Gene UTK12 (M.brevicollis)
UTK12
Species: M.brevicollis
Alias: UTK12
External Links:
Annotation:
Sequence
Protein domains of UTK12.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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ANF_receptor | UTK12.AA | ANF_receptor | 50-153 | 22 | 2.2e-08 | 30.49 | Pfam | 1-106 (364) | Show / Hide |
Range on Protein: 50-153 Range on HMM: 1-106/364 Sequence Identity: 22% (26 aa) QTEFAYRAALDYFST----VDPSVQFETIYQESSTTVNKSAAIRCT-----ETAQALVAND-VHLVIGPSTSSCSMPGATVFAEAGIAQISDSATAEAFD | . | | |.... .| . .. ..... . |. |. ... . | .||||.|. ..| | . ....| .|| ..|..... QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCY---------CSDCQAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLT N--TTRFPTFFRVSPS . .|.|.|||. || DKAKNRYPYFFRTVPS |
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ANF_receptor | UTK12.AA | ANF_receptor | 156-238 | 18 | 1.900063 | 2.45 | Pfam | 134-229 (364) | Show / Hide |
Range on Protein: 156-238 Range on HMM: 134-229/364 Sequence Identity: 18% (18 aa) DDTW--ALGL---SRTVIATLREHNVTVSNV-IHVASGVSSDIMYAAIEQLRA---GETSVNYILALRDDA----VRIMESAVALDMVGNGWTWLG ||.. |. ... .||||.... .. . ..| . ... ... .. | .. . ||. .||. |. | | . |. |.. DDDYYYWRGGCYFMEAFQDELREHGGNCVYYAYVSMVIPWDDDFMDYLKKIKDIIKMKARVIVMCCYPDDMGLLQRQIMQQAHELGMMSGGYVWIY |
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Kinase | UTK12.AA | UTK | 347-612 | 32 | 9.69999999999e-119 | 400.77 | In-house | 3-296 (296) | Show / Hide |
Range on Protein: 347-612 Range on HMM: 3-296/296 Sequence Identity: 32% (97 aa) QTELTRFARLGDISNMELVKCANHMLLARRALHAGSGIHGPARSSPCGSG-----EAA---FMAQLD-HPHLLKLIGIVSLGQPLMLVTKYYANGSLDAF . ..... . |.........|..||.....|... . |..|. .|.. . ||. .|.|.. ||..|.|.|... ..|.|.|| |..||.|... LGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ-HHADAQQEPEP-YPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY LRRHHDTTG---LKFSLASKLHLANDVADAMVYLSSRKLIHCDIACRNVLVSASG-------DCALADFG---LSRNSN--------------YSAVDRP ||||..|.. . ..| ..|. |.|.|..| ||.|....|.|.|.||.|| ... .|..|||| .||. | ....... LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR VPVKWTAPEALIDG-KFTIASDVWSFGILLVELMANGNTPYPGMSNESVRVAICAGGYKYVTNLSAGHPRLPEVPLEVYQLMLDCWAYSPEDRPDFPTIR .|..|.|||||... .||..|||||||... |....|..|||||||. | ...|.||. . .|. ...|..||.||..||.|.|..||||.... WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGR-------YRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLV AEL ... QQM |
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Kinase | UTK12.AA | TK | 394-612 | 21 | 2.7e-82 | 275.58 | In-house | 81-486 (486) | Show / Hide |
Range on Protein: 394-612 Range on HMM: 81-486/486 Sequence Identity: 21% (87 aa) GSG-----EAAFMAQLD-----HPHLLKLIGIVSLG------------QPLMLVTKYYANGS----LDAFLRRHHDTTGL-------------------- | | ||. |.... ||....|.|... | .|.|.|. | ..|. |. .||...... G-GEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHC ---------------------------------------------------KFSLASKLHLANDVADAMVYLSSR------KLIHCDIACRNVLVSASGD ..... .| . ..|..| ||.|. ...| |.|.||.||. .. MKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNV -----------CALADFGLSRN------------SNYSAVD-------------------------RPVPVKWTAPEALI---------DGKFTIASDVW | .|||||||. ..| ... . .|..|.|||.| .||||..|||| CKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVW SFGILLVELMANGNTPYPG-MSN---------ESVRVAICAG-----------GYKYVTNLSAGHP-----RLPEVP-----LEVYQLMLDCWAYSPEDR |||.|. |.. .| .||.| ||| . | ...| ||.. .. | | | |.|.||..||.| |||| SFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDR PDFPTIRAEL |.| ... .| PTFSQLHEQL |
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Kinase | UTK12.AA | Pkinase_Tyr | 397-612 | 37 | 2.8e-82 | 279.29 | Pfam | 53-270 (270) | Show / Hide |
Range on Protein: 397-612 Range on HMM: 53-270/270 Sequence Identity: 37% (86 aa) EAAFMAQL-DHPHLLKLIGIVS-LGQP--LMLVTKYYANGSLDAFLRRHHDTTGLKFSLASKLHLANDVADAMVYLSSRKLIHCDIACRNVLVSASGDCA ||. | || .||....|.|... |.| ...|. | ..|.|. .||.| . . .... .|. . ..|..| ||.|...|| |.|.||.||. .. . EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR-EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK LADFGLSRNS----NY--SAVDRPVPVKWTAPEALIDGKFTIASDVWSFGILLVELMANGNTP-YPGMSNESVRVAI-CAGGYKYVTNLSAGHPRLPEVP .||||.| .| .. . ..|.||.|||.. .||||..|||||||.|. |.. | .| ||||||| | .| |. |. . | ICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR---------MPCPENCP LEVYQLMLDCWAYSPEDRPDFPTIRAEL |.|.||..||.| ||||| | |. .| DEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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Kinase | UTK12.AA | Src | 397-612 | 40 | 3e-66 | 224.07 | In-house | 44-255 (255) | Show / Hide |
Range on Protein: 397-612 Range on HMM: 44-255/255 Sequence Identity: 40% (90 aa) EAAFMAQLDHPHLLKLIGIVSLGQPLMLVTKYYANGSLDAFLRRHHDTTGLKFSLASKLHLANDVADAMVYLSSRKLIHCDIACRNVLVSASGDCALADF || | .|.|..|..| ..| . | || | ..||| ..|.. |..| . .| . .| ||. | ||.|...|| | | |||||. . | ||| EAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK--DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADF GLSRNSN-----Y-SAVDRPVPVKWTAPEALIDGKFTIASDVWSFGILLVELMANGNTPYPGMSNESVRVAICAGGYKYVTNLSAGHPRLPEVPLEVYQ- || | | . . .|.|||||||. |.||| |||||||||| |.. | .|||||.|. | .. .| |. |. ...| |.|. GLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERG-YRM--------PCPHNCPDELYEQ LMLDCWAYSPEDRPDFPTIRAEL .|| || .||.|| | ... | IMLQCWHKDPEQRPTFEYLQWFL |
