Gene RTKE4 (M.brevicollis)

RTKE4

Species: M.brevicollis
Alias: RTKE4
External Links:
Annotation:

Classification

Group: TK
Family: RTKE

Sequence

Name Sequence Type Origin Length Description Download
RTKE4.AA Protein None 1347 None Fasta, JSON
RTKE4.kin_dom Protein Kinase Domain None 290 None Fasta, JSON
RTKE4.kin_dom2 Protein Kinase Domain None 214 None Fasta, JSON

Protein domain

Protein domains of RTKE4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LDLa RTKE4.AA LDLa 375-413 22 0.000646 9.08 SMART 1-47 (47) Show / Hide 
Range on Protein: 375-413
Range on HMM: 1-47/47
Sequence Identity: 22% (11 aa)

PVMPR----LSCLSAPNVHLDPTEICDGTAQCPDGEDE------AGCRF
.  |       |    .  .. .  |||   |.||.||      ..|  
TCPPDHPNQFQCG--NGRCIPKSWVCDGDNDCGDGSDEWPFFDPENCPQ
Kinase RTKE4.AA RTKE 561-774 25 2.8e-102 346.09 In-house 60-293 (293) Show / Hide 
Range on Protein: 561-774
Range on HMM: 60-293/293
Sequence Identity: 25% (61 aa)

GSQSRASTILLVVIVIVVLVSLSLGAAGFLWFNRRTEASQVKVSVQAN----------IRFLRQLAAGLSFLEDLKLIHGRVCTESVLVMNNAPLVKLFG
.........|....|...|....... .|..........|.....|..          |..|.|.|.|.||||.|...|...|...|........||...
VQEMTMMCKLHHPNVVHLLHVVQMKQ-HFMMVYEYMPGGQLEDWLQDHHGRPTSHEDQIHCLHQVACGMSFLERLGIVHRDLCAHNVYCCRCWNDVKVAD

FATPTVPDQEDLAIKPESHTIVPVWDPATWGSTRYFAPELLLCPHPTNPGDVFSYGALMYEVMANGTPIFAGLDGQQVLMRQRQAQLP-----------P
........................|.|.||||.|..|||.....|.....||..||.|..||..||....|..|.||...|..|.|.|           .
YGLSRDMYLGQEYMQCYYRIKTRRWMPTTWGSRRWWAPEVWKDQHFSFKSDVWAYGCLCWEVWNNGQMPYAHMDDQQFMQRIVQCQMPSGGHLGDHEPVH

LPQTHNLPAATALYTECIAADPKERPAFRSIYQQL
.|..|..|.|..|...|....|..||.|...||..
APPVHCPPWADRLMQWCLCINPEHRPNFAQLYQMW
Kinase RTKE4.AA TK 609-774 17 5.9e-25 79.94 In-house 238-486 (486) Show / Hide 
Range on Protein: 609-774
Range on HMM: 238-486/486
Sequence Identity: 17% (43 aa)

IRFLRQLAAGLSFLEDL------KLIHGRVCTESVLVMNNAP----------LVKLFGFA---------TPTVPDQEDLAIKPESHTIVPVWD-------
. . .|.|.|...|...      ...|. ...  .|| .| .           .|.  |          .  ... .|   | .  | .|. .       
L-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPW

-------PATWGSTRYFAPELLLCPH---------PTNPGDVFSYGALMYEVMANG-TPIFAGLDG---------QQVLMRQRQAQ-------------L
       . ..   |. ||| |.  .          |   ||.|.| ||.|.. .| .|   |..          |.|. . |. .             .
QDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRM

PPLPQTHNL--------------PAATALYTECIAADPKERPAFRSIYQQL
.. .  |                ..   | ..| ..||..|| |. ...||
RMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RTKE4.AA TK-Unique 684-774 29 3e-14 45.63 In-house 201-294 (294) Show / Hide 
Range on Protein: 684-774
Range on HMM: 201-294/294
Sequence Identity: 29% (28 aa)

RYFAPELLL--CPHP-TNPGDVFSYGALMYEVMANGTPIFAGLDGQQVLMRQRQAQLPPLPQTHNLPAATALYTECIAADPKERPAFRSIYQQL
|. ||| |.    .  |  .|| |.| ||.|.. .| . . |..  ... . |.   .|.|.    .. . |. .|.  .|.||| ||.| ..|
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase RTKE4.AA TKL 681-774 20 3.4e-13 43.86 In-house 235-364 (364) Show / Hide 
Range on Protein: 681-774
Range on HMM: 235-364/364
Sequence Identity: 20% (26 aa)

GSTRYFAPELLLCPHPTNPG----------------DVFSYGALMYEVMANGTPIFAGLDGQQV---------LMRQRQAQLPPLP----------QTHN
|..|. |||.|    ...                  ||.|.| ...|...  .| .     ...          |.    . ||.|          . ..
GTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPD

LPA-ATALYTECIAADPKERPAFRSIYQQL
 |     | ..| ..||..|| |  | ..|
CPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase RTKE4.AA Fer 701-775 22 1.3e-11 35.94 In-house 200-283 (283) Show / Hide 
Range on Protein: 701-775
Range on HMM: 200-283/283
Sequence Identity: 22% (19 aa)

DVFSYGALMYEVMANGTPIFAG---------LDGQQVLMRQRQAQLPPLPQTHNLPAATALYTECIAADPKERPAFRSIYQQLL
||.|.| ...|...||   ..|         ...|..   ..    .|.|. .  . .  . . | ..||..|| . .|.|.| 
DVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase RTKE4.AA Pkinase 681-774 21 5.6e-10 36.37 Pfam 173-293 (293) Show / Hide 
Range on Protein: 681-774
Range on HMM: 173-293/293
Sequence Identity: 21% (26 aa)

GSTRYFAPELLL-CPHPTNPGDVFSYGALMYEVMANGTPIFAGL------DGQQVLMRQRQAQLPPLPQTHNL-------------------PAATALYT
|. .| |||... ... . . |..|.| ..||..  | |.| |       | .|.. | ....|.   .. .                    ...  . .
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK

ECIAADPKERPAFRSIYQQ--L
 |.. |||.|| .. | |   .
WCLCKDPKKRPTAEQILQHPWF
Kinase RTKE4.AA UTK 687-774 27 3.1e-08 24.26 In-house 207-296 (296) Show / Hide 
Range on Protein: 687-774
Range on HMM: 207-296/296
Sequence Identity: 27% (25 aa)

APELLLCP-HPTNPGDVFSYGALMYEVMANGTPIFAGLDGQQVLMRQRQAQL-PPLPQTHNLPAAT-ALYTECIAADPKERPAFRSIYQQL
||| | .  ..|.  ||.|.| ...|....|   ..|. . . .  |  ..    .|. .  |..   |...| ..|| ||| |. ..||.
APEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGM-SNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase RTKE4.AA Frk 602-778 26 7.2e-08 22.99 In-house 94-260 (260) Show / Hide 
Range on Protein: 602-778
Range on HMM: 94-260/260
Sequence Identity: 26% (48 aa)

KVSVQANIRFLRQLAAGLSFLEDLKLIHGRVCTESVLVMNNAPL-VKLFGFATPTVPDQEDLAIKPESHTIVPVWDPATWGSTRYFAPELLLCPHPTNPG
.. .|  .    |.|||. .||.   ||  .    ||| ..  . .  || |   . |.||.    ||.. . .  |  |      |||     . |   
QCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIY---ESRHGARF--PIKW-----TAPEAANYNKFTIKS

DVFSYGALMYEVMANGTPIFAGLDGQQVLMRQRQAQLPPLPQTHNLPAAT-ALYTECIAADPKERPAFRSIYQQLLQCE
||.|.| |..|..  |   ..|. ...||    .     .||  | |     .  ||  .||..|| |  .  .| .  
DVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYR--MPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase RTKE4.AA Src 701-774 29 8.3e-05 12.21 In-house 182-255 (255) Show / Hide 
Range on Protein: 701-774
Range on HMM: 182-255/255
Sequence Identity: 29% (23 aa)

DVFSYGALMYEVMANGTPIFAGLDGQQVLMRQRQAQLPPLPQTHNLPAATALYT----ECIAADPKERPAFRSIYQQL
|| |.| |..|..  |     | . ..|| .  .     .|. || |.   ||     .|  .||..|| |  ... |
DVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYR--MPCPHNCPD--ELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase RTKE4.AA Csk 755-774 40 0.00014 11.6 In-house 232-251 (251) Show / Hide 
Range on Protein: 755-774
Range on HMM: 232-251/251
Sequence Identity: 40% (8 aa)

ECIAADPKERPAFRSIYQQL
.| ...|..|| || . .||
QCWHLNPAKRPTFRQVREQL
Kinase RTKE4.AA Jak 700-776 20 0.000222 11.57 In-house 207-299 (299) Show / Hide 
Range on Protein: 700-776
Range on HMM: 207-299/299
Sequence Identity: 20% (19 aa)

GDVFSYG-ALMYEVM----------------ANG-TPIFAGLDGQQVLMRQRQAQLPPLPQTHNLPAATALYTECIAADPKERPAFRSIYQQLLQ
.|..|.| .  .|..                 .|  |. .     ..  .... .||  . .  ...   | ..| ..|| .||.||.|  .| |
MDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSC--WDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ
Kinase RTKE4.AA Pkinase_Tyr 754-774 42 0.000252 15.27 Pfam 250-270 (270) Show / Hide 
Range on Protein: 754-774
Range on HMM: 250-270/270
Sequence Identity: 42% (9 aa)

TECIAADPKERPAFRSIYQQL
..| ..||..|| |. |..||
KQCWHYDPEDRPTFSEIHEQL
Kinase RTKE4.AA Jak 614-644 38 0.000262 11.31 In-house 126-156 (299) Show / Hide 
Range on Protein: 614-644
Range on HMM: 126-156/299
Sequence Identity: 38% (12 aa)

QLAAGLSFLEDLKLIHGRVCTESVLVMNNAP
|.. |...||| ..||| ||.  .|| ....
QICWGMHYLEDKRYIHGDVCARNILVDREGH
Kinase RTKE4.AA TK-Unique 588-639 17 0.000659 9.5 In-house 94-166 (294) Show / Hide 
Range on Protein: 588-639
Range on HMM: 94-166/294
Sequence Identity: 17% (13 aa)

GFLWFNRRTEASQ------------VKVSVQAN-IR------FLRQLAAGLSFLED--LKLIHGRVCTESVLV
..|...|..  ..            .. ... . |       |. |.| |...|.    | .|...|.  ||.
HYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLL
Kinase RTKE4.AA Fer 609-629 38 0.021693 4.08 In-house 114-134 (283) Show / Hide 
Range on Protein: 609-629
Range on HMM: 114-134/283
Sequence Identity: 38% (8 aa)

IRFLRQLAAGLSFLEDLKLIH
||.. | |.|. .|.  . ||
IRMCYQAACGMEYLHSKNCIH
Kinase RTKE4.AA UTK 609-639 19 0.039706 3.08 In-house 121-151 (296) Show / Hide 
Range on Protein: 609-639
Range on HMM: 121-151/296
Sequence Identity: 19% (6 aa)

IRFLRQLAAGLSFLEDLKLIHGRVCTESVLV
. . .. |.|...|.  ...|. ..   .||
LCMAWDIARGMQYLHSCGFVHRDLAARNCLV
Kinase RTKE4.AA Pkinase_Tyr 701-729 36 0.043646 7.69 Pfam 196-225 (270) Show / Hide 
Range on Protein: 701-729
Range on HMM: 196-225/270
Sequence Identity: 36% (11 aa)

DVFSYGALMYEVMANG-TPIFAGLDGQQVL
|| |.| ||.|..  | .| ..|.. ..|.
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVY
Kinase RTKE4.AA Pkinase_Tyr 609-629 33 0.230861 5.24 Pfam 114-134 (270) Show / Hide 
Range on Protein: 609-629
Range on HMM: 114-134/270
Sequence Identity: 33% (7 aa)

IRFLRQLAAGLSFLEDLKLIH
. . .| |.|...||. ..||
LQMCWQIAKGMEYLESKNCIH
Kinase RTKE4.AA RTKE 1016-1305 45 2.1e-164 552.44 In-house 1-293 (293) Show / Hide 
Range on Protein: 1016-1305
Range on HMM: 1-293/293
Sequence Identity: 45% (141 aa)

LKFVRNLGAGAFGEVMLMEL-----------EGISSEDQRKQRLVAVKRLLDSEVKDEFVQEMTTMRKLKHANLVQLLHVVDDDAHPGLVIEYLDGGSLA
|.|.|.||.|.||||.||..           |.||||.||..|.||||.|...|...|||||||.|.||.|.|.|.|||||....|...|.||..||.|.
LTFMRALGSGEFGEVWLMTMPNHAHSPNYSKETISSEQQRSTRQVAVKTLHNHECHHEFVQEMTMMCKLHHPNVVHLLHVVQMKQHFMMVYEYMPGGQLE

DWLDDHHARPLDTDLSIHVLHSIANGMAELVRCGVVHRDLAARN--CSFSWVDIQVSDYGLSRATAVSHEGASEYYRIQTSRPLP-----LRWLAPEMLK
|||.|||.||.... .||.||..|.||..|.|.|.|||||.|.|  |...|.|..|.||||||......|....||||.|.|..|     .||.|||..|
DWLQDHHGRPTSHEDQIHCLHQVACGMSFLERLGIVHRDLCAHNVYCCRCWNDVKVADYGLSRDMYLGQEYMQCYYRIKTRRWMPTTWGSRRWWAPEVWK

DKMANEATDVYAYGVLMHELF-EDDLPLAHLDDAAFMGLLVELSRKSSGLIRQRRSSLGSSGDHVEMQARAPAFEPPAHCPPALASVMRWCIDLNPMHRP
|.......||.|||.|..|.. ....|.||.||..||. .|.....          |.|..|||      .|...||.||||.....|.||...||.|||
DQHFSFKSDVWAYGCLCWEVWNNGQMPYAHMDDQQFMQRIVQCQMP----------SGGHLGDH------EPVHAPPVHCPPWADRLMQWCLCINPEHRP

TFAQLQDKW
.||||...|
NFAQLYQMW
Kinase RTKE4.AA TK 1016-1305 18 3.6e-72 241.03 In-house 1-486 (486) Show / Hide 
Range on Protein: 1016-1305
Range on HMM: 1-486/486
Sequence Identity: 18% (92 aa)

LKFVRNLGAGAFG---EVMLMELEGIS--------------------SEDQRKQRLVAVKRLLDSEVKDE-----------------FVQEMTTMR--KL
..... ||.|.||   ||.. |..|..                    .|... .  |..... |.. ..|                 ...||  |.  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHANLVQLLHVVDDD------------AHPGLVIEYLDGGS----LADWLDDHHARPLD-----------------------------------------
.| |.|.|. |. ..             .. .| || ..|.    | |.| ... .  .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------TDLSIHVLHS-----------------------IANGMAELVRC------GVVHRDLAARNC--SFSWVD----------IQVSDYGLS--
         ..|. . |..                       ||.||. | ..      ..||||||||||  . . |.          . ..|.|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----RATAVSHEG---------------------ASEYYRIQTSRPLPLRWLAPEMLKDKM---------ANEATDVYAYGVLMHELFEDD-LPLA----
    .| .. ...                     ...||| |... ||.||.||| |.|.            ...||...||||.|.|     | .    
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

-------HLDDAAFMGLLVELSRKSSGLIRQRRSSLGSSGDHVEMQARAPAFEPPAHCP--------------PALASVMRWCIDLNPMHRPTFAQLQDK
       . |.. .| .|.. .|  ..       | |  . .  .. .    ..|.|||              .... .|. | ...| .||||.||...
NQDVWKDG-DNQEVMEYLRRGGRL-CR-------S-G--L-N--EVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQ

W
 
L
Kinase RTKE4.AA TyrKc 1016-1305 25 1.7e-52 181.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 1016-1305
Range on HMM: 1-280/280
Sequence Identity: 25% (81 aa)

LKFVRNLGAGAFGEVMLMELEGISSEDQRKQRLVAVKRLLDSEVKDEFVQEMTTMRKL--KHANLVQLLHVVDDD-------AHPGLVIEYLDGGSLADW
... . || ||||||.. ..           . |||| | ..  . .| .|.  |.||  .| |.|.|. |. ..         . .| || ..|.| | 
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LDDHHARPLDTDLSIHVLHSIANGMAELVRCGVVHRDLAARNCSFSWVD-IQVSDYGLSRATAVS---HEGASEYYRIQT--SRP--LPLRWLAPEMLKD
| .|. . | ..  ..  . ||.||. | . ...|||||||||  .    . .|| ||||.          ...||| ..  ..   ||.||.||| ...
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECINY

KMANEATDVYAYGVLMHELFED-DLPLAH-----LDDAAFMGLLVELSRKSSGLI----RQRRSSLGSSGDHVEMQARAPAFEPPAHCPPALASVMRWCI
.. ....||...||.| |.| . . |        ....  . .. .  |                                |    .||... ..|..| 
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------F---VCCPDEMYQIMKQCW

DLNPMHRPTFAQLQDKW
. .|  ||||... ...
HEDPEDRPTFSEIHECF
Kinase RTKE4.AA UTK 1016-1218 27 1.4e-39 133.12 In-house 1-234 (296) Show / Hide 
Range on Protein: 1016-1218
Range on HMM: 1-234/296
Sequence Identity: 27% (64 aa)

LKFVRNLGAGAFGEVMLMELEGIS--SEDQRKQRLVAVKRLLDSEVKD---EFVQEMT---TMRKLK-HANLVQLLHVVDDDAHPGLVIEYLDGGSLADW
... | ||.|||||| ..... .|  ......   |....  .   ..   .|  | .    | ... | |...|..|. ..  . .|.||  .|.|.. 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LDDHHARP------LDTDLSIHVLHSIANGMAELVRCGVVHRDLAARNCSFSWV--------DIQVSDYG---LSRATA-----VSHEGASEYYRIQTSR
| .|.  |      |. .  ..    ||.||. | .||.||||||||||             .. ..|.|   .||. .     .  .. |.||. |  .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSN-RYWESYYYMAQHQD

PLPLRWLAPEMLKDK-MANEATDVYAYGVLMHELF
..|.|| ||| | .     ...||...||...|..
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIW
Kinase RTKE4.AA TK-Unique 1016-1218 28 9.3e-34 113.83 In-house 1-233 (294) Show / Hide 
Range on Protein: 1016-1218
Range on HMM: 1-233/294
Sequence Identity: 28% (69 aa)

LKFVRNLGAGAFGEVMLMELEGISSEDQRKQRLVAVKRLL--DSEV-KDEFVQEMTTMRKLK-HANLVQLLHVVDDDA-HPGLVIEYLDGGSLADWLD--
|.. ...| ||||.|   |..||. ... ||. |||| |    ... |..| .|   |..|. | |.||.| .  ..   . ...||. .|.| . |   
LEVGDVIGEGAFGQVWRGEVWGIW-KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

-----DH-------------HARPLDTDLSIHVLHSIANG----MAELVR--CGVVHRDLAARNCSFSWVDIQ--VSDYGLSRATAVSHEGASEYYRIQT
     .|              ..|.....| . | ..| .    |. | .  ...|||||.|||. ..  | .  ..|.|..| .        .| ....
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE-DKVCKICDFGMARDVYT----NGVYSMMCS

SRPLPLRWLAPEMLK--DKMA-NEATDVYAYGVLMHELF
. ..|.||.||| ||  ..|. .. .||...|||| |.|
QGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIF
Kinase RTKE4.AA TKL 1022-1305 18 1.2e-33 118.12 In-house 1-364 (364) Show / Hide 
Range on Protein: 1022-1305
Range on HMM: 1-364/364
Sequence Identity: 18% (73 aa)

LGAGAFGEVMLMELEGISSEDQ--RKQRLVAVKRLLDSE-----------------------------VKDEFVQEMTTMRKLKHANLVQLLHVVDDDAH
.| |.||||   .. |...     .. . ||||..   .                              ......|.  |..|.| |.||.. .. .  .
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

-------------PGLVIEYLDGGSLADWLDDHHARPLDTDLSIHVLHSIANGMAELVRCG--------VVHRDLAARNCSFS--WV-------------
             ...| || .|||| . |          .. ..  ..|| ||. |  ..        ..||||  .|.     |              
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

DIQVSDYGLSR-ATAVSHEGASE----------YYRIQTSRPL-PLRWLAPEMLKDK----------------MANEATDVYAYGVLMHELFEDDLPLAH
.. ..|.||||  .  ..  ...           .| .|...   .||.|||.|...                 ..|..|||..|... |..   .| ..
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

LD----------DAAFMGLLVELSRKSSGLIRQRRSSLGSSGDHVEMQARAPAFEPPAHCPPALASVMRWCIDLNPMHRPTFAQLQDKW
..          .. ||.  ..  |     | |.            .     .  |. .||| ... | .| | .|  ||.| .. .. 
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQN------------HH--K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase RTKE4.AA S_TKc 1016-1306 18 6.6e-33 116.57 SMART 1-231 (231) Show / Hide 
Range on Protein: 1016-1306
Range on HMM: 1-231/231
Sequence Identity: 18% (57 aa)

LKFVRNLGAGAFGEVMLMELEGISSEDQRKQRLVAVKRLLDSEVKDEFVQEMTTMRKLKHANLVQLLHVVDDDAHPGLVIEYLDG--GSLADWLDDHHAR
 ...| .| ||||.|..    .        .|.||.|..      . . .|.  ..| .| |.|.|. | .|  |  .| ||.||  |.| | ....  .
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

P----LDTDLSIHVLHSIANGMAELVRCGVVHRDLAARNCSFSWVDIQVSDYGLSRATAVSHEGASEYYRIQTSRPLPLRWLAPEMLKDKMANE-ATDVY
.    ..     .... |..... . . |..||||   |  ..   | ..| ||.|                |.    . ..|||.|     .  . |..
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWW

AYGVLMHELFEDDLPLAHLDDAAFMGLLVELSRKSSGLIRQRRSSLGSSGDHVEMQARAPAFEPPAHCPPALASVMRWCIDLNPMHRPTFAQLQD-----
. |... |..    |    .... . ...                                       .| . . .| | . .| .|||  ..       
SCGCILYEMLCGYPPFP--QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

---KWV
    |.
KCHPWF
Kinase RTKE4.AA Pkinase_Tyr 1016-1149 33 1.4e-32 110.93 Pfam 1-142 (270) Show / Hide 
Range on Protein: 1016-1149
Range on HMM: 1-142/270
Sequence Identity: 33% (48 aa)

LKFVRNLGAGAFGEVMLMELEGISSEDQRKQRLVAVKRL--LDSEV---KDEFVQEMTTMRKL-KHANLVQLLHVVD-DDAH--PGLVIEYLDGGSLADW
..| . ||.||||||.. .. |   ... ..  |||| |    ..    ...| .|. .|..| .| |.|.|. |.  .. .  . .| ||  .|.| | 
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LDDH--HARPLDTDLSIHVLHSIANGMAELVRCGVVHRDLAARNC
| .|    .||..   ..  . ||.||. | . . .|||||||||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNC
Kinase RTKE4.AA Csk 1016-1218 30 2.8e-28 93.64 In-house 1-191 (251) Show / Hide 
Range on Protein: 1016-1218
Range on HMM: 1-191/251
Sequence Identity: 30% (64 aa)

LKFVRNLGAGAFGEVMLMELEGISSEDQRKQRLVAVKRLLDS--EVKDEFVQEMTTMRKLKHANLVQLLHVVDDDA-HPGLVIEYLDGGSLADWLDDHHA
|.     |.| || ||. |. .         | |||| . .   .  . |. |   | .|.| |||||. |. ..  |  .|.||.  |.| |.|     
LHLGECIGHGEFGDVMQGEYQN---------RKVAVKCIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGR

RPLDTDLSIHVLHSIANGMAELVRCGVVHRDLAARNCSFSWVDI-QVSDYGLSRATAVSHEGASEYYRIQTSRPLPLRWLAPEMLKDKMANEATDVYAYG
  . ..  .     ...||. |    .|||||||||   |  ..  |||.||...     . .       ||  .|  | ||| |. |      ||  .|
HVITRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKEECSQQDDS-------TSGKFPIKWTAPEALRHKKFSTKSDVWSFG

VLMHELF
.|. |..
ILLWEIY
Kinase RTKE4.AA Frk 1016-1217 29 1.6e-24 81.62 In-house 1-195 (260) Show / Hide 
Range on Protein: 1016-1217
Range on HMM: 1-195/260
Sequence Identity: 29% (61 aa)

LKFVRNLGAGAFGEVMLMELEGISSEDQRKQRLVAVKRLLDSEVK-DEFVQEMTTMRKLKHANLVQLLHVVDDDAHPGLVIEYLDGGSLADWLD--DHHA
....| ||.| ||||     ||        .  ||||.|    .  ..|..|   |.||.|. |.||  |   .    .. | .  ||| ..|   ... 
IQLIRRLGSGQFGEVW----EGL----WNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKG

RPLDTDLSIHVLHSIANGMAELVRCGVVHRDLAARNCSFSWVDI-QVSDYGLSRATAVSHEGASEYYRIQTSRPLPLRWLAPEMLKDKMANEATDVYAYG
| .     . .   .| ||| |     .||||||||       | .. |.|| |   .  |   . |  ..   .|..| |||  . .      ||...|
RQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNE---DIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFG

VLMHEL
.|. |.
ILLTEI
Kinase RTKE4.AA Jak 1016-1218 24 1.2e-23 80.09 In-house 1-221 (299) Show / Hide 
Range on Protein: 1016-1218
Range on HMM: 1-221/299
Sequence Identity: 24% (55 aa)

LKFVRNLGAGAFGEVMLMELEGISS----EDQRKQ-RLVAVKRLLDS---EVKDEFVQEMTTMRKLKHANLVQLLHVV--DDDAHPGLVIEYLDGGSLAD
||. ..|| |.|| | .. .. | .    ||| .   .|.|| ....   .. ..| .|  .|... | ..| .  |.  . ..   .|.||.  |.| |
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

WLD---DHHARPLDT--DLSIHVLHSIANGMAELVRCGVVHRDLAARNCSFSWVDI----QVSDYGLSRATAVSHEGASEYYRIQTSRPLPLRWLAPEML
.|    . |.  ...  |   .. . |..||  | ... .|.|..|||      ..    . ....|. .      .  ||||  ..|  . .| ||| |
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPW----CSDKEYYREMMDRDERIPWYAPECL

KDKMANE--ATDVYAYG-VLMHELF
..  ...  |.|. ..| |  .|..
TNCKFYLTLAMDKWSFGRVTLWEIC
Kinase RTKE4.AA Fer 1093-1220 28 1.7e-23 76.97 In-house 86-214 (283) Show / Hide 
Range on Protein: 1093-1220
Range on HMM: 86-214/283
Sequence Identity: 28% (39 aa)

LVIEYLDGGSLADWLDDHHARPLDTDLSIHVLHSIANGMAELVRCGVVHRDLAARNCSFSWVDIQ----VSDYGLSRA----TAVSHEGASEYYRIQTSR
.|.|. .|||| . |   ... . ..  |  .. .|.||. |   ...|||.|||||  .  ...    .|| |.||.    .  . ..        ...
IVMEFCNGGSLDSYLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKE-------KAC

PLPLRWLAPEMLKDKMANEATDVYAYGVLMHELFED
 .| |||||| ....  ...|||...||.. | |..
KVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTN
Kinase RTKE4.AA Src 1049-1218 33 1.7e-21 69.74 In-house 26-194 (255) Show / Hide 
Range on Protein: 1049-1218
Range on HMM: 26-194/255
Sequence Identity: 33% (59 aa)

VAVKRLLDSEVKDE-FVQEMTTMRKLKHANLVQLLHVVDDDAHPGLVI-EYLDGGSLADWLD-DHHARPLDTDLSIHVLHSIANGMAELVRCGVVHRDLA
|||| |     . | | ||  .| ||.| .||||. |....  | . . ||   ||| |.|  |   | |     |     .|.||| | .  ..|||||
VAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE-PIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLA

ARNCSFSWVDIQ-VSDYGLSRATAVSHEGASEYYRIQTSRPLPLRWLAPEMLKDKMANEATDVYAYGVLMHELF
|||   .   .  | | || | . .      . |  ..   .| .| ||| .     .  .||  .|.|..|..
ARNVLVGENNVCKVADFGLARLIKED----DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIV
Kinase RTKE4.AA Pkinase 1016-1144 25 7.2e-19 67.8 Pfam 1-134 (293) Show / Hide 
Range on Protein: 1016-1144
Range on HMM: 1-134/293
Sequence Identity: 25% (36 aa)

LKFVRNLGAGAFGEVMLMELEGISSEDQRKQRLVAVKRLLDSEVKDEFVQ------EMTTMRKLKHANLVQLLHVVDDDAHPGLVIEYLDGG----SLAD
....| .|.|.||.| .    | .        .||||..  .. |... |      |   |..|.| | |.|.... |. |. .| ||..||    .|.|
YHIGRKIGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

WLDDHHARPL--DTDLSIHVLHSIANGMAELVRCGVVHRDL
..  .  ...  . .  ....  |. |.. . ..|..||||
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDL
Kinase RTKE4.AA Pkinase_Tyr 1158-1218 33 8.9e-14 47.29 Pfam 152-208 (270) Show / Hide 
Range on Protein: 1158-1218
Range on HMM: 152-208/270
Sequence Identity: 33% (21 aa)

VSDYGLSRATAVSHEGASEYY-RIQTSRPLPLRWLAPEMLKDKMANEATDVYAYGVLMHELF
..| ||.|.         .|| | ... .|| .|.||| ....  ....||...|||| |.|
ICDFGLARDI-----YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIF
Kinase RTKE4.AA Csk 1271-1305 45 4.7e-09 27.07 In-house 217-251 (251) Show / Hide 
Range on Protein: 1271-1305
Range on HMM: 217-251/251
Sequence Identity: 45% (16 aa)

EPPAHCPPALASVMRWCIDLNPMHRPTFAQLQDKW
|.|  |||.   ||. | .||| .||||.|.. . 
EAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase RTKE4.AA Src 1273-1305 38 1.7e-08 24.95 In-house 222-255 (255) Show / Hide 
Range on Protein: 1273-1305
Range on HMM: 222-255/255
Sequence Identity: 38% (13 aa)

PAHCPPALAS-VMRWCIDLNPMHRPTFAQLQDKW
|..||. |   .|. | .  |. ||||. ||.. 
PHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase RTKE4.AA Pkinase_Tyr 1271-1305 28 1e-06 23.15 Pfam 236-270 (270) Show / Hide 
Range on Protein: 1271-1305
Range on HMM: 236-270/270
Sequence Identity: 28% (10 aa)

EPPAHCPPALASVMRWCIDLNPMHRPTFAQLQDKW
..| .||. . ..|. | . .| .||||.... . 
PCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase RTKE4.AA TK-Unique 1273-1305 29 1e-06 18.76 In-house 261-294 (294) Show / Hide 
Range on Protein: 1273-1305
Range on HMM: 261-294/294
Sequence Identity: 29% (10 aa)

PAHC-PPALASVMRWCIDLNPMHRPTFAQLQDKW
|.|| .... ..|. |. ..| .||.|.|. .. 
PEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase RTKE4.AA Frk 1273-1309 40 3e-06 17.16 In-house 224-260 (260) Show / Hide 
Range on Protein: 1273-1309
Range on HMM: 224-260/260
Sequence Identity: 40% (15 aa)

PAHCPPALASVMRWCIDLNPMHRPTFAQLQDKWVAVG
|. ||. | ..|  |   .||.||||  || |     
PPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase RTKE4.AA Fer 1016-1081 22 2.7e-05 14.1 In-house 1-74 (283) Show / Hide 
Range on Protein: 1016-1081
Range on HMM: 1-74/283
Sequence Identity: 22% (19 aa)

LKFVRNLGAGAFGEVMLMELEGISSEDQRKQRL------------VAVKRL---LDSEV-KDEFVQEMTTMRK-LKHANLVQL
 ..   || |||||| . .        . ....            |.||..   ....  . || .|.  ||. ..| | |..
VTLGKKLGEGAFGEVYKGR--------R-TLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKF
Kinase RTKE4.AA Src 1016-1030 60 7.5e-05 12.37 In-house 1-15 (255) Show / Hide 
Range on Protein: 1016-1030
Range on HMM: 1-15/255
Sequence Identity: 60% (9 aa)

LKFVRNLGAGAFGEV
.|..| ||.| ||||
IKLCRKLGQGQFGEV
Kinase RTKE4.AA Fer 1272-1306 30 0.000125 11.81 In-house 248-283 (283) Show / Hide 
Range on Protein: 1272-1306
Range on HMM: 248-283/283
Sequence Identity: 30% (11 aa)

PPAHCPPALASVMR-WCIDLNPMHRPTFAQLQDKWV
.| |.||.....|   | . .|. |||..... |  
MPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase RTKE4.AA Pkinase 1188-1226 17 0.00065 14.92 Pfam 175-214 (293) Show / Hide 
Range on Protein: 1188-1226
Range on HMM: 175-214/293
Sequence Identity: 17% (7 aa)

LRWLAPEMLK-DKMANEATDVYAYGVLMHELFEDDLPLAH
....||| .. ...   . |....|....|..   .|  .
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPG
Kinase RTKE4.AA UTK 1271-1305 28 0.000757 9.05 In-house 262-296 (296) Show / Hide 
Range on Protein: 1271-1305
Range on HMM: 262-296/296
Sequence Identity: 28% (10 aa)

EPPAHCPPALASVMRWCIDLNPMHRPTFAQLQDKW
..|..|| ..  .|. |   .|  ||.| .| .. 
PCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase RTKE4.AA Pkinase 1270-1306 19 0.003697 12.25 Pfam 237-293 (293) Show / Hide 
Range on Protein: 1270-1306
Range on HMM: 237-293/293
Sequence Identity: 19% (11 aa)

FEPPAHCP-------------------PALASVMRWCIDLNPMHRPTFAQLQDK-WV
|. |  |.                   ... ....||....|  |||..|.    |.
FDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase RTKE4.AA Jak 1273-1301 27 0.021758 4.49 In-house 265-293 (299) Show / Hide 
Range on Protein: 1273-1301
Range on HMM: 265-293/299
Sequence Identity: 27% (8 aa)

PAHCPPALASVMRWCIDLNPMHRPTFAQL
|. |..... .|. | . .|  ||.|. .
PDSCWDEIYNLMQQCWHYDPNQRPSFRTI