RTKB7

Species: M.brevicollis
Alias: RTKB7
External Links:
Annotation:

Classification

Group: TK
Family: RTKB

Sequence

Name Sequence Type Origin Length Description Download
RTKB7.AA Protein None 1038 None Fasta, JSON
RTKB7.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of RTKB7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RTKB7.AA RTKB 592-845 43 1.1e-162 546.76 In-house 1-264 (264) Show / Hide
Range on Protein: 592-845
Range on HMM: 1-264/264
Sequence Identity: 43% (114 aa)

VHLAHQLGSGAFGLVYQGLVQLQGMNTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALGPHPNLVDLLGHCLGDTPLMGLFTLGNLGSLRELLRASRQP-
|.|...||.||||.|.|..|....|||.|..|..||...||.||...||........||.|||.....||||.|.|...|..|..||.||..||..|.. 
VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQ

SDSLSLKGANLTSLARDVACGMAYLSLHGIQHGYLCAANVLVDSDRACRVSRH---------CAPLPAHRTYERWLAPELWEASAPLSQPGDVWAFGVTA
....|||.|.|.......|||||.|..|...|..|||.|||||....|.....         |......|....|.|||.|.........||||.||||.
HNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTM

WEIFTLGATPYVTQPVFELKPWLASGHRLEKPRLASAATFALLTDCWAAEAQQRPDFTALNDAF
||||.||.|||..........||.|||||.|||....|.......||..|||.||||..|.|||
WEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF

Kinase RTKB7.AA TK 592-845 16 1.6e-63 211.48 In-house 1-486 (486) Show / Hide
Range on Protein: 592-845
Range on HMM: 1-486/486
Sequence Identity: 16% (79 aa)

VHLAHQLGSGAFG---LVYQGLVQLQ---------------------GMNTTQIVAVEVLPG--SASLEEQDA--------------FCTYLGRLEA-LG
..| ..||.|.||    ||.|... .                     . .... ||| .|    ..| ||. .              ..  .  . . ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHPNLVDLLGHCLGD------------TPLMGLFTLGNLGS----LRELLRASRQP--------------------------------------------
 |||.| |.|.|. .             |.| .  . ..|.    ||. ||..| .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------SDSLSLKGANLTS-------------------LARDVACGMAYLSLH------GIQHGYLCAANVLVDSDRA-----------CRVSR------
       ....|  . | .                    ....||||.||. .      .. |. |.| |.||...             |...       
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----HCAPLPAHRTYER---------------------------------WLAPELWEASAP--------LSQPGDVWAFGVTAWEIFTLG-ATPYVTQP
    ..  .. .  | |                                 |.||| ..   .         .   |||.|||. |||||.| ...|   .
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

V---------FELKPWLASG--------------HRLEKPRLAS--------------AATFALLTDCWAAEAQQRPDFTALNDAF
           |.   | .|              .|...| ...              .. . |...||......||.|..| ...
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase RTKB7.AA TK-Unique 592-845 28 1.4e-50 172.6 In-house 1-294 (294) Show / Hide
Range on Protein: 592-845
Range on HMM: 1-294/294
Sequence Identity: 28% (83 aa)

VHLAHQLGSGAFGLVYQGLVQL--QGMNTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALGPHPNLVDLLGHCLGDT-PLMGLFTLGNLGSLRELLRASR
. .  ..|.|||| |. | |     . . ...|||  |  .|.......|   .  . .||.|||.|..|| |  .. | | ..     |.|. .|| .|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

QP-------------------SDSLS-LKGANLTSLARDVACGMAYLSL--HGIQHGYLCAANVLVDSDRACRVSRH-CAP-----------LPAHRTYE
..                   ..... ..   | . | ..||||.||.   ..| |. ||| |||. .|  | ..    |.              .|.. 
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWLAPELWE--ASAPLSQPGDVWAFGVTAWEIFTLGATPYVTQPVFELKPWLASGHRLEKPRLA-SAATFALLTDCWAAEAQQRPDFTALNDAF
||.|||          .  .|||.|||. ||||||||.||   |  ..   .  |.|...|    | ... |.  ||  |...||.|... . .
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL

Kinase RTKB7.AA TyrKc 592-845 26 7.7e-40 139.6 SMART 1-280 (280) Show / Hide
Range on Protein: 592-845
Range on HMM: 1-280/280
Sequence Identity: 26% (79 aa)

VHLAHQLGSGAFGLVYQGLVQLQGMNTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALG-PHPNLVDLLGHCLGD-------TPLMGLFTLGNLGSLREL
..| ..||.|||| ||.|          . ||| .|  .|    . .|.  .  .  ||  |||.| |.| |. .        ||| .. .  .|.|.. 
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LRASRQPSDSLSLKGANLTSLARDVACGMAYLSLHGIQHGYLCAANVLVDSDR---------ACRVSRH----------------CAP--LPAHRTYERW
||..|       |. . | | . ..||||.||. ... |  | | |.||....         .  .  .                ..   ||      ||
LRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI-----RW

LAPELWEASAPLSQPGDVWAFGVTAWEIFTLGATPYVT-----QPVFELKPWLASGHRLEKPRL--------ASAATFALLTDCWAAEAQQRPDFTALND
.||| .      .   |||.|||. |||||.|..||        . .|.  .. .|.|...|          .... . . ..||.... .|| |... .
MAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

AF
 |
CF

Kinase RTKB7.AA Pkinase_Tyr 755-845 30 2.3e-28 96.67 Pfam 179-270 (270) Show / Hide
Range on Protein: 755-845
Range on HMM: 179-270/270
Sequence Identity: 30% (28 aa)

RWLAPELWEASAPLSQPGDVWAFGVTAWEIFTLGATP-YVTQPVFELKPWL-ASGHRLEKPRLASAATFALLTDCWAAEAQQRPDFTALNDAF
.|.||| .  .   .   |||.|||. |||||.|..| |   . .|.. ..  .|.|...|.....    |...||......|| |...   .
KWMAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase RTKB7.AA Pkinase_Tyr 592-741 30 6.4e-26 88.41 Pfam 1-153 (270) Show / Hide
Range on Protein: 592-741
Range on HMM: 1-153/270
Sequence Identity: 30% (47 aa)

VHLAHQLGSGAFGLVYQGLVQLQGMNTTQIVAVEVLPGSASLEE--QDAFCTYLGRLEALGPHPNLVDLLGHCL-GDTP--LMGLFTLGNLGSLRELLRA
... ..||.|||| ||.|    .. ||.. ||| .|. .|. |.  ...|   .  .  || |||.| |.| |.  . |  ..  . .  .|.|.. ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

SRQPSDSLSLKGANLTSLARDVACGMAYLSLHGIQHGYLCAANVLVDSDRACRVS
 |  .|  .|.   | . ....|.||.||. ... |  |.| |.||.... ....
HR--EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKIC

Kinase RTKB7.AA FGFR 773-845 41 1.5e-25 84.06 In-house 220-293 (293) Show / Hide
Range on Protein: 773-845
Range on HMM: 220-293/293
Sequence Identity: 41% (31 aa)

DVWAFGVTAWEIFTLGATPYVTQP-VFELKPWLASGHRLEKPRLASAATFALLTDCWAAEAQQRPDFTALNDAF
||| .||  |||.|.| .|| . | | ||   | .|||.||| . |   . .. .|| ....||| |. | ...
DVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL

Kinase RTKB7.AA UTK 592-741 28 3.1e-21 69.38 In-house 1-167 (296) Show / Hide
Range on Protein: 592-741
Range on HMM: 1-167/296
Sequence Identity: 28% (48 aa)

VHLAHQLGSGAFGLVYQG-LVQLQGMNTTQIVAVEVLPGSASLEEQDAF--------CT---YLGRLEALGPHPNLVDLLGHCLGDTPLMGLFTLGNLGS
|.|  |||.|||| |. . ..|  .  ....||| |.  . .  .|.          ..    .....    |||.. |.| |. . |.| .  .   |.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ-HHADAQQEPEPYPDFMEEARELQMMKQFH---WHPNVLRLVGVCTQEEPWMIVTEYMENGD

LRELLRASRQ-PS-DSLSLKGANLTSLARDVACGMAYLSLHGIQHGYLCAANVLVDSDR-------ACRVS
|| .|| .|. |  . ..|.   ... |.|.|.||.||. .|. |. |.| |.||...|        |...
LRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIA

Kinase RTKB7.AA EGFR 773-846 35 2.2e-20 64.2 In-house 185-258 (258) Show / Hide
Range on Protein: 773-846
Range on HMM: 185-258/258
Sequence Identity: 35% (26 aa)

