Gene N3 (M.brevicollis)

N3

Species: M.brevicollis
Alias: N3
External Links:
Annotation:

Classification

Group: TK-assoc
Family: SH2
Subfamily: RasA1

Sequence

Name Sequence Type Origin Length Description Download
N3.AA Protein None 850 None Fasta, JSON

Protein domain

Protein domains of N3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 N3.AA SH2 1-86 31 2.8e-28 101.18 SMART 1-87 (87) Show / Hide 
Range on Protein: 1-86
Range on HMM: 1-87/87
Sequence Identity: 31% (29 aa)

FRWFHGCLSRDEATKLLQP--TAPGTYLLRESIRHKGDYSISFKAPSGVKHFQVRRIISHSYGGFFLAD---NAFQSLGDVVEFYCNHFLC
  |.|| .||.|| .||.     .|..|.|.| ...|||..|..  ..|||...||  .   |......     |.|| . |..|  . | 
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDD---GKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 N3.AA SH2 3-80 35 4.2e-26 78.47 Pfam 1-81 (81) Show / Hide 
Range on Protein: 3-80
Range on HMM: 1-81/81
Sequence Identity: 35% (30 aa)

WFHGCLSRDEATKLLQP--TAPGTYLLRESIRHKGDYSISFKAPS---GVKHFQVRRIISHSYGGFFLADNA-FQSLGDVVEFY
|.|| .|| || .||.     .||.|.||| ...|||..|..  .    |||....|       |......  |.|| . ||.|
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNG---GYYITGRHKFCSLQELVEHY
SH3 N3.AA SH3 108-165 37 2.7e-13 51.43 SMART 1-58 (58) Show / Hide 
Range on Protein: 108-165
Range on HMM: 1-58/58
Sequence Identity: 37% (22 aa)

KVVMATADYQAMTPDELSFLNGDKMTVVNDEDHHWLWCVRSGVQQAGFVPRSLVVACG
..| |  |||| .||||||  ||..||....| .|... . .  | |..| . |  . 
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 N3.AA SH3_1 111-158 38 6.1e-11 39.96 Pfam 1-49 (49) Show / Hide 
Range on Protein: 111-158
Range on HMM: 1-49/49
Sequence Identity: 38% (19 aa)

MATADYQAMTPDELSFLNGDKMTVVNDEDH-HWLWCVRSGVQQAGFVPR
 |  ||||..||||||  ||...|....|  .|  . . .  | |..| 
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 N3.AA SH3_2 109-164 20 4.7e-08 31.1 Pfam 1-68 (68) Show / Hide 
Range on Protein: 109-164
Range on HMM: 1-68/68
Sequence Identity: 20% (14 aa)

VVMATADYQA-MTPDE-----LSFLNGDKMTVV---NDEDHHWLWCV-RS-GVQQA--GFVPRSLVVAC
.. .. ||..   ..|     |.|  ||. .|    . ....| |.. .. .  ..  |..|.. |  |
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNW-WWCWETIWGGRRMRGWFPSQWVEEC
SH2 N3.AA SH2 186-266 35 4.6e-19 70.56 SMART 1-87 (87) Show / Hide 
Range on Protein: 186-266
Range on HMM: 1-87/87
Sequence Identity: 35% (32 aa)

SRWLHGRISREETIDYLQG--QPVGSFLIRESSN---PYSLSIKLGPDKIKHMRIEASDQSRYTCGE---RHFDCLEAIVLRYINTPIM
  | ||.|||||  . |..  .| |.||.|.|..    |.||.. . .|.|| ||. .| ..| ..|   | |..|  .|  |  .|. 
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 N3.AA SH2 188-260 39 1.3e-18 56.45 Pfam 1-81 (81) Show / Hide 
Range on Protein: 188-260
Range on HMM: 1-81/81
Sequence Identity: 39% (32 aa)

WLHGRISREETIDYLQG--QPVGSFLIRESS-NP--YSLSIKLGP--DKIKHMRIEASDQSRYTCGERH-FDCLEAIVLRY
| || |||.|  ..|.   .| |.||.|||. .|  |.|| . .   |..|| ||   |.  | ...|| |. |  .|  |
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
PH N3.AA PH 331-428 27 9.5e-21 77.47 Pfam 1-92 (92) Show / Hide 
Range on Protein: 331-428
Range on HMM: 1-92/92
Sequence Identity: 27% (27 aa)

YEKMGEITRKVKRSKKWKTMYFALQSAKSRLFCFETKDAIKPKGIIDLRSSYLTTVDDSLFGRPNCFQIVVNGS-EVHLCTDTPQERDSWLEALYEHCA
 .|.|....|. ..|.|| ..| |..  ..|.... ..  .|||.|.|..  .|.|.|.  .||.||||.  .  ..........|...|..|. ..|.
VIKEGWLHKKG-KRKSWKKRWFVLFN--NCLYYYKDDK-YRPKGSIPLSDCQVTKVPDN--KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR
PH N3.AA PH 331-430 21 3.9e-19 70.8 SMART 1-82 (82) Show / Hide 
Range on Protein: 331-430
Range on HMM: 1-82/82
Sequence Identity: 21% (21 aa)

YEKMGEITRKVKRSKKWKTMYFALQSAKSRLFCFETKDAIKPKGIIDLRSSYLTTVDDSLFGRPNCFQIVVNGSEVHLCTDTPQERDSWLEALYEHCAEC
 .| | ...|   . .||  .| | .  ..|.... |   ||||.|.|..  ..  .        ||.|.  . . ........|...|..|. ......
VIKEGWLYKKS--K-RWKKRWFVLFN--DCLYYYKDK---KPKGSIPLSDCTVRE-P--------CFEIHH-DRTYYFQCESEEEMQEWMQAIQKAIHNN
RasGAP N3.AA RasGAP 590-760 30 2.6e-61 209.56 Pfam 1-213 (213) Show / Hide 
Range on Protein: 590-760
Range on HMM: 1-213/213
Sequence Identity: 30% (65 aa)

LIGYLMAHHMQTEESPGTLFRGNTLVTKVMDQYMKF-IAIDYLQDTVEHCIVDI-C--DEKRSFEMDDSRGG---------------------------R
.. ... . ..  ..|..|||||...|| |..||.  .. .||.||    | .| .  ||. ..|.| |.                              
FFKEMIQEEIERCDDPNDLFRGNSCWTKMMEHYMRRPFGQEYLKDTLGPVIMEIIIIEDEDLDCEVDPSKIYESWINQEESQTGRPSDRPYDVSEQAIED

PA-------ESARILKTHCQNICNSIFASVDRCPPPLRRVFGVLQQQAKKRFPGDA--HVQ-YTSVSAFLFLRLFCPAIINPKLFNMMSEHP-TDTLARN
|        |  . |. .|. ....|. ||.|||...| ..  ... ....||..    .. |. |..|.|||.|||||.||.||. ...|| ...  ||
PEIVREMIEENLQNLRQYCEKFWDAICNSVHRCPYEIRWICKQIYECVQEKFPDADHPDEIEYNAVGGFIFLRFFCPAIVNPELFGIVDDHPISPRQRRN

LTLVAKVIQNLAN
|||.|||.|||||
LTLIAKVLQNLAN
RasGAP N3.AA RasGAP 516-848 28 5e-60 206.64 SMART 1-390 (390) Show / Hide 
Range on Protein: 516-848
Range on HMM: 1-390/390
Sequence Identity: 28% (111 aa)

LRKGTIGALSIVLSSLRGTPPVILPVKAYEPLKLELERKDMV-------LQSALAEHLRA-SLNAFANHLIRIWINDGRDEELIGYLMAHHMQTEESP-G
|..|... | .    .  .   |.|  .|||. |||  . .        . .||.| ..   ..  |  ..|.    .| .... .| ..    .  .  
LKQGDQMSLRLKTRYQTDH---IMPMEYYEPF-LELLCFNYDVQPVTTSICMALEEVCSVRCKDEVATKMVRLFQHRHRGHPFLWQLIMQEVERCDDMDN

TLFRGNTLVTKVMDQYMKFIAIDYLQDTVEHCIVDICDEKR-SFEMDDSRGG--------------RPAESARILKTHCQNICNSIFASVDRCPPPLRRV
|.||||.| || |.|||| .. .||..| .  |  ||.||  |.| | .. .                 .... |  .|. . ..|. |.||||. || .
TIFRGNSLATKCMEQYMKWVGMQYLHTTLKPVIKRICEEKKHSCEVDPCKMKVNDRCSFHDPQEGEDLETNRENLRQYCERFFDAIINSSDRCPYGLRWI

FGVLQQQAKKRFPGD-AHVQYTSVSAFLFLRLFCPAIINPKLFNMMSEHPTDTLARNLTLVAKVIQNLANMAE-----FGQKEAFMQPM--NEFIMLNRG
.  |.|.| .|||..  .|.|. || |.|||.|||||..||||| ...|| .. .|.|||.|||||||||...     || || .|.||  |.||  . .
CKCLYQCACHRFPDNHQDVRYRAVSSFIFLRFFCPAIVSPKLFNIVDHHPDPQTRRTLTLIAKVIQNLANHSQSKSHQFGGKEPWMCPMYKNPFIKQHWH

KMQTFLNSVS----SS----TRGEHEVKVAS-----ASRDLAAVARMCSQT-DKLETVLDS---------------YKVQSPLVSIIRALESKN
.|  ||   .    .|    ...|| . . .      .|.... ...|    |.. . . .                .... .  . . |   .
RMKDFLDEICNVPEPSDYLMDKYEHDPQKNNPVITISGREISFLHSICWEHWDMIHRKKNNNHDHKAVQEHPFDKMCFKLRWFQMCTHKLTYHK