Gene Madm (Fruit Fly)

Madm

Species: Fruit Fly
Alias: CG1098, Madm
External Links: Flybase Link
Annotation:

Classification

Group: Other
Family: NRBP

Sequence

Name Sequence Type Origin Length Description Download
Madm.AA Protein None 637 None Fasta, JSON
Madm.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of Madm.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Madm.AA NRBP 114-376 67 1.2e-169 569.89 In-house 1-261 (261) Show / Hide 
Range on Protein: 114-376
Range on HMM: 1-261/261
Sequence Identity: 67% (181 aa)

QRDVPGIDCVHLAMDTEEGVEVVWNEVQYASLQELKSQEEKMRQVFDNLLQLDHQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSLKQFLKRTKRNAKR
|||||||||..|||||||||||||||||.......|.||||.|||||||.|||||||||||.|||||... .|||.||||||||||.|||||.||.|.|.
QRDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEE-KPRVIFITEYMSSGSMKQFLKKTKKNHKN

LPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHNGLVKIGSVVPDAVHYSVRRGRERERERERGAHYFQAPEYG--AADQLTAALDIYAFGM
.....|.||||||||||||||||.|||||||||||.||||||||.|||.|.|||.|..||..||..|.     ..|.|||||  ....||.|.|||.|||
MNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGCVWPDAIHHHVRTCREEMRN-----MHFFAPEYGILEVTDLTTAVDIYSFGM

CALEMAALEIQP--SNSESTAINEETIQRTIFSLENDLQRDLIRKCLNPQPQDRPSANDLLFHPLLF
||||||.||||.  .|.||....||.|||.|.|||...|||.|||||...|..||||..||||..||
CALEMAVLEIQSGCQNGESEYVTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF
Kinase Madm.AA WNK 123-261 41 9e-34 106.41 In-house 15-148 (261) Show / Hide 
Range on Protein: 123-261
Range on HMM: 15-148/261
Sequence Identity: 41% (59 aa)

VHLAMDTEEGVEVVWNEVQYASLQELKSQE-EKMRQVFDNLLQLDHQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSLKQFLKRTKRNAKRLPLESWRR
|  ..||| .||| |.|.|   .| |. .|   ..   . | .| | |||.|  ||  . .  .  .| .|| | || || .||| |.   .      |.
VYRGLDTETWVEVAWCELQ---DQKLSKNERQRFKEEAEMLKKLQHPNIVRFYDYWESVLCGKK-CIVLVTELMTSGTLKTYLKRFKKMKPKV----LRS

WCTQILSALSYLHSCSP-PIIHGNLTCDSIFIQ-HNGLVKIG
|| |||. |..||.. | ||||  | || |||   .| ||||
WCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIG
Kinase Madm.AA TKL 141-261 18 5.5e-16 54.06 In-house 37-196 (364) Show / Hide 
Range on Protein: 141-261
Range on HMM: 37-196/364
Sequence Identity: 18% (32 aa)

QYASLQELKSQE---------------------EKMRQVFDNLLQLDHQNIVKFHRYWTDTQQAE--------RPRVVFITEYMSSGS-LKQFLKRTKRN
.. .. ...|||                     .. ...   ...|.|.|||.|  | .. .. .         .   ...||.. || | ...      
HNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------

AKRLPLESWRRWCTQILSALSYLHSCS------PPIIHGNLTCDSIFIQHNGL--------------VKIG
     ..   ||. .| ....||||.       ||||| .|. . |..  |.               .||.
-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC
Kinase Madm.AA TK 162-261 12 1.1e-15 48.32 In-house 94-293 (486) Show / Hide 
Range on Protein: 162-261
Range on HMM: 94-293/486
Sequence Identity: 12% (24 aa)

LLQ---LDHQNIVKFHRYWTDTQQ-------AERPRVVFITEYMSSGS----LKQFLKRTKRNAKR----------------------------------
...   ..|.|||... . |. .         ... .  ..|||. |.    |...|.. .....                                   
MMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSP

------------------LPLESWRR-------------------WCTQILSALSYLHSCSP----PIIHGNLTCDSIFIQHNGL-----------VKIG
                  |..    .                   .| || ....||||.       ..|..| .  . . .|.            .||.
CPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIA
Kinase Madm.AA S_TKc 122-375 20 2.5e-14 33.19 SMART 14-231 (231) Show / Hide 
Range on Protein: 122-375
Range on HMM: 14-231/231
Sequence Identity: 20% (57 aa)

CVHLAMDTEEGVEVVWNEVQYASLQELKSQEEKMRQVFDNLLQLDHQNIVKFHRYWTDTQQAERPRVVFITEYMSS--GSLKQFLKRTKRNAKR--LPLE
.|... ... | .|   ..            |..|.  . | . .| ||||.. .. |       .. ...||..   |.|....|. .|. .|  .|  
KVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

SWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHNGLVKIG-----SVVPDAVHYSVRRGRERERERERGAHYFQAPEYGAADQLTA-ALDIYAFGM
  |... ||..|| |.||    |||  |  . |.. .   .||.      ..                    |  .. |||     . .  . |....| 
HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

CALEMAALEI--QPSNSESTAINEETIQRTIFSLENDLQRDLIRKCLNPQPQDRPSANDLLF-------HPLL
.  ||.. .   .         ..... . |     .  .|.|||||.  |..||.| ..|        || .
ILYEMLCGYPPFP---------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Madm.AA Ciliate-E2-Unclassified 144-260 21 2.5e-13 42.6 In-house 50-188 (352) Show / Hide 
Range on Protein: 144-260
Range on HMM: 50-188/352
Sequence Identity: 21% (31 aa)

SLQELKSQEEKMRQVFD--------NLLQLDHQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSLKQFLK-------------RTKRNAKRLPLESWR--
.....  .. |.  ...         ||...| .|||.. . .|.|      . ...||.  |.|.|..|             ..... |... .  .  
MNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQ-----NIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYK

---RWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHNG---LVKI
   ... |||..|.|||.    ||| ..... |... ||    .||
KAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKI
Kinase Madm.AA Ciliate-E2 147-260 22 4.5e-13 41.21 In-house 61-197 (365) Show / Hide 
Range on Protein: 147-260
Range on HMM: 61-197/365
Sequence Identity: 22% (34 aa)

ELKSQEEKMRQVFD----------NLLQLDHQNIVKFHRYWT--DTQQAERPRVVFITEYMSSGSLKQFLK--RTKRNAK-----RLPLESWRRWCTQIL
| ..||... .  .          .| ||.| ||.|.. ..   |..      . ...|| . |.|....|  ..||| .     .. ..  ..  .|||
EQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNN-----IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQIL

S---------------ALSYLHSCSPPIIHGNLTCDSIFIQHNGLVKI
.               || ||||  . ||| ..  . |..     .||
QGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-----IKI
Kinase Madm.AA UTK 162-261 21 7.2e-13 40.36 In-house 63-167 (296) Show / Hide 
Range on Protein: 162-261
Range on HMM: 63-167/296
Sequence Identity: 21% (24 aa)

LLQLD-HQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSLKQFLKRTKRNAK----RLPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHNG
. |.. |.|....  . |. ..        .||||. |.| ..| | ....      | |..   .. .| ....|||||   ..|..| .  ... ...
MKQFHWHPNVLRLVGVCTQEEP-----WMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCG--FVHRDLAARNCLVHMHR

-------LVKIG
       ..||.
MMWHCMMVCKIA
Kinase Madm.AA Pkinase 162-242 22 7.9e-13 46.44 Pfam 54-131 (293) Show / Hide 
Range on Protein: 162-242
Range on HMM: 54-131/293
Sequence Identity: 22% (20 aa)

LLQLDHQNIVKFHRYWTDTQQAERPRVVFITEYMSSG----SLKQFLKRTKRNAKRL--PLESWRRWCTQILSALSYLHSCSPPIIH
.. |.| |||.......|     .... ...||.  |    .|. ....  .. ...  . .  .....|||..| |.||.   |||
MKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIH
Kinase Madm.AA CAMK 163-260 20 1e-12 36.56 In-house 88-237 (425) Show / Hide 
Range on Protein: 163-260
Range on HMM: 88-237/425
Sequence Identity: 20% (32 aa)

