Gene UTK03 (M.brevicollis)
UTK03
Species: M.brevicollis
Alias: UTK03
External Links:
Annotation:
Sequence
Protein domains of UTK03.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | UTK03.AA | UTK | 301-516 | 40 | 4.5e-106 | 358.71 | In-house | 57-296 (296) | Show / Hide |
Range on Protein: 301-516 Range on HMM: 57-296/296 Sequence Identity: 40% (98 aa) AR---IMRAYAVPHHMNVLRFLGLCWDSETLMVVTEFCSRGSLQHVLRNARPSQGQDSPHLNLLDRIKMAADVARGMAYLANQEFVHRDLCARNCLVHEN || .| . . .|.||||..|.|...| .|.|||....|.|...||..||..... .|.| .|..||.|.||||.||... ||||||.|||||||.. ARELQMMKQFH--WHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMH -------MTAKISGFD---ASTMVN---------QSPMDMQNGQNILNVRWMAPQVLTEA-RFSNKSDVWSFGVLLFECMTFASKPYADLSNGDVCHQRG |..||..| | .|| .|.. |...|... .|||||..||.. ||..|||||||||...|..|....||...|| .|.|| . RMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVC FK---LTRSAWGTGMSSYRIMRSCWHMGPSSRPDFEDLLSAL . . .. |. ... ||.|..|||. |. |||||||.... NGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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Kinase | UTK03.AA | TK | 301-516 | 20 | 6.9e-71 | 236.64 | In-house | 89-486 (486) | Show / Hide |
Range on Protein: 301-516 Range on HMM: 89-486/486 Sequence Identity: 20% (82 aa) ARIMRAYA--VPHHMNVLRFLGLCWDSET------------LMVVTEFCSRGS----LQHVLRNARPSQGQDSP-------------------------- |..| . || |..|..| | ..|. .|.|.|... |. |.. ||. || . .. AEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSH ------------------------------------------HLNLLDRIKMAADVARGMAYLANQ------EFVHRDLCARNCLVHENMT--------- .|.. ... |....|.||.||. . ||||||.||||||.||.. ESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCG --AKISGFDAST-----MVNQSPMD-----MQNG----------------------QNILNVRWMAPQVLT---------EARFSNKSDVWSFGVLLFEC .||. | | . . | .... . | .||||| .|. . .|. ||||||||||..|. PVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI MTFASKPYAD-LSNGDVCH-----------------------QRGFKLTRS--AWGTG-------------MSSYRIMRSCWHMGPSSRPDFEDLLSAL .|.. .||. .|| ||.. . | .. . . . |..|..||| |. ||.|..|...| FTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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Kinase | UTK03.AA | Pkinase_Tyr | 279-475 | 34 | 2e-57 | 195.11 | Pfam | 30-227 (270) | Show / Hide |
Range on Protein: 279-475 Range on HMM: 30-227/270 Sequence Identity: 34% (70 aa) QVAVKACSMPPGSPE--YSNFVIAARIMRAYAVPHHMNVLRFLGLCW-DSET--LMVVTEFCSRGSLQHVLRNARPSQGQDSPHLNLLDRIKMAADVARG .|||| . ... | |.||. . .|| |..|..| | ..| ...|.|.. |.| . ||. | | ..|.. | ..|....|.| PVAVKMLKEGAMHEQNCREDFMREAKIMKQL--GHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR----EDKQPLTMKDLLQMCWQIAKG MAYLANQEFVHRDLCARNCLVHENMTAKISGFDASTMVNQSPMD-MQNGQNILNVRWMAPQVLTEARFSNKSDVWSFGVLLFECMTFASKP-YADLSNGD |.||... ..||||.||||||.||...||. | . . . | | ..|||| .. . .|. ||||||||||..| .|. .| |...|| . MEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE VCHQ |... VYEY |
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Kinase | UTK03.AA | TK-Unique | 278-516 | 31 | 5.4e-55 | 188.06 | In-house | 31-294 (294) | Show / Hide |
Range on Protein: 278-516 Range on HMM: 31-294/294 Sequence Identity: 31% (83 aa) KQVAVKACSMPPGSPEYSNFVIAARIMRAYAVPHHMNVLRFLGLCWDS-ETLMVVTEFCSRGSLQHVLRNARPS-----------------QGQDSPH-L |.||||.. . . ..| ...|. ... | |....|| | .| | | . |.|..|.||| ||. || .... . KCVAVKMLKDNATDTDKQDFLKEIQMMK--ELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPI NLLDRIKMAADVARGMAYLAN--QEFVHRDLCARNCLVHENMTAKISGFDASTMVNQ-SPMDMQNGQNILNVRWMAPQVLT--EARF-SNKSDVWSFGVL .. | . | ..|.||.||| ...|||||||||.|. |. ..||..| .. |. . .|. .|. . .||||| .| . . . |||||||||| SPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVL LFECMTFASKPYADLSNGDV--CHQRGFKLTRSAWGTGMSSYRIMRSCWHMGPSSRPDFEDLLSAL ..|..|. . || .... |. | ..|. . . . | .|.|||. |..||.|..... | MWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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TyrKc | UTK03.AA | TyrKc | 241-516 | 27 | 8.4e-54 | 185.98 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 241-516 Range on HMM: 1-280/280 Sequence Identity: 27% (89 aa) LKALSK----------KSHADLFGGPRSSKRVRQELITEFDDWCLSSKQVAVKACSMPPGSPEYSNFVIAARIMRAY-AVPHHMNVLRFLGLCWDS---- .. . | | ... ||||| . | ||||. . || |..|..| | .. ITLGKKLGEGAFGEVYKGTWK--------------------------IQVAVKMLKEDA----REDFMREARIMCKLGG--HHPNIVRLYGVCTQQGRNF ---ETLMVVTEFCSRGSLQHVLRNARPSQGQDSPHLNLLDRIKMAADVARGMAYLANQEFVHRDLCARNCLVHENMTAKISGFDASTMVNQS-------P | ||.|.|... |.|.. ||. || |.. | .... ..|.||.||. . ..|||| ||||||.|| |.||| | | . MYIEPLMIVMEYMPHGDLKDYLRKHRPK-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKD MDMQ----NGQNILNVRWMAPQVLTEARFSNKSDVWSFGVLLFECMTFASKPYAD-----LSNGDVCH--QRGFKLTRSAWG-------TGMSSYRIMRS . .. .| | .||||| .. . .|. |||||||||...| .|. .|| . .|| .| . ..|. . . . . |.||.. YYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQ CWHMGPSSRPDFEDLLSAL ||| |..|| |... . . CWHEDPEDRPTFSEIHECF |
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Kinase | UTK03.AA | Abl | 311-516 | 34 | 1.5e-44 | 146.21 | In-house | 53-252 (252) | Show / Hide |
Range on Protein: 311-516 Range on HMM: 53-252/252 Sequence Identity: 34% (72 aa) HHMNVLRFLGLCWDSETLMVVTEFCSRGSLQHVLRNARPSQGQDSPHLNLLDRIKMAADVARGMAYLANQEFVHRDLCARNCLVHENMTAKISGFDASTM .| |. . || | ..||| . | | ||.. | .|. . . ||. .| || || ...|.|||| |||||| |. |. | . | KHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLREC------DREELPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARM VNQSPMDMQNGQNILNVRWMAPQVLTEARFSNKSDVWSFGVLLFECMTFASKPY--ADLSNGDVCHQRGFKLTRSAWGTGMSSYRIMRSCWHMGPSSRPD ... . | ..| || | .|| ||||| |||||.| |. || |||. ..|... | | . |..|| ||. .. || MKDDTYTAHAGAK-FPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYPGIDLSHVYHKLEKGYRMERPE-GCPPKVYELMRQCWQWSHTDRPS FEDLLSAL |... |. FKEIHHAM |
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Kinase | UTK03.AA | Src | 312-516 | 36 | 2.3e-44 | 148.64 | In-house | 53-255 (255) | Show / Hide |
Range on Protein: 312-516 Range on HMM: 53-255/255 Sequence Identity: 36% (76 aa) HMNVLRFLGLCWDSETLMVVTEFCSRGSLQHVLRNARPSQGQDSPHLNLLDRIKMAADVARGMAYLANQEFVHRDLCARNCLVHENMTAKISGFDASTMV | .... . | . | |||. |.|||. |.. .. ||.| . | ||| ||.||||| . ..|||| ||| || || .|. | .. HEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-----DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLI N--QSPMDMQNGQNILNVRWMAPQVLTEARFSNKSDVWSFGVLLFECMTFASKPYADLSNGDVCHQ--RGFKLTRSAWGTGMSSYR-IMRSCWHMGPSSR .. | . . ..|.|| ... ||. ||||||||.|| | .|. || .| .| | ||... . . . | ||. ||| | | KEDDDEYCARHGAK-FPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHN-CPDELYEQIMLQCWHKDPEQR PDFEDLLSAL | || | . | PTFEYLQWFL |
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Kinase | UTK03.AA | Musk | 356-516 | 33 | 2.3e-44 | 144.35 | In-house | 121-282 (282) | Show / Hide |
Range on Protein: 356-516 Range on HMM: 121-282/282 Sequence Identity: 33% (54 aa) PHLNLLDRIKMAADVARGMAYLANQEFVHRDLCARNCLVHENMTAKISGFDASTMVNQSPMDMQNGQNILNVRWMAPQVLTEARFSNKSDVWSFGVLLFE | |. ... .||...| ||||| |||||| ||||. |.| ||. | | . .. . .|||.| . .|. ||||..||.| | PQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESIWYNQFTYESDVWAYGVCLWE CMTFASKPYADLSNGDVCH--QRGFKLTRSAWGTGMSSYRIMRSCWHMGPSSRPDFEDLLSAL .| || .. .| . |. | . . .. | .|| || |. || | .. . IFSYALQPYYGMTHEEVIYYIRQGNILS-CPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI |
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Kinase | UTK03.AA | CTKA | 311-516 | 35 | 1.1e-43 | 144.6 | In-house | 67-290 (290) | Show / Hide |
Range on Protein: 311-516 Range on HMM: 67-290/290 Sequence Identity: 35% (80 aa) HHMNVLRFLGLCWDSETLMVVTEFCSRGSLQHVLRNARPSQGQDSP--------------HLNLLDRIKMAADVARGMAYLANQEFVHRDLCARNCLVHE || |||| ||.| .. . ..|. . | |. .|| || || | . . ||...| || ||| |||||| .||||. HHPNVLRLLGVCTQHKPWHMIMEHMQYGDLHCYLRACRPADGQVCPARARRSIPRSFHPIEVHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQ NMTAKISGFDASTMVNQS-PMDMQNGQNILNVRWMAPQVLTEARFSNKSDVWSFGVLLFECMTFASKPYADLSNGDVC-----H-QRGFKLTRSAWGTGM . ||. | . . | .. |||||| | . .|| ||||.|||||.| |... ||.. .| || | | .. |.. . YCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRLPVPRNCPQV-- SSYRIMRSCWHMGPSSRPDFEDLLSAL | | || | || || |. | -LYHCMQECWKFEPNQRPTFETLQRML |
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Kinase | UTK03.AA | Frk | 280-520 | 33 | 5.8e-43 | 146.58 | In-house | 26-260 (260) | Show / Hide |
Range on Protein: 280-520 Range on HMM: 26-260/260 Sequence Identity: 33% (81 aa) VAVKACSMPPGSPEYSNFVIAARIMRAYAVPHHMNVLRFLGLCWDSETLMVVTEFCSRGSLQHVLRNARPSQGQDSPHLNLLDRIKMAADVARGMAYLAN |||| . ||. . .|. |.||. | ... .| | ....|| .||||. |. | .|. .... . ||| || ||||| . VAVKT--LKPGTMDPNDFLREAQIMKKL---RHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQ-AINDKGR---QCQMQQLVDMAAQVAAGMAYLES QEFVHRDLCARNCLVHENMTAKISGFDAST--MVNQSPMDMQNGQNILNVRWMAPQVLTEARFSNKSDVWSFGVLLFECMTFASKPYADLSNGDVCHQ-- | ..|||| ||| || |. || | |... . . . ..| || .|. ||||||||.|| | .|. ||. . | .| .. QNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVD RGFKLTRSAWGTGMSSYRIMRSCWHMGPSSRPDFEDLLSALSEEL .|... . . . | || ||| | || || | | . . HGYRMPQPP-NCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF |
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Kinase | UTK03.AA | Tec | 427-518 | 40 | 8.6e-26 | 87.15 | In-house | 162-254 (254) | Show / Hide |
Range on Protein: 427-518 Range on HMM: 162-254/254 Sequence Identity: 40% (38 aa) VRWMAPQVLTEARFSNKSDVWSFGVLLFECMTFASKPYADLSNGDVCHQ--RGFKLTRSAWGTGMSSYRIMRSCWHMGPSSRPDFEDLLSALSE |.| .| |. |.| |||||.|||| | . || .|| .| . .|..| | |. |.|| .||| .| || |..||... | VKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYENMSNSEVVEHVSQGHRLYRPHLCS-MHIYQIMYHCWHEKPEERPTFQQLLRQITE |
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Kinase | UTK03.AA | InsR | 279-405 | 34 | 3.6e-23 | 74.57 | In-house | 33-163 (278) | Show / Hide |
Range on Protein: 279-405 Range on HMM: 33-163/278 Sequence Identity: 34% (46 aa) QVAVKACSMPPGSPEYSNFVIAARIMRAYAVPHHMNVLRFLGLCWDSETLMVVTEFCSRGSLQHVLRNARPSQGQDSPHLN-------LLDRIKMAADVA ..|.| . . | .| | .| . . .| | || | . .|| |. .| | || || ... | .| | . . |||... RCAIKTVNENASMRERIEFLNEASVMKEF---NCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRPEEEFNNPGCNRNQHVPCLDQMHQMAAEIC RGMAYLANQEFVHRDLCARNCLVHENMTAKISGF |||||| |||||| .|||.| . | || | DGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDF |
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Kinase | UTK03.AA | Tec | 312-405 | 35 | 7.3e-19 | 62.59 | In-house | 53-141 (254) | Show / Hide |
Range on Protein: 312-405 Range on HMM: 53-141/254 Sequence Identity: 35% (33 aa) HMNVLRFLGLCWDSETLMVVTEFCSRGSLQHVLRNARPSQGQDSPHLNLLDRIKMAADVARGMAYLANQEFVHRDLCARNCLVHENMTAKISGF | . .. | | . .|||. ..|.| || . .. . . .| ..| || ||||| . |.|||| |||||| .. |.| | HPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHK---HHFQKNMAIL--LEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDF |
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Kinase | UTK03.AA | InsR | 427-472 | 54 | 8.5e-19 | 59.67 | In-house | 185-230 (278) | Show / Hide |
Range on Protein: 427-472 Range on HMM: 185-230/278 Sequence Identity: 54% (25 aa) VRWMAPQVLTEARFSNKSDVWSFGVLLFECMTFASKPYADLSNGDV |||||| |.. |. .||||||||.|.| |... || ||| | VRWMAPESLKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQV |
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S_TKc | UTK03.AA | S_TKc | 260-516 | 16 | 3.4e-14 | 31.16 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 260-516 Range on HMM: 1-231/231 Sequence Identity: 16% (47 aa) KRVRQEL----------ITEFDDWCLSSKQVAVKACSMPPGSPEYSNFVIAARIMRAYAVPHHMNVLRFLGLCWDSETLMVVTEFCSR--GSLQHVLRNA .. ... .. . . ..||.| . .. .|.. || |. .... . | . | .|.|.|. |.| ..... YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR RP----SQGQDSPHLNLLDRIKMAADVARGMAYLANQEFVHRDLCARNCLVHENMTAKISGFDASTMVNQSPMDMQNGQNILNVRWMAPQVLTEARFSN- .. .. .. . .... ......|. .. ..|||| | |. | . ||. | .. . . .||| || .. GRHGLRFP------FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKC KSDVWSFGVLLFECMTFASKPYADLSNGDVCHQRGFKLTRSAWGTGMSSYRIMRSCWHMGPSSRPDFEDLLS---------AL |.|.||.|..|.|... |. .|. ||. . . ..| |... |. || ..| . KCDWWSCGCILYEMLC-GYPPFP-------QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | UTK03.AA | Pkinase | 311-458 | 22 | 7.5e-14 | 50.05 | Pfam | 58-207 (293) | Show / Hide |
Range on Protein: 311-458 Range on HMM: 58-207/293 Sequence Identity: 22% (37 aa) HHMNVLRFLGLCWDSETLMVVTEFCSRG----SLQHVLRNARPSQGQDSPHL--NLLDRIKMAADVARGMAYLANQEFVHRDLCARNCLVHENMTA---- .| |..|... . |. . .|.|.| | .| .... ... . . .... ..||..|. .. ..|||| |.|...|.. NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACV KISGFDAST---MVNQSPMDMQNGQNILNVRWMAPQVLT-EARFSNKSDVWSFGVLLFECMT ||. | . |.| |. | ..||| |. . |.|.||.|..|.| .. KICDFGLAKQFDY-NNS-MTTFCG----TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC |
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Kinase | UTK03.AA | Pkinase_Tyr | 492-516 | 40 | 1.2e-07 | 26.56 | Pfam | 246-270 (270) | Show / Hide |
Range on Protein: 492-516 Range on HMM: 246-270/270 Sequence Identity: 40% (10 aa) YRIMRSCWHMGPSSRPDFEDLLSAL |..|..||| |. || |..... | YDLMKQCWHYDPEDRPTFSEIHEQL |
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Kinase | UTK03.AA | InsR | 492-518 | 33 | 3e-07 | 20.28 | In-house | 252-278 (278) | Show / Hide |
Range on Protein: 492-518 Range on HMM: 252-278/278 Sequence Identity: 33% (9 aa) YRIMRSCWHMGPSSRPDFEDLLSALSE . .|. ||. |. || | |... | . QELMMMCWQYQPKMRPTFLDIIHYLCD |
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Kinase | UTK03.AA | Pkinase | 494-516 | 24 | 1.231859 | 3.33 | Pfam | 269-293 (293) | Show / Hide |
Range on Protein: 494-516 Range on HMM: 269-293/293 Sequence Identity: 24% (6 aa) IMRSCWHMGPSSRPDFEDLLSA--L ....|... |..|| .|..| . FIKWCLCKDPKKRPTAEQILQHPWF |