Gene RTKE1 (M.brevicollis)
RTKE1
Species: M.brevicollis
Alias: RTKE1
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
RTKE1.AA | Protein | None | 1344 | None | Fasta, JSON |
RTKE1.kin_dom | Protein Kinase Domain | None | 272 | None | Fasta, JSON |
RTKE1.kin_dom2 | Protein Kinase Domain | None | 246 | None | Fasta, JSON |
Protein domains of RTKE1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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LDLa | RTKE1.AA | LDLa | 306-341 | 27 | 1.4e-05 | 24.15 | SMART | 1-47 (47) | Show / Hide |
Range on Protein: 306-341 Range on HMM: 1-47/47 Sequence Identity: 27% (13 aa) AVA------MTCPDASAQISSWQYCDGQQDCADGWDE------HDCSQ . .|.. |.... |||. ||.|| || .|.| TCPPDHPNQFQCGNGR-CIPKSWVCDGDNDCGDGSDEWPFFDPENCPQ |
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Kinase | RTKE1.AA | RTKE | 568-816 | 29 | 5.3e-136 | 458.12 | In-house | 1-293 (293) | Show / Hide |
Range on Protein: 568-816 Range on HMM: 1-293/293 Sequence Identity: 29% (86 aa) QHYMLAATSPTMHV------------------------ALALPRTTATVEEEHAVLSALVEARILLTMKDHPNVLHLVNVIHERQNIMLVYEPARLGVLS . |.|..|..... ..............|......|..........||||.||..|....|..|.|||....|.|. LTFMRALGSGEFGEVWLMTMPNHAHSPNYSKETISSEQQRSTRQVAVKTLHNHECHHEFVQEMTMMCKLHHPNVVHLLHVVQMKQHFMMVYEYMPGGQLE QALSST--SVSREQQQAICG-QVASACSYLESLGIVHRNLGAHSVYACQSIDDVRLAGFVMAKDVYLTQEYVATVSKGRAKLTPD-----RYFWSPEVWR ..|... .......|..|. |||...|.||.||||||.|.||.||.|....||..|......|.||.|||.............. |..|.||||. DWLQDHHGRPTSHEDQIHCLHQVACGMSFLERLGIVHRDLCAHNVYCCRCWNDVKVADYGLSRDMYLGQEYMQCYYRIKTRRWMPTTWGSRRWWAPEVWK DSVFSFKSDVYAFGRFCWQVCHGGQIPYADMSPTNFVQQSVNGSLP------------DLPPTENEFLEDLIKSCTQLAVKARPTFATLAAAL |..|||||||.|.|..||.|...||.|||.|....|.|..|....| ..|.........|...|.......||.||.|.... DQHFSFKSDVWAYGCLCWEVWNNGQMPYAHMDDQQFMQRIVQCQMPSGGHLGDHEPVHAPPVHCPPWADRLMQWCLCINPEHRPNFAQLYQMW |
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Kinase | RTKE1.AA | TK | 604-816 | 15 | 6e-47 | 154.97 | In-house | 88-486 (486) | Show / Hide |
Range on Protein: 604-816 Range on HMM: 88-486/486 Sequence Identity: 15% (63 aa) EARILLTMKD----HPNVLHLVNVIHERQN------------IMLVYEPARLGV----LSQALSSTS--------------------------------- ||... |. |||...|. |... .. .|.| | . .| | . | . . EAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYS --------------------------------------------VSREQQQAICGQVASACSYLESL------GIVHRNLGAHSVYACQSIDD------- .. .|. .| |.|....||.|. ..|||.| |. . ... . HESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGC ---VRLAGFV--------MAKDVYLTQEYVATVSKGRAKLTPD--------------------RYFWSPEVWRDSV---------FSFKSDVYAFGRFCW ...| | .|.|.| ..|... |.|.... . .||...| | |. ||||..|| ..| GPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMW QVCHGG-QIPYADMSP---------TNFVQQSVNG--------------SLPDLPPTEN--------------EFLEDLIKSCTQLAVKARPTFATLAAA .. | . .| .|| . .... ..| . || |...||...| .. . ||||..| . EIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQ L | L |
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Kinase | RTKE1.AA | UTK | 576-816 | 23 | 2.9e-30 | 100.75 | In-house | 27-296 (296) | Show / Hide |