LQ-----LDHQNIVKFHRYWTD-----------TQQAE----RPRVVFIT---EYMSSG----SLKQFLKRTKRNA-----------KRLPLESWRRWCT
||     ||| ||.|.. .. |           | .      . ......   ||.| |     | ..... ...            .|.. .  ||.  
LQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR

QILSALSYLHSCSPPIIHGNLTCDSIFIQHN-----------------GLVKI
||.||. |.||.   |.|  | .. | ...|                 . .||
QICSAVHYCHSHN--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKI
Kinase Madm.AA STE 305-375 19 1.4e-09 30.08 In-house 250-359 (359) Show / Hide 
Range on Protein: 305-375
Range on HMM: 250-359/359
Sequence Identity: 19% (21 aa)

DIYAFGMCALEMAALEIQPSN-SESTAINEETIQ--------------RTIFSLEN----------------------DLQRDLIRKCLNPQPQDRPSAN
||. .| ...|||  .   .. .   |. . ..                .. .|..                      .  .| |.|||.  |..||.|.
DIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTAS

DLLF--HPLL
.||   || .
QLLKSEHPFI
Kinase Madm.AA STE 160-260 25 2.6e-09 29.17 In-house 80-188 (359) Show / Hide 
Range on Protein: 160-260
Range on HMM: 80-188/359
Sequence Identity: 25% (29 aa)

DNLLQLD--HQNIVKFHRYWTDTQ--QAERPRVVFITEYMSSGSLKQFLKRT-KRNA---------KRLPLESWRRWCTQILSA-LSYLHSCSPPIIHGN
. . ...  |.||||.. .  .    . ..  .  . |||. ||| ...|.. ...          .|.| .  .. | ||| . |.||||    |||  
KIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRD

LTCDSIFIQHNGLVKI
. .. |..     ||.
IKPANILL-----VKL
Kinase Madm.AA PEK 348-375 42 4e-09 27.12 In-house 628-655 (655) Show / Hide 
Range on Protein: 348-375
Range on HMM: 628-655/655
Sequence Identity: 42% (12 aa)

QRDLIRKCLNPQPQDRPSANDLLFHPLL
|.|.|...|...||.|||| ..| |...
QADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase Madm.AA TyrKc 139-375 19 1.4e-08 -84.12 SMART 14-280 (280) Show / Hide 
Range on Protein: 139-375
Range on HMM: 14-280/280
Sequence Identity: 19% (55 aa)

EVQYA---------SLQELKSQEEKMRQVFDNLLQL--DHQNIVKFHRYWTDTQQAER----PRVVFITEYMSSGSLKQFLKRTKRNAKRLPLESWRRWC
||  .         .|.| .  .| ...    . .|  .|.|||... . |. .  ..    . .  ..|||. |.||..|......   |...    .|
EVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQG--RNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LCMKDLLSFC

TQILSALSYLHSCSPPIIHGNLTCDSIFIQHNGLVKIG------SVVPD------AVHYSVRRGRERERERER--GAHYFQAPEYGAADQLTAALDIYAF
.|| .  .||||   ..||  | .  . . .|. |||.       .  |         |...      .. ..        |||       | . |...|
WQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKE-----HKGGKTMLPIRWMAPECINYGKFTTKSDVWSF

GMCALEMAALEIQPSNSEST--AINEETIQRTIFSLENDLQRD---------------LIRKCLNPQPQDRPSANDLLFHPLL
| |  |.  .  ||   .      |.| |..       .   .               ....| . .| |||. ...  | ..
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Madm.AA WNK 303-321 63 5.8e-08 21.71 In-house 184-202 (261) Show / Hide 
Range on Protein: 303-321
Range on HMM: 184-202/261
Sequence Identity: 63% (12 aa)

ALDIYAFGMCALEMAALEI
. |.|||||| |||| .|.
SVDVYAFGMCMLEMATSEY
Kinase Madm.AA Pkinase_Tyr 164-261 28 1.9e-07 25.81 Pfam 59-153 (270) Show / Hide 
Range on Protein: 164-261
Range on HMM: 59-153/270
Sequence Identity: 28% (28 aa)

QL-DHQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSLKQFLKRTKRNAKRLPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHNGLVKIG
|| .|.|||...   || ..    ..  ..|||  |.|. .|.. . . ..|...    .|.|| ....||.|    .||  | .  . . .|. |||.
QLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKIC
Kinase Madm.AA Ciliate-E2 350-375 32 2.6e-07 21.13 In-house 335-365 (365) Show / Hide 
Range on Protein: 350-375
Range on HMM: 335-365/365
Sequence Identity: 32% (10 aa)

DLIRK----CLNPQPQDRPS-ANDLLFHPLL
|||.|    .|. .|. |.. ....| || .
DLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Madm.AA CAMK 349-375 40 3.9e-07 18.27 In-house 399-425 (425) Show / Hide 
Range on Protein: 349-375
Range on HMM: 399-425/425
Sequence Identity: 40% (11 aa)

RDLIRKCLNPQPQDRPSANDLLFHPLL
.|||||.|.. |..|... . | || .
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Madm.AA Ciliate-E2-Unclassified 346-375 33 1e-06 18.99 In-house 323-352 (352) Show / Hide 
Range on Protein: 346-375
Range on HMM: 323-352/352
Sequence Identity: 33% (10 aa)

DLQRDLIRKCLNPQPQDRPSANDLLFHPLL
|. .||..|.|. .|  |......| ||..
DFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase Madm.AA PEK 192-261 18 4e-06 16.41 In-house 362-474 (655) Show / Hide 
Range on Protein: 192-261
Range on HMM: 362-474/655
Sequence Identity: 18% (21 aa)

TEYMSSGSLKQFLKRTK----------------------------------------RNAKRLPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIF
.|| . ..|.. ... .                                        .|.. .. .  .|.  |||..| |.||.   .||  |.   ||
MEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQG--MIHRDLKPSNIF

I-QHNG----LVKIG
. ...     .||||
LDCDGQHHQMQVKIG
Kinase Madm.AA WNK 349-375 33 9e-06 14.45 In-house 235-261 (261) Show / Hide 
Range on Protein: 349-375
Range on HMM: 235-261/261
Sequence Identity: 33% (9 aa)

RDLIRKCLNPQPQDRPSANDLLFHPLL
...| ||.  . ..|||...|| |  .
KEIIEKCIRHNKEERPSIQQLLNHDFF
Kinase Madm.AA Pkinase 349-375 40 1e-05 21.31 Pfam 267-293 (293) Show / Hide 
Range on Protein: 349-375
Range on HMM: 267-293/293
Sequence Identity: 40% (11 aa)

RDLIRKCLNPQPQDRPSANDLLFHPLL
.|.|..||.. |..||.| ..| || .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Madm.AA TKL 305-373 15 3e-05 14.88 In-house 271-364 (364) Show / Hide 
Range on Protein: 305-373
Range on HMM: 271-364/364
Sequence Identity: 15% (15 aa)

DIYAFGMCALEMAALEIQPSNSEST------------AINEETIQR-TIF---------SLENDL---QRDLIRKCLNPQPQDRPSANDLLFHP
|.|.||..  |... ..  ..  .             ... .  .| .|          . ..|     ..|. .| .. |..|||....| . 
DVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Madm.AA TK 338-373 21 0.02113 3.0 In-house 448-486 (486) Show / Hide 
Range on Protein: 338-373
Range on HMM: 448-486/486
Sequence Identity: 21% (9 aa)

RTIFSLEN-----DLQRDLIRKCLNPQPQDRPSANDLLFHP
|. . .       ..  ||...| ...|.|||.  .|.   
RYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Madm.AA UTK 350-370 38 0.025628 3.74 In-house 273-293 (296) Show / Hide 
Range on Protein: 350-370
Range on HMM: 273-293/296
Sequence Identity: 38% (8 aa)

DLIRKCLNPQPQDRPSANDLL
.| ..| .. ||.||.. ||.
RLMHRCWHYDPQERPDFEDLV
Kinase Madm.AA Pkinase_Tyr 350-375 34 0.248788 5.13 Pfam 247-270 (270) Show / Hide 
Range on Protein: 350-375
Range on HMM: 247-270/270
Sequence Identity: 34% (9 aa)

DLIRKCLNPQPQDRPSANDLLFHPLL
||...| ...|.|||.  ..  |  |
DLMKQCWHYDPEDRPTFSEI--HEQL