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TyrKc | UTK12.AA | TyrKc | 316-612 | 25 | 3.8e-62 | 213.7 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 316-612 Range on HMM: 1-280/280 Sequence Identity: 25% (85 aa) FKTIGTADNGTLLVVLLFYYIRSRNSKPYDFQTELTRFARLGDISNMELVKCANHMLLARRALHAGSGIHGPARSSPCGSGEAAFMAQL--DHPHLLKLI . . . .| .| . .. . ||. .. |.... || | .| .||....|. ITLGKKLGEGAFGEVYKGTWK------------------------IQVAVKMLKEDA--REDFMR----------------EARIMCKLGGHHPNIVRLY GIVSLG-------QPLMLVTKYYANGSLDAFLRRHHDTTGLKFSLASKLHLANDVADAMVYLSSRKLIHCDIACRNVLVSASGDCALADFGLSRNS---- |... . .|||.|. | ..|.|. .||.|... .... .|. . ..|. | ||.|...|| |.|.||.||.. . . .||||||. GVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDD -------NYSA----VDR-PVPVKWTAPEALIDGKFTIASDVWSFGILLVELMANGNTPYPG-----MSNESVRVAICAGGYKYVTNL-----SAGHPRL |.. . ..|..|.|||.. .||||..|||||||... |.. .| .|||| |||. |. . .|.. . QQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF------ PEVPLEVYQLMLDCWAYSPEDRPDFPTIRAEL .. | |.||.|..||.. ||||| | .|. .. VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | UTK12.AA | Eph | 396-612 | 40 | 1.8e-59 | 198.4 | In-house | 53-264 (264) | Show / Hide |
Range on Protein: 396-612 Range on HMM: 53-264/264 Sequence Identity: 40% (92 aa) GEAAFMAQLDHPHLLKLIGIVSLGQPLMLVTKYYANGSLDAFLRRHHDTTGLKFSLASKLHLANDVADAMVYLSSRKLIHCDIACRNVLVSASGDCALAD .||. | | |||. ..| |.|. ..|.| || | .|||||.|||.| . .|. . . . .| .| |||. .| | | ||.||.. | .| SEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG----QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSD FGLSR--------NSNYSAVDRPVPVKWTAPEALIDGKFTIASDVWSFGILLVELMANGNTPYPGMSNESVRVAICAGGYKYVTNLSAGHPRLP---EVP ||||| . | .|..||||||. .||| ||||||.||.. | |. | || ||| | || || ||| . | FGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEQ-GY-----------RLPPPMDCP LEVYQLMLDCWAYSPEDRPDFPTIRAEL .|||||||.. ...|| | .| . | EALHQLMLDCWQKDRNHRPHFQQIVSIL |
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Kinase | UTK12.AA | SRM | 401-613 | 39 | 8.5e-57 | 188.45 | In-house | 49-253 (253) | Show / Hide |
Range on Protein: 401-613 Range on HMM: 49-253/253 Sequence Identity: 39% (85 aa) MAQLDHPHLLKLIGIVSLGQPLMLVTKYYANGSLDAFLRRHHDTTGLKFSLASKLHLANDVADAMVYLSSRKLIHCDIACRNVLVSASGDCALADFGLSR | .| | |...| ..|.| | .| . |.| ..|| | . .. | .| || | || ... || | | ||||| | .|||| | MKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLR---DSDEKALPIPHLLDFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLAR ---NSNY-SAVDRPVPVKWTAPEALIDGKFTIASDVWSFGILLVELMANGNTPYPGMSNESVRVAICAGGYKYVTNLSAGHPRLPEVPLEVYQLMLDCWA . | | .|.|||||||. . . . |||||||||| |. | |||||.| | . || |. | | ||. |||.|| LIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYPGMTNHETFQQIDR-GYRM--------PCPAECPPEVHKLMLECWC YSPEDRPDFPTIRAELT .||.|| | . | || RDPEQRPCFKDLREKLT |
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Kinase | UTK12.AA | RTKD | 397-614 | 34 | 2.3e-55 | 186.46 | In-house | 52-262 (262) | Show / Hide |
