Gene 33960 (M.brevicollis)

33960

Species: M.brevicollis
Alias: 33960
External Links:
Annotation:

Classification

Group: TK-assoc
Family: SH2
Subfamily: Vav

Sequence

Name Sequence Type Origin Length Description Download
33960.AA Protein None 1003 None Fasta, JSON

Protein domain

Protein domains of 33960.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

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Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
CH 33960.AA CH 7-70 25 3e-06 25.91 Pfam 1-73 (119) Show / Hide 
Range on Protein: 7-70
Range on HMM: 1-73/119
Sequence Identity: 25% (19 aa)

WDEALHWFQAAGT----ISTQISTLVDF-VQVLRDGVALCATLNFIVPGA-IPDVHAA-PN-QR---VSHLHRAR
....| | ..        . .|.. |.|  . .|||||||| .... ||. | |..   |  .|   ........
EKAFLRWCNRHLEKYGHWGVPITP-VNFFFTDWRDGVALCALIHKYCPGLLI-DWKKVFPPRMRKMPFHCMENIN
CH 33960.AA CH 6-100 15 0.000722 12.13 SMART 1-100 (100) Show / Hide 
Range on Protein: 6-100
Range on HMM: 1-100/100
Sequence Identity: 15% (17 aa)

EWDEALHWFQAAGTISTQISTLVDFVQVLRDGVALCATLNFIVP-GAIPDVHAAPNQRVSHLHRARSLPPRP-----LPLP----PGQLYHG----HQFD
.....| |... .       .  .| . ..|||.||. .| |.| ..|. .|  . ..   .... ..  .      .. .    |  .. |    . . 
QEETFLRWCNSHL-------PVNNFSTDWKDGVVLCQLINKIRPQDSIDWWH--RFHCMENINYFLNFCEKYGMFLGVCCVVNFDPEDIVDGNNNRKDIL

QVLSTLSLV
.|. .|.. 
GVIWCLMQL
RhoGEF 33960.AA RhoGEF 172-348 23 7.1e-38 131.8 Pfam 1-196 (196) Show / Hide 
Range on Protein: 172-348
Range on HMM: 1-196/196
Sequence Identity: 23% (47 aa)

AIEEVQETEKNYIDGLRTMLQDFKKPLAVLVYQPDPPVTQAQLDTLFSHLDEFEALHSQLYKDIVD----------HPDQ--LAHCF--IQ-RRDTFSSY
.|.|  .||..|.  |........|||  .     | ... ...|.|| ..|   .|.....|. .          ....  ...||  .. ... |  |
VIQEIIQTERSYVRDLNIIIEHYMKPLRNCA--NPPILSPDEIHTIFSNIEEIYEFHQRFLEDLEERDRMECWNPPDYQCQTIGDCFMFLKHMFPFFKMY

ADYAIGQAAALQLLDELQKKSE-VKAALD--RL-VSFSNQRFK-LKDLLMLPIQRFLKYPLLLSEIQKRLP--EHDVHAKRNIKAAITTVKDIAKHIDA
 .|   .  |..||....||.. ... |.  .. ..  ..|   |...|..|.||  .||||| |. |. |  .|    ..... |.  .|..|.||..
SEYCNNYPKAMKLLKKCRKKNPKFQQFLKWCEKENDPCCRRLDLLQSFLIKPVQRIPRYPLLLKELLKHTPPCDHP-KDYEDLQKALEAMKEVASHINE
RhoGEF 33960.AA RhoGEF 172-348 23 1.8e-35 125.07 SMART 1-211 (211) Show / Hide 
Range on Protein: 172-348
Range on HMM: 1-211/211
Sequence Identity: 23% (49 aa)

