Gene 1850 (M.brevicollis)

1850

Species: M.brevicollis
Alias: 1850
External Links:
Annotation:

Classification

Group: TK-assoc
Family: PTP

Sequence

Name Sequence Type Origin Length Description Download
1850.AA Protein None 1636 None Fasta, JSON

Protein domain

Protein domains of 1850.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 1850.AA STE20 14-284 42 8.8e-116 390.95 In-house 2-288 (288) Show / Hide 
Range on Protein: 14-284
Range on HMM: 2-288/288
Sequence Identity: 42% (127 aa)

DLKEVVGEGAYGKVHRGVLKNLKQI----VAVKIIPIVP-----EEKEEIALELQVLAKFSSHHNIARFYGGYFQPVPREDKDGILRKQLWLVMQYCANG
.| |..|.|.||||...  |  ...    ||.|.... .     .|.|.|  | ......  | || ..|| |.   .        . .||.|| ||. |
ELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTC-------DDELWIVMEYCGGG

TATRLVK---ALRK-PKPK-----HVIAYIMKEALNGLAYLHDNKIIHRDIKGGNILLTRGFRVKLVDFGVCAQLQH-----ESSKRDTVIGTPYWMAPE
..| ..|    . |  |         ||||..|.| ||.||| |.|||||||..|||||   .|||.||||||||..     ...||.|..|||||||||
SLTDIMKHCMKCGKNHK-GHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPE

VIMCDLSPPGTVHYDARADIWSLAITAIELADGEPPLSKMPAMKALHKIP--SNKPPTLSS--NHKWTKYFYEFLVVALKKNPTKRPNAEQLKSHPWL
||.|. .|     || ..||||| |||||.|.||||...|..|.|. .||  .|.||||..   |||.. | .|. . | |.| ||| |.|| .||..
VIQCMEGP--DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 1850.AA STE 13-284 30 4.8e-107 361.93 In-house 1-359 (359) Show / Hide 
Range on Protein: 13-284
Range on HMM: 1-359/359
Sequence Identity: 30% (113 aa)

VDLKEVVGEGAYGKVHRGVLKN---------------LKQIVAVKIIPIVP------------------EEKEEIALELQVLAKFSS-HHNIARFYGGYF
 .. |..|.||.|.|.... ..                ..|.|.|.... .                  ||...|  |.... |... | || ..|| ||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

---QPVPREDKDGILRKQ---LWLVMQYCANGTATRLVK-ALRKPKP------------KHVIAYIMKEALNG-LAYLHDNKIIHRDIKGGNILLTRGFR
    .           |.   ||..| |...|... ..|    ..||             ..|||| .. | | |.|||...|||||||..||||     
KEGHN----------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----

VKLVDFGVCAQLQHE----------------SSKRDTVIGTPYWMAPEVIMCDLSPPGTVHYDARADIWSLAITAIELADGEPPLSKMPAMKALHKIPSN
|||.|||||.||...                ..||.|..||| |||||||... ..    .||...||||| .|.||.|.|.||...|. |.|.  || |
VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFN

---------------KPPTLSS-----------------NHKWTKYFYEFLVVALKKNPTKRPNAEQLKS--HPWL
               .||.| .                  |||.. | .|.   |.|.| |||.|.|| .  ||..
YHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 1850.AA MSN 13-284 48 3.6e-103 341.56 In-house 1-265 (265) Show / Hide 
Range on Protein: 13-284
Range on HMM: 1-265/265
Sequence Identity: 48% (132 aa)

VDLKEVVGEGAYGKVHRGVLKNLKQIVAVKIIPIVPEEKEEIALELQVLAKFSSHHNIARFYGGYFQPVPREDKDGILRKQLWLVMQYCANGTATRLVKA
 .| |||| |.||.|..|. .   |..|.|.. .  .| ||| .|. .| |.| |.||| .|| ...  |        ..|||.|| .|. |  | ||| 
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPP-----GHDHQLWMVMEFCGAGSVTDLVKM

LRKPKPK-HVIAYIMKEALNGLAYLHDNKIIHRDIKGGNILLTRGFRVKLVDFGVCAQLQHESSKRDTVIGTPYWMAPEVIMCDLSPPGTVHYDARADIW
 .    |   |||| .| | |||.|| .|.||||||| |.|||    |||||||| |||..   .| | |||||||||||| || .|  |  || |.|.|
TKGQSLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDAT--YDYRSDLW

SLAITAIELADGEPPLSKMPAMKALHKIPSNKPPTLSSNHKWTKYFYEFLVVALKKNPTKRPNAEQLKSHPWL
|. |||||.|.|.||| .|  |.||  || | ||.|  ..||.| | .|.   | ||  .||..||.  ||..
SVGITAIEMAEGQPPLCDMHPMRALFLIPRNPPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase 1850.AA YSK 16-284 39 1.5e-96 291.26 In-house 4-257 (257) Show / Hide 
Range on Protein: 16-284
Range on HMM: 4-257/257
Sequence Identity: 39% (107 aa)

KEVVGEGAYGKVHRGVLKNLKQIVAVKIIPI--VPEEKEEIALELQVLAKFSSHHNIARFYGGYFQPVPREDKDGILRKQLWLVMQYCANGTATRLVKA-
 |..| | .| |  |. .  ...||.|||      .| | |. | |.|.   |  .| ..|| | . .            || .| ||. | .  | |. 
QECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSP-YITKYYGSYLKDT-----------KLWIIMEYCGGGSCLDLMKPK

LRKPKPKHVIAYIMKEALNGLAYLHDNKIIHRDIKGGNILLTRGFRVKLVDFGVCAQLQHESSKRDTVIGTPYWMAPEVIMCDLSPPGTVHYDARADIWS
   . .   || |..| | || ||| .. ||||||  |.||.    ||| |||| .|.   . ||.| .|||||||||||....     . ||. |||||
YVGQFDEKYIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEV-----SYYDFKADIWS

LAITAIELADGEPPLSKMPAMKALHKIPSNKPPTLSSNHKWTKYFYEFLVVALKKNPTKRPNAEQLKSHPWL
| |||.|.| ||||.... .|...  ||.|.||.|.  ....| | ||  . |.|.| .|| |..| .|   
LGITAYEMAKGEPPYCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase 1850.AA NinaC 14-284 45 2.5e-96 326.35 In-house 2-267 (267) Show / Hide 
Range on Protein: 14-284
Range on HMM: 2-267/267
Sequence Identity: 45% (125 aa)

DLKEVVGEGAYGKVHRGVLKNLKQIVAVKIIPIVPEEKEEIALELQVLAKFSSHHNIARFYGGYFQPVPREDKDGILRKQLWLVMQYCANGTATRLVKAL
   | .| | |||| .   |   ||.||||   . .  |||  | ..| ....| |. |||| |.       || .   |||.|| ||. |..| .|| |
EIYETIGKGTYGKVFKVKNKDNGQIAAVKIQHYIHDHDEEIEAEYNILRDYCDHPNVVRFYGMYYK------KDKCNGDQLWFVMEYCNGGSVTDMVKGL

RKPKPK---HVIAYIMKEALNGLAYLHDNKIIHRDIKGGNILLTRGFRVKLVDFGVCAQLQHESSKRDTVIGTPYWMAPEVIMCDLSPPGTVHYDARADI
 |        .||||..||. ||  || |..||||.|| |||||.  .|||.|||| |||.    .| | .|||.||||||| |  .   .  ||||.|.
LKCGRRMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPD--YDARCDV

WSLAITAIELADGEPPLSKMPAMKALHKIPSNKPPTLSSNHKWTKYFYEFLVVALKKNPTKRPNAEQLKSHPWL
||| ||||||.||.||.  |  |.|. ||| | ||||    .| . | .|    | |.  |||   ..  || .
WSLGITAIELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase 1850.AA MST 14-284 43 1.3e-82 262.43 In-house 2-254 (254) Show / Hide 
Range on Protein: 14-284
Range on HMM: 2-254/254
Sequence Identity: 43% (117 aa)

DLKEVVGEGAYGKVHRGVLKNLKQIVAVKIIPIVPEEK-EEIALELQVLAKFSSHHNIARFYGGYFQPVPREDKDGILRKQLWLVMQYCANGTATRLVKA
|. |  |.|.||.|.. . |  ..|||.|..|.  .|  .||  |   .    |  .| ..|| ||     . |.    ...|.|| ||. | .  ..|.
DIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKS-KYIVKYYGSYF-----DAKN----NHCWIVMEYCGMGSVCDIMKI

LRKPKPKHVIAYIMKEALNGLAYLHDNKIIHRDIKGGNILLTRGFRVKLVDFGVCAQLQHESSKRDTVIGTPYWMAPEVIMCDLSPPGTVHYDARADIWS
 ...     || | . .| ||.||||||.|||||| |||||      || |||| .|| .   ||.||||||||||||||.        . ||  |||||
TQRTLNEQQIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQ-------EIKYDCKADIWS

LAITAIELADGEPPLSKMPAMKALHKIPSNKPPTLSSNHKWTKYFYEFLVVALKKNPTKRPNAEQLKSHPWL
| |||||.| |.||.|   .| |. .||.. |||..  ..|   |  |.   | ||| .|. |||| .||  
LGITAIEMAEGMPPYSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase 1850.AA SLK 17-284 40 5.6e-79 266.06 In-house 2-259 (259) Show / Hide 
Range on Protein: 17-284
Range on HMM: 2-259/259
Sequence Identity: 40% (111 aa)

EVVGE---GAYGKVHRGVLKNLKQIVAVKIIPIVPEEK-EEIALELQVLAKFSSHHNIARFYGGYFQPVPREDKDGILRKQLWLVMQYCANGTATRLVKA
|..||   ||.|||.. . |. |.. | |.| |  ||. |.   |...|..   | || . |. |.             ..||... .|. |    ..  
EIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECK-HPNIVKLYEAYY-----------YDNKLWMMIEFCDGGAVDNIMVE

LRKPKPKHVIAYIMKEALNGLAYLHDNKIIHRDIKGGNILLTRGFRVKLVDFGVCAQLQHESSKRDTVIGTPYWMAPEVIMCDLSPPGTVHYDARADIWS
| .|   . |.|. |. ...| .||.||.||||.| ||||.|    |.| |||| |...|.  |||| |||||||||||.||. .      || .|||||
LEHPLTEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETF--KDQPYDYKADIWS

LAITAIELADGEPPLSKMPAMKALHKIPSNKPPTLSSNHKWTKYFYEFLVVALKKNPTKRPNAEQLKSHPWL
| || ||.|..||| . |  |. | ||    ||||    .|.| | .||  .|.|.| .|. ..||  |.|.
LGITLIEMAQMEPPHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase 1850.AA S_TKc 13-284 28 6.9e-77 262.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-284
Range on HMM: 1-231/231
Sequence Identity: 28% (81 aa)

VDLKEVVGEGAYGKVHRGVLKNLKQIVAVKIIPIVPEEKEEIALELQVLAKFSSHHNIARFYGGYFQPVPREDKDGILRKQLWLVMQYCAN--GTATRLV
 .. ...|.||.|||.... |. ..|||.|||.      | |  |.|.| |   | || ..|. .              . |..|| || .  |.  .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD------------DHLYMVMEYCDGDLGDLFDYI

KALRKP-----KPKHVIAYIMKEALNGLAYLHDNKIIHRDIKGGNILLTRGFRVKLVDFGVCAQLQHESSKRDTVIGTPYWMAPEVIMCDLSPPGTVHYD
|  ...      |  .....|.. ...|.|.|...|||||.|  ||||..  ..|. |||...||       .|..|||..|||||.          .|.
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----------GYG

A-RADIWSLAITAIELADGEPPLSKMPAMKALHKIPSNKPPTLSSNHKWTKYFYEFLVVALKKNPTKRPNAEQLKS-------HPWL
  ..|.||. .. .|.. |.|| .    .. ..||              .. . .|.   |.|.|.||| | ..         |||.
KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 1850.AA PAKA 14-284 35 1.2e-71 244.35 In-house 2-260 (260) Show / Hide 
Range on Protein: 14-284
Range on HMM: 2-260/260
Sequence Identity: 35% (100 aa)

DLKEVVGEGAYGKVHRGVLKNLKQI--VAVKIIPIVPEEKE-EIALELQVLAKFSSHHNIARFYGGYFQPVPREDKDGILRKQLWLVMQYCANGTATRLV
.  | .|.|| |.| ..  .  .|   ||.| . .  . |   |  |. |. | . | || ...  |           ..  .||.|| | . |  | ..
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVM-KECKHKNIVNYIDSY-----------LVDDELWVVMEYMEGGCLTDVI

KALRK----PKPKHVIAYIMKEALNGLAYLHDNKIIHRDIKGGNILLTRGFRVKLVDFGVCAQLQHESSKRDTVIGTPYWMAPEVIMCDLSPPGTVHYDA
.. ..    . .   |||. .| | || ..|....||||||  ||||    .||. ||| ||||. | .||.|. |||||||||||           || 
TQCCNIQCNYMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIR-------RKQYDE

RADIWSLAITAIELADGEPPLSKMPAMKALHKIPSNKPPTLSSNHKWTKYFYEFLVVALKKNPTKRPNAEQLKSHPWL
  ||||| | |||...||||  ..|  .|.  | .|  | . . .||.. | .||   |.... .|. |..| .|| |
KVDIWSLGIMAIEMIEGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase 1850.AA KHS 14-284 38 3.5e-70 235.21 In-house 2-258 (258) Show / Hide 
Range on Protein: 14-284
Range on HMM: 2-258/258
Sequence Identity: 38% (106 aa)

DLKEVVGEGAYGKVHRGVLKNLKQIVAVKIIPIVPEEKEEIALELQVLAKFSSHHNIARFYGGYFQPVPREDKDGILRKQLWLVMQYCANGTATRLVKAL
.|   || | || |..   .. ....|||.| . |..  ..  .  .. |  .| ||  ..| |           . |..||..| ||  |    . . .
ELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSY-----------LRRDKLWICMEYCGGGSLQDIYH-V

RKPKPKHVIAYIMKEALNGLAYLHDNKIIHRDIKGGNILLTRGFRVKLVDFGVCAQLQHESSKRDTVIGTPYWMAPEVIMCDLSPPGTVHYDARADIWSL
  |     |||. .|.|.||.||| .. .|||||| |||||    ||| |||| ||.    .||   |||||||||||   .        |.   |||..
TGPLSELQIAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVER----KGGYNQLCDIWAV

AITAIELADGEPPLSKMPAMKALHKIP--SNKPPTLSSNHKWTKYFYEFLVVALKKNPTKRPNAEQLKSHPWL
 |||||||.  ||.  .  |.||  .   . .||.|   |||.. | .|. .|| ||| |||.||.| .||..
GITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase 1850.AA Pkinase 13-284 26 2.8e-69 241.26 Pfam 1-293 (293) Show / Hide 
Range on Protein: 13-284
Range on HMM: 1-293/293
Sequence Identity: 26% (83 aa)

VDLKEVVGEGAYGKVHRGVLKNLKQIVAVKIIPIVPEEKEE---IAL--ELQVLAKFSSHHNIARFYGGYFQPVPREDKDGILRKQLWLVMQYCANG---
  .....|.|..|.| ... |.  .|||||||. . |....    ..  |.|..... .| || |.| ..|.           .. ...|| || .|   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLY-DWFED----------KDHIYMVMEYCEGGLYV

-TATRLVK-ALRKPK--PKHVIAYIMKEALNGLAYLHDNKIIHRDIKGGNILLTRGFRV----KLVDFGVCAQL-QHESSKRDTVIGTPYWMAPEVIMCD
    ....   ...   . ...  .|.. | ||.|.|...|||||.|  |||. .   .    |. |||...|.    .|  .|. |||..||||||.  
MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR--

LSPPGTVHYDARADIWSLAITAIELADGEPPLSKM----PAMKALHKIPSNKPPTLSSNHKWT---------------------KYFYEFLVVALKKNPT
    |  .|. ..|.||. .. .|.. |.|| .      . .  ...|  ...| |...  |.                     . . .|.   |.|.|.
----GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

KRPNAEQLKSHPWL
|||.|||.. |||.
KRPTAEQILQHPWF
Kinase 1850.AA PAKL 122-284 46 4.7e-62 212.48 In-house 100-256 (256) Show / Hide 
Range on Protein: 122-284
Range on HMM: 100-256/256
Sequence Identity: 46% (77 aa)

IAYIMKEALNGLAYLHDNKIIHRDIKGGNILLTRGFRVKLVDFGVCAQLQHESS-KRDTVIGTPYWMAPEVIMCDLSPPGTVHYDARADIWSLAITAIEL
|. | . .|.|| |||   |||||||  ||||. .  ||. ||||  ||| | .      ||||||||||.|           |.  .||||| |||||.
ISVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIIN-------KQNYNNKCDIWSLGITAIEM

ADGEPPLSKMPAMKALHKIPSNKPPTLSSNHKWTKYFYEFLVVALKKNPTKRPNAEQLKSHPWL
|||.||.. || |.|.  ||   |||.|  ..| . |  ||   . | | ||. . .| .|| .
ADGFPPHYDMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase 1850.AA Pkinase_Tyr 13-281 22 5.2e-25 85.32 Pfam 1-269 (270) Show / Hide 
Range on Protein: 13-281
Range on HMM: 1-269/270
Sequence Identity: 22% (67 aa)

VDLKEVVGEGAYGKVHRGVLK----NLKQIVAVKII--PIVPEE--KEEIALELQVLAKFSSHHNIARFYGGYFQPVPREDKDGILRKQ--LWLVMQYCA
. . .. ||||.|.|..|..|    | |. ||||..     .|.  .|.   |.... .. .|.|| |.||               ...  ...|| |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT----------DQGEPNQIYIVMEYMP

NGTATRLVKALRKP-------KPKHVIAYIMKEALNGLAYLHDNKIIHRDIKGGNILLTRGFRVKLVDFGVCAQLQHESSK-RDTV--IGTPYWMAPEVI
.|    | . |||.       ..|. .  .  .  .|..||.....||||.   |.|.|... ||  ||| .  .....   | .        |||||.|
HG---DLLDYLRKHREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECI

MCDLSPPGTVHYDARADIWSLAITAIELAD-GEPP-LSKMPAMKALHKI-PSNKPPTLSSNHKWTKYFYEFLVVALKKNPTKRPNAEQLKSH
.          .    |.||  ..  |.   || |    |.    ...|  ..    .   .. ..  |. .    ...| .||  ... ..
NYGK-------FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR--MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQ
Kinase 1850.AA TyrKc 13-284 22 4.9e-16 36.51 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-284
Range on HMM: 1-280/280
Sequence Identity: 22% (69 aa)

VDLKEVVGEGAYGKVHRGVLKNLKQIVAVKIIPIVPEEKEEIALELQVLAKF-SSHHNIARFYGGYFQPVPREDKDGILRKQLWLVMQYCANGTATRLVK
. |... ||||.|.|..|..|   . |||| .      .|..  |.... |.  .| || |.||   |.  .     .  ..|..|| |...|    | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHG---DLKD

ALRKPK---PKHVIAYIMKEALNGLAYLHDNKIIHRDIKGGNILLTRGFRVKLVDFGVCAQLQHE----SSKRDTVI----GTP-----YWMAPEVIMCD
 |||..   .     ...  . .| .|||....||||.   |.|......||  ||| .  . ..     ||   .     |.       |||||.|   
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---

LSPPGTVHYDARADIWSLAITAIELA-DGEPPLSK-----MPAMKALHKIPSNKPPTLSSNHK------WTKYFYEFLVVALKKNPTKRPNAEQLKSHPW
     .  .    |.||  ..  |.  .|..| .      |..  ..... . . .    |.        ..  |.      . .| .||. ...  |  
----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HEC

L
.
F
Kinase 1850.AA PAKL 14-61 32 2.3e-05 16.31 In-house 2-50 (256) Show / Hide 
Range on Protein: 14-61
Range on HMM: 2-50/256
Sequence Identity: 32% (16 aa)

DLKEVVGEGAYGKVHRGVLKNLKQIVAVKIIPIVPE-EKEEIALELQVL
 ..|  |.|.|| | ... | .    |.| |.| .  | ..|  | |.|
EFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQIL
MYSc 1850.AA MYSc 325-1133 29 1.3e-227 763.39 SMART 1-771 (771) Show / Hide 
Range on Protein: 325-1133
Range on HMM: 1-771/771
Sequence Identity: 29% (263 aa)

GEDMRA--TDNLAKMRNFSEAAIVTTLQQRYAKDIIYTDIGDILVACNPFKSI-DIYNRNFQEVFS------ASNQQRNPFPHVYNMAQATMRSLVHSGQ
 . .    .| .. . . .|.|.. .|..||..|.||| ||....| ||.| .  ||.. . . ..        ..  .| ||..  | .  |.. . ..
MNPPKFEGVDDMCMLTYLNEPAVLHNLKKRYMNDQIYTYIGPVCIAVNPYKQLPPIYTPDVIKQYRNRKFDDGKHRYEMP-PHIFAIADNAYRNMLNDKE

NQCCIISGESGAGKTETAKYFVRQLLYTAAHHASGAFDATQWSSLEQRILASNPILEAFGNAKTIMNNNSSRFGKFLLIKFDTRHRLQGVSIAQYLLEKS
|||.||||||||||||..|.  . | . ..          | ...||.||.|||||||||||||. |||||||||.  | ||    ..| .| .||||||
NQCIIISGESGAGKTENTKKIMQYLAAVSG----------QVERVEQQILQSNPILEAFGNAKTVRNNNSSRFGKYMEIHFDEKGKICGAKIENYLLEKS

RVVQQGPSERNFHVFYYLVSGNDITAERNALLLNT----SLDFVYLGG-----TSTENVDEALVKEHARQGGNAEELAALEDMGQDEAVKGYAT----LM
|||.| . |||.|.||.| .| .  .... ..| .      |. ||        . .                    . ... | | | . ..     . 
RVVYQNKGERNYHIFYQLCAGAS-EEQKQEFHLKPFSHNPEDYHYLNQGGHYWNN-K-R---------------HQSQCFTVDGIDDA-EEFKETCEQTC

SEMLALGFSGAELVEVKLILALILHLGNVSFGVVDG--AESAE----VFGLAALKHCSSLLGVELDVLSRALTKRVTVLRGE---EMVKPLKPFQAEDNR
. |  .|||  |  ..  |.| ||||||..|   ..  ...|.    | .  .|. ...||||. ..| ..||.|... ..|   . .|||.. ||.. |
NAMRVMGFSEEEQEWIFRIVAAILHLGNIEFEQGRNQYDNQAVCSEKVKDEEELQNACELLGVDPEDLEKWLTHRKMKTGHEGGTWITKPLNVEQAIYAR

DAAAKAIYGRLFAWIVTRINNTLLPDLEEEMREVGVLDIFGFENFRLNSFEQLCINVANEQLQYYFNQNVFAWELEELKSEGVNVANITFE--NNKPLLD
|| |||||.||| ||| ||| ..        . .|||||.|||.|  |||||.||| .||.||..||. .|  | || . ||... .| |   .|.| .|
DALAKAIYSRLFDWIVKRINQSM------HNYFIGVLDIYGFEIFEHNSFEQFCINYCNEKLQQFFNHHMFKLEQEEYQREGIEWTFIDFFMYDNQPCCD

MFLQR---PHGLFAILDEESYF---PQATDESLANKL-----HTNFANANKYYGAP----------KSSHTLEFSINHFASQVHYNLPGFLEKNRDRLSE
   ..   | |.|..||||. |   |..||.....||     |....| .. .  |          |  .  .|.|.|.|  |.||  |.||||.| |..
LIEKKGKRPMGIFSLLDEECMFHAQPKGTDQTFLEKLNKQDYHQHHKN-HPHFSKPHKSHRCCKPKKRMGRTHFIIKHYAGDVTYNVEGWLEKNKDTLFD

GVERMLLECGIPLVRMFFRHEVGAT------------------------GIMGSNWQADIDRSNATTVLRSLTPDKFRNQLRRKASMESNMAGAAEPSLR
 ..  . ..  |...  | .....|                        .                                                  
DLIQLMQSSKNPFIKQLFPEYEDQTSQTPQEKSSQGKNKSRRKKRMMQMK--------------------------------------------------

SRGGDESLISASMRRTATHKSRRRRSRAALTPQAAPQHGK----AKKAPTVSTHFRQSLTDLMSKMMQAQPHFVRCIKPNPRQIGDRFEEEFVLRQLQYT
                                       |     |. |||.. |. .| .||..... .||..||||||  .    |... ||.||.. 
---------------------------------------KTCMQKKRFPTVGFQFK-QLNELMETLNSCHPHYIRCIKPNEEKKPWDFDDDLVLHQLRCC

GVMQTVEIRKEGFPVRLDFDEFVRRYQVLGYRPGALLE-------ESKAQLACVKILTQAG--IEQNSQGASRSSVWELGKTKIFLK-YFVTDRLAAQLE
||. .. ||..|||.|. ..||..||..|     .  .        . .. ||..|| | |  |.   |    .. . .||||.|.. . .  .|  . |
GVLENIRIRRAGFPYRWPYQEFYQRYKMLCPPTWPNWGNPWKNQLFGDPKKACEAILQQLGEYIQ--HQ-NWDPDMYQFGKTKVFFRNPGQLFHLEEMRE

K
.
R
Myosin_head 1850.AA Myosin_head 331-1120 28 3.7e-200 676.05 Pfam 1-765 (765) Show / Hide 
Range on Protein: 331-1120
Range on HMM: 1-765/765
Sequence Identity: 28% (253 aa)

TDNLAKMRNFSEAAIVTTLQQRYA-KDIIYTDIGDILVACNPFKSIDIYNRNFQEVFSASNQQRNPFPHVYNMAQATMRSLVHSGQNQCCIISGESGAGK
..... . . .|...   |..||. .| |||..|..... ||.| ..||   . . ..  ... .| ||..  | .  |...| ..|||.||.|||||||
VEDMVMLTYLNEPSVLHNLKKRYMTGDLIYTYSGHFCISVNPYKQLPIYTQDMIQEYRGKHRYEMP-PHIFAIADEAYRHMRHDRENQCIIICGESGAGK

TETAKYFVRQLLYTAAHHASGAFDATQWSSLEQRILASNPILEAFGNAKTIMNNNSSRFGKFLLIKFDTRHRL----QGVSIAQYLLEKSRVVQQGPSER
|| .||  . . . .. ...      . ...|| ||.|||||||||||||. |||||||||.. | ||   ..     |  |  ||||||||| | | ||
TENTKYVMQYFASVSGSNPG-----VNMGRVEQQILQSNPILEAFGNAKTTRNNNSSRFGKYMEIHFDKTGKINPTAVGGNIENYLLEKSRVVYQTPGER

NFHVFYYLVSGNDITAERNALLLN-T-SLDFVYLGGTS---TENVDEALVKEHARQGGNAEELAALEDMGQDEAVKGYATLMSEMLALGFSGAELVEVKL
|||.||.| .| .  .|...|.|  .   |. ||       .  |                      | | | | ...  . . | ..||.. |  ..  
NFHIFYQLLAGASQQEEKKELHLTSADPKDYHYLNQSGTNPCYTV----------------------DDGIDDA-EEFQHTRNAMDIIGFTHEEQRSIFR

ILALILHLGNVS-FGVVDGAESAEVFGLAA-LKHCSSLLGVELDVLSRALTKRVTVLR----GEEMVKPLKPFQAEDNRDAAAKAIYGRLFAWIVTRINN
|.| ||||||.  | . .  |.|.| .... .   ..|.||   .. ..|..|. . .     |  .||. . || . ||| |||||.|.| |||.|||.
IVAAILHLGNMKGFKQDQNEEQAVVDDTEEICEIICELMGVDPEEFEKWLCYRRIKTGGGKRREWVTKPQNCEQAMYARDALAKAIYSRMFDWIVNRINQ

TLLPDL-----------------------------EEEMREVGVLDIFGFENF-RLNSFEQLCINVANEQLQYYFNQNVFAWELEELKSEGVNVANITF-
..   .                              .    .|||||.||| |   |||||.||| .||.||..||...|  | || . ||... .| . 
AICHKTQNTDDSDGQAAQWDDTVSITVVDVPDPAFDKRNYFIGVLDIYGFEIFCEKNSFEQFCINYCNEKLQQFFNHHMFKLEQEEYVREGIQWTFIDYG

ENNKPLLDMFLQR--PHGLFAILDEESYFPQATDESLANKLHTNFANANK--YY-GAP-K-----SSHTLEFSINHFASQVHYNLPGFLEKNRDRLSEGV
 .|.|  |  .    | |....||||. ||.|||.... ||. .. . .    .   | .     .    .|.| |.| .| ||  |.||||.| |....
FDNQPCCD-LIEKKKPMGILSLLDEECWFPKATDQTFLQKLYQTHSSKHPRLHFAQKPGRFYKRHRQGNTHFIIKHYAGDVWYNCEGWLEKNKDPLFDDL

ERMLLECGI-PLVRMFFRH-EVGATGIMGSNWQADIDRSNATTVLRSLTPDKFRNQLRRKASMESNMAGAAEPSLRSRGGDESLISASMRRTATHKSRRR
.  . ..   |.....|.  |  .   |                                                                        
IELMWCSWDNPFMQELFPDWEWAEWAHMQ-----------------------------------------------------------------------

RSRAALTPQAAPQH----------------GKAKK--A-PTVSTHFRQSLTDLMSKMMQA---QPHFVRCIKPNPRQIGDRFEEEFVLRQLQYTGVMQ-T
      ....|..|                ...||    .||.  |..... ||  . |     ||.||||||| ... . |... || ||.. ||   .
------IDFEADFHEEEFKRRYNRNGCQKGKQGKKKWFMQTVWFQFKEQCNHLMKWLYQCAWWHPHYVRCIKPNENKQPWQFDNSMVLHQLRCNGVLEIN

VEIRKEGFPVRLDFDEFVRRYQVLGYRPGALLEE------SKAQLACVKILTQA---GIEQNSQGASRSSVWELGKTKIFLK
. |. .||| |. .|||..||..|.  | .. .         .. .| ||| .    ...        .. . .||||||..
IRICRAGFPYRWTYDEFFQRYRILC--PKTWWSWIWPEWNGDTKQGCEKILQHLSWGNMD--------KEEYQFGKTKIFFR
Kinase 1850.AA SLK 623-653 35 0.197395 0.45 In-house 2-32 (259) Show / Hide 
Range on Protein: 623-653
Range on HMM: 2-32/259
Sequence Identity: 35% (11 aa)

ALILHLGNVSFGVVDGAESAEVFGLAALKHC
 .|  ||.  || |  |.. |   .|| | .
EIIGELGDGAFGKVYKAQHKEQKVFAAAKMI
IQ 1850.AA IQ 1135-1155 28 0.000208 18.15 Pfam 1-21 (21) Show / Hide 
Range on Protein: 1135-1155
Range on HMM: 1-21/21
Sequence Identity: 28% (6 aa)

GEAAVSLQRAAKGFWARRNLK
 .||. .|.. .|..||....
HRAAIKIQAWWRGYLARKHYR
PTPc 1850.AA PTPc 1271-1536 28 5.5e-90 306.17 SMART 1-308 (308) Show / Hide 
Range on Protein: 1271-1536
Range on HMM: 1-308/308
Sequence Identity: 28% (93 aa)

FSAEEYNAIDMAL------------VSKKRIPPGTS--NLNRYN-NILPNPRTRVRLSKLNDD----DITTYINANYVHGYDGAHGTYIATQGPTPTTTP
  .||.. ....               .  . |     . |||  .|.....|||.|......      . ||||||. || .   .||.|||| | |  
GFWEEFERLQRMTPWDLMSNYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGY-WRPKRYICTQGPLPHTIE

DFWRMVWETNANSIVMVTGLQEK--------GREKCARYWPTVLFNEREGLGDMQAGFVNVAVLAGVRSN-GYIATKLRIKHDKS--------DTERIVM
|||||||. .  .||| . . ||        |||||..|||            |. |   |  .  .  . .|. .........         . .|.|.
DFWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE---------PMTYGHITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSETRTVT

HYWFNSWPDHGVPSETGNVVKMLQAVREWSDDP-------------------ERPWIVHCSAGVGRTGTFITIDIGMRLLQERGRCNVNEIIRRLRKDRC
||.. .|||||||. .  . .....||.|.                      . | .||||||.||||||..||| ......    .. .|....|. |.
HYHYTNWPDHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIEN---VDIFQIVKMMRNQRP

AMVQHPEQAEFAYKVLSEYAA
 ||| .||  | |... ||. 
GMVQTEEQYIFCYRCILEYIK
Y_phosphatase 1850.AA Y_phosphatase 1293-1533 36 6.2e-87 299.92 Pfam 1-243 (243) Show / Hide 
Range on Protein: 1293-1533
Range on HMM: 1-243/243
Sequence Identity: 36% (92 aa)

TSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGR-EK-CARYWPTVLFN-
  . ||| .|... .|||.|. ...|. . ||||||. |...   .||.|||| | |  |||||||. .  .|||.. . |.|| || |..|||.   | 
NKEKNRYKDIPCYDHTRVKLQPIPGDEDSDYINANYIDGPYWNPKAYICTQGPMPHTIEDFWRMVWQQKCTCIVMLCNCMEMGRDEKTCHQYWPD---NK

--EREGLGDMQAGFVNVAVLAGVRSNGYIATKLRIKHDKS--DTERIVMHYWFNSWPDHGVPSE-TGNVVKMLQAVREWSDDPER---PWIVHCSAGVGR
  . .  ||.|   |.. .      ..|. ....... ..  . .|.|.||.. .|||||||.  . ....... ||.|. .|..   | .||||||.||
EGQPMTYGDFQVTCVSEEH-----CPDYTVRTFEVTN-GDQKQETRTVTHYHYTNWPDHGVPESQPKSMLDFIRQVRKWQPNPDHGCPPIVVHCSAGCGR

TGTFITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSE
||||..||| ...... | ... .|....|. |. ||| .|| .| |... |
TGTFCAIDIMCQQMEHEGTVDIFQIVKHMRNQRPGMVQTEEQYIFCYQCILE
PTPc_motif 1850.AA PTPc_motif 1432-1533 36 5.4e-37 130.13 SMART 1-92 (92) Show / Hide 
Range on Protein: 1432-1533
Range on HMM: 1-92/92
Sequence Identity: 36% (39 aa)

IVMHYWFNSWPDH-----GVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEF
.|.||....||||     |||.   ........||.       | .||||||.||||||..||. |..       .. ......|| |. |||  ||  |
TVHHYHYTNWPDHVEKDSGVPE--DSILEFIRHVRK-------PIVVHCSAGCGRTGTFCAIDMMMQQ------VDIFQTVKEMRKQRPGMVQTEEQYIF

AYKVLSE
 |... |
CYRCILE