Gene DCLK2 (Mouse)
DCLK2
Sequence
Protein domains of DCLK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| DCX | DCLK2.AA | DCX | 67-158 | 44 | 1.3e-44 | 155.46 | SMART | 1-96 (96) | Show / Hide |
Range on Protein: 67-158 Range on HMM: 1-96/96 Sequence Identity: 44% (43 aa) SEKKAKKARFYRNGDRYFKGLVFAISNDR-FRSFDALLIELTR-SLSDNVNLPQGVRTIYTIDGSRKVTSLDELLEG-ESYVCASNE-PFRKVDYT ...|.|. .||||||..||| ...|.... |.|||.|| ..|. .|......|.|||.|||.||...||||||. .| ..|||.... .|..|||. HHWKPKRICFYRNGDPFFKGVRLVINRKWQFKSFDHLLQDVTQTKLHVKMDCPHGVRHIYTTDGRHRVTSLDEFEDGDDFYVCCCTNEKFKPVDYD |
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| DCX | DCLK2.AA | DCX | 89-153 | 52 | 4.7e-35 | 125.98 | Pfam | 1-68 (68) | Show / Hide |
Range on Protein: 89-153 Range on HMM: 1-68/68 Sequence Identity: 52% (36 aa) FAISNDRFRSFDALLIELTRSLSDNVNLPQG-VRTIYTIDGSRKVTSLDE-LLEGESYVCA-SNEPFR ......||..||||| ..|.||.|.|.||.| ||.||| ||...|||||| |..|..|||. .||.|. MVVNRRRFKTFDALLDDITESLHDKVQLPFGAVRKIYTPDGGHRVTSLDEFLQDGGCYVCCCGNERFK |
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| DCX | DCLK2.AA | DCX | 191-279 | 31 | 1.2e-36 | 129.0 | SMART | 1-96 (96) | Show / Hide |
Range on Protein: 191-279 Range on HMM: 1-96/96 Sequence Identity: 31% (30 aa) DFIKPKLVTVIRSGVKPRKAVRILLNKKT-AHSFEQVLTDITE---AIKLDSG-VVKRLCTLDG-KQVTCLQDFFGDDDVFIACGPE-KYRYAQDD .. ||| ....|.|....|.||...|.|. ..||...|.|.|. ..|.|.. .|... |.|| ..||.|..|...||....|. . | .....| HHWKPKRICFYRNGDPFFKGVRLVINRKWQFKSFDHLLQDVTQTKLHVKMDCPHGVRHIYTTDGRHRVTSLDEFEDGDDFYVCCCTNEKFKPVDYD |
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| DCX | DCLK2.AA | DCX | 213-274 | 30 | 2.2e-24 | 88.56 | Pfam | 1-68 (68) | Show / Hide |
Range on Protein: 213-274 Range on HMM: 1-68/68 Sequence Identity: 30% (21 aa) ILLNKKTAHSFEQVLTDITE----AIKLDSGVVKRLCTLDG-KQVTCLQDFFGDDDVFIAC-GPEKYR ...|......|...|.|||| ...|..| |....|.|| ..|| |..|. |......| | |... MVVNRRRFKTFDALLDDITESLHDKVQLPFGAVRKIYTPDGGHRVTSLDEFLQDGGCYVCCCGNERFK |
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| Kinase | DCLK2.AA | DCAMKL | 409-666 | 64 | 1.7e-217 | 684.01 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 409-666 Range on HMM: 1-279/279 Sequence Identity: 64% (180 aa) YRIGKVIGDGNFAVVKECVDRYTG-KEFALKI-----------------IDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATDLFLVMELVKGG |.||..|||||||||.||..| || ...|.|| |||.||.||||.|.|||||....|||.||.|.|...|.|...||||.|.|| YQIGRIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQIDKRKCKGKEHMIDNEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYVQGG DLFDAITSSTKYTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETGYGLKV |||||||..||.||||...|...|..||.|||...||||||||||||||...||.|||||.|||||..|.| ||||||||||||||||..|||||.|| DLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLACHVNGDFGPLYTVCGTPTYVAPEILMETGYGCKV DVWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILSHPWV |.||||||.||||||||||||..| ||.|||||..||.|||.||||||.||||.|||.||||..|.|.||..|..|||| DIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV |
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| Kinase | DCLK2.AA | CAMK1 | 409-666 | 42 | 3.1e-138 | 404.48 | In-house | 1-276 (276) | Show / Hide |
Range on Protein: 409-666 Range on HMM: 1-276/276 Sequence Identity: 42% (119 aa) YRIGKVIGDGNFAVVKECVDRYT---GKEFALKIID-KAKCCGKE----HLIENEVSILRRV---KHPNIIMLVEEMETATDLFLVMELVKGGDLFDAIT | .||.|| | |..|..|... | ||..|.|.|| | .|. ..|||..|...| .||||| . | |. ... ||||||.||.||| | YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV SSTKYTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLK--LGDFGLATVVE-G--PLYTVCGTPTYVAPEIIAE---TGYGLKVDV ..|||.| . . ... |. |.||. |||||.|||||| .. .| .| . ||||.. .. . ..|.|||| |||||... ..|. ..|. EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLL-YYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM WAAGVITYILLCGFPPFRSEN-NLQEDLFDQILAGKLEFPAPYWDNITDS-AKELISQMLQVNVEARCTAGEILSHPWV | .||||||||||.||| .|| . . ||..|. ...||| |.|||| |. ||..|..|| |. . | |. ..| |||. WSIGVITYILLCGYPPFYDENVDNE--LFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | DCLK2.AA | CAMK | 414-666 | 25 | 1.1e-126 | 410.49 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 414-666
Range on HMM: 1-425/425
Sequence Identity: 25% (110 aa)
VIGDGNFAVVKECVDRYTG------------KEFALKIIDKAKCCG---------------------------KEHLIENEVSILRR-------VKHPNI
..| |.|..||.|... |. ...| ||||| | . ... ...|..|... ..||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
IMLVEEME------------TATD--------LFLVM---ELVKGG----DLFDAITSSTK---------------YTERDGSAMVYNLANALRYLHSLS
| | | .| | .. ...|| |.. || |||| |.. .. .|||. . .. .. |..|.||.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
IVHRDIKPENLLVCEYPDGT-------------KSLKLGDFGLATVVEG--------------------------PLYTVCGTPTYVA-PEIIA------
|||||.||||.|... |.. .|. |||.|..... ...|.|||| |.| ||..
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
--------ETGYGLKVDVWAAGVITYILLCGFPPFRSENN-----------LQEDLFDQILAGKLEFPAPY------------WDNITDS--------AK
...|| |.|.|..|||.||.|||.|||..... ...|| .|..|| .|| || ||.|.|. .|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK
ELISQMLQVNVEARCTAGEILSHPWV
||..||||. | | |. ..|.|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | DCLK2.AA | RAD53 | 409-666 | 36 | 1.4e-124 | 373.16 | In-house | 1-305 (305) | Show / Hide |
Range on Protein: 409-666
Range on HMM: 1-305/305
Sequence Identity: 36% (113 aa)
YRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDK-------AKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETA-TDLFLVMELVKGGDLFDAITSST
| ..|..| |||..||..... |.. .| ||||| . .|. ..||| ||....||.|| . . .|. .....|.||. ||.||. | |.
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK
K----YTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGT--------------KSLKLGDFGLATVVEGP--LYTVCGTPTYVAPEIIAE
. ..| .. . | . .|..|||.. |.|||.|||| | .. ... ..|. ||||. .|. . | ||||.|||||.|.
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITS
---------------TGYGLKVDVWAAGVITYILLCGFPPFRSENNLQ----EDLFDQILA-GKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEI
.||. |||.| .|.|.||.|||.||| |. | .||.||. ||..|| |||| |...|| ||..||.|..|.| |. |.
KGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPF-SDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEA
LSHPWV
|.|||
LNHPWM
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| Kinase | DCLK2.AA | S_TKc | 409-666 | 35 | 2.9e-103 | 350.26 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 409-666 Range on HMM: 1-231/231 Sequence Identity: 35% (97 aa) YRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATDLFLVMELVKG--GDLFDAITSSTK----- |.|...|| | |..|. |... ||...|.|||. |..|..||.. .||||. | . ... ..|..|||.. | ||||| | . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -YTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGL-KVDVWAAGVITYIL ..| . ..| ...|| |.||. |.|||.||||.|..| .|..|||||... .|.|||| |.|||.. ||| |.|.|. |.| |.. PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM LCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILS-------HPWV ||| |||. .. .|..|. ...||..|...||.. | | || |.| |||. LCGYPPFP----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | DCLK2.AA | CAMK-Unique | 409-666 | 27 | 6.9e-98 | 323.73 | In-house | 1-363 (363) | Show / Hide |
Range on Protein: 409-666
Range on HMM: 1-363/363
Sequence Identity: 27% (99 aa)
YRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDKAKCC-GKEHL------------------IENEVSILRRVKHPNIIMLVEE----METAT-------
|. ...||.||| .|.|| || |||..| |.. |.. | .. ..|..|...|.||||| |.. ....
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI
--------DLFLVMELVKGGDLFDAITS--------------------STKYTE--RDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDG----
....|||.. ||||||.| . ....| .| . . |. |. |.||..|||||.|.||..||. ..
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH
--------TKSLKLGDFGLATVVE-GPLY----TVCGTPTYVAP--------------EIIAETGYGLKV----DVWAAGVITYILLCGFPPFRSENNLQ
. .|| ||||.. .. . |.|||| |.|| |.|.. .|. .. | |. |||.|..||| ||| .|..
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR
------EDLFDQILAGKL-EFPAPYWDN---ITDSAKELISQMLQVNVEARCTAGEILSHPWV
.|. |..|.. .|. ..|. |...|| .. . ..| . | .| |.|.|.|.
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
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| Kinase | DCLK2.AA | CAMKL | 409-666 | 34 | 4.6e-95 | 303.81 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 409-666 Range on HMM: 1-297/297 Sequence Identity: 34% (105 aa) YRIGKVIGDGNFAVVKECVD-RYTGKEFALKIIDKAKCCGKEHLIEN--------------EVSILRRVK---HPNIIMLVEEM-------ETATDLFLV |||||..| |.|..|| ... |.||.. | ||||| |.. ... | |..|..... ||||| | | . || ....|| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV MELVKGGD--LFDAITSS----TKYTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKS--LKLGDFGLATV---V----EGPLYTVCG ||.. ||. ||| | . . .|.. . . |. |.||. ||||||||||.|. | .. .|. |||... . . | | || MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILL----DENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCG TPTYVAPEIIAE--T-GYGLKVDVWAAGVITYILLCGFPPFRSENN------LQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGE .| | ||||.. . .| |||.|..||| | ..|| ||. ... . |. .| | ..| .| . ... ||..||||| | | |. . SPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYH--VS-DCRDLIRKMLQVNPEKRPTIHQ ILSHPWV |..|||. IMNHPWM |
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| Kinase | DCLK2.AA | Pkinase | 409-666 | 34 | 3.1e-93 | 320.86 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 409-666 Range on HMM: 1-293/293 Sequence Identity: 34% (102 aa) YRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDK--AKCCGKEHLIE-NEVSILRRVKHPNIIMLVEEMETATDLFLVMELVKGG----DLFDAIT--SS |.||..|| |.|..|..|... |||..|.|||.| .|.. ..... .|..|..|..||||. | . .|. ... .|||.. || |||| |. .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH TKY--TERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLA----TVVEGPLYTVCGTPTYVAPEIIA-ETGYGLKVDVWAA ... .|.. ..| .. .| |.|| .|.|||.||||.|. . .. ..|..||||| . . ..|.|||| |.|||.| ..|| |||.|.. GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC GVITYILLCGFPPFRSE----NNLQEDLFDQILAGKLEFPAPYWDNIT-----------------DSAKELISQMLQVNVEARCTAGEILSHPWV |.| |..||| |||... |. | ....|. ..|.|. |.|..| ...|..|. .|... . |.|| .|| |||. GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | DCLK2.AA | CDPK | 409-666 | 36 | 3.5e-86 | 264.35 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 409-666 Range on HMM: 1-271/271 Sequence Identity: 36% (101 aa) YRIGKVIGDGNFAVVKECVDR-YTGKEF-ALKIIDKAKCCGKEH-LI-ENEVSILRRVKHPNIIMLVEEMETATDLFLVME--LVKGGDLFDAITSSTKY | |.||.| |.| .|. .... |. | | ||| | .. || . ||. ||. ||||| . | . ..||| ...||.||| |.. .. YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF TERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGT---KSLKLGDFGLATVVE-------GPLYTVCGTPTYVAPEIIAETGYGLKVDVWAA ||.. . .. . .|. | || |||||.||||.| . |.. . .|. |.|... . ... ||||.|.|||.. | |.|.| . TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWSC GVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILSHPWV ||| |||||| ||| .| ... .... || .| | ||.|.|.|| ||..||... . | .| ..| |||. GVILYILLCGYPPFYGKN--DQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
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| Kinase | DCLK2.AA | RSK | 411-666 | 29 | 1.3e-85 | 290.68 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 411-666 Range on HMM: 1-278/278 Sequence Identity: 29% (83 aa) IGKV--IGDGNFAVVKECVDRYTGKEFALKIIDKAKCCGK----EHLIENEVSILRRVK-HPNIIMLVEEMETATDLFLVMELVKGGDLFDAITSSTK-- . .| | . ....|... ||...| |...||| . . .| . |..|| |.. ||.|. | . .| . |.|.||...||.||. . LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMT-ERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFG -YTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATV--VE--GPLYTVCGTPTYVAPEIIA----ETGYGLKVDVWAA .|.. .. .... |...||.. |.|||.|||| | . . ..|| |||.. . ....| |.| |.|||... . |.. .|.| CFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL GVITYILLCGFPPFRS-ENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCT-----AGEILSHPWV ||. | .| |.|||.. . | .......|. ||. .. | |..... ||.||..||... . | . | ||..||| GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | DCLK2.AA | MARK | 409-666 | 35 | 6.2e-83 | 270.93 | In-house | 1-262 (262) | Show / Hide |
Range on Protein: 409-666 Range on HMM: 1-262/262 Sequence Identity: 35% (97 aa) YRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDKAKCCG-KE-HLIENEVSILRRVKHPNIIMLVEEME--TATD-LFLVMELVKGGDLFDAITSS--TK |...|.|| |..|.|| .... ||...|.||..| | .. .. |..|.....||||| | . .| | . ..|.||.. ||.|.| | . . YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR YTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTK--SLKLGDFGLATVV-EGP-LYTVCGTPTYVAPEIIAETGYG-LKVDVWAAGVIT .|.. .. . |. |.|| .||||||||||.|. | . |. |||... . .| | | |||| | ||||. | |||.|. ||. LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILI----DENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVL YILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILSHPWV |...|| ||. .. ...|. .||.|| ..| . .... ||...|.|| | | |. ||..|||. YFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH----VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | DCLK2.AA | RSK | 409-666 | 33 | 1.4e-77 | 264.09 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 409-666 Range on HMM: 1-271/271 Sequence Identity: 33% (91 aa) YRIGKVIGDGNFA---VVKECVDRYTGKEFALKIIDKAKCCGK-EHLIENEVSILRRVKHPNIIMLVEEMETATDLFLVMELVKGGDLFDAITSSTKYTE | . ..|| | | |.| |. . |....| |||.||. | |.| ||| . ||.|. | . .... ....|.. .|||||| . .| YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE RDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLA---TVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDVWAAGVITYILLC |. .. ...|.|. ||||. ||||| |||| |. . ..|. |||.| .| |.| |.| |.|||.. |.. .|.| ||. |. | REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT GFPPFRSENNLQEDLFDQIL---AGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTA-----GEILSHPWV |..|| . .. ......|. |.. . ..||.|.| ||.|...|| .. . | .| .|..|||. GCTPFQNKPR--DTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF |
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| Kinase | DCLK2.AA | TyrKc | 409-666 | 22 | 6.6e-15 | 18.36 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 409-666 Range on HMM: 1-280/280 Sequence Identity: 22% (67 aa) YRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDKAKCCGKEHLIENEVSILRRV--KHPNIIMLVEEMETA-------TDLFLVMELVKGGDLFDAITSS . ||..| |.| .| ... . . | | . . . . . .| .|.... .||||. |. . |..|||....||| | . .. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH TK-YTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGP-------LYTVC----GTPT-----YVAPEIIAETG . . .| . . |. .|||| ..|||. | || | | .||||. .. | . |. | ||| | . RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK YGLKVDVWAAGVITY-ILLCGFPPFRS-EN--NLQEDLFDQILAG-KLEFPAPYWDN-----ITDSAKELISQMLQVNVEARCTAGEILSHPWV . | |||. || . |. | .| . .... .. .| .. |. . .| ....| . . | |.| || | FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | DCLK2.AA | Pkinase_Tyr | 409-591 | 27 | 3e-14 | 48.87 | Pfam | 1-199 (270) | Show / Hide |
Range on Protein: 409-591 Range on HMM: 1-199/270 Sequence Identity: 27% (57 aa) YRIGKVIGDGNFAVVKECVDR----YTGKEFALKIIDKAKCCGKEH-----LIENEVSILRRV-KHPNIIML---VE-EMETATDLFLVMELVKGGDLFD ..||..| |.| .|.... . |. . | |.. | . .|. ... |..|.. .||||. | . . | ...|||....||| | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLD AITS----STKYTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVV-EGPLY-TVCG---TPT-YVAPEIIAETGYG . . | | | . |... ||.| ..|||. | || | .. | .||||| . . | .. | | ||| |.. . YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFT LKVDVWA | |||. TKSDVWS |
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