Gene RTKA4 (M.brevicollis)
RTKA4
Species: M.brevicollis
Alias: RTKA4
External Links:
Annotation:
Sequence
Protein domains of RTKA4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Ldl_recept_a | RTKA4.AA | Ldl_recept_a | 138-155 | 45 | 1e-05 | 20.24 | Pfam | 22-41 (41) | Show / Hide |
Range on Protein: 138-155 Range on HMM: 22-41/41 Sequence Identity: 45% (9 aa) QVCNGVDDCPNGEDE--ASC .||.| .|| .|.|| ..| WVCDGDPDCHDGSDEWPENC |
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LDLa | RTKA4.AA | LDLa | 117-157 | 27 | 1.7e-05 | 23.43 | SMART | 1-47 (47) | Show / Hide |
Range on Protein: 117-157 Range on HMM: 1-47/47 Sequence Identity: 27% (13 aa) FCPKP-AEHVECPSSGSILDIVQVCNGVDDCPNGEDE------ASCFG || .. |. .| .. .||.|..||..|.|| . | TCPPDHPNQFQCG-NGRCIPKSWVCDGDNDCGDGSDEWPFFDPENCPQ |
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Kinase | RTKA4.AA | RTKA | 385-621 | 52 | 4.3e-178 | 597.95 | In-house | 1-309 (314) | Show / Hide |
Range on Protein: 385-621 Range on HMM: 1-309/314 Sequence Identity: 52% (163 aa) ITAEHVVGHGHFSKVYQASLLDGA----HEPHPVAIKECD----ADKTTLSAWLREIMLLHSLCDRPDIIGLHGVLLRATG---QSTLSVVLEWAPHGNL .. .|||||||||.||||||.|.. ..|..||||||| .||||||||.||||||||..|.|.|||||||.|... ||....|.||.||||| MQVRHVVGHGHFSQVYQASLQDMEDEMRQGPQCVAIKECDDLMLNDKTTLSAWMREIMLLHSMRDCPHIIGLHGVCLPREDKHHQSHCGMVCEWCPHGNL RDFIRRHP------------------------LSETQLHQALRQTV-------SALAYLAKLEIVHRDVAARNVLVITTNPALVCKLGDFGLSRVMPSSE |||.|.|| |||.|.||||.|.. .|.|||||..|||||||||||||....||..|||.|||||||||||. RDFVRQHPHFSAPVVATIAMQHSGEPNASPKLLSEAQCHQALLQMCPCWAQVAQAMAYLAKCGIVHRDVAARNVLVMSLQPAFHCKLADFGLSRVMPSSD YYKSVADSEMPYRWMALECLMERRYSEWSDVWAFGVLVWELVTGGATPWR------------------------------GLGLPAIIQQLKAGATLKLP ||||.||.|||.||||.||.|||||||.||||.||||||||.|.|.|||. |..|..|||.||.|.||..| YYKSRADDEMPFRWMAPECIMERRYSEHSDVWSFGVLVWELLTHGQTPWQNCESHQIVALLMRGERLTFAPTINAALRDSGCDLHHIIQMLKQGQTLPMP HGAPLIAQR ...| ..|| PCCPPCLQR |
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Kinase | RTKA4.AA | TK | 385-616 | 18 | 1e-73 | 246.29 | In-house | 1-444 (486) | Show / Hide |
Range on Protein: 385-616 Range on HMM: 1-444/486 Sequence Identity: 18% (83 aa) ITAEHVVGHGHFS---KVYQASLLDGA----------------------HEPHPVAIKECDADKTTLSAW------------------LREIMLLHS-LC || ... |.|.| .||.. . .. ...|||.| . .. .. .. ..|...... |. ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG DRPDIIGLHGVLLRA---------TGQSTLSVVLEWAPHGN----LRDFIRRH----------------------------------------------- . | |. |.|| .. ..| . .|.|..|||. |||. |.. HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY ----------PLSETQLHQ-------------------ALRQTVSALAYLAKL------EIVHRDVAARNVLVITTNPA--------LVCKLGDFG---- ||....|.| .| ....||... .||||.||||.|| |. .|||..||| DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ ----LSRVMPS------------------------SEYYKSVADSEMPYRWMALECLM---------ERRYSEWSDVWAFGVLVWELVTGGATPWRG-LG |.| ..| ..||.. . .| |||| |||. ...... ||||.||||.||..| |..|. | . GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS L---------PAIIQQLKAG--------------ATLKLPHGAP ....|..| .. | ..| NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCP |
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Kinase | RTKA4.AA | RTKF | 385-616 | 36 | 6e-66 | 211.33 | In-house | 1-238 (272) | Show / Hide |
Range on Protein: 385-616 Range on HMM: 1-238/272 Sequence Identity: 36% (86 aa) ITAEHVVGHGHFSKVYQASLLDGAHEPHPVAIKEC-DADKTT-LSAWLREIMLLHSLCDRPDIIGLHGVLLRATGQSTLSVVLEWAPHGNLRDFIRRHP- |. . ..||||| .| .. ||||| ..| .. ||| .. . | || ..|.| | ... |.| |||| .| . .| IMLGEQLGHGHFGRVHHGYWRQQKGQRQPVAIKHIHTQDMMNWRRQMLRECCAMNRVGQHPHIIQFFGILMTPFEQNEMAFVMEFAPHGDMRRYLQQHDV -LSETQLHQALRQ-TVSALAYLAKLEIVHRDVAARNVLVITTNPALVCKLGDFGLSRVMPSS-EYYKSVADSEMPYRWMALECLMERRYSEWSDVWAFGV | .. .| .| .|... . |||||||||||| . | . || |||| || . .|| | . | | |||| | | ||... |||| ||. DLGRAHMLDAAHQVVAEAMVFISRQGLVHRDVAARNVLVFEDQPRMYVKLTDFGLARVLSQHQDYYRSMQNEELPFRWMAPEAIMHRRFTQKSDVWSFGM LVWELVTGGATPWRGLGLPAIIQQLKAGATLKLPHGAP . .||.|.| |. . |...| | ||..| .| MLFELFTRGDVPYGNMPHPVVLQFIRRGKTLQMPDSCP |
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Kinase | RTKA4.AA | Pkinase_Tyr | 385-616 | 31 | 3e-64 | 218.2 | Pfam | 1-242 (270) | Show / Hide |
Range on Protein: 385-616 Range on HMM: 1-242/270 Sequence Identity: 31% (78 aa) ITAEHVVGHGHFSKVYQASLL-DGAHEPHPVAIKEC--DADKTT--LSAWLREIMLLHSLCDRPDIIGLHGVLLRATGQSTLSVVLEWAPHGNLRDFIRR || .. |.|.| .||.. . |. . |||.| . .|.. . . .||. ....|.. | |. |.|| .. ... . .|.| .|||.|.|. |. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK H-----PLSETQLHQALRQTVSALAYLAKLEIVHRDVAARNVLVITTNPALVCKLGDFGLSRVMPSSEYY-KSVADSEMPYRWMALECLMERRYSEWSDV | ||. .| | .| ....||. ..|||.||||.|| .|.| .||||.| . . .|| .. .. .| .|||.||........ ||| HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV WAFGVLVWELVTGGATP-WRGLGLPAIIQQL-KAGATLKLPHGAP |.|||| ||..| |..| . |. ..... . | .. |...| WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCP |
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Kinase | RTKA4.AA | RTKL | 385-616 | 37 | 3.3e-60 | 157.7 | In-house | 1-231 (259) | Show / Hide |
Range on Protein: 385-616 Range on HMM: 1-231/259 Sequence Identity: 37% (91 aa) ITAEHVVGHGHFSKVYQASLLDGAHEPHPVAIKECDADKTTL--SAWLREIMLLHSLCDRPDIIGLHGVLLRATGQSTLSVVLEWAPHGNLRDFIRRH-- . | | | || ||||.. .. | |||| . | |.| .||| | . |.|| .||. . . . ..|| || |||| . | FILENELGRGQFSRVYQARSC-SRMVPTQVAIKIAHEQQSKNQMDAVLYEAVLLHQL-HHPHIIQMHGCTAVPQR---MAMILELAPNGNLREYLRHDDA PLSETQLHQALR---QTVSALAYLAKLEIVHRDVAARNVLVITTNPALVCKLGDFGLSRVMPSS-EYYKSVADSEMPYRWMALECLMERRYSEWSDVWAF | | . . | | | .||||. ..||| |.|||| . | |||| |||||| . .|| . ..|.||| .| | |||||| PSSSWPQRQRLQWLCQVAQALAYIHQRRMIHRDLASRNVLLV---PMMVCKLSDFGLSRRLQNEQDYYRPQQNDHVPFRWMSPETLNGKPHTMASDVWAF GVLVWELVTGGATPWRGLGLPAIIQQLKAGATLKLPHGAP ||. .| .| | |. .. | .. || | || | | GVVCYEVIT-GQVPYADTDMPQVVALLKNEGRLALPAGTP |
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Kinase | RTKA4.AA | UTK | 392-617 | 27 | 2.3e-57 | 194.77 | In-house | 8-269 (296) | Show / Hide |
Range on Protein: 392-617 Range on HMM: 8-269/296 Sequence Identity: 27% (74 aa) GHGHFSKVYQASLLDGA-HEPH-PVAIKECD--ADKTTLSA----WLREI--MLLHSLCD-RPDIIGLHGVLLRATGQSTLSVVLEWAPHGNLRDFIRRH |.|.| |. |.. . . |.. ||.|.|. ||... .. ...| . . . .. .| ...| || .. . . .|.| .. |.||.. ||| GQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP---WMIVTEYMENGDLRSYLRRH PL---------SETQLHQALRQTVSALAYLAKLEIVHRDVAARNVLVITTN----PALVCKLGDFG---LSRVMP---------SSEYYKSVADSEMPYR . ...|. . .. ....||. .||||.||||.|| . .|||..||| .|| .. .|.||.. . ..| | RPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIR WMALECLMER-RYSEWSDVWAFGVLVWELVTGGATPWRGLGLPAIIQQLKAG--ATLKLPHGAPL ||| |.| .. |... ||||.|||..||..|.|..|. |.. .....|. .| . .. |.. |. WMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPH |
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Kinase | RTKA4.AA | TyrKc | 385-618 | 26 | 4.2e-50 | 173.69 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 385-618 Range on HMM: 1-280/280 Sequence Identity: 26% (77 aa) ITAEHVVGHGHFSKVYQASLLDGAHEPHPVAIKECDADKTTLSAWLREIMLLHSL-CDRPDIIGLHGVLLRATGQ----STLSVVLEWAPHGNLRDFIRR || ... |.|.| .||.. . .||.| . .|. . . .||. ....| . | |. |.|| . .. | .|.| .|||.|.|..|. ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK HP--LSETQLHQALRQTVSALAYLAKLEIVHRDVAARNVLVITTNPALVCKLGDFGLSRVMPSS-------EYYKSVA--DSE--MPYRWMALECLMERR | |. .|.. | . .||.. ..||| ||||.|| . ..| .|||||| . .||.. .. .|.||||.||..... HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK YSEWSDVWAFGVLVWELVTGGATPWRG-----LGLPAIIQQLKAGATLKLPHG--------AP--------------------------LI ... ||||.|||. ||. | |..|. | . .|...|.| .. |. .| .. FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | RTKA4.AA | TK-Unique | 385-612 | 28 | 1e-46 | 159.14 | In-house | 1-261 (294) | Show / Hide |
Range on Protein: 385-612 Range on HMM: 1-261/294 Sequence Identity: 28% (77 aa) ITAEHVVGHGHFSKVYQASLLDGA---HEPHPVAIKECD--ADKTTLSAWLREIMLLHSLCDRPDIIGLHGVLLRATGQSTLSVVLEWAPHGNLRDFIR- .. . |.| | |. |. . . . ... ||.| . |..|. .. |.|| .. .| | | |. . |. . . ..|..| |||....| LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD--EPWMIIMEYCPCGNLQHYLRT ------RH--------------------PLSETQLHQALRQTVSALAYLAK--LEIVHRDVAARNVLVITTNPALVCKLGDFGLSR-VMPSSEYYKSVAD .| |.|. .| . . | ....|||. .|||||..|||||. .|||..|||..| |. .| .. CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE---DKVCKICDFGMARDVYTNGVYSMMCSQ SEMPYRWMALECLM--ERRY-SEWSDVWAFGVLVWELVTGGATPWRGLGLPAIIQQLKAGATLKLP ...|.||||.| | .. | .. ||||.|||| ||..| ||.| .|. . |......| ....| GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQP |
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Kinase | RTKA4.AA | Met | 386-590 | 33 | 2.3e-39 | 126.53 | In-house | 1-219 (271) | Show / Hide |
Range on Protein: 386-590 Range on HMM: 1-219/271 Sequence Identity: 33% (74 aa) TAEHVVGHGHFSKVYQASLLDGAHEPHPVAIKECD----ADKTTLSAWLREIMLLHSLCDRPDIIGLHGVLLRATGQSTLSVVLEWAPHGNLRDFIR--R . |.| ||| || . ..|.. . |..|.| | |. ||| .. . | | . | |. |. | . . |||.. || |. ||| HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHF-DHPNVLSLIGICLDPEGHMPW-VVLPYMKHGDLKTFIRNPQ HPLSETQLHQALRQTVSALAYLAKLEIVHRDVAARNVLVITTNPALVCKLGDFGLSRVM-PSSEYYKSVADSE---MPYRWMALECLM--------ERR- . . .| .| |.| . |||| |.|| . .. | .||||.| | ||| | .|||.||| .| NNPCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCML---DEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQ YSEWSDVWAFGVLVWELVTGGATP .. |||| |||. ||| | ||.| FTTKSDVWSFGVVMWELMTRGAPP |
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Kinase | RTKA4.AA | EGFR | 385-612 | 33 | 8.7e-39 | 126.29 | In-house | 1-225 (258) | Show / Hide |
Range on Protein: 385-612 Range on HMM: 1-225/258 Sequence Identity: 33% (79 aa) ITAEHVVGHGHFSKVYQASLL-DGAHEPHPVAIKEC--DADKTTLSAWLREIMLLHSLCDRPDIIGLHGVLLRATGQSTLSVVLEWAPHGNLRDFIRRH- . | | | | .|| .| |||||. .. . |.| . . |. | | .. | || . .|.. .| |.|.| |..| | LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASV-DHPHLVRLLGVCM----HSQMQLVTQYMPYGCLLDYVRQHK -PLSETQLHQALRQTVSALAYLAKLEIVHRDVAARNVLVITTNPALVCKLGDFGLSRVMPSSEYYKSVADSEMPYRWMALECLMERRYSEWSDVWAFGVL . .| | . . || . ..|||| ||||||| . |. | | ||||...... | ... || .||||||. .|.| ||||..|| DNIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKS--PNHV-KITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVT VWELVTGGATPWRGLGLPAIIQQLKAGATLKLP .|||.| |. |. |. . | . |. | |. | CWELMTFGQKPYDGIPAREIPDLLEKGERLPQP |
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Kinase | RTKA4.AA | CTKA | 500-616 | 38 | 1.4e-38 | 127.11 | In-house | 146-262 (290) | Show / Hide |
Range on Protein: 500-616 Range on HMM: 146-262/290 Sequence Identity: 38% (46 aa) YLAKLEIVHRDVAARNVLVITTNPALVCKLGDFGLSRVMPSS-EYYKSVADSEMPYRWMALECLMERRYSEWSDVWAFGVLVWELVTGGATPWRGLGLPA ||| . .|||| |.||.|. . . |. |||..| . || . . || |||| | | . ..| |||||||||.||. ..| .|||.. YLAEMGFVHRDLACRNCLLGQYC---HIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQE IIQQLKAG--ATLKLPHGAP . | .. |..| .| VCQAYTSHGMRRLPVPRNCP |
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Kinase | RTKA4.AA | HMTK | 492-606 | 34 | 1.5e-31 | 107.34 | In-house | 135-252 (291) | Show / Hide |
Range on Protein: 492-606 Range on HMM: 135-252/291 Sequence Identity: 34% (42 aa) RQTVSALAYLAKLEIVHRDVAARNVLVITTNPALVCKLGDFGLSRVMP-SSEYYKSVADS-EMPYRWMALECLM--ERRYSEWSDVWAFGVLVWELVTGG .|. |..||.|. ||.|.||||.|| | ..|..||||.| .. |... . .| .||| |.. ... || ||||||||..||... | VQCASGMAYIASQRMVHMDLAARNCLVGHNN---QVKIADFGLTRRLDPGQDYWHLRKHMVKLPIKWMAPEAMDGKRKIFSEKSDVWAFGVTMWEIWMYG ATPWR--GLGLPAIIQQLKAG ..|. .. . .. ....| EQPYESQQIKNKEVQRHVREG |
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Kinase | RTKA4.AA | S_TKc | 385-618 | 20 | 1.7e-28 | 101.9 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 385-618 Range on HMM: 1-231/231 Sequence Identity: 20% (56 aa) ITAEHVVGHGHFSKVYQASLLDGAHEPHPVAIKECDADKTTLSAWLREIMLLHSLCDRPDIIGLHGVLLRATGQSTLSVVLEWAPH--GNLRDFIRRHP- . ..|.| |.|||.. . . ||||. . .||| .|.. . | |. |..| . | .|.| ... |.|.|.|.... YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGR ------LSETQLHQALRQTVSALAYLAKLEIVHRDVAARNVLVITTNPALVCKLGDFGLSRVMPSSEYYKSVADSEMPYRWMALECLMERRYSE-WSDVW ..| . ..|...||.|. .. |.|||. |.|. . . |..||||.|.. .|| | | |. .|.| HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWW AFGVLVWELVTGGATPWRGLGLPAIIQQLKAGATLK---------LPH--------G-------APLI ..|....|... | .|.. . ....... .| | | . SCGCILYEMLC-GYPPFP--QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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Kinase | RTKA4.AA | Pkinase | 385-593 | 20 | 1.5e-26 | 94.98 | Pfam | 1-214 (293) | Show / Hide |
Range on Protein: 385-593 Range on HMM: 1-214/293 Sequence Identity: 20% (48 aa) ITAEHVVGHGHFSKVYQASLLDGAHEPHPVAIKECDADKTTLSAW---LR--EIMLLHSLCDRPDIIGLHGVLLRATGQSTLSVVLEWAPHG----NLRD .. . ..| | |..||.. . . ||.|. . ... . . .| || ....| . | |. |... . . . .|.|....| | | YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED---KDHIYMVMEYCEGGLYVMDLFD FIR---RHPL--SETQLHQALRQTVSALAYLAKLEIVHRDVAARNVLVITTNPALVC----KLGDFGLSRV--MPSSEYYKSVADSEMPYRWMALECLM- .|. . .. || .. ..|....|.|. . |.|||. |.|. . .. |..||||... ... ..... . ...|| | .. YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI---DNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGT---PWYMAPEVIRG ERRYSEWSDVWAFGVLVWELVTGGATPWRG . |. .|.|..|....|...| .|..| GQYYGPKVDMWSCGCILYEMLCGR-PPFPG |
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Kinase | RTKA4.AA | HMTK | 385-417 | 24 | 0.000257 | 11.07 | In-house | 1-57 (291) | Show / Hide |
Range on Protein: 385-417 Range on HMM: 1-57/291 Sequence Identity: 24% (14 aa) ITAEHVVGHGHFS-----------------KVYQASLL-------DGAHEPHPVAIK ..| | |.|.| ||| | . |.. .||..| | LKAIKVIGAGQFGMVQCLRLAPPDEGCTSLKVYLAEWSVKDGDGKDDSNQPHHRAVK |