Range on Protein: 397-614 Range on HMM: 52-262/262 Sequence Identity: 34% (77 aa) EAAFMAQLDHPHLLKLIGIVSLGQPLMLVTKYYANGSLDAFLRRH-HDTTGLKFSLASKLHLANDVADAMVYLSSRKLIHCDIACRNVLVSASGDCALAD |||||||. |.. | |.| || ..| | |||.|.|| |. . . . .| ||| . ||. | .| ||| ||.|.. ..| EAAFMAQFNHDNIVRLHGVVTTNQPHIMVMEYCEHGSLQAYLRENGEDMD-----NQHRFRMARDVAMGLAYLHFRGCCHRDIAARNILLDSNYRAKIGD FGLSR------NSNYSAVDRPVPVKWTAPEALIDGKFTIASDVWSFGILLVELMANGNTPYPGMSNESVRVAICAGGYKYVTNLSAGHPRLPEVPLEVYQ |||.| . | . .. .|| | |||.| . || |||||| .... | .. || .|.|. | . ..|| .| . | .... FGLTRQQANGDSEYYISHGQAIPVRWCAPEVLEEHKFSQASDVWSWAVFVYEIWTQAQLPYRDMHNQKVWHYV-IQGYRL--------TRPMQCPRDIWA LMLDCWAYSPEDRPDFPTIRAELTR || |||| |..|| . . .| LMMDCWAEDPKERPRMCQVVDQMTK |
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Kinase | UTK12.AA | Fer | 397-613 | 32 | 6.2e-54 | 182.08 | In-house | 58-283 (283) | Show / Hide |
Range on Protein: 397-613 Range on HMM: 58-283/283 Sequence Identity: 32% (76 aa) EAAFMAQ-LDHPHLLKLIGIVSLGQPLMLVTKYYANGSLDAFLRRHHDTTGLKFSLASKLHLANDVADAMVYLSSRKLIHCDIACRNVLVSA-SGDCA-- || .| . .|||. |..|. .. ||.|.| . .|||| .|. .. |.. |. . ..|. | || |.. || ||| ||.|... . EARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYLKKNKNK---TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCK LADFGLSRNS---NYSAVDRP----VPVKWTAPEALIDGKFTIASDVWSFGILLVELMANGNTPYPG----MSNESVR-VAICAGGYKYVTNLSAGHPRL ..|||.||. |. ... ||..|.|||.. .| .. ..||||||... | ..|| .|||| | . |. |. | ... .| ISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQAR-----KWIIKKGYMMPMP PEVPLEVYQLML-DCWAYSPEDRPDFPTIRAELT ...| |..|.|. .||.. ||||| . .|. .| NHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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Kinase | UTK12.AA | SrcB | 396-613 | 38 | 1.1e-52 | 176.48 | In-house | 43-251 (251) | Show / Hide |
Range on Protein: 396-613 Range on HMM: 43-251/251 Sequence Identity: 38% (86 aa) GEAAFMAQLDHPHLLKLIGIVSLGQPLMLVTKYYANGSLDAFLRRHHDTTGLKFSLASKLHLANDVADAMVYLSSRKLIHCDIACRNVLVSASGDCALAD .|| | .| | .| .| .|. |. ..| | |.|.| ||. | | || . .. .|. | |. . || |. |.|||.. | .|| AEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDE---GSKLSLPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIAD FGLSR--NS-NYSAVD-RPVPVKWTAPEALIDGKFTIASDVWSFGILLVELMANGNTPYPGMSNESVRVAICAGGYKYVTNLSAGHPRLPEVPLEVYQLM ||| | .. | | . |.|||||||. | ||| ||||||||||.|.. | |||||.| | .. ||. || . | |.|..| FGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGMTNPEVIRNLER-GYRM--------PRPDNCPEELYNIM LDCWAYSPEDRPDFPTIRAELT || ||.|| | ... | MMCWKERPEERPTFDYLQSVLD |
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Kinase | UTK12.AA | TK-Unique | 397-612 | 30 | 1.7e-52 | 179.33 | In-house | 53-294 (294) | Show / Hide |
Range on Protein: 397-612 Range on HMM: 53-294/294 Sequence Identity: 30% (76 aa) EAAFMAQLD-HPHLLKLIGIVSLGQ-PLMLVTKYYANGSLDAFLRRHHDT--TG-----LK--------------FSLASKLHLANDVADAMVYLSS--R |...| .|. ||......|. . | |.. |...|.|. .||. .. .. || |. . .| | ..| .| ||.| . EIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRK KLIHCDIACRNVLVSASGDCALADFGLSR----NSNYSAVDR--PVPVKWTAPEALI--DGKF-TIASDVWSFGILLVELMANGNTPYPGMSNESVRVAI | .| |.. ||||.. . | ..|||..| | || .. ..|..| |||.| .| . |. |||||||.|. |.. .| .|||||.... KIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD----- CAGGYKYVTNLSAGH--PRLPEV-PLEVYQLMLDCWAYSPEDRPDFPTIRAEL .... .|. |. ... . |.|.|| || ..||.||.| .|. .| ------IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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Kinase | UTK12.AA | Frk | 397-616 | 38 | 1.8e-52 | 180.05 | In-house | 44-260 (260) | Show / Hide |
Range on Protein: 397-616 Range on HMM: 44-260/260 Sequence Identity: 38% (88 aa) EAAFMAQLDHPHLLKLIGIVSLGQPLMLVTKYYANGSLDAFLRRHHDTTGLKFSLASKLHLANDVADAMVYLSSRKLIHCDIACRNVLVSASGDCALADF || | .| || |..| . . .|....| .||| .|. | .| . . . .| || | || |. || |.| ||||| . | .||| EAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAIND-KGRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADF GLSR---NSNY----SAVDRPVPVKWTAPEALIDGKFTIASDVWSFGILLVELMANGNTPYPGMSNESVRVAICAGGYKYVTNLSAGHPRLPEVPLEVYQ || | | | .. .|.||||||| |||| |||||||||| |.. | ||||| | | . . . ||. |. |. | ..|. GLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEV-LQMVDHGYRM--------PQPPNCPQQLYE LMLDCWAYSPEDRPDFPTIRAELTRLE .||.|| |. || | |.. | IMLECWHSDPMKRPTFETLQWKLEDYF |
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Kinase | UTK12.AA | Pkinase | 397-612 | 18 | 3.4e-21 | 76.04 | Pfam | 50-293 (293) | Show / Hide |
Range on Protein: 397-612 Range on HMM: 50-293/293 Sequence Identity: 18% (47 aa) EAAFMAQLDHPHLLKLIGIVSLGQPLMLVTKYYANG----SLDAFLRRHHDTTGLKF--SLASKLHLANDVADAMVYLSSRKLIHCDIACRNVLVSASGD |.. |. |.||. ..|.... .. . .|. | .| .| ..... . .| | . . .. .. |. |.. ||.|. |.|.. |. EIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGH C----ALADFGLSR---NSNYSAVDRPVPVKWTAPEALI-DGKFTIASDVWSFGILLVELMANGNTPYPGM----SNESVRVAICAGGY-KYVTNLSAGH . ..||||.. . |.|. .. . . ||| . . . . ..|.||.|..| |.. |..|.|| . . .. || .. .. . . . IDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWC PRL-------------PEVPLEVYQLMLDCWAYSPEDRPDFPTIRAE--L .. .... | ... .|... |..|| .. | . SISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | UTK12.AA | S_TKc | 348-615 | 17 | 7.4e-16 | 55.6 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 348-615 Range on HMM: 1-231/231 Sequence Identity: 17% (49 aa) TELTRFARLGDISNMELVKCAN-HMLLARRALHAGSGIHGPARSSPCGSGEAAFMAQLDHPHLLKLIGIVSLGQPLMLVTKYYAN--GSLDAFLRRHHD- |. | | . ... . . . | .. | . . . .||.. ||... . | .|. | . |.| ..... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH TTGLKFSLASKLHLANDVADAMVYLSSRKLIHCDIACRNVLVSASGDCALADFGLSRNSNYSAVDRPVPVKWTAPEALIDGKFTI-ASDVWSFGILLVEL .. .|. ... ...|. |. |.. ||.|. |.|.. ..||||.| . . ||| | ... ..|.||.|..| |. GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM MANGNTPYPGMSNESVRVAICAGGYKYVTNLSAGHPRLPEVPLEVYQLMLDCWAYSPEDRPDFPTIRA-E-----LTRL .. | .|.| . . . | . |. ... |. . ||.|| . . | . LC-GYPPFP-----QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |