Gene ABL2 (Mouse)

ABL2

Species: Mouse
Alias: Abl2, ABL2, ARG
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: TK
Family: Abl

Sequence

Name Sequence Type Origin Length Description Download
ABL2.kin_dom Protein Kinase Domain None 252 None Fasta, JSON
ABL2.AA Protein None 1182 None Fasta, JSON
ABL2.NA RNA None 10714 None Fasta, JSON

Protein domain

Protein domains of ABL2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 ABL2.AA SH3 110-166 32 4e-18 67.47 SMART 1-58 (58) Show / Hide 
Range on Protein: 110-166
Range on HMM: 1-58/58
Sequence Identity: 32% (19 aa)

NLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSK--NGQGWVPSNYITPVN
  ..||||. |.... ||..||....||  . ...| ..| .  . .||.||||.....
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 ABL2.AA SH3_1 113-159 34 4e-17 60.7 Pfam 1-49 (49) Show / Hide 
Range on Protein: 113-159
Range on HMM: 1-49/49
Sequence Identity: 34% (17 aa)

VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSK--NGQGWVPS
|||||..|.... ||..||... |.  . ...| ..|..  . .||.||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 ABL2.AA SH3_2 111-165 17 1.1e-10 40.25 Pfam 1-68 (68) Show / Hide 
Range on Protein: 111-165
Range on HMM: 1-68/68
Sequence Identity: 17% (12 aa)

LFVALYDFVA-SGDNT-----LSITKGEKLRVL---GYNQNGEWSEV-RS--KNGQ--GWVPSNYITPV
..... |.|. .. |      |...||....|.   ..... .| .. ..  ..    ||.||... ..
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWD-NWWWCWETIWGGRRMRGWFPSQWVEEC
SH3_3 ABL2.AA SH3_3 127-163 33 4.3e-05 18.56 Pfam 18-55 (55) Show / Hide 
Range on Protein: 127-163
Range on HMM: 18-55/55
Sequence Identity: 33% (13 aa)

SITKGEKLRVLGYNQNG-EWSEVRSKNGQGWV-PSNYIT
.. .|.|. |.|  |||  | ... ... |||  |.|..
QLPNGTKVNVIGC-QNGYGWYKINYNGKTGWVLSSDYVS
SH2 ABL2.AA SH2 173-248 48 2.3e-43 129.14 Pfam 1-81 (81) Show / Hide 
Range on Protein: 173-248
Range on HMM: 1-81/81
Sequence Identity: 48% (39 aa)

WYHGPVSRSAAEYLLSS--LINGSFLVRESESSPGQLSISLRYEG---RVYHYRINTTTDSKVYVTAESRFSTLAELVHHH
||||..||. || || .    .|.||||||||.||. ..|.|..|   ||.||||..| . ..|.| . .|..|.|||.|.
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 ABL2.AA SH2 171-254 43 5.4e-36 126.82 SMART 1-87 (87) Show / Hide 
Range on Protein: 171-254
Range on HMM: 1-87/87
Sequence Identity: 43% (38 aa)

HSWYHGPVSRSAAEYLLSS--LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTTDSKVYVTA--ESRFSTLAELVHHHSTVADG
. ||||..||. || || .    .|.||||.|||.||....|.|..|.|.||||... |.|.|..   . .|..| |||.|... ..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase ABL2.AA Abl 288-539 83 6.1e-200 670.52 In-house 1-252 (252) Show / Hide 
Range on Protein: 288-539
Range on HMM: 1-252/252
Sequence Identity: 83% (211 aa)

ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECSREEVTAVVLL
|.||||||||||||||.||||....||||||||||||||.|||||||.|||.||||||||||||| ||||||.||.|.|||||||||||.|||..|||||
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYP
||||||.|.|.||||..|||||||||||||||.|.||||||||.|.|..||||||||||||||||||||||||.||.|||||||||||||||||||||||
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYP

GIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAF
|||||.||..||||||||.|||||||||||||.||.||..|||||.|.|.|.
GIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase ABL2.AA Pkinase_Tyr 288-539 52 3.4e-154 522.84 Pfam 1-270 (270) Show / Hide 
Range on Protein: 288-539
Range on HMM: 1-270/270
Sequence Identity: 52% (141 aa)

ITMKHKLGGGQYGEVYVGVWK----KYSLTVAVKTLKEDTMEV----EEFLKEAAVMKEI-KHPNLVQLLGVCT-LEPP--FYIVTEYMPYGNLLDYLRE
||. .||| |..|||| |.||    .  ..||||.|||..|.     |.|..||..||.. .|||.|.|.||||  . |   |||.||||.|.||||||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

C--SREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM-TGDTY-TAHAGAKFPIKWTAPESLAYNTFSIKSDVWAF
   ... .|   || |..||...||||| ||.||||||||||||.||.|||..||||.|..   |.| ... |.|.||||.|||...|. |..|||||.|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVLLWEIATYGMSP-YPGIDLSQVYDLL-EKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAF
|||.||| |||..| |||.. ..||... |.||||..||.||...|.||. ||.. |.|||.|.| |. .
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ABL2.AA TyrKc 288-539 46 8.10000000001e-151 508.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 288-539
Range on HMM: 1-280/280
Sequence Identity: 46% (133 aa)

ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI--KHPNLVQLLGVCTLE-------PPFYIVTEYMPYGNLLDYLRECSR
||...||| |..|||| |.||   ..||||.||||.  .|.|..|| .|...  .|||.|.|.|||| .       .| .||.||||.|.|.||||.. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

EEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGD--------TYTAHA--GAK--FPIKWTAPESLAYNTFSIKS
. ..   ||....||.. ||||..||.||||||||||||||||.||..||||||  . |        .|..    |.|  .||.|.|||.. |..|..||
K-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVWAFGVLLWEIATYGMSPYPG-----IDLSQVYDLLEKGYRMEQPEG--------CPPKVYELMRACWKWSPADRPSFAETHQAF
|||.|||..||| |||..||||     .. ..|. ....||||.||.         ||...|..|. ||.  |.|||.|.| |. |
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ABL2.AA SFK-Src 288-543 53 2.9e-148 442.84 In-house 1-259 (259) Show / Hide 
Range on Protein: 288-543
Range on HMM: 1-259/259
Sequence Identity: 53% (138 aa)

ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECSREEVTAVVLL
| .. ||| ||.|.|. |.| . .  |||||||  .|  ||||.||.|||  .||||.||  |||   | ||.|| | || |||||.|   .  .   | 
IRLEKKLGSGQFGDVWKGRWNN-TTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLV

YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDT-YTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSP
 || |. . | ||| .||.|||||||| |||.| |.||.|||.|| |   |  |||| ||||||||||||   .|.||||||||.||.|. || |||  |
DMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIP

YPGIDLSQVYDLLEK--GYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF
|||     |   ...  ||||. | .||.. |..|..||.  | ||| |       |  |
YPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase ABL2.AA SFK-Abl 288-538 55 9.1e-147 482.2 In-house 1-251 (251) Show / Hide 
Range on Protein: 288-538
Range on HMM: 1-251/251
Sequence Identity: 55% (140 aa)

ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLR-ECSREEVTAVVL
| . | ||.|||||||.|.|     .||.|| |.. ||  .|.||| .|| ..|||||.|.|||| | | |||.|.|.||||||||. . || ..  | .
IILGHRLGEGQYGEVYKGIWNNH--RVAIKTIKDESMETKDFMKEAHIMKRMQHPNLVRLIGVCTREGPMYIVQEFMNYGNLLDYLQSPQSRIQIDHVSM

LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPY
.. | ||   |  || ..||||||||||||||.|  .||||||. |.   | |.|  | |.||||||||||.|  |.||||||.||. ||||||||  ||
MHCAQQIADGMSFLEEQHFIHRDLAARNCLVGDNLQIKVADFGMARFVDSDFYEARIGTKMPIKWTAPESLCYDIFTIKSDVWSFGITLWEIATYGDVPY

PGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAE-THQA
|||. ..| . |. |||| .|..||  .|. |  ||   |  |||| .  || 
PGIHHRDVINQLMMGYRMQRPQDCPMEIYNIMTQCWDVNPDERPSFHDLQHQL
Kinase ABL2.AA Src 288-539 53 9.90000000001e-138 463.86 In-house 1-255 (255) Show / Hide 
Range on Protein: 288-539
Range on HMM: 1-255/255
Sequence Identity: 53% (136 aa)

ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLR-ECSREEVTAVVL
|... ||| ||.|||. |.|.. .  |||||||..||..| ||.|| .||. .|..||||. ||. | |.|||||||  |.|||||. .    ..    |
IKLCRKLGQGQFGEVWMGYWNG-NTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQL

LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT--GDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMS
..||.|... |.|||..|.||||||||| ||||| |.||||||| ||.    | |.|. |||||||||||| . |..|.|||||| ||.||.|| |||  
IDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRV

PYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE-LMRACWKWSPADRPSFAETHQAF
|||| .  .| . .|.|||| .|..||...|| .|. ||. .| .|| |.  .. .
PYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ABL2.AA TK 288-539 28 2.1e-129 436.21 In-house 1-486 (486) Show / Hide 
Range on Protein: 288-539
Range on HMM: 1-486/486
Sequence Identity: 28% (137 aa)

ITMKHKLGGGQYG---EVYVGVWKKYS-------------------------LTVAVKTLKED-TMEVEE--------------FLKEAAVMKEIK----
||. .||| ||.|   ||| | |.  .                          .||||.|||. .|. ||              ||.||..||  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVQLLGVCTLE------------PPFYIVTEYMPYGN----LLDYLRECS----------------------------------------------
 |||.|.|.|||| .            .|..||.||||.|.    |.||||.|.                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------REEVTAVVLLYMATQISSAMEYLEKK------NFIHRDLAARNCLVGENHV-----------VKVADFG---
                            .. .|   || |. ||...||||..|      ||.||||||||||||||.|           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRLM-TGDTYTAHA------------------------GAKFPIKWTAPESLA---------YNTFSIKSDVWAFGVLLWEIATYG-MSPYPGI
     |.| .  .| |...                         |.|.||.|.|||.|.         |..|..|||||.||||.||| ||| . .|.|.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

DL---------SQVYDLLEKG--------------YRMEQPEGCP--------------PKVYELMRACWKWSPADRPSFAETHQAF
.           .|...|..|              .||.||..||              . .|.||. ||.. |.|||.|.. |...
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ABL2.AA Src-Unclassified 288-539 43 1e-117 397.36 In-house 1-284 (284) Show / Hide 
Range on Protein: 288-539
Range on HMM: 1-284/284
Sequence Identity: 43% (125 aa)

ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED---TMEVEEFL--------KEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLREC
.  . ||| || |||. | |.  .  |||||....   ||  | ||        .||..||. .|.|||.|..||. | |.||.||||  | ||..||| 
VHLLRKLGRGQFGEVWYGKWRG-KVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREG

SREEVTAVVL------------LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH-----VVKVADFGLS--RLMTGDTYTAHAGAKFPIKWTAPESL
         .             ..|.|. | |.||| |  .|||||||| |.|.|      ||||.||||   .||  | | .  ||.||.||.|||  
GGQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECF

AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQP--EGCPPKVYE-LMRACWKWSPADRPSFAETHQAF
 | .|||||||| .|.|||||.|.|  |||| .   |   .| ||||  |  ..||  .|| .|  ||   |  || |      |
IYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase ABL2.AA Tec 288-541 45 3.1e-117 395.76 In-house 1-254 (254) Show / Hide 
Range on Protein: 288-541
Range on HMM: 1-254/254
Sequence Identity: 45% (116 aa)

ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECSREEVTAV-VL
.|.   || ||.| |  | |.  .  ||.|..|| .|  |.|. || ||..  ||.|||| |||. . | |||||||  | ||.||||   .  ... .|
LTFMKELGSGQFGVVHLGKWRH-QYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAIL

LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPY
|.|  ... .|.|||...||||||||||||||...||||.|||..|    | ||   |.|||.|| .|| . |. .| |||||||||| ||. . |  ||
LEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPY

PGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFET
.  . |.| .   .|.|...|. |. ..|. |  ||. .| .||.|..  .. . 
ENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase ABL2.AA UTK 288-539 38 9.5e-111 374.23 In-house 1-296 (296) Show / Hide 
Range on Protein: 288-539
Range on HMM: 1-296/296
Sequence Identity: 38% (114 aa)

ITMKHKLGGGQYGEVYVGVWKK-----YSLTVAVKTLKEDTM---EVE---EFLKEAA---VMKEIK-HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDY
.    .|| |..|||... ...     | . ||||..... .   | |   .|..||.   .||  . |||...|.|||| | |..||||||. |.|..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRECSR------EEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH-------VVKVADFG---LSRLMT---------GD-TYTAHAGAK
|| ...      . .|   .|.|| .|...|.||. ..|.|||||||||||....       |.|.||||   .||..          ..  |.|.   .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

FPIKWTAPESLAYN-TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKG--YRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAF
 ||.|.|||.|... .|..|||||.|||..||| |.|  ||||.   ||   ...|  |||..|..||  ||.||..||. .|..||.| .  |..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ABL2.AA Csk 288-539 48 7.1e-109 368.0 In-house 1-251 (251) Show / Hide 
Range on Protein: 288-539
Range on HMM: 1-251/251
Sequence Identity: 48% (123 aa)

ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED-TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEP-PFYIVTEYMPYGNLLDYLRECSREEVTAVV
...  . | | .| | .| ..     |||| .|.|    .. || ||.|| ...|||||||.||   ..   |||.|||  |||.||||   |. .|   
LHLGECIGHGEFGDVMQGEYQ--NRKVAVKCIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVITRRQ

LLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH--AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGM
||  |  . ..|.|||.|.|.|||||||| || |  | || ||||..    .... .  .. |||||||||| |    || ||||| ||.|||||  .| 
LLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKE---ECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFGR

SPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAF
 ||| | |. |    ||||||| ||||||.||..|. ||  .||.||.|..  .  
VPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase ABL2.AA Frk 288-543 49 2.8e-108 366.04 In-house 1-260 (260) Show / Hide 
Range on Protein: 288-543
Range on HMM: 1-260/260
Sequence Identity: 49% (129 aa)

ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLR--ECSREEVTAVV
| . ..|| ||.|||. | |   .  |||||||  ||. ..||.|| .||...|| |.||  |||.| | ||.|| |  | |..||.  .   ...    
IQLIRRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQ

LLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDT--YTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYG
|. || |. . | |||..|.||||||||| ||||. ..|.||||| | ||  .   | .. ||.|||||||||   || |.||||||.||.|| || |||
LVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYG

MSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF
  ||||.   .| . ...|||| || .||...||.|  ||.  |  || |   .  .|  |
RMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase ABL2.AA S_TKc 288-543 26 2.8e-60 207.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 288-543
Range on HMM: 1-231/231
Sequence Identity: 26% (71 aa)

ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPY--GNLLDYLRECSREE----V
 ..  |.| | .|.|| ...||    ||.| .|      | ...| ...|. .|||.|.|..|.     .|.|.||..   |.|.||.... |.      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

TAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSI-KSDVWAFGVLLWEIAT
.  .  ... || .|.||. ....|||||   | |. |  ..|..||||.|..                . ||| |    ..  |.|.|..|..|.| ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAF-----ETMF
 |  |.|  .. ......            .| . ...| |... |..||.  |  |.         |
-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ABL2.AA Pkinase 288-539 23 1.1e-46 166.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 288-539
Range on HMM: 1-293/293
Sequence Identity: 23% (69 aa)

ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEE---FLK--EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYG----NLLDYLRECSR
.. . |.| | .|.|| ...|... .||||..| .. . ..    ..  |...||...||| |.|..... ..  |.|.||.. |     | ||..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

EEV--TAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVV----KVADFGLSRLMTGDTYTAHAGAKFP---IKWTAPESLA-YNTFSIKSDV
  .  .  ..  ...|| ...||. ....|||||   |.|. .| ..    |..||||....    |     .. .   . . ||| .  ..  . |.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WAFGVLLWEIATYGMSPYPGI------DLSQVYDLLEKGYRMEQ-PEGCP-------------------PKVYELMRACWKWSPADRPSFAETHQA--F
|..|..|.| .. |  |.||       |  |....  ..  ... |. |.                   .   .... |... |..||....  |   |
WSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
F_actin_bind ABL2.AA F_actin_bind 1020-1182 59 1.1e-120 411.98 Pfam 1-179 (179) Show / Hide 
Range on Protein: 1020-1182
Range on HMM: 1-179/179
Sequence Identity: 59% (106 aa)

EGGKKAAPGPMPSSGKPGRPV-MPPPQVPLPTSSISPAKMANGTA----------GTKVALRKTKQAAEKISADKISKEALLECADLLSSAIT----EPV
|||||..|.. |...|..||| |||||||.||.|.||.||||||.          .|.|.||||.|..|.|..|||.||..|.|.|.|.||||    ..|
EGGKKPVPPAVPKPQKTARPVGMPPPQVPVPTTSPSPSKMANGTQPSSTAFIPLISTRVSLRKTRQPPERIASDKITKEVVLDCTDALCSAITRNSEQMV

PNSQLVDTGHQLLDYCSGYVDSIPQTRNKFAFREAVSKLELSLQELQVSSTAAG-VPGTNPVLNNLLSCVQEISDVVQR
|.||.|||||||.|||..|||.|.|.|||||||||..|||..|.|||.....|| ||.||...|.||||||||||.|||
PHSQVVDTGHQLYDYCVSYVDCIQQMRNKFAFREAINKLENNLRELQICPATAGSVPATNQDFNKLLSCVQEISDIVQR
FABD ABL2.AA FABD 1061-1182 42 3e-69 237.3 SMART 1-153 (153) Show / Hide 
Range on Protein: 1061-1182
Range on HMM: 1-153/153
Sequence Identity: 42% (65 aa)

GTAGTKVALRKTK--------------QAAEKISADKISKEALLECADLLSSAIT----------EPVPNSQLV---DTGHQLLDYCSGYVDS-IPQTRN
.....|||||||.              |.||.|..|||||...|||...|.||..          ..|...|..   |.||||..||.||.|. |.|..|
PQIMHKVALRKTRTQLTIYATPIAKLTQPAERIPSDKISKDMILECTECLCSAFHNLFNLATHSEQMVSHQQWLQMSDKGHQLHNYCMGYADCGIMQMHN

KFAFREAVSKLELSLQELQVSSTAAG---VPGTNPVLNNLLSCVQEISDVVQR
||.|||.|..||.....|...||.||   .|..|....||.|||.||||||||
KFQFRELVTRLENQNRQLRFCSTSAGSRNSPNNNQDFMNLHSCVKEISDVVQR