Range on Protein: 576-816 Range on HMM: 27-296/296 Sequence Identity: 23% (66 aa) SPTMHVALALPRTTATVEEEHA-VLSA--LVEAR---ILLTMKDHPNVLHLVNVIHERQNIMLVYEPARLGVLSQALS----STS-----VSREQQQAIC ...|.||. ...|. . |.. . . ||| .. . ||||| || | . .|.|.| .. | |.. | .. .. .|. . MYEMDVAVKVCQHHADAQQEPEPY--PDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMA GQVASACSYLESLGIVHRNLGAHSVYACQS------IDDVRLAGFV---MAKDVY---------LTQEYVATVSKG-----RAKLTPDRYFWSPEVWRDS ..|.. .||.| |.|||.| | .. ... ....|.| |...|. ...| |.. . | ||. . WDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMA----------PEALTHH -VFSFKSDVYAFGRFCWQVCHGGQIPYADMSPTNFVQQSVNG--SLPDLPPTENEFLEDLIKSCTQLAVKARPTFATLAAAL |..||||..|| .|| ....|. ||..|| . ..| .|| .. |. . . .| ..| . . ||.| .| ... TRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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Kinase | RTKE1.AA | TK-Unique | 604-816 | 23 | 3.9e-19 | 62.72 | In-house | 53-294 (294) | Show / Hide |
Range on Protein: 604-816 Range on HMM: 53-294/294 Sequence Identity: 23% (59 aa) EARILLTMKDHPNVLHLVNVIHERQ-NIMLVYEPARLGVLSQALSSTS---------------------------VSREQQQAICGQVASACSYLES--L |.... .||||..... . . . . |...|... | | | .. .| .. .. |.|.. .||.| EIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRK GIVHRNLGAHSVYACQSIDDVRLAGFVMAKDVYLTQEYVATVSKGRAKLTPDRYFWSPEVWR--DSVF-SFKSDVYAFGRFCWQVCHGGQIPYADMSPTN .||||.| |. | .. . ...| ||.||| ...|. . |.|| .| |. .||. . . .. . ||||..|| . | .. |. || .|.... KIVHRDLCARNV-LLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR---IPIRWM-APESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD FVQQSVNGSLPDLPPTE-NEFLEDLIKSCTQLAVKARPTFATLAAAL .... .|. ...|. .. . |.|||.|. . ||.|.... | IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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Kinase | RTKE1.AA | Fer | 730-817 | 25 | 6e-17 | 54.35 | In-house | 186-283 (283) | Show / Hide |
Range on Protein: 730-817 Range on HMM: 186-283/283 Sequence Identity: 25% (25 aa) SPEVWRDSVFSFKSDVYAFGRFCWQVCHGGQIPYAD----MSPTNF----VQQSVN-GSLPDLPPTENEFLEDLIK-SCTQLAVKARPTFATLAAALW .||.|.. ..|.|.||..|| || ... |. ||.. | .|| ... .. | . .|. ... ... .| | . . |||.... | APETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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Kinase | RTKE1.AA | Frk | 602-820 | 26 | 1.5e-16 | 53.56 | In-house | 42-260 (260) | Show / Hide |
Range on Protein: 602-820 Range on HMM: 42-260/260 Sequence Identity: 26% (60 aa) LVEARILLTMKDHPNVLHLVNVIHERQNIMLVYEPARLGVLSQALS-----STSVSREQQQAICGQVASACSYLESLGIVHRNLGAHSVYACQSIDDVRL | ||.|. .. || ...| | . |... | | | | . | .. .|. . |||. |||| .|| | | | .. ... LREAQIMKKLR-HPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHN-ICKI AGFVMAKDVYLTQE--YVATVSKGRAKLTPDRYFWSPEVWRDSVFSFKSDVYAFGRFCWQVCHGGQIPYADMSPTNFVQQSVNGSLPDLPPTENEFLEDL | | .|. . .| | . . |.. | .. || . . |. ||||..|| . |..||. | . .|. .| || .. | .. ADFGLARVLMKDNEDIYESRH---GARF-PIKWT-APEAANYNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEI IKSCTQLAVKARPTFATLAAALWEDD . | . . |||| || | . MLECWHSDPMKRPTFETLQWKLEDYF |
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TyrKc | RTKE1.AA | TyrKc | 558-816 | 21 | 2.4e-16 | 41.71 | SMART | 4-280 (280) | Show / Hide |
Range on Protein: 558-816 Range on HMM: 4-280/280 Sequence Identity: 21% (64 aa) TRVLEHQPFAQHYMLAATSPTMHVALALPRTTATVEEEHAVLSALVEARILLTM-KDHPNVLHLVNVIHER-------QNIMLVYEPARLGVLSQALSST ..| . | . | .. . || . | . . ||||. ..|||.. |. |. . . .|.| | . .| | . | .. GKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH S--VSREQQQAICGQVASACSYLESLGIVHRNLGA------HSVYACQSIDDVRLAGFVMAKDVYLT-------QEYVATV-SKGRAKLTPDRYFW-SPE .. .. .| |.|. ..||.| ...|| | | . |. . | ...|.| . |... . |.. | . | .|| RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP---IRWMAPE VWRDSVFSFKSDVYAFGRFCWQVCHGGQIPYAD-----MSPTNFVQQSVNGSLPDLPPT--------ENEFLEDLIKSCTQLAVKARPTFATLAAAL ......|..||||..|| .| .. || || . ||.. ... .| .. || . . ...|.| . . ||||... . CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | RTKE1.AA | Pkinase_Tyr | 730-816 | 29 | 3.2e-14 | 48.8 | Pfam | 182-270 (270) | Show / Hide |
Range on Protein: 730-816 Range on HMM: 182-270/270 Sequence Identity: 29% (26 aa) SPEVWRDSVFSFKSDVYAFGRFCWQVCHGGQIP-YADMSPTNFVQQS-VNGSLPDLPPTENEFLEDLIKSCTQLAVKARPTFATLAAAL .||......|. ||||..|| .| .. |..| |..||.. .... .| . |. . . ||.|.| . . ||||. . | APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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Kinase | RTKE1.AA | CTKA | 730-816 | 31 | 1.3e-11 | 35.18 | In-house | 202-290 (290) | Show / Hide |
Range on Protein: 730-816 Range on HMM: 202-290/290 Sequence Identity: 31% (28 aa) SPEVWRDSVFSFKSDVYAFGRFCWQVCHGGQIPYADMSPTNFVQQSVNG---SLPDLPPTENEFLEDLIKSCTQLAVKARPTFATLAAAL .|| . || |||.||| | . .| |.. || .| . || .|.. . | . . | . . ..||||.|| | APEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRLP-VPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML |
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Kinase | RTKE1.AA | TKL | 730-816 | 19 | 2.4e-09 | 29.82 | In-house | 241-364 (364) | Show / Hide |
Range on Protein: 730-816 Range on HMM: 241-364/364 Sequence Identity: 19% (24 aa) SPEVWRDS----------------VFSFKSDVYAFGRFCWQVCHGGQIPYA--DMSPTNFV-------QQSVNGSLPDLPPT----------ENEF---L .||| |.. .| |.|||.|| | .. . . ||. ...| | . .. .|. ..|. .. . . APEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSM EDLIKSCTQLAVKARPTFATLAAAL .|.. | . ..||.| .. | KKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | RTKE1.AA | Src | 731-816 | 29 | 1.1e-07 | 22.07 | In-house | 169-255 (255) | Show / Hide |
Range on Protein: 731-816 Range on HMM: 169-255/255 Sequence Identity: 29% (26 aa) PEVWRDSVFSFKSDVYAFGRFCWQVCHGGQIPYADMSPTNFVQQSVNG-SLPDLPPTENEFLEDLIKSCTQLAVKARPTFATLAAAL || . .|. |||| || . . |..|| |. .|| .| .| . |. |.... | . . ||||..| | PEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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Kinase | RTKE1.AA | Pkinase_Tyr | 604-680 | 28 | 2.3e-07 | 25.59 | Pfam | 53-137 (270) | Show / Hide |
Range on Protein: 604-680 Range on HMM: 53-137/270 Sequence Identity: 28% (24 aa) EARILLTMKDHPNVLHLVNVIH-ERQN--IMLVYEPARLGVLSQALSST-----SVSREQQQAICGQVASACSYLESLGIVHRNL ||.|. .. .|||.. |. |. ... |..| | . .| | | . ... .. .| |.|....|||| ...|| | EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL |
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Kinase | RTKE1.AA | Pkinase | 600-678 | 22 | 2.7e-07 | 26.9 | Pfam | 44-132 (293) | Show / Hide |
Range on Protein: 600-678 Range on HMM: 44-132/293 Sequence Identity: 22% (20 aa) SALV--EARILLTMKDHPNVLHLVNVIHERQNIMLVYEPARLG----VLSQALS---STSV--SREQQQAICGQVASACSYLESLGIVHR ... |..|.. . .|||.. | . .....| .| | .. | |. .| .... | .. . .. |.... |. | ||.|| THRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHR |
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Kinase | RTKE1.AA | DDR | 604-680 | 27 | 4e-06 | 17.26 | In-house | 63-160 (306) | Show / Hide |
Range on Protein: 604-680 Range on HMM: 63-160/306 Sequence Identity: 27% (27 aa) EARILLTMKDHPNVLHLVNVIHERQNIMLVYEPARL-GVLSQALSSTS--------------------VSREQQQAICGQVASACSYLESLGIVHRNL |..... | |||. .|| | . . .. | | | | .. .| |. || |.||. ||||. .||| | EIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLGDLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDL |
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Kinase | RTKE1.AA | Fer | 602-678 | 35 | 1.1e-05 | 15.4 | In-house | 56-135 (283) | Show / Hide |
Range on Protein: 602-678 Range on HMM: 56-135/283 Sequence Identity: 35% (28 aa) LVEARILLTMKDHPNVLHLVNVIHERQNIMLVYEPARLGVLSQALSSTS---VSREQQQAICGQVASACSYLESLGIVHR . ||||... ||||| . |.. .| ||.| | . | | .| .. || . .| |.|. ||.| ...|| MHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHR |
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Kinase | RTKE1.AA | TKL | 602-680 | 16 | 0.000522 | 10.34 | In-house | 72-166 (364) | Show / Hide |
Range on Protein: 602-680 Range on HMM: 72-166/364 Sequence Identity: 16% (17 aa) LVEARILLTMKDHPNVLHLVNVIHERQN-------------IMLVYEPARLGV-LSQALSSTSVSREQQQAICGQVASACSYLESLG--------IVHRN ..| .. . .|||..... . . .. ...|.| . | |.. . .| .. ..|....|| | . |.||. EEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRD L | L |
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Kinase | RTKE1.AA | CTKA | 662-682 | 42 | 0.017945 | 3.96 | In-house | 139-159 (290) | Show / Hide |
Range on Protein: 662-682 Range on HMM: 139-159/290 Sequence Identity: 42% (9 aa) QVASACSYLESLGIVHRNLGA |.| .|| ..|.||| | . QIAAGMNYLAEMGFVHRDLAC |
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Kinase | RTKE1.AA | Src | 662-682 | 52 | 0.059667 | 2.36 | In-house | 105-125 (255) | Show / Hide |
Range on Protein: 662-682 Range on HMM: 105-125/255 Sequence Identity: 52% (11 aa) QVASACSYLESLGIVHRNLGA |||. .|||| ..|| | | QVAEGMAYLESMNYIHRDLAA |
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Kinase | RTKE1.AA | DDR | 792-816 | 24 | 0.091604 | 2.0 | In-house | 282-306 (306) | Show / Hide |
Range on Protein: 792-816 Range on HMM: 282-306/306 Sequence Identity: 24% (6 aa) EDLIKSCTQLAVKARPTFATLAAAL ..|...| . . ||.|. . | NQLMCRCWRRDQSQRPSFEEIHKFL |
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Kinase | RTKE1.AA | Pkinase | 726-749 | 28 | 7.382503 | 0.58 | Pfam | 175-199 (293) | Show / Hide |
Range on Protein: 726-749 Range on HMM: 175-199/293 Sequence Identity: 28% (7 aa) RYFWSPEVWR-DSVFSFKSDVYAFG ... .||| | .. . |.|....| PWYMAPEVIRGGQYYGPKVDMWSCG |
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Kinase | RTKE1.AA | RTKE | 1038-1305 | 47 | 5.8e-172 | 577.57 | In-house | 1-293 (293) | Show / Hide |
Range on Protein: 1038-1305 Range on HMM: 1-293/293 Sequence Identity: 47% (140 aa) LTFVRQLGEGEFGVVSLMTLLT---------------TEGS-RHVAVKTLHNMTFMEDFKSEVAMMIKLRHPNLVGLLHTTSFGAREPAMILEYMPGGSL |||.|.||.||||.|.|||... ...| |.||||||||......|..|..||.||.|||.|.|||...... ...|..||||||.| LTFMRALGSGEFGEVWLMTMPNHAHSPNYSKETISSEQQRSTRQVAVKTLHNHECHHEFVQEMTMMCKLHHPNVVHLLHVVQMKQ-HFMMVYEYMPGGQL ETWLQER-GRGTGPEDLLYIAHQVTNGMAELARLGIVHRDLAARNVLVGRCLN-VKVADYGLSRTMTIGIASSESYYRIKTSRPLP-----IRWMAPSSI |.|||.. ||.|..||.....|||..||..|.|||||||||.|.||...||.| ||||||||||.|..|......||||||.|..| .||.||... EDWLQDHHGRPTSHEDQIHCLHQVACGMSFLERLGIVHRDLCAHNVYCCRCWNDVKVADYGLSRDMYLGQEYMQCYYRIKTRRWMPTTWGSRRWWAPEVW LDQKVSTQTDVWSFGCLCYEIWSCGQIPFGNLSDPEVVQRLILAQQ---GQLREDEPVLASPASCPPMISALMQTCLTVNGELRPSFATLSRRT .||..|...|||..||||.|.|..||.|. ...|....||.. .|. |.|...|||.|.|..|||....|||.||..|.|.||.||.|.... KDQHFSFKSDVWAYGCLCWEVWNNGQMPYAHMDDQQFMQRIVQCQMPSGGHLGDHEPVHAPPVHCPPWADRLMQWCLCINPEHRPNFAQLYQMW |
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Kinase | RTKE1.AA | TK | 1038-1305 | 20 | 2.8e-90 | 302.82 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 1038-1305 Range on HMM: 1-486/486 Sequence Identity: 20% (100 aa) LTFVRQLGEGEFG---VVSLMTLLT-----------------------TEGSRHVAVKTLH---NMTFMEDFK-------------SEVAMMIKLR---- .|....||||.|| .| . .. . ..| ||||.|. .|. .| | .|...| ... ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG -HPNLVGLLHTTSFGA-----------REPAMILEYMPGGS----LETWLQERGRG-------------------------------------------- |||.| |. . |. . . ...||||.|. | ..|... .. HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY -------------------------------TGPEDLLYIAHQVTNGMAELARL------GIVHRDLAARNVLVGRCLN-----------VKVADYGLSR ...|| ...|. .||. |... ..|||||||||.|||. .. .|.||.|||| DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR T----MTIGIAS-----------------------SESYYRIKTSRPLPIRWMAPSSILDQK---------VSTQTDVWSFGCLCYEIWSCG-QIPFGNL . .. | | ...||| .... |||||||| ...|.. .|..||||||.|..||.. | . . |.. QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM SD---------PEVVQRLILAQQGQLR------EDEPVLASPASCP--------------PMISALMQTCLTVNGELRPSFATLSRRT |. ||...| .. .| .. .. |. || ... ||| | . | ||.|..| .. SNQDVWKDGDNQEVMEYLRRGGRL-CRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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Kinase | RTKE1.AA | Pkinase_Tyr | 1038-1305 | 33 | 4.9e-78 | 264.92 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 1038-1305 Range on HMM: 1-270/270 Sequence Identity: 33% (94 aa) LTFVRQLGEGEFGVVSLMTLL--TTEGSRHVAVKTLHNMTFMED------FKSEVAMMIKL-RHPNLVGLLHTTSFGARE--PAMILEYMPGGSLETWLQ .|| ..||||.||.| . |. .. .||||.| . . |.. | .|...| .| .|||.| |. . . . ...||||.|.| . |. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR ER---GRGTGPEDLLYIAHQVTNGMAELARLGIVHRDLAARNVLVGRCLNVKVADYGLSRTMTIGIASSESYY-RIKTSRPLPIRWMAPSSILDQKVSTQ .. .. ..||| ...|. .||. |.. ...||||||||.||.. . ||..| ||.|.. ...|| | ... .|||.|||| .| . | .|. KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-----YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTK TDVWSFGCLCYEIWSCGQIP-FGNLSDPEVVQRLILAQQGQLREDEPVLASPASCPPMISALMQTCLTVNGELRPSFATLSRRT .|||||| |..|| . |..| . ..|. ||.... ...|. .. | ||. | ||. | . | ||.|. . .. SDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI--YEDGYR------MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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Kinase | RTKE1.AA | TyrKc | 1038-1305 | 34 | 4.4e-76 | 259.98 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1038-1305 Range on HMM: 1-280/280 Sequence Identity: 34% (100 aa) LTFVRQLGEGEFGVVSLMTLLTTEGSRHVAVKTLHNMTFMEDFKSEVAMMIKL--RHPNLVGLLHTTSFGA------REPAMILEYMPGGSLETWLQERG .|. ..||||.||.| . |. . ||||.|.. . .||| .| .| || .|||.| |. . . . ...||||.|.| |.... ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR RGTGPEDLLYIAHQVTNGMAELARLGIVHRDLAARNVLVGRCLNVKVADYGLSRTMTIG--IASSESYYRIKT--SRP--LPIRWMAPSSILDQKVSTQT . ..|||....|. .||. |.. ...||||||||.|||. . ||..| |||| . . |..||| |. .. |||||||| .| . | .|.. PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS DVWSFGCLCYEIWSCGQIPFGN-----LSDPEVVQRLILAQQGQLREDEPVLASPAS----CPPMISALMQTCLTVNGELRPSFATLSRRT |||||| ...|| . || | . .|. ||.... .|| .. | | ||. . .|..| . | ||.|... .. DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV---KQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | RTKE1.AA | UTK | 1038-1305 | 29 | 4.8e-68 | 231.87 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 1038-1305 Range on HMM: 1-296/296 Sequence Identity: 29% (89 aa) LTFVRQLGEGEFGVVSLMTLLTTE---GSRHVAVKTLH----NMTFME---DFKSEVA---MMIKLR-HPNLVGLLHTTSFGAREPAMILEYMPGGSLET . . ||||.|.||.|..... . . .||||.. ...| || | . || ... |||...|... . . .....|||..|.| . VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS WLQERGRGTG-------PEDLLYIAHQVTNGMAELARLGIVHRDLAARNVLVGRC-------LNVKVADYG---LSRTMT-----IGIASSESYYRIKT- |. .. .. ...|. | .. .||. |.. |.|||||||||.||.. . .|.||.| .|| . ..|||| .. YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSN--RYWESYYYMAQH SRPLPIRWMAPSSILDQ-KVSTQTDVWSFGCLCYEIWSCGQIPFGNLSDPEVVQRLILAQQGQLREDEPVLASPASCPPMISALMQTCLTVNGELRPSFA ...||||||| .. .. . .|..|||||| .|.|||. |. |....|...|.. . .| .| ...|..|| . ||. | . . . ||.| QDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWH--QVCNGGRYR-----MPCPWDCPHPVYRLMHRCWHYDPQERPDFE TLSRRT .| . DLVQQM |
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Kinase | RTKE1.AA | TK-Unique | 1038-1305 | 28 | 1.6e-60 | 207.34 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 1038-1305 Range on HMM: 1-294/294 Sequence Identity: 28% (89 aa) LTFVRQLGEGEFGVVSLMTLLTTE---GSR-HVAVKTLH-NMTFME--DFKSEVAMMIKLR-HPNLVGLLHTTSFGAREPAMILEYMPGGSLETWLQERG |.. ...|||.|| | .. .. . . .||||.|. | |. . ||..| .|| .| |||.| .| . . . .|.||.|.|.|.. |.... LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR RG-------------------------TGPEDLLYIAHQVTNGMAELAR--LGIVHRDLAARNVLVGRCLNVKVADYGLSR-TMTIGIASSESYYRIKTS .. |.||. .| |. .||. ||. .||||||.|||||... ...|..|.|..| ..| . | ..... PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-----NGVYSMMCSQ RPLPIRWMAPSSIL--DQKV-STQTDVWSFGCLCYEIWSCGQIPFGNLSDPEVVQRLILAQQGQLREDEPVLASPASC-PPMISALMQTCLTVNGELRPS ..||||||| |.. .. .|..||||||.| .|| . |. |............. . |..| .. . ||..|.. . | ||| GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGY---------RMPQPEHCCSHEMYNLMKSCWQWEPEERPS FATLSRRT |... | FRQIKHRL |
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Kinase | RTKE1.AA | Src | 1038-1305 | 36 | 4.2e-58 | 195.97 | In-house | 1-255 (255) | Show / Hide |
Range on Protein: 1038-1305 Range on HMM: 1-255/255 Sequence Identity: 36% (99 aa) LTFVRQLGEGEFGVVSLMTLLTTEGSRHVAVKTLHNMTFM--EDFKSEVAMMIKLRHPNLVGLLHTTSFGAREPAMIL-EYMPGGSLETWLQ--ERGRGT ....|.||.| || | . |. .|||||| | | |.| | | ||||..|| |. | || | ||| ||| ..|. ..|| IKLCRKLGQGQFGEVWMGYW---NGNTKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCS--QEEPIYIVTEYMSHGSLLDYLKKDGEGRHL GPEDLLYIAHQVTNGMAELARLGIVHRDLAARNVLVGRCLNVKVADYGLSRTMTIGIASSESYYRIKTSRPLPIRWMAPSSILDQKVSTQTDVWSFGCLC ..|...| || .||| | . ..|||||||||||| . .|||| || | . . . | .. .||.|.|| |. .. .. .|||||| | HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED----DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILL YEIWSCGQIPFGNLSDPEVVQRLILAQQGQLREDEPVLASPASCPPMISA-LMQTCLTVNGELRPSFATLSRRT .|| . |..| . .||.|.. | . |. ||. . .|. | | || |..| TEIVTYGRVPYPGMTNHEVLQQV---------ERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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Kinase | RTKE1.AA | CTKA | 1139-1305 | 39 | 5.9e-50 | 165.98 | In-house | 135-290 (290) | Show / Hide |