AIEEVQETEKNYIDGLRTMLQDFKKPLAVLVYQPD-PPVTQAQLDTLFS-HLDEFEALHSQLYKDIVDH---------------------PDQLAHCFIQ
.| |  .||.||.. |....| . ||.   . ..  |.... .....|.  ..|   .|....... .                      .|....||..
VIQELMQTERNYVRDLHIIVQHYMKPMQKEEKCHKLPFLSPDEVNHIFGPNIEEIYEFHRRFLDELEERIEEWDCSMDWKSFRNFQIRDICDRIGDCFMK

R---RDTFSSYADYAIGQAAALQLLDEL---QKKSEVKAALDRLVSFSNQR------FKLKDLLMLPIQRFLKYPLLLSEIQKRLPEHDVHAKRNIKAAI
     . |  |. |.  .  ||..|...   .|........... | .| |      ..|.|.|..|.||..|||||| || |  |. | . . ... |.
WFHAEEMFKMYSEYCNNHPYALKHLKKWMCCKKNPRFQKFCKECESHPNCRSNSEHRLTLEDFLIKPMQRITKYPLLLKEILKHTPP-DHPDYEDLQKAL

TTVKDIAKHIDA
  .||.|.|...
DCMKDVAQHCNE
PH 33960.AA PH 403-485 16 1e-06 26.51 Pfam 17-92 (92) Show / Hide 
Range on Protein: 403-485
Range on HMM: 17-92/92
Sequence Identity: 16% (14 aa)

QRRYAFLFMRALLVCKPKGSRYNLQYAMNIANFKADSVTIRGQPLAIRLHSAHPSDHPFNCLIQLRNPVEQQEWMQALSTVGK
..|...|| . |. .|...  |....  .. . . . |.  ..|  ..... ..       ..|  .. | ..||||.. . .
KKRWFVLFNNCLYYYKDDK--YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DR----RTYYFQAESEEEMNDWMQAIQSACR
PH 33960.AA PH 385-487 15 1.7e-05 25.5 SMART 1-82 (82) Show / Hide 
Range on Protein: 385-487
Range on HMM: 1-82/82
Sequence Identity: 15% (16 aa)

KLLDADLRITLDSDPKNAQRRYAFLFMRALLVCKPKGSRYNLQYAMNIANFKADSVTIRGQPLAIRLHSAHPSDHPFNCLIQLRNPVEQQEWMQALSTVG
 ..   |..       . ..|...|| . |. .|.|     ..  ... . . .  .      ....|. .        ..| ... |.||||||.  . 
VIKEGWLYKKS---K-RWKKRWFVLFNDCLYYYKDK----KPKGSIPLSDCTVRE-P------CFEIHH-DR-----TYYFQCESEEEMQEWMQAIQKAI

KQA
...
HNN
C1_1 33960.AA C1_1 498-545 32 3.5e-09 37.36 Pfam 1-50 (55) Show / Hide 
Range on Protein: 498-545
Range on HMM: 1-50/55
Sequence Identity: 32% (16 aa)

HRFEVT-PFEPGLRCQQCDLILWG-LFDQGVTCRGCNFAAHIDCVAKVPA
|.....  |    .| .|. ..|| |. ||. |. |.. .| .|. |||.
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPP
C1 33960.AA C1 498-545 30 1.1e-08 36.15 SMART 1-52 (61) Show / Hide 
Range on Protein: 498-545
Range on HMM: 1-52/61
Sequence Identity: 30% (16 aa)

HRFEVTPFEPGLRCQQCDLILWGLF-----DQGVTCRGCNFAAHIDCVAKVPA
|... ..|  . .|..|.  .||.|     .||. |. |....| .|..|||.
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQ
SH3 33960.AA SH3 726-786 27 2.2e-12 48.39 SMART 1-58 (58) Show / Hide 
Range on Protein: 726-786
Range on HMM: 1-58/58
Sequence Identity: 27% (17 aa)

DILEAVHSFEHHRERQAGDLAFKRGDYVKVLESAPGNWWRGQHMGTMEQGLIPINFFRKPD
    |.....    .....| ||.|| . |||   ..||.|.. .| ..|..| |. .. |
PYVRALYDYQA---QNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 33960.AA SH3_1 740-779 34 2.8e-08 31.06 Pfam 9-49 (49) Show / Hide 
Range on Protein: 740-779
Range on HMM: 9-49/49
Sequence Identity: 34% (14 aa)

RQAGDLAFKRGDYVKVLESAPG-NWWRGQHMGTMEQGLIPI
.|...| ||.|| ..|.|  .. .||.|.  .| ..|..| 
QQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 33960.AA SH3_2 735-785 19 2e-05 21.87 Pfam 6-68 (68) Show / Hide 
Range on Protein: 735-785
Range on HMM: 6-68/68
Sequence Identity: 19% (12 aa)

EHHRE-RQAGD-----LAFKRGDYVKVL---ESAPGNWWRG-QHMGTMEQ--GLIPINFFRKP
....  . ...     | ||.|| .||.   .  ..|||..    .. .   |..|... .. 
CDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 33960.AA SH2 840-921 31 7e-16 60.01 SMART 1-87 (87) Show / Hide 
Range on Protein: 840-921
Range on HMM: 1-87/87
Sequence Identity: 31% (28 aa)

EYWYLGPMDKPEAHQRFVG--LPQGSFGVRRTPD-KGAYRLVVKFGQTVKHLRIHAAN-NQYMLGM--AATFDTIPQLVKHYRHQSLA
. || |.... ||.|   .   | |.| ||     .|.| | |.... ||| ||.  . ..| ..     .|... .|| ||.| .| 
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 33960.AA SH2 842-915 32 4.9e-14 43.04 Pfam 1-81 (81) Show / Hide 
Range on Protein: 842-915
Range on HMM: 1-81/81
Sequence Identity: 32% (26 aa)

WYLGPMDKPEAHQRFVG--LPQGSFGVRRTP-DKGAYRLVVKFGQ---TVKHLRIHAANN-QYMLGMAATFDTIPQLVKHY
|| |.. . ||...      | |.| ||     .| | | |...     ||| ||.  .| .| ..   .|.....|| ||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH3 33960.AA SH3 944-1003 30 7.6e-12 46.59 SMART 1-58 (58) Show / Hide 
Range on Protein: 944-1003
Range on HMM: 1-58/58
Sequence Identity: 30% (18 aa)

HRVRVLRNYKAADASEMSLREGDQIHVVATEGHGPGRWFGTNLQNDKSGRFPASVVAPAQ
 .||.| .|.| .. |.|...|| |.|.  .  ..| | |..  . . | ||.. |.. .
PYVRALYDYQAQNPDELSFKKGDIITVLEKD--DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_2 33960.AA SH3_2 945-1002 18 2.6e-10 39.0 Pfam 1-68 (68) Show / Hide 
Range on Protein: 945-1002
Range on HMM: 1-68/68
Sequence Identity: 18% (13 aa)

RVRVLRNYKA-ADASE-----MSLREGDQIHVV---ATEGHGPGRWFG-TNLQNDKS--GRFPASVVAPA
..||...|.. ....|     .....||.|.|     .. .  . |.. ... . .   |.|| . |.. 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWD--NWWWCWETIWGGRRMRGWFPSQWVEEC
SH3_1 33960.AA SH3_1 947-996 30 8.3e-07 26.09 Pfam 1-49 (49) Show / Hide 
Range on Protein: 947-996
Range on HMM: 1-49/49
Sequence Identity: 30% (15 aa)

RVLRNYKAADASEMSLREGDQIHVVATEGHGPGRWFGTNLQNDKSGRFPA
..|  |.| ...|.|...||.|||.. .   .. |.| .. . . | ||.
VALYDYQAQQPDELSFKKGDIIHVIEKSDD-WDWWKGRCNNTGQEGWFPS