DVWAFGVTAWEIFTLGATPYVTQPVFELKPWLASGHRLEKPRLASAATFALLTDCWAAEAQQRPDFTALNDAFG
|||..||| ||. | |. ||   |  |    |  | ||. |   .   . ..  || . .. || |  |   | 
DVWSYGVTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK

Kinase RTKB7.AA Fer 755-846 31 4.8e-19 61.61 In-house 183-283 (283) Show / Hide
Range on Protein: 755-846
Range on HMM: 183-283/283
Sequence Identity: 31% (32 aa)

RWLAPELWEASAPLSQPGDVWAFGVTAWEIFTLGATPYVTQPVFE-----L----KPW-LASGHRLEKPRLASAATFALLT-DCWAAEAQQRPDFTALND
|||||| |.     |   |||.|||..||||| ||.|| .||  .     .    . |   .|...  |  .  .   ... .||...  .|| .. .  
RWLAPETWQTGI-YSPKTDVWSFGVMCWEIFTNGAEPYPGQPH-GMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQ

AFG
 . 
KLK

Kinase RTKB7.AA UTK 755-845 32 1.5e-18 60.1 In-house 204-296 (296) Show / Hide
Range on Protein: 755-845
Range on HMM: 204-296/296
Sequence Identity: 32% (30 aa)

RWLAPELWEASAPLSQPGDVWAFGVTAWEIFTLGATPYVTQPVFELKPWLASG--HRLEKPRLASAATFALLTDCWAAEAQQRPDFTALNDAF
|| |||     .  ..  |||.|||. |||.| |..||      ..   .  |  .|...|.  ... . |...||... | ||||  | ...
RWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM

Kinase RTKB7.AA Tie 773-845 36 1.6e-17 49.25 In-house 195-267 (267) Show / Hide
Range on Protein: 773-845
Range on HMM: 195-267/267
Sequence Identity: 36% (27 aa)

DVWAFGVTAWEIFTLGATPYVTQPVFELKPWLASGHRLEKPRLASAATFALLTDCWAAEAQQRPDFTALNDAF
|||..||  ||| .|| |||      ||   |  |.|.|.||      . |.  ||     .|| |. .   .
DVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL

Kinase RTKB7.AA ALK 773-847 33 7.6e-16 51.18 In-house 199-273 (273) Show / Hide
Range on Protein: 773-847
Range on HMM: 199-273/273
Sequence Identity: 33% (25 aa)

DVWAFGVTAWEIFTLGATPYVTQPVFELKPWLASGHRLEKPRLASAATFALLTDCWAAEAQQRPDFTALNDAFGQ
|||.|||  |||| ||  ||  .   |    ...| |.. ||      . . |.||  ..  ||.|. .   .  
DVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY

Kinase RTKB7.AA VEGFR 773-845 36 5.2e-15 53.2 In-house 259-332 (332) Show / Hide
Range on Protein: 773-845
Range on HMM: 259-332/332
Sequence Identity: 36% (27 aa)

DVWAFGVTAWEIFTLGATPYVT-QPVFELKPWLASGHRLEKPRLASAATFALLTDCWAAEAQQRPDFTALNDAF
|||..||  ||||.||. || . |.  |. . | .| |...| ..  .      |||  |  .|| | .|   .
DVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL

Kinase RTKB7.AA Tie 601-741 26 1.7e-12 33.64 In-house 2-156 (267) Show / Hide
Range on Protein: 601-741
Range on HMM: 2-156/267
Sequence Identity: 26% (42 aa)

GAFGLVYQGLVQLQGMNTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALGPHPNLVDLLGHCLGDTPLMGLFTLGNLGSLRELLRASR----------QP
| || | .  ..  |.     ||.  .   || ...  |   |  .  .| |||.. |.| |     |         | | . || ||          ..
GNFGQVMKAMIKKDGLKME--VAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAFAREH

SD------SLSLKGANLTSLARDVACGMAYLSLHGIQHGYLCAANVLVDSDRACRVS
.       . .|    .   | ||| || |||  .. |  | | |.||    .|...
TTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIA

Kinase RTKB7.AA EGFR 592-734 29 7.5e-12 35.46 In-house 1-136 (258) Show / Hide
Range on Protein: 592-734
Range on HMM: 1-136/258
Sequence Identity: 29% (42 aa)

VHLAHQLGSGAFGLVYQGLVQLQGMNTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALGPHPNLVDLLGHCLGDTPLMGLFTLGNLGSLRELLRASRQPS
. .   ||||||| || |.   .| |    ||. ||  . . . ....      .  .  ||.|| ||| |.... ..    .  .|.| . .|  .   
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVD-HPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVRQHKD--

DSLSLKGANLTSLARDVACGMAYLSLHGIQHGYLCAANVLVDS
    .   .|   .  .| || ||  | . |  | | |||| |
---NIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKS

Kinase RTKB7.AA S_TKc 592-846 17 1.5e-11 -7.46 SMART 1-231 (231) Show / Hide
Range on Protein: 592-846
Range on HMM: 1-231/231
Sequence Identity: 17% (49 aa)

VHLAHQLGSGAFGLVYQGLVQLQGMNTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALGPHPNLVDLLGHCLGDTPLMGLFTLGNL--GSLRELLRASRQ
 ..  ..|.|||| ||..        | .|||. ...        . ..  .  |.    |||.| |....   . |   . . .   |.|.....  . 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

PSDSLSLKGANLTSLARDVACGMAYLSLHGIQHGYLCAANVLVDSDRACRV-------SRHCAPLPAHRTY---ERWLAPELWEASAPLSQ-PGDVWAFG
.     .      .... ..|...|.  ||| |  |  .|.|.|.    ..       .|.       .|.     ..|||.     . .  . |.|..|
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCG

VTAWEIFTLGATPYVTQPVFELKPWLASGHRLEKPRLASAATFALLTDCWAAEAQQRPDFTALN-------DAFG
.. .| .. | .|.  |.   .|  .            |     ..  |.  . ..||   ||.       . . 
CILYEMLC-GYPPFP-QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF

Kinase RTKB7.AA ALK 592-715 31 1.7e-10 32.47 In-house 1-127 (273) Show / Hide
Range on Protein: 592-715
Range on HMM: 1-127/273
Sequence Identity: 31% (42 aa)

VHLAHQLGSGAFGLVYQGLVQL-QGMNTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALG----PHPNLVDLLGHCLGDTPLMGLFTLGNLGSLRELLRA
. |   || |||| || |...   |      ||.  || ..| ...  ||      |||      |.| | ..| |.  .|.| .  .   | ..  || 
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCM-----EALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRE

SRQPSDSL---SLKGANLTSLARDVACGMAYL
.|    ||   .|    |  ...|||.|  ||
CRPHPESLQPSQLTMKDLLQCCCDVAQGCHYL

Kinase RTKB7.AA VEGFR 592-662 36 8.6e-08 25.67 In-house 1-72 (332) Show / Hide
Range on Protein: 592-662
Range on HMM: 1-72/332
Sequence Identity: 36% (26 aa)

VHLAHQLGSGAFGLVYQGL-VQLQGMNTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALGPHPNLVDLLGHC
 .|  .|| |||| | ..  . ...| |...|||  |   |  .|  |  . |  |  .| | | | .|| |
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCC

Kinase RTKB7.AA FGFR 592-732 27 1.1e-05 15.35 In-house 1-169 (293) Show / Hide
Range on Protein: 592-732
Range on HMM: 1-169/293
Sequence Identity: 27% (47 aa)

VHLAHQLGSGAFGLVYQGLVQ-LQGM--NTTQIVAVEVLPGSASLEEQDAFCTYLGRLEALGPHPNLVDLLGHCLGDTPLMGLFTLGNLGSLRELLRASR
  | . || |.|| |  . .  ..    . . .|||  |  ... ..       .  .   | |.| . ||| | .. ||  .  .   | ||. ||| |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

QPS-----DSL------------S--------LKGANLTSLARDVACGMAYLSLHGIQHGYLCAANVLV
 |      ||                      |    |.|.|  || || ||    . |  | | ||||
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLV

Kinase RTKB7.AA Fer 592-624 38 1.3e-05 15.17 In-house 1-39 (283) Show / Hide
Range on Protein: 592-624
Range on HMM: 1-39/283
Sequence Identity: 38% (15 aa)

VHLAHQLGSGAFGLVYQG---LVQLQGMNTTQ---IVAV
|.|  .||.|||| ||.|   |  . |.. ..    |.|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKV