Gene DCLK1 (Mouse)

DCLK1

Species: Mouse
Alias: Dcamkl1, DCLK1, DCAMKL1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: CAMK
Family: DCAMKL

Sequence

Name Sequence Type Origin Length Description Download
DCLK1.AA Protein None 756 None Fasta, JSON
DCLK1.NA RNA None 7851 None Fasta, JSON
DCLK1.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of DCLK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DCX DCLK1.AA DCX 52-143 40 8.7e-46 159.34 SMART 1-96 (96) Show / Hide 
Range on Protein: 52-143
Range on HMM: 1-96/96
Sequence Identity: 40% (39 aa)

SEKKAKKVRFYRNGDRYFKGIVYAISPDR-FRSFEALLADLTR-TLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEG-ESYVCGSIE-PFKKLEYT
...|.|...||||||..|||....|.... |.||..|| |.|.  |......|.|||.|||.|| ... |||....| ..|||.. . .||...|.
HHWKPKRICFYRNGDPFFKGVRLVINRKWQFKSFDHLLQDVTQTKLHVKMDCPHGVRHIYTTDGRHRVTSLDEFEDGDDFYVCCCTNEKFKPVDYD
DCX DCLK1.AA DCX 74-138 47 2.6e-33 119.84 Pfam 1-68 (68) Show / Hide 
Range on Protein: 74-138
Range on HMM: 1-68/68
Sequence Identity: 47% (32 aa)

YAISPDRFRSFEALLADLTRTLSDNVNLPQG-VRTIYTIDGLKKISSLDQ-LVEGESYVCG-SIEPFK
......||..|.|||.|.|..|.|.|.||.| ||.||| || ... |||. |..|..|||  . |.||
MVVNRRRFKTFDALLDDITESLHDKVQLPFGAVRKIYTPDGGHRVTSLDEFLQDGGCYVCCCGNERFK
DCX DCLK1.AA DCX 181-269 31 1.4e-37 132.11 SMART 1-96 (96) Show / Hide 
Range on Protein: 181-269
Range on HMM: 1-96/96
Sequence Identity: 31% (30 aa)

DFIRPKLVTIIRSGVKPRKAVRILLNKKT-AHSFEQVLTDITD---AIKLDSG-VVKRLYTLDG-KQVMCLQDFFGDDDIFIACGPE-KFRYQDDF
.. .|| ....|.|....|.||...|.|. ..||...|.|.|.   ..|.|.. .|...||.|| ..| .|..|...||....|. . ||.. |..
HHWKPKRICFYRNGDPFFKGVRLVINRKWQFKSFDHLLQDVTQTKLHVKMDCPHGVRHIYTTDGRHRVTSLDEFEDGDDFYVCCCTNEKFKPVDYD
DCX DCLK1.AA DCX 203-264 30 2e-23 85.19 Pfam 1-68 (68) Show / Hide 
Range on Protein: 203-264
Range on HMM: 1-68/68
Sequence Identity: 30% (21 aa)

ILLNKKTAHSFEQVLTDITD----AIKLDSGVVKRLYTLDG-KQVMCLQDFFGDDDIFIAC-GPEKFR
...|......|...|.|||     ...|..| |...||.|| ..|  |..|. |......| | |.|.
MVVNRRRFKTFDALLDDITESLHDKVQLPFGAVRKIYTPDGGHRVTSLDEFLQDGGCYVCCCGNERFK
Kinase DCLK1.AA DCAMKL 406-663 62 1.8e-217 683.9 In-house 1-279 (279) Show / Hide 
Range on Protein: 406-663
Range on HMM: 1-279/279
Sequence Identity: 62% (175 aa)

YKVGRTIGDGNFAVVKECIERSTA-REYALKI-----------------IKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGG
|..||.|||||||||.||..|.|. ..||.||                 |.|.||.||||||.|||||....|||.|..|.|..|..|..|||||.|.||
YQIGRIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQIDKRKCKGKEHMIDNEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYVQGG

DLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDG---PLYTVCGTPTYVAPEIIAETGYGLKV
|||||||.. |.|||||. |...|..|.||||..||||||||||||||..|.||.|||||.|||||..|.|   ||||||||||||||||..|||||.||
DLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLACHVNGDFGPLYTVCGTPTYVAPEILMETGYGCKV

DIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQRFSAVQVLEHPWV
||||||||.|||||||||||....||| |||||..|...||.|||||.|||||.||..|| |....|..|.|...||||
DIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV
Kinase DCLK1.AA CAMK1 406-663 41 1.1e-145 426.51 In-house 1-276 (276) Show / Hide 
Range on Protein: 406-663
Range on HMM: 1-276/276
Sequence Identity: 41% (117 aa)

YKVGRTIGDGNFAVVKECIERST---AREYALKIIK-KSKCRGKE----HMIQNEVSILRRV---KHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAIT
|..| .|| | |..|..|....|    ..||.|.|. |.   .|.     ...||..|...|   .||||. ..|  . ....|||||||.||.||| | 
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

STSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLK--LGDFGLATIVD-G--PLYTVCGTPTYVAPEIIAE---TGYGLKVDI
   .|||.||.    ...||..|.||..|||||.|||||| |. .|    .|  . ||||..|.| .   ..|.|||| |||||...    ..|. ..|.
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLL-YYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM

WAAGVITYILLCGFPPFRGSGDD-QEVLFDQILMGQVDFPSPYWDNVSDS-AKELINMMLLVNVDQRFSAVQVLEHPWV
| .||||||||||.|||   ... .. ||..|. ....||||.|||.||. ||..|. || |.  .|... |.|.|||.
WSIGVITYILLCGYPPFY--DENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase DCLK1.AA CAMK 411-663 26 2.2e-128 416.03 In-house 1-425 (425) Show / Hide 
Range on Protein: 411-663
Range on HMM: 1-425/425
Sequence Identity: 26% (114 aa)

TIGDGNFAVVKECIERSTA------------REYALKIIKKSKCRG---------------------------KEHMIQNEVSILRR-------VKHPNI
|.| |.|..||.||...|             ...| |||.|.| ..                           .......|..|...       ..||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VLLIEEMDV-------------------PTELYLVM---ELVKGG----DLFDAITSTSK---------------YTERDASGMLYNLASAIKYLHSLNI
. |.| ..                    ....|.||   |.. ||    |||| |.. ..               .|||.|. .   ..||..|.||.||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDIKPENLLVYEHQDGS-------------KSLKLGDFGLATIVDG--------------------------PLYTVCGTPTYVA-PEIIA-------
||||.||||.|. .. |.|               .|. |||.|...|.                          ...|.|||| |.| ||..        
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------ETGYGLKVDIWAAGVITYILLCGFPPFRGS-----------GDDQEVLFDQILMGQVDFPSPY------------WDNVSDS--------AKE
       ...|| |.|.|..|||.||.|||.|||.|.           |.... || .|. |. |||.||            ||..||.        .| 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LINMMLLVNVDQRFSAVQVLEHPWV
||. || |. ..|... |.|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase DCLK1.AA RAD53 406-663 35 1.5e-119 357.86 In-house 1-305 (305) Show / Hide 
Range on Protein: 406-663
Range on HMM: 1-305/305
Sequence Identity: 35% (109 aa)

YKVGRTIGDGNFAVVKECIERSTAREYALKIIKK-------SKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVP-TELYLVMELVKGGDLFDAITSTS
| .....| |||..||...|..| . .| |||.|       .. ..|.  ..||| ||....||.|. ...  |.| . .|.|.||. ||.||. | |  
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

K----YTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDG--------------SKSLKLGDFGLATIVDGP--LYTVCGTPTYVAPEIIAE
.    ..| ..   .| .  |.||||...|.|||.|||| |  .  ..              | ..|. ||||. .|.    . | ||||.|||||.|. 
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITS

---------------TGYGLKVDIWAAGVITYILLCGFPPFR-GSGD--DQEVLFDQILM-GQVDFPSPYWDNVSDSAKELINMMLLVNVDQRFSAVQVL
               .||. |||.| .|.|.||.|||.|||  ....      ||.||.  |   ||.|||| .|..|| ||. || |... |......|
KGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEAL

EHPWV
 ||| 
NHPWM
Kinase DCLK1.AA S_TKc 406-663 35 1e-106 361.73 SMART 1-231 (231) Show / Hide 
Range on Protein: 406-663
Range on HMM: 1-231/231
Sequence Identity: 35% (97 aa)

YKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKG--GDLFDAITSTSK-----
|...|.|| | |..|. |....| |..|.||||         .|..|..||.. .||||| |.. ..  ..||.|||.. |  ||||| | .  .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-YTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGL-KVDIWAAGVITYIL
 ..| .|  ..| ...|..|.||..|.|||.||||.|. |       .|..|||||...    .|.|||| |.|||..   |||  |.|.|. |.| |..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQRFSAVQVLE-------HPWV
||| |||.    .....|..|.              |..||..|. .| .. ..| .| ..|.       |||.
LCGYPPFP----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DCLK1.AA Pkinase 406-663 33 1.5e-99 341.8 Pfam 1-293 (293) Show / Hide 
Range on Protein: 406-663
Range on HMM: 1-293/293
Sequence Identity: 33% (99 aa)

YKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRGKEHMIQ---NEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGG----DLFDAIT--ST
|..||.|| |.|..|..|....| ...|.|||||.. . .....    .|..|..|..||||| |.. .  ....|.|||.. ||    |||| |.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

SKY--TERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLA----TIVDGPLYTVCGTPTYVAPEIIA-ETGYGLKVDIWAA
 ..  .|...  ..| ......|.|| .|.|||.||||.|. .. . . ..|..|||||    .  .. ..|.|||| |.|||.|   ..|| |||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVITYILLCGFPPFRGS----GDDQEVLFDQILMGQVDFPSPYWDNVS-----------------DSAKELINMMLLVNVDQRFSAVQVLEHPWV
|.| |..||| |||.|.    ..|| .....|......|..|.|...|                 ...|..|. .| ..  .| .| |.|.|||.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DCLK1.AA CAMKL 406-663 33 6.3e-98 313.11 In-house 1-297 (297) Show / Hide 
Range on Protein: 406-663
Range on HMM: 1-297/297
Sequence Identity: 33% (103 aa)

YKVGRTIGDGNFAVVKECIE-RSTAREYALKIIKKSKCRGKEHMIQN--------------EVSILRRVK---HPNIVLLIEEMDVPTE------LYLVM
|..|.|.| |.|..|| ..  | | ...| |||.|.|.. ...| .|              |..|.....   ||||. | | .. |.       .||||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELVKGGD--LFDAITST----SKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATI---V----DGPLYTVCGTPT
|.. ||.  ||| | .      . .|..|  .   . ||..|.||..||||||||||.|. |...    .|. |||....   .    .  | | ||.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YVAPEIIAE--T-GYGLKVDIWAAGVITYILLCGFPPFRGS-----GDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQRFSAVQVLEH
| ||||..   .  .| |||||..||| | ..||  ||..      |.|   ..  . |..  .  | |  || ... ||  || || ..|... |...|
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG--YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PWV
||.
PWM
Kinase DCLK1.AA CDPK 406-663 40 2.5e-97 299.07 In-house 1-271 (271) Show / Hide 
Range on Protein: 406-663
Range on HMM: 1-271/271
Sequence Identity: 40% (110 aa)

YKVGRTIGDGNFAVVKECIER-STAREY-ALKIIKKSKCRGKE--HMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVME--LVKGGDLFDAITSTSKY
|| ....| |.| .|. .... .|  |  | |||.||... ||   . .||. ||.   ||||. . |        |.|||  ...||.||| |......
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

TERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGS---KSLKLGDFGLATIVD-------GPLYTVCGTPTYVAPEIIAETGYGLKVDIWAA
||..|..  . . ||. | || ||||||.||||.|     |.|   . .|. |.|.... |         ... ||||.|.|||..    |  |.||| .
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWSC

GVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQRFSAVQVLEHPWV
||| |||||| ||| |   |||. ....  |. .|  | ||..||.|| ||. || .. ..|.|| |.|.|||.
GVILYILLCGYPPFYGK-NDQEI-MEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase DCLK1.AA CAMK-Unique 406-663 28 3e-93 308.16 In-house 1-363 (363) Show / Hide 
Range on Protein: 406-663
Range on HMM: 1-363/363
Sequence Identity: 28% (102 aa)

YKVGRTIGDGNFAVVKECIERSTAREYALKIIKK-SKCRGKEHM------------------IQNEVSILRRVKHPNIVLLIEE----MDVPT-------
|| .| ||.||| .|.||. |.|  ..| |..||    . | .                     .|..|...|.||||. | .        ..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------ELYLVMELVKGGDLFDAITS--------------------TSKYTE--RDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDG----
        ..|.|||.. ||||||.| .                      ...|  .|..     |.||..|.||..|||||.|.||..|..  .     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------SKSLKLGDFGLATIVD-GPLY----TVCGTPTYVAP--------------EIIAETGYGLKV----DIWAAGVITYILLCGFPPFRGSGDDQ
         . .|| ||||.. ..    .    |.|||| |.||              |.|.. .|. ..    |||. |||.|..||| ||| ....| 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

------EVLFDQILMGQV-DFPSPYWDN---VSDSAKELINMMLLVNVDQRFSAVQVLEHPWV
        .|. |. |.. .|....|.    .|..|| ..   . | .|.| || . |||.|.
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase DCLK1.AA RSK 406-663 30 4.7e-89 302.16 In-house 1-278 (278) Show / Hide 
Range on Protein: 406-663
Range on HMM: 1-278/278
Sequence Identity: 30% (87 aa)

YKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRGKEH---MIQNEVSILRRVK-HPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTSK---
 ||  ..| | . ....|. . | ..|| |..||.| . ..        |..|| |.. ||.|| | .  . ...|||.||...||.||. .        
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

YTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGS-KSLKLGDFGLATI--VD--GPLYTVCGTPTYVAPEIIA----ETGYGLKVDIWAA
 .|..|.  ......|...||.. |.|||.|||| | |.... .  ..|| |||.. .   |  ....| |.|  |.|||...    . |..  .|.|  
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENIL-YDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GVITYILLCGFPPFRGSGDD--QEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQRFS-----AVQVLEHPWV
||. | .| |.|||.| ..|  .......|. |. ....| |...|. ||.||..|| ..  .| .     | ....||| 
GVLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase DCLK1.AA MARK 406-663 36 5.8e-86 280.98 In-house 1-262 (262) Show / Hide 
Range on Protein: 406-663
Range on HMM: 1-262/262
Sequence Identity: 36% (99 aa)

YKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRG-KE-HMIQNEVSILRRVKHPNIVLLIEEMD--VPTE-LYLVMELVKGGDLFDAITST--SK
||...||| |..|.|| .. . | |..|.||..| |    ..  ... |..|.....||||. | . ..   ..  .||.||.. ||.|.| | .    .
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

YTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSK--SLKLGDFGLATIV--DGPLYTVCGTPTYVAPEIIAETGYG-LKVDIWAAGVIT
 .|..|  .   . ||..|.|| |||||||||||.|.    |  .    |. |||.....  .  | | |||| | ||||.    |   |||||. ||. 
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILI----DENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVL

YILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQRFSAVQVLEHPWV
|...||  ||.|.. |.. |. .|| |. |.|.     ||.... ||. .| || ..| .. ....|||.
YFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH----VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase DCLK1.AA Ciliate-E2 406-663 27 1.5e-82 280.6 In-house 1-365 (365) Show / Hide 
Range on Protein: 406-663
Range on HMM: 1-365/365
Sequence Identity: 27% (106 aa)

YKVGRTIGDGNFAVVKECIERST-----------------------AREYALKIIKKS--KCRGKEHMIQ----------NEVSILRRVKHPNIVLLIEE
||. . || |||..|..|  ...                       . .||.||.||.  .   .|  |           || .||....||||. ..| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

MD--VPTELYLVMELVKGGDLFDAIT------------STSKYTERDASGMLYNLAS---------------AIKYLHSLN-IVHRDIKPENLLVYEHQD
      . .|||||...|||||| |                ..||. .. . . ...               |..|||| | |.||||||||.|.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

GSKSLKLGDFGLATIVDGP----------------------------------LYTVCGTPTYVAPEIIA---------ETGYGLKVDIWAAGVITYILL
    .|. ||||....| .                                   .|.|||| |.||||.          ..||. |.|||..||| |..|
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

CGFPPFRGSGDDQEVLFDQILMGQVDFPSP--------------YWDNVSDSAKELINM----MLLVNVDQRFS-AVQVLEHPWV
.| |||          ..||. ...|||.|               |...|...| ||.     || .. ..|.. . |.|.||| 
FGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase DCLK1.AA Pkinase_Tyr 406-588 27 6.4e-19 64.71 Pfam 1-199 (270) Show / Hide 
Range on Protein: 406-588
Range on HMM: 1-199/270
Sequence Identity: 27% (57 aa)

YKVGRTIGDGNFAVVKECIER----STAREYALKIIKKSKCRGKE---HMIQNEVSILRRV-KHPNIVLLI---EEMDVPTELYLVMELVKGGDLFDAIT
 . |...| |.| .|.... .    .|  . | |.. | ..  ..    .  .|..|..   .||||| |.    . . | ..|.|||....||| |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

S----TSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV-DGPLY-TVCG---TPT-YVAPEIIAETGYGLKV
.      . |  |  .| .  |..  ||.| |..|||.   | || |    ..  | .|||||  . .   | .. |    |    ||| |..  .  | 
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKS

DIWA
|.|.
DVWS
Kinase DCLK1.AA TyrKc 406-661 22 1.6e-14 11.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 406-661
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

YKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRV--KHPNIVLLIEEMDVP-------TELYLVMELVKGGDLFDAITST
 . |...| |.| .| ... .   .. | | .|...    . .. .| .|....  .||||| |.     .         |..|||....||| | . ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

SK-YTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLA-TIVDG-------PLYTV----CGTP----TYVAPEIIAETG
 .  . .|   . .  |.   |||| |..|||.   | || | .      | .||||.  | |.         |..    .|         ||| | .  
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YGLKVDIWAAGVITY-ILLCGFPPFRG-SG--DDQEVLFDQILMGQVDFPSPY-----WDNVSDSAKELINMMLL---VNVDQRFSAVQVLEHP
.  | |.|. ||  . |.  | .|  |      . . .. ..  |    . |.             .|. ..|.     . ..| .  .. |  
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF