Gene UTK11 (M.brevicollis)
UTK11
Species: M.brevicollis
Alias: UTK11
External Links:
Annotation:
Sequence
Protein domains of UTK11.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | UTK11.AA | UTK | 268-502 | 33 | 8.8e-98 | 331.16 | In-house | 32-296 (296) | Show / Hide |
Range on Protein: 268-502 Range on HMM: 32-296/296 Sequence Identity: 33% (89 aa) VAVKRLG-ESATESDKT---RFAAEIR---LLSSLK-HPHIVKLLGASTYEGQTAMVLEYAKLGELAAYVRRPPHQLLAPGHISRAD-VLCIAVQIAGAL |||| . ..... ... .| | | ... .. ||....|.| |.|.....|.||.. | |..|.|| .... |..|. . . || |..|| .. VAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGM QFLESMKVIHRDVAARNVLAFSM-------TTFKLADVG---LSRLLGS--------DQEYYRQESQQATAIRWMAPEAMVKH-RFSSQSDVWSFGILLY |.|.|....|||.||||.| .. ...|.||.| .||.... ...||.. .|.. .||||||||...| ||...|||||||.... QYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCW EACTYGSVPYGHLSDMQVPMAVTRG--VLPPEPPTRFPELYAIMGMCWRSEPAQRPTFAQLVHML | .|.|..||...|.||| .|..| ..| |. ..| .| ||...|. ||.| .|| . EIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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Kinase | UTK11.AA | TK | 241-502 | 20 | 9.3e-87 | 290.79 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 241-502 Range on HMM: 1-486/486 Sequence Identity: 20% (100 aa) SMVIIAIGCGA-G---VVVLVAAVLLP-----------------------LQLTVAVKRLGESATESDKT----------------RFAAEIRLLSS--L .. .| |. | .| . . .. . .|||| | | ...|.. ..|.|. .... . ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG KHPHIVKLLGASTYE------------GQTAMVLEYAKLGE----LAAYVR--RP--------------------------------------------- .||.||.|.|..| . . .|.||...| | | | || HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY -------------PHQLLA---------PGHISRADVLCIAVQIAGALQFLESM------KVIHRDVAARNVLAFSMTT-----------FKLADVG--- ..|| ..... .. | ...||| ....|.|. ...|||.||||.| .. . |.|| | DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR -----LSRLLGSD-----------------------QEYYRQESQQATAIRWMAPEAMV---------KHRFSSQSDVWSFGILLYEACTYG-SVPYGHL |.| ..|| |.||||.|. |||||||.. ...|...|||||||.|..| .||| .|| . QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM SD---------MQVPMAVTRG-------------VLPPEPPTRFP--------------ELYAI-MGMCWRSEPAQRPTFAQLVHML |. .| ..|| .....| | |.|.. | .||. .|..||||.||...| SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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Kinase | UTK11.AA | Pkinase_Tyr | 265-502 | 34 | 2e-82 | 279.8 | Pfam | 28-270 (270) | Show / Hide |
Range on Protein: 265-502 Range on HMM: 28-270/270 Sequence Identity: 34% (86 aa) QLTVAVKRLGESATESD--KTRFAAEIRLLSSL-KHPHIVKLLGAST-YEGQ--TAMVLEYAKLGELAAYVRRPPHQLLAPGHISRADVLCIAVQIAGAL ...|||| | |.|.... . | .|......| .||.||.|.|. | ... .|.||...| | | |.. ..... | |....||| .. KIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR---EDKQPLTMKDLLQMCWQIAKGM QFLESMKVIHRDVAARNVLAFSMTTFKLADVGLSRLLGSDQEYY-RQESQQATAIRWMAPEAMVKHRFSSQSDVWSFGILLYEACTYGSVP-YGHLSDMQ ..|||.. ||||.||||.| . . | .| ||.|.. . .|| |. . |.|||||.. .|...|||||||.|..| .||| | | .|. . EYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE VPMAV-TRGVLPPEPPTRFPELYAIMGMCWRSEPAQRPTFAQLVHML | .. .| | |. .|.| .| .||. .|..||||......| VYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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Kinase | UTK11.AA | TyrKc | 241-502 | 32 | 2.1e-78 | 267.7 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 241-502 Range on HMM: 1-280/280 Sequence Identity: 32% (96 aa) SMVIIAIGCGA-GVVVLVAAVLLPLQLTVAVKRLGESATESDKTRFAAEIRLLSSL--KHPHIVKLLGASTYE-------GQTAMVLEYAKLGELAAYVR . .|.|| |.|.. . ..|||| | |.| . | |.|....| .||.||.|.|. | . .. .|.||...| | | | ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR RPPHQLLAPGHISRADVLCIAVQIAGALQFLESMKVIHRDVAARNVLAFSMTTFKLADVGLSRLLGSD------QEYYRQ----ESQQATAIRWMAPEAM .. .. .. .| | ...||| ..|.|...|||| ||||.| . | | .| |||| ...| ..|||. . |||||||.. KHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI VKHRFSSQSDVWSFGILLYEACTYGSVPYGH-----LSDMQVPMAVTRGVLPPEPPT--------RFPELYAIMGMCWRSEPAQRPTFAQLVHML ...|...|||||||....| .||| || .|. .| | .| .| || .|.| || .||. .|..||||..... . NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | UTK11.AA | TK-Unique | 265-502 | 33 | 2.5e-72 | 246.59 | In-house | 30-294 (294) | Show / Hide |
Range on Protein: 265-502 Range on HMM: 30-294/294 Sequence Identity: 33% (90 aa) QLTVAVKRLGESATESDKTRFAAEIRLLSSLK-HPHIVKLLGASTYEG-QTAMVLEYAKLGELAAYVR--RPPHQLL-------------APGH----IS | |||| | ..||. || | ||.....|. ||.||..||..| . .. ...||. | | | | ||.. .. || QKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPIS RADVLCIAVQIAGALQFLES--MKVIHRDVAARNVLAFSMTTFKLADVGLSRLLGSDQEYYRQESQQATAIRWMAPEAMV--KHRF-SSQSDVWSFGILL |.. .|.||| ....|.| .|..|||..||||| . . |..| |..| . ...| ...||. . |||||||.. .. . ...|||||||.|. PKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLM YEACTYGSVPYGHLSDMQVPMAVTRGVLPPEPPTR-FPELYAIMGMCWRSEPAQRPTFAQLVHML .| .|.|. ||. ... .. ....|. .| |. .|.| .| ||..|| .||.|.|..|.| WEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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Kinase | UTK11.AA | CTKA | 268-502 | 36 | 4e-61 | 204.09 | In-house | 37-290 (290) | Show / Hide |
Range on Protein: 268-502 Range on HMM: 37-290/290 Sequence Identity: 36% (94 aa) VAVKRLGESATESDKTRFAAEIRLLS--SLKHPHIVKLLGASTYEGQTAMVLEYAKLGELAAYVRR----P-----------------PHQLLAPGHISR |||| | . ||| | | .| ..|| . || .. ||| | . |. |. .| | |.|. . | . |. ... VAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDLHCYLRACRPADGQVCPARARRSIPRSFHPIEVHAHEQVY- ADVLCIAVQIAGALQFLESMKVIHRDVAARNVLAFSMTTFKLADVGLSRLLGSDQEYYRQESQQATAIRWMAPEAMVKHRFSSQSDVWSFGILLYEACTY | ||| .| .| .||| |.||.| . . |.|| |..|.| . || || .|||||||. .||..||||.||.||.| . -----MAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSM GSVPYGHLSDMQVPMAVTRG---VLPPEPPTRFPELYAIMGMCWRSEPAQRPTFAQLVHML | |. |.|| | |.| . ||. |.. || | ||. ||.|||||..| || GEKPWRHMSDQEVCQAYTSHGMRRLPV-PRNCPQVLYHCMQECWKFEPNQRPTFETLQRML |
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Kinase | UTK11.AA | Src | 268-502 | 38 | 5.1e-57 | 192.24 | In-house | 26-255 (255) | Show / Hide |
Range on Protein: 268-502 Range on HMM: 26-255/255 Sequence Identity: 38% (91 aa) VAVKRLGESATESDKTRFAAEIRLLSSLKHPHIVKLLGASTYEGQTAMVLEYAKLGELAAYVRRPPHQLLAPGHISRADVLCIAVQIAGALQFLESMKVI |||| | . . . | .|. .. .|.|...|.|. . | | || . | | .| .. .|.. . . .| |.| ..||||..| VAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYI HRDVAARNVLAFSMTTFKLADVGLSRLLGSDQEYYRQESQQATAIRWMAPEAMVKHRFSSQSDVWSFGILLYEACTYGSVPYGHLSDMQVPMAVTRGVLP ||| |||||| | || || ||. | . | .. |.|.|||| .||. ||||||||||.| ||| ||| . ..| .| || HRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRM PEPPTRFPELYA-IMGMCWRSEPAQRPTFAQLVHML | |.. .||| || .||...| |||||. | . | PCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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Kinase | UTK11.AA | RTKE | 265-502 | 29 | 2.7e-56 | 190.59 | In-house | 42-293 (293) | Show / Hide |
Range on Protein: 265-502 Range on HMM: 42-293/293 Sequence Identity: 29% (78 aa) QLTVAVKRLGESATESDKTRFAAEIRLLSSLKHPHIVKLLGASTYEGQTAMVLEYAKLGELAAYVRRPPHQLLAP-GHISRADVLCIAV-QIAGALQFLE .. ||||.| ... ... | .| .... |.||..|.||. .. .||.||. .| |. .. . | .... . . |.| .. ||| TRQVAVKTLHNHECHHE---FVQEMTMMCKLHHPNVVHLLHVVQMKQHFMMVYEYMPGGQLEDWLQ-------DHHGRPTSHEDQIHCLHQVACGMSFLE SMKVIHRDVAARNVLAFSMTT-FKLADVGLSR--LLGSD--QEYYRQESQQATA-----IRWMAPEAMVKHRFSSQSDVWSFGILLYEACTYGSVPYGHL .....|||..|.||.. . . |.|| |||| || . |.||| ..... . .||.|||. ||..||||..| |..| .. | || |. RLGIVHRDLCAHNVYCCRCWNDVKVADYGLSRDMYLGQEYMQCYYRIKTRRWMPTTWGSRRWWAPEVWKDQHFSFKSDVWAYGCLCWEVWNNGQMPYAHM SDMQVPMAVTRGVLP-----------PEPPTRFPELYA-IMGMCWRSEPAQRPTFAQLVHML .| |. .... ...| ..||.. |.. . .| | . |. ||.||||. |. DDQQFMQRIVQCQMPSGGHLGDHEPVHAPPVHCPPWADRLMQWCLCINPEHRPNFAQLYQMW |
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Kinase | UTK11.AA | FAK | 263-507 | 34 | 9.8e-56 | 185.16 | In-house | 49-285 (285) | Show / Hide |
Range on Protein: 263-507 Range on HMM: 49-285/285 Sequence Identity: 34% (85 aa) PLQLTVAVKRLGESATESDKTRFAAEIRLLSSLKHPHIVKLLGASTYEGQTAMVLEYAKLGELAAYVRRPPHQLLAPGHISRADVLCIAVQIAGALQFLE | .. ||.| . ... | .| .| . . |||||||.| . | . ...| .|.||| .| .| .| . | . . |.. |. .|| PDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICE-EMPIWIIMELCKYGELRHYLQRNKNSL------KHATLILYCYQLCMAMAYLE SMKVIHRDVAARNVLAFSMTTFKLADVGLSRLLGSDQEYYRQESQQATAIRWMAPEAMVKHRFSSQSDVWSFGILLYEACTYGSVPYGHLSDMQVPMAVT | | .|||.|||||| | . ||.| ||||.. .|..||. . . |.||.|| || . |||| ||. . | || |. . | . SKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWM-HDHSYYKASPKGKLPIKWMSPESINFRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIE RGVLPPEPPTRFPELYAIMGMCWRSEPAQRPTFAQLVHMLSELQV .| | || | || .| || .| .|| | .|. |.... NGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ |
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Kinase | UTK11.AA | Frk | 243-506 | 34 | 2.6e-54 | 186.56 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 243-506 Range on HMM: 1-260/260 Sequence Identity: 34% (93 aa) VIIAIGCGAGVVVLVAAVLLPLQLTVAVKRLGESATESDKTRFAAEIRLLSSLKHPHIVKLLGASTYEGQTAMVLEYAKLGELAAYVRRPPHQLLAPGHI . . |.| | | . ||||.| . | . | .| ... .|.|| ...| | | .. | . | | |.. . |. IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTL--KPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQ----AINDKGRQ SRADVLC-IAVQIAGALQFLESMKVIHRDVAARNVLAFSMTTFKLADVGLSRLLGSDQE-YYRQESQQATAIRWMAPEAMVKHRFSSQSDVWSFGILLYE . | .| |.| . .|||. ||||.|||||| .|.|| || |.| |.| | . |.| ||||. ..|. .||||||||||.| CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTE ACTYGSVPYGHLSDMQVPMAVTRGVLPPEPPTRFPELYAIMGMCWRSEPAQRPTFAQLVHMLSELQ ||| .|| . . .| | .| |.|| ..|| || ||.|.| .|||| | | . IITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF |
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Kinase | UTK11.AA | Trk | 242-502 | 35 | 1.1e-53 | 180.37 | In-house | 2-275 (275) | Show / Hide |
Range on Protein: 242-502 Range on HMM: 2-275/275 Sequence Identity: 35% (97 aa) MVIIAIGCGA-GVVVLVAAVLLPLQ---LTVAVKRLGESATESDKTRFAAEIRLLSSLKHPHIVKLLGASTYEGQTAMVLEYAKLGELAAYVRR--PPHQ . . .| || |.|.| |. . . |||| | . |.|. .. | | .|| |.|.||||. | | . || || | | | | | | . VLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKD-ASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDAM LLAPGHI-------SRADVLCIAVQIAGALQFLESMKVIHRDVAARNVLAFSMTTFKLADVGLSRLLGSDQEYYRQESQQATAIRWMAPEAMVKHRFSSQ ..| . . | || ||| . .. | ..||| |.|| | | .| |.|| . | .||| . . . |||| ||. . ..|. CYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTYE SDVWSFGILLYEACTYGSVPYGHLSDMQVPMAVTRGVLPPEPPTRFP-ELYAIMGMCWRSEPAQRPTFAQLVHML |||||||. . | ||| |. || | .. | . .| | | | |.|.|| ||. || || . .. ... SDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII |
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Kinase | UTK11.AA | DDR | 268-502 | 33 | 2.1e-50 | 173.75 | In-house | 43-306 (306) | Show / Hide |
Range on Protein: 268-502 Range on HMM: 43-306/306 Sequence Identity: 33% (88 aa) VAVKRLGESATESDKTRFAAEIRLLSSLK-HPHIVKLLGASTYEGQTAMVLEYAKL-GELAAYVRRPPHQ---LLAPG---------HISRADVLCIAVQ |||| | . |.. .. | ||. .|..| || ||.|.|. | . |..|| | | . . . | . || . . |. | VAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLGDLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQ IAGALQFLESMKVIHRDVAARNVLAFSMTTFKLADVG--LSRLLGSDQEYYRQES-----QQATAIRWMAPEAMVKHRFSSQSDVWSFGILLYEACTYGS || .. .|||| .||| |.||.| . | .| | .|| | | |.||| | . |||||.|. . |.. ||||.||. ..| . . IASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYS-QDYYRVEGFTGRQRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCR V-PYGHLSDMQV-------PMAVTRGVLPPEPPTRFPELY-AIMGMCWRSEPAQRPTFAQLVHML ||..|.| || . |..| || |.| | |||... |||.|.... | EQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQSQRPSFEEIHKFL |
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Kinase | UTK11.AA | Pkinase | 267-502 | 21 | 3.9e-34 | 121.77 | Pfam | 26-293 (293) | Show / Hide |
Range on Protein: 267-502 Range on HMM: 26-293/293 Sequence Identity: 21% (61 aa) TVAVKRLGESATESDKTRFAA---EIRLLSSLKHPHIVKLLGASTYEGQTAMVLEYAKLG----ELAAYVRRPPHQLLAPGHI--SRADVLCIAVQIAGA .||||.. . ..|.| . .. ||... .|.||.||.|... .... ||.||. | .|..|... . | . | .. ... ||. . IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-----WRHGCFYFSEWECKFYMYQILRG LQFLESMKVIHRDVAARNVLAFSMTTF----KLADVGLSRLLGSDQEYYRQESQQATAIRWMAPEAMV-KHRFSSQSDVWSFGILLYEACTYGSVPYGHL |... ||..||||. |.| . . |..| ||.... . . | ...|||| .. .|.||.|..||| .. | |. . LEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGT-PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGH -----SDMQVPMAVTRGVLPPEPPTRF---------------------PELYAIMGMCWRSEPAQRPTFAQLVHM--L |... .. ..| .... .|. .. |.. |..|||..|... . CWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | UTK11.AA | S_TKc | 241-502 | 23 | 1.9e-31 | 111.72 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 241-502 Range on HMM: 1-231/231 Sequence Identity: 23% (64 aa) SMVIIAIGCGAGVVVLVAAVLLPLQLTVAVKRLGESATESDKTRFAAEIRLLSSLKHPHIVKLLGASTYEGQTAMVLEYAKL--GELAAYVRRPPHQLLA .. || || .| . . ||.|.. .. ||..|.. .||.||||... . ||.||. |.| | .. ... | YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL- PGH--ISRADVLCIAVQIAGALQFLESMKVIHRDVAARNVLAFSMTTFKLADVGLSRLLGSDQEYYRQESQQATAIRWMAPEAMVKHRFSS-QSDVWSFG . .. .. ... ||. ||... |...||||. |.| . . |..| ||.|.| . . .|||| . .. .|.||.| --RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG ILLYEACTYGSVPYGHLSDMQVPMAVTRGVLPPEPPTRFPELYAIMGMCWRSEPAQRPTFAQLVH---------ML ..||| .. | |. .||. . . . ||. .. |.. .|..||| .. . . CILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |