Gene UTK05 (M.brevicollis)

UTK05

Species: M.brevicollis
Alias: UTK05
External Links:
Annotation:

Classification

Group: TK
Family: UTK

Sequence

Name Sequence Type Origin Length Description Download
UTK05.AA Protein None 916 None Fasta, JSON
UTK05.kin_dom Protein Kinase Domain None 225 None Fasta, JSON
UTK05.kin_dom2 Protein Kinase Domain None 168 None Fasta, JSON

Protein domain

Protein domains of UTK05.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase UTK05.AA Pkinase 91-108 35 5.579868 1.01 Pfam 277-293 (293) Show / Hide 
Range on Protein: 91-108
Range on HMM: 277-293/293
Sequence Identity: 35% (7 aa)

NMKKRCSQTPMEEALQH--I
..|||..    |..|||  .
DPKKRPT---AEQILQHPWF
SH2 UTK05.AA SH2 186-279 17 0.000662 7.29 SMART 1-87 (87) Show / Hide 
Range on Protein: 186-279
Range on HMM: 1-87/87
Sequence Identity: 17% (17 aa)

YAEIH--AGRRILNMELLSYASVPGAYLVSKRALTGPRDASFFRLTYIAGKRAGPQHLKITQYPSSSTGIKYGIND--GMRYVTIDELMEHYHNETDG
.   |    |      |...   .|..||  .      .. .. |..  .   . .| .| . ..     || | .  .... .. || .||.   .|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSES----NPGDYVLSVRWK--GKVKHYRIRRNDD----GKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase UTK05.AA UTK 318-575 31 6.5e-98 331.6 In-house 1-277 (296) Show / Hide 
Range on Protein: 318-575
Range on HMM: 1-277/296
Sequence Identity: 31% (92 aa)

IARLQKLGEGQFGEVFKGKFTRSG---QSYDVALKVLK----DQASPD---EFMLEAS---VMVHLD-HPNIVRLLGLVAYGDLHNYLKANRSDPARTGI
......||.|.||||.|..||.     .  |||.||..    .| .|.   .||.||    .| ... |||..||.|.. ..                  
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP----------------

DILHSYIVQVRANDITMPCRGVESRNARLGPVSPHCLVSYAWQIAKGMEHLASKGLVHRDLAARNVLVASVH-------QVKINDFG---LSRVLG----
 ... .  ... . ... .|  .. .|.   .. |.....||.|| ||..|.|.|.|||||||||.||.. .       ..||.|||   .|| ..    
-WMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHF

-----NSDYYTASERGMWPIKWYAPESIYNN-RFHEKSDVWSYGVTCWETLMRGKKPWPKLKGSQVVELLNSG--QRLERPADCNDALWNILQQ
     .|.||.|.....|||.|.|||..... ||..||||||.||.|||....|..|.| .   ||.. .  |  .|...|.|| .........
SNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHR
Kinase UTK05.AA TK 318-575 21 5.1e-91 305.31 In-house 1-467 (486) Show / Hide 
Range on Protein: 318-575
Range on HMM: 1-467/486
Sequence Identity: 21% (102 aa)

IARLQKLGEGQFG---EVFKGKFTR-----------------------SGQSYDVALKVLK--DQASPDEFML--------------EASVMVHLD----
|  ..||||||||   ||.||.  .                       .|.  .|| |.||  | .|..||..              ||..|  ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVRLLG-------------------------LVAYGD----LHNYLKANR----------------------------------------------
 |||||||.|                         ....||    |..||...|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----SDPARTGIDILHSYIVQVRANDITMPCRGVESRNARLGPVSPHCLVSYAWQIAKGMEHLASK------GLVHRDLAARNVLVASVHQ---------
    .... . ..  . . ..  .  .|           . .....|.|. ..||||.|||.|.||      ..|||||||||.||.. ..         
DDDLIKDHPPPLTTKDLLQMAWQWC-LT-----------CKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCG

--VKINDFG--------LSRVLGNSDYYTASE------------------------RGMWPIKWYAPESIY---------NNRFHEKSDVWSYGVTCWET
  .|| |||        |.| ....|.|....                        .|..||.|.|||..          ...| .||||||.||..|| 
PVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI

LMRGKKPWPKLKG----------SQVVELLNSG--------------QRLERPADCN--------------DALWNILQQ
...|..|..               .|.|.| .|               |...|..|               ...  ..||
FTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQ
Kinase UTK05.AA TyrKc 318-579 32 9.8e-88 298.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 318-579
Range on HMM: 1-280/280
Sequence Identity: 32% (104 aa)

IARLQKLGEGQFGEVFKGKFTRSGQSYDVALKVLKDQASPDEFMLEASVMVHL--DHPNIVRLLGLVA--------------------YGDLHNYLKANR
|  ..|||||.||||.||. .     ..|| |.||. |   .|| ||..| .|  .|||||||.| .                     .|||..||...|
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

SDPARTGIDILHSYIVQVRANDITMPCRGVESRNARLGPVSPHCLVSYAWQIAKGMEHLASKGLVHRDLAARNVLVASVHQVKINDFGLSRVLGNS----
 .                                     ...  |.|..||||.|||.|.||...||||||||.||.. |.||| |||||| ...     
PK-------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG

---DYYTA----SERGMWPIKWYAPESIYNNRFHEKSDVWSYGVTCWETLMRGKKPWPK-----LKGSQVVELLNSGQRLERPAD--------CNDALWN
   |||..    ....|.||.|.|||.|  ..| .||||||.||..|| . .|..|.|      .. ..|.|.. .| |...|..        | |.. .
ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ

ILQQ---------------VGLL
| .|               . ..
IMKQCWHEDPEDRPTFSEIHECF
Kinase UTK05.AA Pkinase_Tyr 381-575 36 2e-74 252.68 Pfam 88-251 (270) Show / Hide 
Range on Protein: 381-575
Range on HMM: 88-251/270
Sequence Identity: 36% (72 aa)

LVAYGDLHNYLKANRSDPARTGIDILHSYIVQVRANDITMPCRGVESRNARLGPVSPHCLVSYAWQIAKGMEHLASKGLVHRDLAARNVLVASVHQVKIN
....|||..||...|                                     .|.... |....||||||||.|.||...||||||||.||.. ..||| 
YMPHGDLLDYLRKHR----------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKIC

DFGLSRVLGNSDYY-TASERGMWPIKWYAPESIYNNRFHEKSDVWSYGVTCWETLMRGKKP-WPKLKGSQVVELL-NSGQRLERPADCNDALWNILQQ
||||.| . | ||| .... |..||||.|||.| ...| .||||||.||..|| . .|..| .| .. ..|.|..  .|.|...| .| | . ....|
DFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQ
Kinase UTK05.AA Syk 446-565 52 1.2e-57 196.98 In-house 114-234 (257) Show / Hide 
Range on Protein: 446-565
Range on HMM: 114-234/257
Sequence Identity: 52% (63 aa)

QIAKGMEHLASKGLVHRDLAARNVLVASVHQVKINDFGLSRVLG-NSDYYTASERGMWPIKWYAPESIYNNRFHEKSDVWSYGVTCWETLMRGKKPWPKL
|.| ||  | .|  |||||||||||    |. || |||.|. || .|.||.|   | ||.||||||.||   |  ||||||.||| || . .|.||  . 
QVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMWEMFSYGQKPYGEM

KGSQVVELLNSGQRLERPADC
||. |.... .| |...|. |
KGQEVMKFIENGHRMNCPNGC
Kinase UTK05.AA Ack 438-575 41 2.7e-51 171.3 In-house 105-247 (266) Show / Hide 
Range on Protein: 438-575
Range on HMM: 105-247/266
Sequence Identity: 41% (60 aa)

HCLVSYAWQIAKGMEHLASKGLVHRDLAARNVLVASV-HQVKINDFGLSRVLG-NSDYYTASERG--MWPIKWYAPESIYNNRFHEKSDVWSYGVTCWET
| |  .. |||.||  | .|...||||||||.|..|    ||| ||||.| || | |||. ...     |. | |||..   .|  .||||..||| || 
HTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVTLWEM

LMRGKKPWPKLKGSQVVELLN-SGQRLERPADCNDALWNILQQ
   | .||  . |.|. ...   |.||.|| .|  .. ... |
FSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQ
Kinase UTK05.AA EGFR 437-565 45 3.3e-50 164.82 In-house 100-228 (258) Show / Hide 
Range on Protein: 437-565
Range on HMM: 100-228/258
Sequence Identity: 45% (59 aa)

PHCLVSYAWQIAKGMEHLASKGLVHRDLAARNVLVASVHQVKINDFGLSRVLGNSDYYTASERGMWPIKWYAPESIYNNRFHEKSDVWSYGVTCWETLMR
.. |. .. ||||||. |  . .|||||||||||| |  .||| ||||...|   .     . |  |||| | |.| . ..  .|||||||||||| .  
SQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTF

GKKPWPKLKGSQVVELLNSGQRLERPADC
|.||.  .. ... .||  |.||. |  |
GQKPYDGIPAREIPDLLEKGERLPQPPIC
Kinase UTK05.AA TK-Unique 434-575 41 6.8e-48 163.24 In-house 127-275 (294) Show / Hide 
Range on Protein: 434-575
Range on HMM: 127-275/294
Sequence Identity: 41% (62 aa)

PVSPHCLVSYAWQIAKGMEHLAS--KGLVHRDLAARNVLVASVHQVKINDFGLSR-VLGNSDYYTASERGMWPIKWYAPESIY--NNRF-HEKSDVWSYG
|.||. |...|||||.|||.|||  |. |||||.|||||... ...||.|||..| |  | .| .  ..|. ||.| ||||..   . .  .||||||.|
PISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFG

VTCWETLMRGKKPWPKLKGSQVVELLNSGQRLERPADC-NDALWNILQQ
|. || .  |. | |... ....|..  | |...|. | .... |....
VLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKS
Kinase UTK05.AA FAK 440-565 49 1.5e-47 157.34 In-house 126-251 (285) Show / Hide 
Range on Protein: 440-565
Range on HMM: 126-251/285
Sequence Identity: 49% (62 aa)

LVSYAWQIAKGMEHLASKGLVHRDLAARNVLVASVHQVKINDFGLSRVLGNSDYYTASERGMWPIKWYAPESIYNNRFHEKSDVWSYGVTCWETLMRGKK
|. |..|... |  | ||  |||| |||||||.|   ||  |||||| .  ..|| ||  |  |||| .||||   ||   |||| .||  || || |.|
LILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWMHDHSYYKASPKGKLPIKWMSPESINFRRFTTASDVWMFGVCMWEILMYGVK

PWPKLKGSQVVELLNSGQRLERPADC
|   .| . |.  .  | ||  |. |
PFQWVKNNDVIGRIENGERLPMPPNC
Kinase UTK05.AA Src 440-575 42 4.6e-46 154.47 In-house 99-236 (255) Show / Hide 
Range on Protein: 440-575
Range on HMM: 99-236/255
Sequence Identity: 42% (58 aa)

LVSYAWQIAKGMEHLASKGLVHRDLAARNVLVASVHQVKINDFGLSRVLG-NSDYYTASERGMWPIKWYAPESIYNNRFHEKSDVWSYGVTCWETLMRGK
|.. |.|.|.||. | |. ..|||||||||||     .|. |||| |..  . | |.|..  . |||| ||| |  .||  ||||||.|.  .|   .|.
LIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGR

KPWPKLKGSQVVELLNSGQRLERPADCNDALWN-ILQQ
 | |  .  .|.. .  | |. .|. | | | . |..|
VPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQ
Kinase UTK05.AA SFK-Src 440-573 44 1.5e-45 132.63 In-house 98-234 (259) Show / Hide 
Range on Protein: 440-573
Range on HMM: 98-234/259
Sequence Identity: 44% (61 aa)

LVSYAWQIAKGMEHLASKGLVHRDLAARNVLVASVHQVKINDFGLSRVLGNSDY-YTASERGMWPIKWYAPESIYNNRFHEKSDVWSYGVTCWETLMRGK
||  | |.| ||  |  .  ||||||||||||     .|. |||.||||.. |  ||| |    |||| |||    |||  ||||||.|.   |    | 
LVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGR

KPWPKLKGSQVVELLNS--GQRLERPADCNDALWNIL
.|.| .    |.  ..   | |.. |  | |....|.
IPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIM
Kinase UTK05.AA HMTK 446-570 44 3.9e-41 141.23 In-house 136-268 (291) Show / Hide 
Range on Protein: 446-570
Range on HMM: 136-268/291
Sequence Identity: 44% (59 aa)

QIAKGMEHLASKGLVHRDLAARNVLVASVHQVKINDFGLSRVLG-NSDYYTASERG-MWPIKWYAPESIY--NNRFHEKSDVWSYGVTCWETLMRGKKPW
|.|.||. .||...||.||||||.||..  |||| ||||.| |    ||..  ...   |||| |||       .| ||||||..|||.|| .| |  |.
QCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYWHLRKHMVKLPIKWMAPEAMDGKRKIFSEKSDVWAFGVTMWEIWMYGEQPY

P--KLKGSQVVELLNSGQRLERPAD--CNDALW
.   .|. .|   .  | ||. | .  |.| .|
ESQQIKNKEVQRHVREGRRLTQPPPDDCPDDFW
Kinase UTK05.AA Pkinase 318-534 24 2.9e-26 93.94 Pfam 1-206 (293) Show / Hide 
Range on Protein: 318-534
Range on HMM: 1-206/293
Sequence Identity: 24% (61 aa)

IARLQKLGEGQFGEVFKGKFTRSGQSYDVALKVLKDQASPDEFML-------EASVMVHLDHPNIVRLLGLVA-----Y--------G----DLHNYLKA
. ...|.|.| ||.|.|..   .|.   ||.|..| . . .. ..       |...| .|.|||||||.. .      |        |    ||. |...
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

NRSDPARTGIDILHSYIVQVRANDITMPCRGVESRNARLGPV--SPHCLVSYAWQIAKGMEHLASKGLVHRDLAARNVLVASVHQV----KINDFGLSRV
                                     | |..  |.. . .|..||..|.|.. |.| .||||   |.|. .  ..    || ||||...
------------------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQ

L-GNSDYYTASERGMWPIKWYAPESIY-NNRFHEKSDVWSYGVTCWETL
.   ..  . .  |   . . ||| |  ..    |.|.||.|....| |
FDY-NNS-MTTFCGT--PWYMAPEVIRGGQYYGPKVDMWSCGCILYEML
Kinase UTK05.AA Pkinase_Tyr 318-380 45 8.2e-24 81.27 Pfam 1-71 (270) Show / Hide 
Range on Protein: 318-380
Range on HMM: 1-71/270
Sequence Identity: 45% (32 aa)

IARLQKLGEGQFGEVFKGKFT--RSGQSYDVALKVLKDQASPDE-----FMLEASVMVHL-DHPNIVRLLG
|  ..|||||.||||.||. .   ... ..|| |.||..|....     || ||..| .| .|||||||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYG
Kinase UTK05.AA Syk 318-380 38 3e-20 66.38 In-house 1-72 (257) Show / Hide 
Range on Protein: 318-380
Range on HMM: 1-72/257
Sequence Identity: 38% (28 aa)

IARLQKLGEGQFGEVFKGKFTRS-----GQSYDVALKVLKDQASP----DEFMLEASVMVHLDHPNIVRLLG
. . . .| | || | ||.. .      .|  .||.|.||....     .||| ||.||  |||| |||..|
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIG
Kinase UTK05.AA SFK-Src 318-378 46 6.1e-19 52.22 In-house 1-59 (259) Show / Hide 
Range on Protein: 318-378
Range on HMM: 1-59/259
Sequence Identity: 46% (29 aa)

IARLQKLGEGQFGEVFKGKFTRSGQSYDVALKVLKDQA-SPDEFMLEASVMVHLDHPNIVRL
|.  .|||.||||.|.||.     .. .|| | ||  | | .||. || ||  | ||| ..|
IRLEKKLGSGQFGDVWKGRWN---NTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQL
Kinase UTK05.AA Ack 318-382 40 1.6e-18 59.06 In-house 1-71 (266) Show / Hide 
Range on Protein: 318-382
Range on HMM: 1-71/266
Sequence Identity: 40% (29 aa)

IARLQKLGEGQFGEVFKGKFTR-SGQSYDVALKVLKDQ--ASP---DEFMLEASVMVHLDHPNIVRLLGLV
| .. |||.| || | .|  |  .|..  || |.|..    .|   |.|. |...|  ||||..||| |.|
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVV
Kinase UTK05.AA Src 318-382 39 1.8e-17 55.88 In-house 1-63 (255) Show / Hide 
Range on Protein: 318-382
Range on HMM: 1-63/255
Sequence Identity: 39% (26 aa)

IARLQKLGEGQFGEVFKGKFTRSGQSYDVALKVLK-DQASPDEFMLEASVMVHLDHPNIVRLLGLV
| ...|||.||||||..|..    .. .|| |.|| .. ||. |  || .|  |.|...|.|.  .
IKLCRKLGQGQFGEVWMGYWN---GNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVC
Kinase UTK05.AA TK-Unique 318-380 35 7.3e-16 51.29 In-house 1-71 (294) Show / Hide 
Range on Protein: 318-380
Range on HMM: 1-71/294
Sequence Identity: 35% (25 aa)

IARLQKLGEGQFGEVFKGKFTR----SGQSYDVALKVLKDQASPDE---FMLEASVMVHLD-HPNIVRLLG
.  ....|||.||.|..|....    ...   ||.| ||| |.. .   |. |...| .|. |||||..||
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLG
Kinase UTK05.AA S_TKc 318-603 19 1e-15 53.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 318-603
Range on HMM: 1-231/231
Sequence Identity: 19% (60 aa)

IARLQKLGEGQFGEVFKGKFTRSGQSYDVALKVLKDQASPDEFMLEASVMVHLDHPNIVRLLGLVAYGDLHNYLKANRSDPARTGIDILHSYIVQVRAND
   |.|.|.| ||.|.|.. ...|.   ||.|..|     . .. | ... . .|||||.|..                          | |.|      
YEILRKIGKGAFGKVYKCRHKKTGR--IVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD---------------------DHLYMVME----

ITMPC--RGVESRNARLGP------VSPHCLVSYAWQIAKGMEHLASKGLVHRDLAARNVLVASVHQVKINDFGLSRVLGNSDYYTASERGMWPIKWYAP
  ..     . ..  . |.       ..    .|..||....|.. |.| .||||   |.|. .  ..|| ||||.|.|                 . ||
-YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAP

ESIYNNRFHE-KSDVWSYGVTCWETLMRGKKPWPKLKGSQVVELLNSGQRLERPADCNDALWNILQQVGLLISTVSGAVC---CVRISTSHIFG------
| .    .   |.|.|| |.. .| |  |. |.|     |. ....                        ... ...  .     |..   ..       
EVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-VDIF
    |
CHPWF
Kinase UTK05.AA EGFR 318-381 40 4.6e-14 42.91 In-house 1-69 (258) Show / Hide 
Range on Protein: 318-381
Range on HMM: 1-69/258
Sequence Identity: 40% (28 aa)

IARLQKLGEGQFGEVFKGKFTRSGQSYD--VALKVLKDQA---SPDEFMLEASVMVHLDHPNIVRLLGL
. ....|| | || |.|| .   |..    || |||..|    . .|.. || ||  .|||..|||||.
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGV
Kinase UTK05.AA HMTK 318-380 26 7.2e-13 41.31 In-house 1-91 (291) Show / Hide 
Range on Protein: 318-380
Range on HMM: 1-91/291
Sequence Identity: 26% (24 aa)

IARLQKLGEGQFG-----------------EVFKGKFT-------RSGQSYD-VALKVLKDQASP---DEFMLEASVMVHLDHPNIVRLLG
.  .. .| ||||                 .|  ..         ... .   .| | |...||.   .||. || ||. |.|||.|.| |
LKAIKVIGAGQFGMVQCLRLAPPDEGCTSLKVYLAEWSVKDGDGKDDSNQPHHRAVKMLRGDASHEDREEFLREAEVMCQLRHPNLVQLVG
Kinase UTK05.AA FAK 318-382 29 9.6e-12 35.46 In-house 1-93 (285) Show / Hide 
Range on Protein: 318-382
Range on HMM: 1-93/285
Sequence Identity: 29% (27 aa)

IARLQKLGEGQFGEVFKGKFTRSGQ-------------------------SYDVALKVLKDQASPDE---FMLEASVMVHLDHPNIVRLLGLV
|   ...||||||.|..| .|   .                           .|| |  | . ..|.   || || .| ..||| ||.|.|..
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGIC
Kinase UTK05.AA UTK 706-821 39 6.4e-53 179.38 In-house 98-244 (296) Show / Hide 
Range on Protein: 706-821
Range on HMM: 98-244/296
Sequence Identity: 39% (58 aa)

VCVMCRCFPSK--RRVDVDKHSPALSHLQVARGMQYMAGQGYVHRDLAARNG-----------------TDFG---LSRGLGF--------ESEYYRASN
.....|. |.   ... ...|.    ....||||||....|.|||||||||                   |||   .||....        ||.||.|..
RSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQH

RGRWPIKWYAPESLYHS-RFTSKSDVWSFGVTLWEGDHHGAKPYSGM
..||||.|.|||.|.|  |||.|||||||||..||  ..|..|| ||
QDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGM
Kinase UTK05.AA TK 628-809 20 1.5e-52 174.08 In-house 54-386 (486) Show / Hide 
Range on Protein: 628-809
Range on HMM: 54-386/486
Sequence Identity: 20% (70 aa)

QVAVRKLMVQEDADIEG-----------------FMREANNMH--RLQHECLVRLFGVTTGEQ-------------LMLVTELAPAGA----LDRYLRAN
.|||  |.   ... |                  ...|.  |.   ..|. .|||.|| | ..             .|.|.|..| |     |. |||..
PVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKC

PHKSIS---------------------------------------------------EILRLMFCVCVMCRCFPSKRRVDVDKHSPALSHLQVARGMQYM
..| .                                                    ..    .  .....| .  .. ... |      .|.|.||.|.
RPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWC-LT-CKHQLTMHQLL-MCWQIACGMEYL

AGQ------GYVHRDLAARN-----G----------------TDFG--------LSRGLGFESEYYRASN-----------------------RGRWPIK
. .      ..|||||||||     .                .|||        |.| .. ...|||.|.                       .|..||.
HSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIR

WYAPESLY---------HSRFTSKSDVWSFGVTLWE
|.|||.|          . .||.|||||||||..||
WMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWE
Kinase UTK05.AA Syk 728-829 52 3.7e-46 156.9 In-house 110-221 (257) Show / Hide 
Range on Protein: 728-829
Range on HMM: 110-221/257
Sequence Identity: 52% (59 aa)

LSHLQVARGMQYMAGQGYVHRDLAARN----------GTDFGLSRGLGFESEYYRASNRGRWPIKWYAPESLYHSRFTSKSDVWSFGVTLWEGDHHGAKP
| | ||| || |  ..  |||||||||            |||.|. ||  |.||.|   |.||.||||||. |   | .||||||||||.||    |.||
LWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMWEMFSYGQKP

YSGMKGREVRQL
| .||| || ..
YGEMKGQEVMKF
Kinase UTK05.AA SFK-Src 732-826 47 2.3e-36 104.83 In-house 104-208 (259) Show / Hide 
Range on Protein: 732-826
Range on HMM: 104-208/259
Sequence Identity: 47% (50 aa)

QVARGMQYMAGQGYVHRDLAARN----------GTDFGLSRGLGFESEYYRASNRGRWPIKWYAPESLYHSRFTSKSDVWSFGVTLWEGDHHGAKPYSGM
||| || |. .| .|||||||||            |||.||.|. ..| | | .  . |||| |||    .||  ||||||||. . |    | .|| ||
QVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPYPGM

KGREV
   ||
TNMEV
TyrKc UTK05.AA TyrKc 617-897 27 3.3e-35 124.2 SMART 17-280 (280) Show / Hide 
Range on Protein: 617-897
Range on HMM: 17-280/280
Sequence Identity: 27% (93 aa)

FGVWQRGSDALQVAVRKLMVQEDADIEGFMREANNMHRL--QHECLVRLFGVTTG--------EQLMLVTELAPAGALDRYLRANPHKSISEILRLMFCV
 |.|      .|||| | .  .   .| |||||. |..|  .|...|||.|| |         |.||.|.|..| |.|. |||.. .|            
KGTWK-----IQVAV-KMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK------------

CVMCRCFPSKRRVDVDKHSPALSHL-----QVARGMQYMAGQGYVHRDLAARN------G----TDFGLSRGLGFE------SEYYRASN--RGR--WPI
                     ...|     |.|.||.| . ....||||||||      .    .|||||| .. .      ..|||..    |.  .||
-------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

KWYAPESLYHSRFTSKSDVWSFGVTLWEGDHHGAKPYSG-----MKGREVRQLSDWP--------DCGGPMLADDATTWADATGPRVFGKQQAPRADSLL
.|.|||.. ...||.|||||||||..||    |..||.|     |. .||... .          |.  | ..                           
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS---------------------------

AYGASPASGCSC---CIALNFWHA-------VSHLHPLF
    .   .|.     | .  ||.        | .| .|
----F--VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase UTK05.AA EGFR 731-829 45 5.7e-33 106.69 In-house 108-215 (258) Show / Hide 
Range on Protein: 731-829
Range on HMM: 108-215/258
Sequence Identity: 45% (50 aa)

LQVARGMQYMAGQGYVHRDLAARNG----------TDFGLSRGLGFESEYYRASNRGRWPIKWYAPESLYHSRFTSKSDVWSFGVTLWEGDHHGAKPYSG
.|.|.||||.  .  |||||||||           |||||.. |  ... |.|.  |. |||| | |.. | ..|..|||||.|||.||    |.||| |
VQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQG-GKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTFGQKPYDG

MKGREVRQL
.. ||. .|
IPAREIPDL
Kinase UTK05.AA Ack 731-826 42 3e-31 102.68 In-house 112-220 (266) Show / Hide 
Range on Protein: 731-826
Range on HMM: 112-220/266
Sequence Identity: 42% (46 aa)

LQVARGMQYMAGQGYVHRDLAARN-----GT------DFGLSRGLGFESEYYRASNRG--RWPIKWYAPESLYHSRFTSKSDVWSFGVTLWEGDHHGAKP
.|.| ||.|   .. .||||||||     .       ||||.| || .  ||| . .     |. | |||.| | .|...||||.|||||||    | .|
MQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVTLWEMFSYGEEP

YSGMKGREV
. |. | ..
WAGCNGYQI
Kinase UTK05.AA Src 732-826 47 5.7e-31 102.43 In-house 105-209 (255) Show / Hide 
Range on Protein: 732-826
Range on HMM: 105-209/255
Sequence Identity: 47% (50 aa)

QVARGMQYMAGQGYVHRDLAARN---GT-------DFGLSRGLGFESEYYRASNRGRWPIKWYAPESLYHSRFTSKSDVWSFGVTLWEGDHHGAKPYSGM
|||.||.|.  . |.||||||||   |.       |||| | .  . . | |.   . |||| ||| . . ||| ||||||||. |.|   .|  || ||
QVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGM

KGREV
. .||
TNHEV
Kinase UTK05.AA Pkinase_Tyr 756-829 47 1.2e-30 104.46 Pfam 153-227 (270) Show / Hide 
Range on Protein: 756-829
Range on HMM: 153-227/270
Sequence Identity: 47% (36 aa)

TDFGLSRGLGFESEYY-RASNRGRWPIKWYAPESLYHSRFTSKSDVWSFGVTLWEGDHHGAKP-YSGMKGREVRQL
.||||.| . .. .|| |..  |..||||.|||.. ...||.|||||||||..||    |..| | ||.  || ..
CDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEY
Kinase UTK05.AA FAK 731-826 43 9.4e-28 89.94 In-house 131-235 (285) Show / Hide 
Range on Protein: 731-826
Range on HMM: 131-235/285
Sequence Identity: 43% (46 aa)

LQVARGMQYMAGQGYVHRDLAARN----------GTDFGLSRGLGFESEYYRASNRGRWPIKWYAPESLYHSRFTSKSDVWSFGVTLWEGDHHGAKPYSG
.|..  | |.    .|||| ||||            |||||| .   ..||.||  |. |||| .|||    |||. |||| ||| .||   .| ||. .
YQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWMH-DHSYYKASPKGKLPIKWMSPESINFRRFTTASDVWMFGVCMWEILMYGVKPFQW

MKGREV
.|  .|
VKNNDV
Kinase UTK05.AA HMTK 756-827 41 7.5e-21 69.51 In-house 170-246 (291) Show / Hide 
Range on Protein: 756-827
Range on HMM: 170-246/291
Sequence Identity: 41% (32 aa)

TDFGLSRGLGFESEYYRASNRG-RWPIKWYAPESLY--HSRFTSKSDVWSFGVTLWEGDHHGAKPYS--GMKGREVR
.||||.| |  .  |..  ... . |||| ||| .     .|  |||||.||||.||   .|. ||.  . |..||.
ADFGLTRRLDPGQDYWHLRKHMVKLPIKWMAPEAMDGKRKIFSEKSDVWAFGVTMWEIWMYGEQPYESQQIKNKEVQ
Kinase UTK05.AA Syk 618-703 29 2e-18 60.05 In-house 18-111 (257) Show / Hide 
Range on Protein: 618-703
Range on HMM: 18-111/257
Sequence Identity: 29% (28 aa)

GVWQRG-----SDALQVAVRKLM--VQEDADIEGFMREANNMHRLQHECLVRLFGVTTGEQLMLVTELAPAGALDRYLRANP-HKSISEILRLM
|. ..         ..||.  |     . || . |||||. |..| | | ||. |.  .|..|.| |.|. |..  ||  .  . . . .| |.
GWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRHEITANNVLELW
Kinase UTK05.AA Ack 618-702 37 2.7e-18 58.31 In-house 18-107 (266) Show / Hide 
Range on Protein: 618-702
Range on HMM: 18-107/266
Sequence Identity: 37% (34 aa)

GVWQR-GSDALQVAVRKLMVQ---EDADIEGFMREANNMHRLQHECLVRLFGVTTGEQL-MLVTELAPAGALDRYLRANPHK-SISEILRL
|.|   |..  ||||  | .     .  .. |.||.. ||.|.|. ||||.||  .  . |.|||||| |.|   ||. . . ..  | .|
GEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRK-HCRTAFFLIHTL
Kinase UTK05.AA TK-Unique 756-829 44 5.8e-18 58.62 In-house 175-251 (294) Show / Hide 
Range on Protein: 756-829
Range on HMM: 175-251/294
Sequence Identity: 44% (34 aa)

TDFGLSRGLGFESEYYRASNRGRWPIKWYAPESLY--HSRF-TSKSDVWSFGVTLWEGDHHGAKPYSGMKGREVRQL
.|||..| .  . .| .   .|| ||.| |||||.  |  . |.|||||||||..||    || ||.||. ......
CDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMEC
Kinase UTK05.AA Pkinase_Tyr 635-708 34 3.3e-15 52.13 Pfam 35-120 (270) Show / Hide 
Range on Protein: 635-708
Range on HMM: 35-120/270
Sequence Identity: 34% (30 aa)

MVQEDADIEG-----FMREANNMHRL-QHECLVRLFGVTT--GEQ--LMLVTELAPAGALDRYLRAN--PHKSISEILRLMFCVCV
|. |.|. |      |||||. |. | .|. .||| || |  ||.  ...|.|..| | |. |||..  . ....    | .|. .
MLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQI
Kinase UTK05.AA EGFR 629-691 35 9.4e-12 35.12 In-house 31-94 (258) Show / Hide 
Range on Protein: 629-691
Range on HMM: 31-94/258
Sequence Identity: 35% (23 aa)

VAVRKL-MVQEDADIEGFMREANNMHRLQHECLVRLFGVTTGEQLMLVTELAPAGALDRYLRAN
||.. |    .    | ...|| .| ...|..|||| ||  ..|..||| . | |.|  |.| .
VAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQH
Kinase UTK05.AA HMTK 732-754 65 8.6e-11 33.96 In-house 136-158 (291) Show / Hide 
Range on Protein: 732-754
Range on HMM: 136-158/291
Sequence Identity: 65% (15 aa)

QVARGMQYMAGQGYVHRDLAARN
|.|.||.|.| |..||.||||||
QCASGMAYIASQRMVHMDLAARN
Kinase UTK05.AA Pkinase_Tyr 731-754 54 4.3e-10 34.82 Pfam 118-141 (270) Show / Hide 
Range on Protein: 731-754
Range on HMM: 118-141/270
Sequence Identity: 54% (13 aa)

LQVARGMQYMAGQGYVHRDLAARN
.|.|.||.| . ....||||||||
WQIAKGMEYLESKNCIHRDLAARN
Kinase UTK05.AA UTK 617-693 30 4.6e-10 30.62 In-house 17-106 (296) Show / Hide 
Range on Protein: 617-693
Range on HMM: 17-106/296
Sequence Identity: 30% (27 aa)

FGVWQRGS---DALQVAVRKLMVQED--ADIE---GFMREAN---NMHRLQ-HECLVRLFGV-TTGEQLMLVTELAPAGALDRYLRANPH
.. ... |     ..||| .. . .|   . |    ||.||.    | ... |. ..|| || | .|..|.|||... | |. ||| ...
KARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRP
Kinase UTK05.AA Src 628-689 38 1e-08 25.69 In-house 25-86 (255) Show / Hide 
Range on Protein: 628-689
Range on HMM: 25-86/255
Sequence Identity: 38% (24 aa)

QVAVRKLMVQEDADIEGFMREANNMHRLQHECLVRLFGVTTGE-QLMLVTELAPAGALDRYLR
.|||  |      . | | .||. |  |.|| ||.|. | . |     |||.   | |  ||.
KVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLK
Kinase UTK05.AA SFK-Src 643-689 41 1.6e-08 20.78 In-house 39-86 (259) Show / Hide 
Range on Protein: 643-689
Range on HMM: 39-86/259
Sequence Identity: 41% (20 aa)

EGFMREANNMHRLQHECLVRLFGV-TTGEQLMLVTELAPAGALDRYLR
| |..||  | .|.|. |..|. | | || .  .|||   | |  ||.
EEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLH
Kinase UTK05.AA TK-Unique 732-754 56 2.1e-08 25.23 In-house 139-163 (294) Show / Hide 
Range on Protein: 732-754
Range on HMM: 139-163/294
Sequence Identity: 56% (14 aa)

QVARGMQYMAG--QGYVHRDLAARN
|.|.||.|.|.  .. |||||.|||
QIACGMEYLASQRKKIVHRDLCARN
Kinase UTK05.AA FAK 625-691 33 7.1e-08 22.29 In-house 50-117 (285) Show / Hide 
Range on Protein: 625-691
Range on HMM: 50-117/285
Sequence Identity: 33% (23 aa)

DALQVAVRKLMVQEDADI-EGFMREANNMHRLQHECLVRLFGVTTGEQLMLVTELAPAGALDRYLRAN
|..|||..    . | |  | || ||  |... |  .|.| |. . .   .. ||.. | |  ||..|
DKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPIWIIMELCKYGELRHYLQRN
Kinase UTK05.AA HMTK 639-666 50 3e-07 21.43 In-house 65-92 (291) Show / Hide 
Range on Protein: 639-666
Range on HMM: 65-92/291
Sequence Identity: 50% (14 aa)

DADIEGFMREANNMHRLQHECLVRLFGV
..|.| |.|||  | .|.|..||.| ||
HEDREEFLREAEVMCQLRHPNLVQLVGV
Kinase UTK05.AA Pkinase 633-710 18 2.1e-05 20.16 Pfam 30-119 (293) Show / Hide 
Range on Protein: 633-710
Range on HMM: 30-119/293
Sequence Identity: 18% (17 aa)

KLMVQEDADIEGFMR-----EANNMHRLQHECLVRLFGVT-TGEQLMLVTELAPAG----ALDRYLRANPHKSI--SEILRLMFCVCVMC
| .  .... .  ..     |.  |.||.|.. |||...  ..  . .|.|... |     | .|...  |...  ||    ...  . .
KIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILR
Kinase UTK05.AA TK-Unique 628-691 30 0.000152 11.73 In-house 30-99 (294) Show / Hide 
Range on Protein: 628-691
Range on HMM: 30-99/294
Sequence Identity: 30% (21 aa)

QVAVRKLMVQEDADIEG---FMREANNMHRLQ-HECLVRLFGVTT--GEQLMLVTELAPAGALDRYLRAN
|. |   |....|. .    |..|.. |  |  |. .|...|..|  .|. |.. | .| | |. ||| .
QKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC
Kinase UTK05.AA Pkinase 785-809 38 0.001045 14.19 Pfam 179-204 (293) Show / Hide 
Range on Protein: 785-809
Range on HMM: 179-204/293
Sequence Identity: 38% (10 aa)

APESLY-HSRFTSKSDVWSFGVTLWE
||| .  ..  ..|.|.||.|..|.|
APEVIRGGQYYGPKVDMWSCGCILYE