Gene 25873 (M.brevicollis)
25873
Species: M.brevicollis
Alias: 25873
External Links:
Annotation:
Sequence
Protein domains of 25873.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Ank | 25873.AA | Ank | 158-190 | 36 | 8.4e-07 | 28.79 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 158-190 Range on HMM: 1-33/33 Sequence Identity: 36% (12 aa) MGNSALHTAAHFGHVDVVHLLLQYQVDCHRLNN .|...|| |.. ||..|| .|||. | . .. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
|||||||||
| PDZ | 25873.AA | PDZ | 348-424 | 27 | 4.4e-09 | 37.42 | SMART | 1-80 (80) | Show / Hide |
Range on Protein: 348-424 Range on HMM: 1-80/80 Sequence Identity: 27% (25 aa) GLLGFSVVGGIEQDALPAIALSDAHSPHYEGQGYQ--------LREGDELLAVDG-HPVAGLSHAGVVDLFRQCES-----RVSLLILPLE | ||||.|| ... | . | .. ||.||..|.|.| || ...|. .||. .|| .|.|.... . GGLGFSIVG-------GIFISSVVPG----GPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG |
|||||||||
| PDZ | 25873.AA | PDZ | 383-421 | 22 | 1.1e-05 | 21.99 | Pfam | 47-86 (86) | Show / Hide |
Range on Protein: 383-421 Range on HMM: 47-86/86 Sequence Identity: 22% (9 aa) LREGDELLAVDGHPVAGLSHAGVVDLFRQCES-RVSLLIL ..||| .....| ......|. .|.. ... . |.|.|. IHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ |
|||||||||
| PDZ | 25873.AA | PDZ | 339-370 | 33 | 4.840431 | 2.68 | Pfam | 1-33 (86) | Show / Hide |
Range on Protein: 339-370 Range on HMM: 1-33/86 Sequence Identity: 33% (11 aa) ALTVRRG-ADGLLGFSVVGGIEQDALPAIALSD .|. .. | ||||..|| .|.... | |. QVTLEKQDKRGGLGFSIKGGNDQRHDQGIYISE |
|||||||||
| Guanylate_kin | 25873.AA | Guanylate_kin | 456-520 | 36 | 4.5e-10 | 35.96 | Pfam | 27-94 (198) | Show / Hide |
Range on Protein: 456-520 Range on HMM: 27-94/198 Sequence Identity: 36% (25 aa) QQQPLLF-YDASVPLTTRTPEAGEVQGQTYHFV-SPQLFHFFLANKHLAEWGQ-YLDHYYGSLKRSIE ...| | .|| |||.| .||| | |||| | . .| . ||.| . ...||..| .|. DEHPHKFDGRYCVPHTTRPPRPGEVDGKHYHFVSSREEMWNMIQNHEFIEWAQVFNGNMYGTSKETIR |
|||||||||
| PDZ | 25873.AA | PDZ | 548-618 | 29 | 3.1e-05 | 20.47 | Pfam | 13-86 (86) | Show / Hide |
Range on Protein: 548-618 Range on HMM: 13-86/86 Sequence Identity: 29% (22 aa) FGFGIHGGTDHR--NLPFIAHIADVAYAPSSPNRIAHGDAILRINDESTLTWSSEQCVQAITSSLN-VLTLVCM .|| |.||.|.| . .|... |. .|| || |..||.... .. ...||||..| . ...|. . LGFSIKGGNDQRHDQGIYISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ |
|||||||||
| GuKc | 25873.AA | GuKc | 442-617 | 17 | 0.000358 | -31.7 | SMART | 1-203 (203) | Show / Hide |
Range on Protein: 442-617 Range on HMM: 1-203/203 Sequence Identity: 17% (39 aa) RERS----GTQASLR----SVTQQQ-P---LLFYDASVPLTTRTPEAGEVQG--QTYHFVS-PQLFHFFLANKHLAEWGQYLDH-YYGSLKRSIEVRPQH . |. | . ... .. .|. | ... ||| |||.| .||| | . ||||| . .. .. . |||.| .. ||| | .. |..| HRRPIVLSGPSGVGKSTLKHMLMQEYPDYPKFEF--SVPHTTRPPRPGEVNGCVVDYHFVSLKEEMEQMIKHNKFLEWGEYHGNLYYGTSKETV--RQVH KSRQAATSAIKICHLTRNAEN----VFGFGIHGGTDHRNLPFIAHIA-----DVAYAP------------SSPNRIAH-GDAILRIN----DESTLTWSS .. . . | . .. . . | |.. .|. .. . .. | || ..... .| ... EQGKHCILDIDPQGVRQLRYARRYSYFY------------PIVIFIKPPSMEELEERLRQPCQRGTETEERIQKRLAHQAQKEMQHYPKCHHEFDYVIVN EQCVQAI-TSSLNVLTLVC .. .|. . .... . . DDLEDACYKELKEIMEQEQ |
|||||||||
| PDZ | 25873.AA | PDZ | 546-621 | 19 | 0.000522 | 18.78 | SMART | 1-80 (80) | Show / Hide |
Range on Protein: 546-621 Range on HMM: 1-80/80 Sequence Identity: 19% (17 aa) NVFGFGIHGGTDHRNLPFIAHIADVAYAPSSP----NRIAHGDAILRIND-ESTLTWSSEQCVQAITSSLN-----VLTLVCMTRT . .|| | | ||... . | . ... || ||..|. ... ... || |... .. . ..||. . GGLGFSIVG------GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG |
|||||||||
| Guanylate_kin | 25873.AA | Guanylate_kin | 1197-1214 | 38 | 10.446037 | 0.5 | Pfam | 181-198 (198) | Show / Hide |
Range on Protein: 1197-1214 Range on HMM: 181-198/198 Sequence Identity: 38% (7 aa) NEKVDAILQHLQSKLDAE | .| .. ||.. |.|| NDDFDKAYWHLKEILEAE |
|||||||||
| PTPc | 25873.AA | PTPc | 1216-1490 | 36 | 3e-110 | 373.47 | SMART | 1-308 (308) | Show / Hide |
Range on Protein: 1216-1490 Range on HMM: 1-308/308 Sequence Identity: 36% (120 aa) GLQTEFSRLQSVGL-----------RHKSCATQANR--DKNRYR-NITAYDHSRVVLQVNPEE----GGCDYYNANYIAGARSPSDYIACQGPTNSSVDD |...||.|||... . .... ..|| |||||. .| .|||.||.|. .|.| .| || ||||| | ..| ||..||| . ..| GFWEEFERLQRMTPWDLMSNYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGYWRPKRYICTQGPLPHTIED FWRMVWQQKTQCIVMVTNLEEQ--------GRMKCLKYWPDLAPGVSADDLRADELPKLQLGPYVVFFKERHEHK-LWTQRVFELEHEGE---------G |||||||||...||| .|..| || || .|||| ... | . | .|. . .. .| |.||... |. FWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE---------------PMTYGHITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSE RMTVTQFHMTAWPDHGVPSEPSDLLYFRQAIRAAFPNP-------------------TSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAASDVPDVRD |||..| |.|||||||. |...| |....|. . |.|..||||||.||.|||.||| |.|.| . .|. . TRTVTHYHYTNWPDHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIEN--------VDIFQ VVHGMRDRRNFMVQTEEQYIFI-YFALEMAL .| ||. |..||||||||||. .|| .. IVKMMRNQRPGMVQTEEQYIFCYRCILEYIK |
|||||||||
| Y_phosphatase | 25873.AA | Y_phosphatase | 1239-1488 | 42 | 2.2e-101 | 347.9 | Pfam | 1-243 (243) | Show / Hide |
Range on Protein: 1239-1488
Range on HMM: 1-243/243
Sequence Identity: 42% (111 aa)
NRDKNRYRNITAYDHSRVVLQVNPEEGGCDYYNANYIAG-ARSPSDYIACQGPTNSSVDDFWRMVWQQKTQCIVMVTNLEEQGR-MK-CLKYWPDLAPGV
|..||||..| .|||.||.|| |.....||.||||| | ..| ||..||| ....||||||||||..||||..|..| || | | .||||
NKEKNRYKDIPCYDHTRVKLQPIPGDEDSDYINANYIDGPYWNPKAYICTQGPMPHTIEDFWRMVWQQKCTCIVMLCNCMEMGRDEKTCHQYWPD-----
SADDLRADELPKLQLGPYVVFFKERHEHKLWTQRVFELEHEG---EGRMTVTQFHMTAWPDHGVPSE-PSDLLYFRQAIRAAFP-NPTS--PMLVHCSAG
. | ... |.. | .. .... .| |.||... | . . |||..|.|.|||||||. | ..| |.. .| . | . . |..||||||
------NKEGQPMTYGDFQVTCVSEEHCPDYTVRTFEVTN-GDQKQETRTVTHYHYTNWPDHGVPESQPKSMLDFIRQVRKWQPNPDHGCPPIVVHCSAG
VGRSGTFIAIDHMLQLILDEARAASDVPDVRDVVHGMRDRRNFMVQTEEQYIFIYFALEM
.||.|||.||| |.|.. .| |. ..| || |..||||||||||.| ..
CGRTGTFCAIDIMCQQMEHEGTV-----DIFQIVKHMRNQRPGMVQTEEQYIFCYQCILE
|
|||||||||
| PTPc_motif | 25873.AA | PTPc_motif | 1382-1488 | 41 | 3.7e-40 | 140.64 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 1382-1488 Range on HMM: 1-92/92 Sequence Identity: 41% (47 aa) TVTQFHMTAWPDH-----GVPSEPSDLLYFRQAIRAAFPNPTSPMLVHCSAGVGRSGTFIAIDHMLQLILDEARAASDVPDVRDVVHGMRDRRNFMVQTE ||...|.|.|||| |||. ...| |....|. |..||||||.||.|||.||| |.|. .|. ..|. ||. |..||||| TVHHYHYTNWPDHVEKDSGVPE--DSILEFIRHVRK-------PIVVHCSAGCGRTGTFCAIDMMMQQ-----------VDIFQTVKEMRKQRPGMVQTE EQYIFIYFALEM |||||.| .. EQYIFCYRCILE |
|||||||||