Range on Protein: 1139-1305 Range on HMM: 135-290/290 Sequence Identity: 39% (67 aa) YIAHQVTNGMAELARLGIVHRDLAARNVLVGRCLNVKVADYGLSRTMTIGIASSE-SYYRIKTSRPLPIRWMAPSSILDQKVSTQTDVWSFGCLCYEIWS | | |. || || .|.||||||.||.|.|. .|.|| |..|| ..| || . .| .|.||||| . | |.. |||.|| | .|| | YMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTL-----RTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMS CGQIPFGNLSDPEVVQRLILAQQGQLREDEPVLASPASCPPMISALMQTCLTVNGELRPSFATLSRRT | |. .|| ||.| .... | | | | .|| . .||.|. ||.|.|| | MGEKPWRHMSDQEVCQ-AYTSH-GMRR-----LPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML |
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Kinase | RTKE1.AA | DDR | 1038-1305 | 30 | 6.7e-49 | 168.63 | In-house | 1-306 (306) | Show / Hide |
Range on Protein: 1038-1305 Range on HMM: 1-306/306 Sequence Identity: 30% (99 aa) LTFVRQLGEGEFGVVSLMTLLTTEGSRH-----------------VAVKTLHN---MTFMEDFKSEVAMMIKLR-HPNLVGLLHTTSFG---AREP-AMI |.|| .|||.|| | | . || ||||.|. || .|.. | ... ||| | |. | || || LIFVEKIGEGQFGEVHLCEV---EGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLV-----GVCTQDEPYCMI LEYMPG-GSLETWLQERGRG------------------TGPEDLLYIAHQVTNGMAELARLGIVHRDLAARNVLVGRCLNVKVADYG--LSRTMTIGIAS .||| | | ...|. | ..||. |. ||. |. . .||||||.||.||| ...|..| | .|| . MEYMENLGDLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRN-----LY SESYYRIKT-----SRPLPIRWMAPSSILDQKVSTQTDVWSFGCLCYEIWS-CGQIPFGNLSDPEVVQRLILAQQGQLREDEPVLASPASCPPMIS-ALM | |||. . ..||||||. ||| | .| .|||.|| .|. . | . |.. |.| |. . . | .. .|. |. || | || SQDYYRVEGFTGRQRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQV--YLPMPPMCPYEIYNQLM QTCLTVNGELRPSFATLSRRT | .. . ||||. . . CRCWRRDQSQRPSFEEIHKFL |
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Kinase | RTKE1.AA | Frk | 1038-1309 | 34 | 2.9e-48 | 165.24 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 1038-1309 Range on HMM: 1-260/260 Sequence Identity: 34% (96 aa) LTFVRQLGEGEFGVVSLMTLLTTEGSRHVAVKTLHNMTF-MEDFKSEVAMMIKLRHPNLVGLLHTTSFGAREPAMIL-EYMPGGSLETWLQ---ERGRGT . ..|.|| | || | | |||||| | .|| | .| ||||| |. | || .|. | | ||| ..|| ..|| IQLIRRLGSGQFGEVWEGLWNNTT---PVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTV--EEPIYIITELMRHGSLQEYLQAINDKGRQC GPEDLLYIAHQVTNGMAELARLGIVHRDLAARNVLVGRCLNVKVADYGLSRTMTIGIASSESYYRIKTSRPLPIRWMAPSSILDQKVSTQTDVWSFGCLC . |. .| || ||| | .|||||||||||| . .|.||.|| | . . | | .. .||.| || . .| ... |||||| | QMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVL---MKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILL YEIWSCGQIPFGNLSDPEVVQRLILAQQGQLREDEPVLASPASCPPMISALMQTCLTVNGELRPSFATLSRRTHPQE .|| |..|. . . ||.| . . . . |. ||. . .|. | .. . || | || . TEIITYGRMPYPGMTNAEVLQMV---------DHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF |
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Kinase | RTKE1.AA | TKL | 1044-1305 | 21 | 6.5e-48 | 165.49 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 1044-1305 Range on HMM: 1-364/364 Sequence Identity: 21% (80 aa) LGEGEFGVVSLMTLLTTEGSRH-------VAVKTLHNMT-----------------------------FMEDFKSEVAMMIKLRHPNLVGLLHTTSFGAR .|.| ||.| .. . | . ||||... . |.. .. |. ||..|||||.| .. . IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC ------------EPAMILEYMPGGSLETWLQERGRGTGPEDLLYIAHQVTNGMAELARLG--------IVHRDLAARNVLVGRCLN-------------- ..... ||.|||||. |. .. .. .|... ||. | . |.|||| .|.|| . .. GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC VKVADYGLSRTMTIGIASSES-----------YYRIKTSRPL-PIRWMAPSSILDQ----------------KVSTQTDVWSFGCLCYEIWSCGQIPFGN .|..|.||||.|. .. . .| .|... .||||| . .| . |...||.||| . .|| .. . |. . CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYYD LSDPEVV------QRLILAQQGQLREDEPVLASP-------ASCPPMISALMQTCLTVNGELRPSFATLSRRT . .... . .... . .|| | . .||| .. ||| | . | |||| .. | YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | RTKE1.AA | S_TKc | 1038-1309 | 22 | 8.6e-44 | 152.72 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1038-1309 Range on HMM: 1-231/231 Sequence Identity: 22% (64 aa) LTFVRQLGEGEFGVVSLMTLLTTEGSRHVAVKTLHNMTFMEDFKSEVAMMIKLRHPNLVGLLHTTSFGAREPAMILEYMPG--GSLETWLQERGRG---- ...|..|.| ||.| . . |.||.| .. |....|.... | .|||.| |. . . |..||..| |.| . ...|||. YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -TGPEDLLYIAHQVTNGMAELARLGIVHRDLAARNVLVGRCLNVKVADYGLSRTMTIGIASSESYYRIKTSRPLPIRWMAPSSILDQKVST-QTDVWSFG . . ....|. .... . ..||.|||| |.|. . ..|..| ||.| . |. .||| . . .. |.||.| PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG CLCYEIWSCGQIPFGNLSDPEVVQRLILAQQGQLREDEPVLASPASCPPMISALMQTCLTVNGELRPSFATLSRRT-----HPQE |. || . |. || ..... ..|. |.... ... ||... | ||. . .. || CILYEMLC-GYPPFP---QMQMMFKKIG------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | RTKE1.AA | Fer | 1038-1306 | 25 | 1.2e-38 | 129.29 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 1038-1306 Range on HMM: 1-283/283 Sequence Identity: 25% (75 aa) LTFVRQLGEGEFGVVSLM----TLLTTEGSR----HVAVKTL----HNMTFMEDFKSEVAMMIK-LRHPNLVGLLHTTSFGAREPAMI-LEYMPGGSLET |. .|||| || | . ... .. |.||.. .. ...| | .| . . ||| | . ..| || .|...||||.. VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYG--VCVDEQPIMIVMEFCNGGSLDS WLQERGRG-TGPEDLLYIAHQVTNGMAELARLGIVHRDLAARNVLVGR-CLNVK--VADYGLSRTMTIGIASSESYYRIK-TSRPLPIRWMAPSSILDQK |.. . ... ...|. .||. | ...|||.||||.|.. ...| ..| |.||. . .. . |. | ... .||||.|| .. . YLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYD----YKMKEKACKVPIRWLAPETWQTGI VSTQTDVWSFGCLCYEIWSCGQIPFGNLSDPEVVQRLILAQQ-----GQLREDEPVLASPASCPPMISALMQ-TCLTVNGELRPSFATLSRRTH |. |||||||..|.|| . |. |... | . .... . .... . | ..|| | .| .| ... | ||..... .. . YSPKTDVWSFGVMCWEIFTNGAEPYPG--QPH-G--MKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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Kinase | RTKE1.AA | Pkinase | 1038-1299 | 21 | 1.1e-31 | 113.17 | Pfam | 1-285 (293) | Show / Hide |
Range on Protein: 1038-1299 Range on HMM: 1-285/293 Sequence Identity: 21% (65 aa) LTFVRQLGEGEFGVVSLMTLLTTEGSRHVAVKTLHNMTFMEDFK------SEVAMMIKLRHPNLVGLLHTTSFGAREPAMILEYMPGG----SLETWLQ- ....|..|.| ||.| . . |. ||||.. . .... ||...| .|.||| | |... ... |..||..|| .| .... YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST ERGRGT--GPEDLLYIAHQVTNGMAELARLGIVHRDLAARNVLVGRCLNV----KVADYGLSRTMTIGIASSESYYRIKTSRPLPIRWMAPSSIL-DQKV .|... .... .. |. |.. . . ||.|||| |.|. . .. |..| ||.. . . ... .. . .. ..||| |. .|. WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTP----WYMAPEVIRGGQYY STQTDVWSFGCLCYEIWSCGQIPFGNL----SDPEVVQRLILAQQGQLREDEPVLASPA--------------SCPPMISALMQTCLTVNGELRPSFA .. |.||.||..|| . |. || . . . |.. . ...|..|.| . |. .. .. ||... . ||... GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE |
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Kinase | RTKE1.AA | CTKA | 1038-1099 | 23 | 0.11248 | 1.24 | In-house | 1-75 (290) | Show / Hide |
Range on Protein: 1038-1099 Range on HMM: 1-75/290 Sequence Identity: 23% (18 aa) LTFVRQLGEGEFGVVSLMTLLTTEGS---------RHVAVKTLH---NMTFMEDFKSEVAMMI--KLRHPNLVGLL . ..||| .| | .| . . |||| | . . | |. . .. ||| ..|| HCIMFKIGEGHYGQV-FRAWLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLL |