Gene RTKB7 (M.brevicollis)
RTKB7
Species: M.brevicollis
Alias: RTKB7
External Links:
Annotation:
Sequence
Protein domains of RTKB7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | RTKB7.AA | RTKB | 592-845 | 43 | 1.1e-162 | 546.76 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 592-845 Range on HMM: 1-264/264 Sequence Identity: 43% (114 aa) VHLAHQLGSGAFGLVYQGLVQLQGMNTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALGPHPNLVDLLGHCLGDTPLMGLFTLGNLGSLRELLRASRQP- |.|...||.||||.|.|..|....|||.|..|..||...||.||...||........||.|||.....||||.|.|...|..|..||.||..||..|.. VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQ SDSLSLKGANLTSLARDVACGMAYLSLHGIQHGYLCAANVLVDSDRACRVSRH---------CAPLPAHRTYERWLAPELWEASAPLSQPGDVWAFGVTA ....|||.|.|.......|||||.|..|...|..|||.|||||....|..... |......|....|.|||.|.........||||.||||. HNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTM WEIFTLGATPYVTQPVFELKPWLASGHRLEKPRLASAATFALLTDCWAAEAQQRPDFTALNDAF ||||.||.|||..........||.|||||.|||....|.......||..|||.||||..|.||| WEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF |
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Kinase | RTKB7.AA | TK | 592-845 | 16 | 1.6e-63 | 211.48 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 592-845 Range on HMM: 1-486/486 Sequence Identity: 16% (79 aa) VHLAHQLGSGAFG---LVYQGLVQLQ---------------------GMNTTQIVAVEVLPG--SASLEEQDA--------------FCTYLGRLEA-LG ..| ..||.|.|| ||.|... . . .... ||| .| ..| ||. . .. . . . || ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG PHPNLVDLLGHCLGD------------TPLMGLFTLGNLGS----LRELLRASRQP-------------------------------------------- |||.| |.|.|. . |.| . . ..|. ||. ||..| . HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY ------SDSLSLKGANLTS-------------------LARDVACGMAYLSLH------GIQHGYLCAANVLVDSDRA-----------CRVSR------ ....| . | . ....||||.||. . .. |. |.| |.||... |... DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ ----HCAPLPAHRTYER---------------------------------WLAPELWEASAP--------LSQPGDVWAFGVTAWEIFTLG-ATPYVTQP .. .. . | | |.||| .. . . |||.|||. |||||.| ...| . GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS V---------FELKPWLASG--------------HRLEKPRLAS--------------AATFALLTDCWAAEAQQRPDFTALNDAF |. | .| .|...| ... .. . |...||......||.|..| ... NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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Kinase | RTKB7.AA | TK-Unique | 592-845 | 28 | 1.4e-50 | 172.6 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 592-845 Range on HMM: 1-294/294 Sequence Identity: 28% (83 aa) VHLAHQLGSGAFGLVYQGLVQL--QGMNTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALGPHPNLVDLLGHCLGDT-PLMGLFTLGNLGSLRELLRASR . . ..|.|||| |. | | . . ...||| | .|.......| . . .||.|||.|..|| | .. | | .. |.|. .|| .| LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR QP-------------------SDSLS-LKGANLTSLARDVACGMAYLSL--HGIQHGYLCAANVLVDSDRACRVSRH-CAP-----------LPAHRTYE .. ..... .. | . | ..||||.||. ..| |. ||| |||. .| | .. |. .|.. PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI RWLAPELWE--ASAPLSQPGDVWAFGVTAWEIFTLGATPYVTQPVFELKPWLASGHRLEKPRLA-SAATFALLTDCWAAEAQQRPDFTALNDAF ||.||| . .|||.|||. ||||||||.|| | .. . |.|...| | ... |. || |...||.|... . . RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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Kinase | RTKB7.AA | TyrKc | 592-845 | 26 | 7.7e-40 | 139.6 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 592-845 Range on HMM: 1-280/280 Sequence Identity: 26% (79 aa) VHLAHQLGSGAFGLVYQGLVQLQGMNTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALG-PHPNLVDLLGHCLGD-------TPLMGLFTLGNLGSLREL ..| ..||.|||| ||.| . ||| .| .| . .|. . . || |||.| |.| |. . ||| .. . .|.|.. ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY LRASRQPSDSLSLKGANLTSLARDVACGMAYLSLHGIQHGYLCAANVLVDSDR---------ACRVSRH----------------CAP--LPAHRTYERW ||..| |. . | | . ..||||.||. ... | | | |.||.... . . . .. || || LRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI-----RW LAPELWEASAPLSQPGDVWAFGVTAWEIFTLGATPYVT-----QPVFELKPWLASGHRLEKPRL--------ASAATFALLTDCWAAEAQQRPDFTALND .||| . . |||.|||. |||||.|..|| . .|. .. .|.|...| .... . . ..||.... .|| |... . MAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE AF | CF |
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Kinase | RTKB7.AA | Pkinase_Tyr | 755-845 | 30 | 2.3e-28 | 96.67 | Pfam | 179-270 (270) | Show / Hide |
Range on Protein: 755-845 Range on HMM: 179-270/270 Sequence Identity: 30% (28 aa) RWLAPELWEASAPLSQPGDVWAFGVTAWEIFTLGATP-YVTQPVFELKPWL-ASGHRLEKPRLASAATFALLTDCWAAEAQQRPDFTALNDAF .|.||| . . . |||.|||. |||||.|..| | . .|.. .. .|.|...|..... |...||......|| |... . KWMAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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Kinase | RTKB7.AA | Pkinase_Tyr | 592-741 | 30 | 6.4e-26 | 88.41 | Pfam | 1-153 (270) | Show / Hide |
Range on Protein: 592-741 Range on HMM: 1-153/270 Sequence Identity: 30% (47 aa) VHLAHQLGSGAFGLVYQGLVQLQGMNTTQIVAVEVLPGSASLEE--QDAFCTYLGRLEALGPHPNLVDLLGHCL-GDTP--LMGLFTLGNLGSLRELLRA ... ..||.|||| ||.| .. ||.. ||| .|. .|. |. ...| . . || |||.| |.| |. . | .. . . .|.|.. ||. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK SRQPSDSLSLKGANLTSLARDVACGMAYLSLHGIQHGYLCAANVLVDSDRACRVS | .| .|. | . ....|.||.||. ... | |.| |.||.... .... HR--EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKIC |
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Kinase | RTKB7.AA | FGFR | 773-845 | 41 | 1.5e-25 | 84.06 | In-house | 220-293 (293) | Show / Hide |
Range on Protein: 773-845 Range on HMM: 220-293/293 Sequence Identity: 41% (31 aa) DVWAFGVTAWEIFTLGATPYVTQP-VFELKPWLASGHRLEKPRLASAATFALLTDCWAAEAQQRPDFTALNDAF ||| .|| |||.|.| .|| . | | || | .|||.||| . | . .. .|| ....||| |. | ... DVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL |
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Kinase | RTKB7.AA | UTK | 592-741 | 28 | 3.1e-21 | 69.38 | In-house | 1-167 (296) | Show / Hide |
Range on Protein: 592-741 Range on HMM: 1-167/296 Sequence Identity: 28% (48 aa) VHLAHQLGSGAFGLVYQG-LVQLQGMNTTQIVAVEVLPGSASLEEQDAF--------CT---YLGRLEALGPHPNLVDLLGHCLGDTPLMGLFTLGNLGS |.| |||.|||| |. . ..| . ....||| |. . . .|. .. ..... |||.. |.| |. . |.| . . |. VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ-HHADAQQEPEPYPDFMEEARELQMMKQFH---WHPNVLRLVGVCTQEEPWMIVTEYMENGD LRELLRASRQ-PS-DSLSLKGANLTSLARDVACGMAYLSLHGIQHGYLCAANVLVDSDR-------ACRVS || .|| .|. | . ..|. ... |.|.|.||.||. .|. |. |.| |.||...| |... LRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIA |
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Kinase | RTKB7.AA | EGFR | 773-846 | 35 | 2.2e-20 | 64.2 | In-house | 185-258 (258) | Show / Hide |
Range on Protein: 773-846 Range on HMM: 185-258/258 Sequence Identity: 35% (26 aa) DVWAFGVTAWEIFTLGATPYVTQPVFELKPWLASGHRLEKPRLASAATFALLTDCWAAEAQQRPDFTALNDAFG |||..||| ||. | |. || | | | | ||. | . . .. || . .. || | | | DVWSYGVTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK |
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Kinase | RTKB7.AA | Fer | 755-846 | 31 | 4.8e-19 | 61.61 | In-house | 183-283 (283) | Show / Hide |
Range on Protein: 755-846 Range on HMM: 183-283/283 Sequence Identity: 31% (32 aa) RWLAPELWEASAPLSQPGDVWAFGVTAWEIFTLGATPYVTQPVFE-----L----KPW-LASGHRLEKPRLASAATFALLT-DCWAAEAQQRPDFTALND |||||| |. | |||.|||..||||| ||.|| .|| . . . | .|... | . . ... .||... .|| .. . RWLAPETWQTGI-YSPKTDVWSFGVMCWEIFTNGAEPYPGQPH-GMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQ AFG . KLK |
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Kinase | RTKB7.AA | UTK | 755-845 | 32 | 1.5e-18 | 60.1 | In-house | 204-296 (296) | Show / Hide |
Range on Protein: 755-845 Range on HMM: 204-296/296 Sequence Identity: 32% (30 aa) RWLAPELWEASAPLSQPGDVWAFGVTAWEIFTLGATPYVTQPVFELKPWLASG--HRLEKPRLASAATFALLTDCWAAEAQQRPDFTALNDAF || ||| . .. |||.|||. |||.| |..|| .. . | .|...|. ... . |...||... | |||| | ... RWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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Kinase | RTKB7.AA | Tie | 773-845 | 36 | 1.6e-17 | 49.25 | In-house | 195-267 (267) | Show / Hide |
Range on Protein: 773-845 Range on HMM: 195-267/267 Sequence Identity: 36% (27 aa) DVWAFGVTAWEIFTLGATPYVTQPVFELKPWLASGHRLEKPRLASAATFALLTDCWAAEAQQRPDFTALNDAF |||..|| ||| .|| ||| || | |.|.|.|| . |. || .|| |. . . DVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL |
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Kinase | RTKB7.AA | ALK | 773-847 | 33 | 7.6e-16 | 51.18 | In-house | 199-273 (273) | Show / Hide |
Range on Protein: 773-847 Range on HMM: 199-273/273 Sequence Identity: 33% (25 aa) DVWAFGVTAWEIFTLGATPYVTQPVFELKPWLASGHRLEKPRLASAATFALLTDCWAAEAQQRPDFTALNDAFGQ |||.||| |||| || || . | ...| |.. || . . |.|| .. ||.|. . . DVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY |
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Kinase | RTKB7.AA | VEGFR | 773-845 | 36 | 5.2e-15 | 53.2 | In-house | 259-332 (332) | Show / Hide |
Range on Protein: 773-845 Range on HMM: 259-332/332 Sequence Identity: 36% (27 aa) DVWAFGVTAWEIFTLGATPYVT-QPVFELKPWLASGHRLEKPRLASAATFALLTDCWAAEAQQRPDFTALNDAF |||..|| ||||.||. || . |. |. . | .| |...| .. . ||| | .|| | .| . DVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL |
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Kinase | RTKB7.AA | Tie | 601-741 | 26 | 1.7e-12 | 33.64 | In-house | 2-156 (267) | Show / Hide |
Range on Protein: 601-741 Range on HMM: 2-156/267 Sequence Identity: 26% (42 aa) GAFGLVYQGLVQLQGMNTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALGPHPNLVDLLGHCLGDTPLMGLFTLGNLGSLRELLRASR----------QP | || | . .. |. ||. . || ... | | . .| |||.. |.| | | | | . || || .. GNFGQVMKAMIKKDGLKME--VAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAFAREH SD------SLSLKGANLTSLARDVACGMAYLSLHGIQHGYLCAANVLVDSDRACRVS . . .| . | ||| || ||| .. | | | |.|| .|... TTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIA |
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Kinase | RTKB7.AA | EGFR | 592-734 | 29 | 7.5e-12 | 35.46 | In-house | 1-136 (258) | Show / Hide |
Range on Protein: 592-734 Range on HMM: 1-136/258 Sequence Identity: 29% (42 aa) VHLAHQLGSGAFGLVYQGLVQLQGMNTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALGPHPNLVDLLGHCLGDTPLMGLFTLGNLGSLRELLRASRQPS . . ||||||| || |. .| | ||. || . . . .... . . ||.|| ||| |.... .. . .|.| . .| . LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVD-HPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVRQHKD-- DSLSLKGANLTSLARDVACGMAYLSLHGIQHGYLCAANVLVDS . .| . .| || || | . | | | |||| | ---NIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKS |
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Kinase | RTKB7.AA | S_TKc | 592-846 | 17 | 1.5e-11 | -7.46 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 592-846 Range on HMM: 1-231/231 Sequence Identity: 17% (49 aa) VHLAHQLGSGAFGLVYQGLVQLQGMNTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALGPHPNLVDLLGHCLGDTPLMGLFTLGNL--GSLRELLRASRQ .. ..|.|||| ||.. | .|||. ... . .. . |. |||.| |.... . | . . . |.|..... . YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR PSDSLSLKGANLTSLARDVACGMAYLSLHGIQHGYLCAANVLVDSDRACRV-------SRHCAPLPAHRTY---ERWLAPELWEASAPLSQ-PGDVWAFG . . .... ..|...|. ||| | | .|.|.|. .. .|. .|. ..|||. . . . |.|..| HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCG VTAWEIFTLGATPYVTQPVFELKPWLASGHRLEKPRLASAATFALLTDCWAAEAQQRPDFTALN-------DAFG .. .| .. | .|. |. .| . | .. |. . ..|| ||. . . CILYEMLC-GYPPFP-QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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Kinase | RTKB7.AA | ALK | 592-715 | 31 | 1.7e-10 | 32.47 | In-house | 1-127 (273) | Show / Hide |
Range on Protein: 592-715 Range on HMM: 1-127/273 Sequence Identity: 31% (42 aa) VHLAHQLGSGAFGLVYQGLVQL-QGMNTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALG----PHPNLVDLLGHCLGDTPLMGLFTLGNLGSLRELLRA . | || |||| || |... | ||. || ..| ... || ||| |.| | ..| |. .|.| . . | .. || ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCM-----EALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRE SRQPSDSL---SLKGANLTSLARDVACGMAYL .| || .| | ...|||.| || CRPHPESLQPSQLTMKDLLQCCCDVAQGCHYL |
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Kinase | RTKB7.AA | VEGFR | 592-662 | 36 | 8.6e-08 | 25.67 | In-house | 1-72 (332) | Show / Hide |
Range on Protein: 592-662 Range on HMM: 1-72/332 Sequence Identity: 36% (26 aa) VHLAHQLGSGAFGLVYQGL-VQLQGMNTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALGPHPNLVDLLGHC .| .|| |||| | .. . ...| |...||| | | .| | . | | .| | | | .|| | LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCC |
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Kinase | RTKB7.AA | FGFR | 592-732 | 27 | 1.1e-05 | 15.35 | In-house | 1-169 (293) | Show / Hide |
Range on Protein: 592-732 Range on HMM: 1-169/293 Sequence Identity: 27% (47 aa) VHLAHQLGSGAFGLVYQGLVQ-LQGM--NTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALGPHPNLVDLLGHCLGDTPLMGLFTLGNLGSLRELLRASR | . || |.|| | . . .. . . .||| | ... .. . . | |.| . ||| | .. || . . | ||. ||| | LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR QPS-----DSL------------S--------LKGANLTSLARDVACGMAYLSLHGIQHGYLCAANVLV | || | |.|.| || || || . | | | |||| PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLV |
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Kinase | RTKB7.AA | Fer | 592-624 | 38 | 1.3e-05 | 15.17 | In-house | 1-39 (283) | Show / Hide |
Range on Protein: 592-624 Range on HMM: 1-39/283 Sequence Identity: 38% (15 aa) VHLAHQLGSGAFGLVYQG---LVQLQGMNTTQ---IVAV |.| .||.|||| ||.| | . |.. .. |.| VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKV |