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGC--- ....||.| | |..|..|.. ...| ||.|..| | . ||... .. . |||| |. . | ..|.| ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLN--------HPNIVRLYDWFED----KDHIYMVMEYCEGGLY --SLYKLIV---KNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLV .|. .| .... . .......|.|.||.|.|| ..||| |.||||||.. VMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID |
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| Kinase | CG11489.AA | YAK | 232-373 | 33 | 6e-25 | 81.36 | In-house | 1-139 (347) | Show / Hide |
Range on Protein: 232-373 Range on HMM: 1-139/347 Sequence Identity: 33% (48 aa) FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRD-ADPMDVK-RERIVRLMNHFTVRGVNGMHTCLVFEALGCSLYKLIV . | || | | | |. . . .| ||.|. . | | ||..|. . || . .|.|.. | . .| ||||| | .|| .. YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHK----NHFCLVFEMLSNNLYEYLK KNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILL |.. |. . .| |.|.|. | .| ||| | |||||.| QNKFCGFSFQLIRQWTKQILDGMCVLENK-QIIHCDLKPENIML |
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| Kinase | CG11489.AA | DYRK1 | 232-374 | 34 | 6.9e-24 | 80.4 | In-house | 1-138 (321) | Show / Hide |
Range on Protein: 232-374 Range on HMM: 1-138/321 Sequence Identity: 34% (49 aa) FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGCSLYKLIVKN . . .| | | | | ....|||.|..| ... | |||||| . .|. . . .||.| .|| | | ||||| | || |. YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEM--KYYIVHLKRHFMFR----NHLCLVFELLSYNLYDLLRNT NYQGLAIAQVRNIIRQVLEGLDYLHS-KCSIIHTDIKPENILLV ...| .. .| . .|.. | .. . .||| |.|||||||. HFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLC |
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| Kinase | CG11489.AA | DYRK | 713-874 | 28 | 1.3e-23 | 84.82 | In-house | 145-320 (320) | Show / Hide |
Range on Protein: 713-874 Range on HMM: 145-320/320 Sequence Identity: 28% (52 aa) RVKIADLGNACYDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLGSIPQSVIFRG--KHGLK ..|..| | .|. .... || | ||. ||.|| ||.| |.|| | || || || .||.. | || |.|.|| .|. .| | .. | TIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF---PGENE---YDQLACIMEVLGMPPKWMIDKGRCRRKHK YFTS------------------YGSLRNITKLKPWSLMNVLVE--KYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWL .|.. |. .... ... . . . .. . . ..| ||.. .|...| | .... |||||. FFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF |
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| Kinase | CG11489.AA | CDK | 706-874 | 26 | 5.4e-17 | 50.75 | In-house | 140-284 (284) | Show / Hide |
Range on Protein: 706-874 Range on HMM: 140-284/284 Sequence Identity: 26% (49 aa) LIDNSNV----RVKIADLGNACYDY---------HHFTEDIQTRQYRSIEVLLGAP-YN--YTADIWSTACLAFELAT---GDYLFDPHAGESYSRDEDH ||.| . |.|||| | |. .| . |. ||. |.|||. |. . |.|| | |..| . .|| |.| | LINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLF---PGDSE---IDQ LAHIVELLGSIPQSVIFRGKHGLKYFTSYGSLRNITKLKPWSLMNVLVEKYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWL | .| ...|. | . | | .. |.| || |.| | || ..||||.. LFKIFRICGT-PTEDNWPGVTKLPDY------------------------------------DLLNKMLCYDPKKRISAEQALQHPYF |
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| Kinase | CG11489.AA | DYRK1 | 714-813 | 39 | 1.5e-16 | 54.16 | In-house | 145-238 (321) | Show / Hide |
Range on Protein: 714-813 Range on HMM: 145-238/321 Sequence Identity: 39% (39 aa) VKIADLGNACYDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLGSIPQSVIFRGKHGLKYFT .|| | | .| . . || | ||| ||||| .|. |.|| |. |. ||. || | | . | . .||| || |. .| .. |||. IKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF------SGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE |
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| Kinase | CG11489.AA | DYRK2 | 714-803 | 36 | 3.2e-15 | 45.64 | In-house | 143-226 (318) | Show / Hide |
Range on Protein: 714-803 Range on HMM: 143-226/318 Sequence Identity: 36% (33 aa) VKIADLGNACYDYH-HFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLGSIPQSVIF .|..| | |... .. .||.| ||. || || .|. |.|| | . || || || .|| . | .| . |.|| .| ...| IKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF---PGENE---NDQFACMMEVLG-MPPKKFF |
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| Kinase | CG11489.AA | DyrkP | 710-772 | 41 | 3.6e-15 | 45.73 | In-house | 143-205 (323) | Show / Hide |
Range on Protein: 710-772 Range on HMM: 143-205/323 Sequence Identity: 41% (26 aa) SNVRVKIADLGNACYDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLF . .||| | | .|. | .| | || ||..| | | |.|| |. || || || PKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLF |
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| Kinase | CG11489.AA | Pkinase | 706-874 | 22 | 5.7e-14 | 50.47 | Pfam | 140-293 (293) | Show / Hide |
Range on Protein: 706-874 Range on HMM: 140-293/293 Sequence Identity: 22% (40 aa) LIDNSNVR---VKIADLGNAC---YDYHHFTEDIQTRQYRSIEVLL-GAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLG--- |||| .. |||.| | |. | .. .| |. |.. ||.. | .| . .|.|| |. .|...| .|. ... . |... |.. .| LIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPL --SIPQSVIFRGKHGLKYFTSYGSLRNITKLKPWSLMNVLVEKYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWL ..|.. . . ... . . . . ||. .|...| | .|...|||||. HFDWPWWCSISYFF-FRH-W-H------------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | CG11489.AA | CDK4 | 296-373 | 35 | 2.1e-13 | 42.15 | In-house | 65-143 (290) | Show / Hide |
Range on Protein: 296-373 Range on HMM: 65-143/290 Sequence Identity: 35% (28 aa) IVRLMNHFTVRGVNG--MHTCLVFEALGCSLYKLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILL ||.|| ..| . . | .||| | .. | |. ... . .| | |.|.||| . ||| | ||.|||. IVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLDKCPPPGMPPCTIKHMMHQLLRGVDFLHSHR-IIHRDLKPQNILV |
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| Kinase | CG11489.AA | DyrkP | 232-373 | 29 | 5.1e-13 | 38.54 | In-house | 1-139 (323) | Show / Hide |
Range on Protein: 232-373 Range on HMM: 1-139/323 Sequence Identity: 29% (42 aa) FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGCSLYKLIVKN . .. || || | |.. .. . .|.. | . . |||.|| | || ..| | . . | |. . | || | YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYN--GDVDEKNVLRYYDYFYHKEHLFIITELLKDNL-YEFYKFNREN NYQG-LAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILL | . . | |.| .|||.|| .|| |.||||||. EQQRYFTVGRLQKITQQILIALDYIHS-LRLIHCDLKPENILM |
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| Kinase | CG11489.AA | CDK | 315-373 | 33 | 1.5e-10 | 29.78 | In-house | 95-141 (284) | Show / Hide |
Range on Protein: 315-373 Range on HMM: 95-141/284 Sequence Identity: 33% (20 aa) LVFEALGCSLYKLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILL .||| . |.|.. ......| |.||.|.||. |.| |.|| |||. MVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNW-IMHRDLKPQNILI |
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| Kinase | CG11489.AA | YAK | 714-812 | 33 | 2.3e-09 | 27.56 | In-house | 147-239 (347) | Show / Hide |
Range on Protein: 714-812 Range on HMM: 147-239/347 Sequence Identity: 33% (33 aa) VKIADLGNACYDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLGSIPQSVIFRGKHGLKYF .|| | | .|. . || | ||| |.... .| | || | || | .| | . | | . . |.. || | .| .|. ||| IKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFLGLPIF-PGNSE-Y----NQIKRIIDMLGYPPSWMIDQGRFKNKYF |
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| Kinase | CG11489.AA | CDK4 | 849-874 | 53 | 9.9e-09 | 25.86 | In-house | 265-290 (290) | Show / Hide |
Range on Protein: 849-874 Range on HMM: 265-290/290 Sequence Identity: 53% (14 aa) DFLLPMLEYNPVIRASAAECLQHPWL |.|. || ||. | || .|||||.. DLLQKMLCYNHHKRMSAYQCLQHPYF |
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| Kinase | CG11489.AA | CDK4 | 738-765 | 46 | 6.3e-08 | 23.06 | In-house | 175-202 (290) | Show / Hide |
Range on Protein: 738-765 Range on HMM: 175-202/290 Sequence Identity: 46% (13 aa) YRSIEVLLGAPYNYTADIWSTACLAFEL ||. |||| ..|| . |.|| .| .|. YRAPEVLLQSYYNTPVDMWSVGCIFAEM |
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| Kinase | CG11489.AA | DYRK2 | 845-874 | 33 | 5e-06 | 15.16 | In-house | 289-318 (318) | Show / Hide |
Range on Protein: 845-874 Range on HMM: 289-318/318 Sequence Identity: 33% (10 aa) KKFSDFLLPMLEYNPVIRASAAECLQHPWL . | ||.. .| | | .... |.|||. ENFIDFIKRCFEWDPSERMTPSQALKHPWI |
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| Kinase | CG11489.AA | DYRK1 | 841-874 | 32 | 9e-06 | 15.66 | In-house | 288-321 (321) | Show / Hide |
Range on Protein: 841-874 Range on HMM: 288-321/321 Sequence Identity: 32% (11 aa) PVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWL ... .|| | .. ||.|.| | . . |||... VEDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF |
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| Kinase | CG11489.AA | CDK | 232-264 | 26 | 1.8e-05 | 13.3 | In-house | 1-38 (284) | Show / Hide |
Range on Protein: 232-264 Range on HMM: 1-38/284 Sequence Identity: 26% (10 aa) FRVVRKLGWGHFSTVWLCRDLKDE-----KYVALKVVK . . |.| |.. .| .||... ..|||| .. YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIR |
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| Kinase | CG11489.AA | DyrkP | 847-874 | 42 | 3.9e-05 | 12.1 | In-house | 296-323 (323) | Show / Hide |
Range on Protein: 847-874 Range on HMM: 296-323/323 Sequence Identity: 42% (12 aa) FSDFLLPMLEYNPVIRASAAECLQHPWL | || .| | .| | |||||. FIDFVRQCLQIDFTRRPTAKEALQHPWF |
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| Kinase | CG11489.AA | TyrKc | 232-475 | 17 | 0.000273 | -153.27 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 232-475 Range on HMM: 1-280/280 Sequence Identity: 17% (55 aa) FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAI--RDADPMDVKRERIVRLMNHFTVRGVNG---MHTCLVFE-ALGCSLY . .||| |.| .|.... || |..|. .| .|.|.. . . . |||| | | | ..|.| . . .| ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHH--------PNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK KLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLVIDNAAAMNQQIDDEINSLRVKGVDF---PDSYIS--------SIEKQTKSR . . |. . | .. .. |. .| .||||| .|| |. |.|. .. .|| || | | . |.... DYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENH---------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG AK--WPL---------------------------------IEPNGST----NTNTNTSNSTATN------SN--------SSTPLAAVIMSTLDKEDTTT .| .|. .| .|. . . | .. . ||.. .|| GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPED -TTSSTLNSNTTSSL | |.. . . RPTFSEI----HECF |
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| Kinase | CG11489.AA | CDK4 | 232-264 | 39 | 0.001438 | 7.87 | In-house | 1-33 (290) | Show / Hide |
Range on Protein: 232-264 Range on HMM: 1-33/290 Sequence Identity: 39% (13 aa) FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVK . | .| | . ||. |||.. . |||| |. YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVR |
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| Kinase | CG11489.AA | YAK | 847-874 | 35 | 0.004302 | 5.91 | In-house | 320-347 (347) | Show / Hide |
Range on Protein: 847-874 Range on HMM: 320-347/347 Sequence Identity: 35% (10 aa) FSDFLLPMLEYNPVIRASAAECLQHPWL | ||. .|. || | .. ||| . FIDFINQLLQLNPRERWKPMQAMQHPFI |
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