Gene UTK22 (M.brevicollis)
UTK22
Species: M.brevicollis
Alias: UTK22
External Links:
Annotation:
Sequence
Protein domains of UTK22.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| ZnF_C3H1 | UTK22.AA | ZnF_C3H1 | 55-83 | 32 | 0.000901 | 19.54 | SMART | 1-31 (31) | Show / Hide |
Range on Protein: 55-83 Range on HMM: 1-31/31 Sequence Identity: 32% (10 aa) SVGTVPCDHWTKQS-PTSCP-GDACTYDHEL . .|.||... .. | || || | . | . RYKTPPCKYFMRRGPPWYCPYGDRCKFAHPP |
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| Kinase | UTK22.AA | UTK | 855-1070 | 31 | 3.1e-98 | 332.65 | In-house | 59-296 (296) | Show / Hide |
Range on Protein: 855-1070
Range on HMM: 59-296/296
Sequence Identity: 31% (74 aa)
DAQMLVKLS-HESLIGLVGTSFNLESWIVIVEP-VRSSLSTFLRSNRPTPD-CPSSVTECQLLEYALDVVDALSFLEEKGVIHNNIQADSVYIALHG---
..||. ... |.....|||. .. | |....| ....|...||..||||. || ..|..|.|..|.|. .....|...|..|....| .... |.
ELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMW
----SAVLGGFG---DARLVE-------AANTPESMARDVESLPIRWMAPEVITDN-QPSVKSDIYSFGVLLWELFTYGRRPWPGYAHAEIAQIVTKQS-
......|| .|.| ......||......||||||||..|.. ... |||..||||..||..|.||.|.||........ |....
HCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGR
ALLLQPDDCPHQVYRVMKQCWKATPSIRPTPKTLDDVL
... .|.||||.|||.|..||...|. ||....|....
YRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
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| Kinase | UTK22.AA | TK | 850-1070 | 16 | 1.1e-57 | 191.54 | In-house | 86-486 (486) | Show / Hide |
Range on Protein: 850-1070
Range on HMM: 86-486/486
Sequence Identity: 16% (65 aa)
LAMVKDAQMLV--KLSHESLIGLVGTSFNL------------ESWIVIVEPVR-SS----LSTFLRSNRPTPDC--------------------------
|. . ..|. .. |. .. |.| .. | |....| . . | ..||..||. .
LEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDIT
-------------------------------------------PSSVTECQLLEYALDVVDALSFLEEK------GVIHNNIQADSVYIALHGS------
.. .| ||| ..... .....|..| ...| .. | . .. ..
YSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFD
-----AVLGGFGDA------RLVEAANTPESMARD------------------------VESLPIRWMAPEVITDNQ---------PSVKSDIYSFGVLL
. .. || . . . . . ... |||||||||...|.. . |||..|||||.
GCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM
WELFTYGRRPWPG-YAH---------AEIAQIVTKQ-------------SALLLQPDDCP--------------HQVYRVMKQCWKATPSIRPTPKTLDD
||.||||. |..| . .|. . ... . ||..|| .|..|.|||.. |. ||| ..| .
WEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHE
VL
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QL
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| Kinase | UTK22.AA | TK-Unique | 843-1070 | 28 | 6.9e-51 | 173.69 | In-house | 41-294 (294) | Show / Hide |
Range on Protein: 843-1070 Range on HMM: 41-294/294 Sequence Identity: 28% (73 aa) PADESVKLAMVKDAQMLVKLS-HESLIGLVGTSF-NLESWIVIVEPVRSS-LSTFLRSNRPT-----------------PDCPSS--VTECQLLEYALDV .|.. | .. | .||. .| |. .. ..| . . |.| | |... . | ..||..||. || |. .....|. .| .. NATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQI VDALSFLEE--KGVIHNNIQADSVYIALHGSAVLGGFGDARLVEAANTPESMARDVESLPIRWMAPEVIT--DNQP-SVKSDIYSFGVLLWELFTYGRRP ....|.. |...|... | | .. .. . ...|| || |.. |.. || . . .||||||||.. ... . |||..|||||.||.||.| .| ACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACP WPGYAHAEIAQIVTKQSALLLQPDDC-PHQVYRVMKQCWKATPSIRPTPKTLDDVL ||. ..| . ... . ..||. | .|..| .||.||. |. ||. .. ..| YPGMPWKDIMECIRDGYR-MPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | UTK22.AA | Frk | 852-1074 | 33 | 1.2e-38 | 131.4 | In-house | 41-260 (260) | Show / Hide |
Range on Protein: 852-1074 Range on HMM: 41-260/260 Sequence Identity: 33% (75 aa) MVKDAQMLVKLSHESLIGLVGTSFNLESWIVIVEPVRSS-LSTFLRSNRPTPDCPSSVTECQLLEYALDVVDALSFLEEKGVIHNNIQADSVYIALHGSA ....||.. || | || | | ..| | .| | ..|.. | ... ||.. | | . .||.. || . | | . | . FLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQA---INDKGRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNIC VLGGFGDARLVEAANTPESMARDVESLPIRWMAPEVITDNQPSVKSDIYSFGVLLWELFTYGRRPWPGYAHAEIAQIVTKQSALLLQPDDCPHQVYRVMK . || ||.. | .| .||.| ||| . |. ..|||..|||.|| |. |||| |.|| ||. |.| .. . || .|| |.| .| KIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMV-DHGYRMPQPPNCPQQLYEIML QCWKATPSIRPTPKTLDDVLTNVL .||.. | ||| || | . . ECWHSDPMKRPTFETLQWKLEDYF |
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| Kinase | UTK22.AA | Pkinase_Tyr | 977-1070 | 43 | 4e-38 | 129.76 | Pfam | 176-270 (270) | Show / Hide |
Range on Protein: 977-1070 Range on HMM: 176-270/270 Sequence Identity: 43% (41 aa) LPIRWMAPEVITDNQPSVKSDIYSFGVLLWELFTYGRRP-WPGYAHAEIAQIVTKQSALLLQPDDCPHQVYRVMKQCWKATPSIRPTPKTLDDVL |||.|||||.| .. ..|||..|||||.||.||||. | .|| .|. . .... . .|..|| .|..|||||.. |. ||| . . | LPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | UTK22.AA | Musk | 975-1070 | 37 | 2.5e-33 | 107.34 | In-house | 188-282 (282) | Show / Hide |
Range on Protein: 975-1070 Range on HMM: 188-282/282 Sequence Identity: 37% (36 aa) ESLPIRWMAPEVITDNQPSVKSDIYSFGVLLWELFTYGRRPWPGYAHAEIAQIVTKQSALLLQPDDCPHQVYRVMKQCWKATPSIRPTPKTLDDVL . |||||.|| | .|| .. ||. ..||.|||.| |. |. | .| |. . .| | |. || .|| .|..||.. |. || . ..... DHIPIRWMPPESIWYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYI-RQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI |
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| Kinase | UTK22.AA | Src | 955-1070 | 41 | 2.7e-33 | 110.46 | In-house | 141-255 (255) | Show / Hide |
Range on Protein: 955-1070 Range on HMM: 141-255/255 Sequence Identity: 41% (48 aa) FGDARLVEAANTPESMARDVESLPIRWMAPEVITDNQPSVKSDIYSFGVLLWELFTYGRRPWPGYAHAEIAQIVTKQSALLLQPDDCPHQVYR-VMKQCW || |||.. | || .||.|.||| |. .. ..||| |||.||.|..|||| | || .| | | .. . .|. || ..| .|.||| FGLARLIKED-DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQV-ERGYRMPCPHNCPDELYEQIMLQCW KATPSIRPTPKTLDDVL ...| ||| ..| ..| HKDPEQRPTFEYLQWFL |
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| Kinase | UTK22.AA | Ack | 977-1070 | 42 | 5.4e-33 | 108.64 | In-house | 173-266 (266) | Show / Hide |
Range on Protein: 977-1070 Range on HMM: 173-266/266 Sequence Identity: 42% (40 aa) LPIRWMAPEVITDNQPSVKSDIYSFGVLLWELFTYGRRPWPGYAHAEIAQIVTKQSALLLQPDDCPHQVYRVMKQCWKATPSIRPTPKTLDDVL .|. |.||| .. | | .||. .||| ||| |.||. || |. ..| | . | ..| .||.|| .| .|.|||...| ||| . | | VPFAWCAPECLRHRQFSHASDVWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL |
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| Kinase | UTK22.AA | SrcB | 851-1071 | 29 | 1.3e-32 | 107.52 | In-house | 40-251 (251) | Show / Hide |
Range on Protein: 851-1071 Range on HMM: 40-251/251 Sequence Identity: 29% (65 aa) AMVKDAQMLVKLSHESLIGLVGTSFNLESWIVIVEPVRSSLSTFLRSNRPTPDCPSSVTECQLLEYALDVVDALSFLEEKGVIHNNIQADSVYIALHGSA | ...| .. .| |. |. | .|. . .| ||.. | | .. .|.... . . . ..|.. || . | . .. . AFLAEANVMKTLQHDRLVRLYAVVTKEPIYIITEYMAKGCLLDFLKT-----DEGSKLSLPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCC VLGGFGDARLVEAANTPESMARDVESLPIRWMAPEVITDNQPSVKSDIYSFGVLLWELFTYGRRPWPGYAHAEIAQIVTKQSALLLQPDDCPHQVYRVMK . || ||..| | ||. ||.| ||| | .|||..|||.|| |. |||| |.|| . .|. . . .. . .|| ||. .|..|. KIADFGLARIIEDN---EYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGMTNPEVIRNL-ERGYRMPRPDNCPEELYNIMM QCWKATPSIRPTPKTLDDVLT .||| | ||| | || MCWKERPEERPTFDYLQSVLD |
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| Kinase | UTK22.AA | Trk | 977-1070 | 39 | 1.9e-31 | 103.78 | In-house | 182-275 (275) | Show / Hide |
Range on Protein: 977-1070 Range on HMM: 182-275/275 Sequence Identity: 39% (37 aa) LPIRWMAPEVITDNQPSVKSDIYSFGVLLWELFTYGRRPWPGYAHAEIAQIVTKQSALLLQPDDCPHQVYRVMKQCWKATPSIRPTPKTLDDVL |||||| || | . .. ||. |||| .|| ||||. || . |. . ... |..| || || .| ||. | | . | . |.. LPIRWMPPESIMYRKFTYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII |
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| Kinase | UTK22.AA | Tec | 978-1072 | 34 | 3.3e-29 | 99.22 | In-house | 161-254 (254) | Show / Hide |
Range on Protein: 978-1072 Range on HMM: 161-254/254 Sequence Identity: 34% (33 aa) PIRWMAPEVITDNQPSVKSDIYSFGVLLWELFTYGRRPWPGYAHAEIAQIVTKQSALLLQPDDCPHQVYRVMKQCWKATPSIRPTPKTLDDVLTN |..| .||| . | |||. .|||| || |. |. |.. . |... |.. | .|. |. ..|..|..||. | ||| . | . .|. PVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYENMSNSEVVEHVSQG-HRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE |
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| TyrKc | UTK22.AA | TyrKc | 792-1070 | 23 | 8.1e-18 | 65.36 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 792-1070 Range on HMM: 1-280/280 Sequence Identity: 23% (74 aa) TTTVCELGQIKLHRCFLAAASDQETRVAV----ADYELDDPSVSQDVFSCFVLAQPADESVKLAMVKDAQMLVKL--SHESLIGLVGTSFNL-------E | .|| . ... .. . ||| .| . .. . |... || .|. .. |.| | ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIE SWIVIVEPVRS-SLSTFLRSNRPTPDCPSSVTECQLLEYALDVVDALSFLEEKGVIHNNIQADSVYIALHGSAVLGGFGDARLVEAA-----NTPESMAR ...| . .| .||..||. .. .||...... . ..|..|..|| . | . .. . . . || .| .. .. ... PLMIVMEYMPHGDLKDYLRKHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKK ---DVES-LPIRWMAPEVITDNQPSVKSDIYSFGVLLWELFTYGRRPWPG-----YAHAEIAQIVTKQSALLLQPDD--------CPHQVYRVMKQCWKA . . |||||||||.| .. . |||..||||..||.|||| |.|| .|. . | || . ||.. || .|..|||||.. EHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV-KQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE TPSIRPTPKTLDDVL |. ||| ... . . DPEDRPTFSEIHECF |
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| S_TKc | UTK22.AA | S_TKc | 792-1070 | 14 | 1.5e-12 | 7.09 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 792-1070 Range on HMM: 1-231/231 Sequence Identity: 14% (41 aa) TTTVCELGQIKLHRCFLAAASDQETRVAVADYELDDPSVSQDVFSCFVLAQPADESVKLAMVKDAQMLVKLSHESLIGLVGTSFNLESWIVIVEPVRS-- . . ..|. ..... . | || ... . . |.| | |. .. | .. . .. .. | . YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-----------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDL -SLSTFLRSNRPTPDCPSSVTECQLLEYALDVVDALSFLEEKGVIHNNIQADSVYIALHGSAVLGGFGDARLVEAANTPESMARDVESLPIRWMAPEVIT .| ........ . . . .| . |. ...|| .. ..|.|| . . . . .. || ||.. . .|||||. GDLFDYIKKRGRHGLR-FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL- DNQPSV-KSDIYSFGVLLWELFTYGRRPWPGYAHAEIAQIVTKQSALLLQPDDCPHQVYRVMKQCWKATPSIRPTPKTLDD---------VL . . |.|..|.|..|.|... |. |.| .... ... .... ...|.. |. ||| . . --GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | UTK22.AA | Pkinase | 979-1018 | 41 | 5.8e-08 | 29.23 | Pfam | 175-214 (293) | Show / Hide |
Range on Protein: 979-1018 Range on HMM: 175-214/293 Sequence Identity: 41% (17 aa) IRWMAPEVIT-DNQPSVKSDIYSFGVLLWELFTYGRRPWPG ...|||||| .. . |.|..|.|..|.|... || |.|| PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPG |
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| Pkinase_Tyr | UTK22.AA | Pkinase_Tyr | 839-934 | 20 | 1e-06 | 23.17 | Pfam | 35-134 (270) | Show / Hide |
Range on Protein: 839-934 Range on HMM: 35-134/270 Sequence Identity: 20% (21 aa) VLAQPADESV--KLAMVKDAQMLVKL-SHESLIGLVGTSF-NLES--WIVIVEPVRS-SLSTFLRSNRPTPDCPSSVTECQLLEYALDVVDALSFLEEKG .| . |... . .. . |... .| .|. .. |.| |. .....| . .| ..||..| . . ..| .||...... .....||.|. MLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR---EDKQPLTMKDLLQMCWQIAKGMEYLESKN VIH || CIH |
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| Kinase | UTK22.AA | Ack | 913-934 | 27 | 0.001874 | 7.52 | In-house | 107-128 (266) | Show / Hide |
Range on Protein: 913-934 Range on HMM: 107-128/266 Sequence Identity: 27% (6 aa) LLEYALDVVDALSFLEEKGVIH |..... .......|| |. || LCDFCMQIAMGMRYLEMKRCIH |
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| Kinase | UTK22.AA | Tec | 856-934 | 25 | 0.008052 | 5.78 | In-house | 45-120 (254) | Show / Hide |
Range on Protein: 856-934 Range on HMM: 45-120/254 Sequence Identity: 25% (21 aa) AQMLVKLSHESLIGLVGTSFNLESWIVIVEPVRS-SLSTFLRSNRPTPDCPSSVTECQ--LLEYALDVVDALSFLEEKGVIH |. ||||. |. | | .. | . .|. .||... . ... ||| .|| . .||....|| AKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHH------FQKNMAILLEMCQDVCEGMAYLERHCFIH |
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