Gene Src4 (M.brevicollis)

Src4

Species: M.brevicollis
Alias: Src4
External Links:
Annotation:

Classification

Group: TK
Family: SFK-Src

Sequence

Name Sequence Type Origin Length Description Download
Src4.AA Protein None 606 None Fasta, JSON
Src4.kin_dom Protein Kinase Domain None 257 None Fasta, JSON

Protein domain

Protein domains of Src4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C2 Src4.AA C2 36-118 22 1.7e-08 31.46 Pfam 1-90 (90) Show / Hide 
Range on Protein: 36-118
Range on HMM: 1-90/90
Sequence Identity: 22% (21 aa)

LVAEIREGRGLPK-------PCQPFVKVAIASEKA--SKQKSDPAREKSTDPVWSTGFRWPLGNAEEYMEDVLELTLWEKGALK-DQFCGRMA
|.  . |.|.||.        . |.||| .  ..   .|.|.  ..   ..|||   | ..  . ..  . .|..|.| .. .. |.| |.  
LRVHVIEARNLPPMDWDKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNT-LNPVWNETFTFD-VPPPDLQH-TLRFTVWDWDRFGRDDFIGQCC
C2 Src4.AA C2 35-133 16 1e-06 29.22 SMART 1-92 (92) Show / Hide 
Range on Protein: 35-133
Range on HMM: 1-92/92
Sequence Identity: 16% (20 aa)

HLVAEIREGRGLPKPCQPFVKVAIASEKASKQKSDPAREKST--DPVWST---GFRWPLGNAEEYMEDVLELTLWEKGALKDQFCGRMAFP---------
 |   | |.|.||    |.|||          |.   .   .   |||      |  .. .      . |....|..     .| |.  .|         
TLTVHIIEARNLP---DPYVKVY---------KTKVVKNTLSGFNPVWNEWMETFYFDVHP------Q-LRFEVWDH-----DFIGHCCIPPNNPHWHQW

-----IGELIENPDPLEG
     . ... .. . . 
DGCIHLSDIL-GYRH-WW
SH3 Src4.AA SH3 158-214 32 2.1e-13 51.75 SMART 1-58 (58) Show / Hide 
Range on Protein: 158-214
Range on HMM: 1-58/58
Sequence Identity: 32% (19 aa)

KVVVALYDNDPRGDMELSMRKDDYLLELRS-DGAWVQCRHLMTNEEGFVPGTFVAPYK
..|.|||| ..... |||..|.| .. |.  |. | ..|.  |..||..|...|....
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 Src4.AA SH3_1 161-207 36 2.1e-08 31.48 Pfam 1-49 (49) Show / Hide 
Range on Protein: 161-207
Range on HMM: 1-49/49
Sequence Identity: 36% (18 aa)

VALYDNDPRGDMELSMRKDDYLLELR-SDG-AWVQCRHLMTNEEGFVPG
||||| ..... |||..| | .  .  ||.  |  .| . |..||..| 
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH2 Src4.AA SH2 221-292 35 9.7e-31 92.08 Pfam 1-81 (81) Show / Hide 
Range on Protein: 221-292
Range on HMM: 1-81/81
Sequence Identity: 35% (29 aa)

WFFGPITRAKAEKLLGVPARKHGCFLIRESESTPGTFSLSMKDGE---NVRHFRVKKVAGG--IKLQGD----LPSLIKYH
|..|.|.|..||.||  |  ..| ||.|||||||| ..|| .|.    .|.|.|... ..|      ..    |. |. ..
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 Src4.AA SH2 219-298 31 3.6e-28 100.82 SMART 1-87 (87) Show / Hide 
Range on Protein: 219-298
Range on HMM: 1-87/87
Sequence Identity: 31% (28 aa)

EPWFFGPITRAKAEKLLGVPARKHGCFLIRESESTPGTFSLSMKDGENVRHFRVKKVA-GGIKLQG-------DLPSLIKYHKRHRGG
.||..|.|.|..||.||  |  ..|.||.|.|||.|| ..||..... |.|.|... . |.  ...       .|  |. .......|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase Src4.AA SFK-Src 331-587 68 8.4e-246 737.47 In-house 1-259 (259) Show / Hide 
Range on Protein: 331-587
Range on HMM: 1-259/259
Sequence Identity: 68% (177 aa)

IVLEKQLGEGQYGEVYKGRWNGTTEVAIKTLKSAATSAEEFLQEAQLMKKLQHDNLVKLHAVCTIGEPIFIITELCKFGSLLDYLRSPAGESLRLPTLID
|.|||.||.||.|.|.|||||.|||||.||||..|.||||||||||.||||.|.||..|.||||.||||.|||||.|.|||||||..|.|.|||.|.|.|
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MASDVAHGMAYLEENNYIHRDLAARNILVGENNICKVADFGLARVVADREEGYTPETLAKFPVRWTAPEAMSTNTYSIKSDVWSFGILLTEIVTYGRKPY
||..|||||||||..|..||||||||.|||.||.|||.|||..||.|...||||....||||..|||||||..|..||||||||||||..|||||||.||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

EGMTNKEVVKFLDK--GERMECPPGCPERLYKLMLDCWRTTPSDRPAFGSLKFQLEDFF
.||||.||....|.  |.||.|||.||...||.|.|||...|.|||.|.|||.|.||||
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase Src4.AA Src 331-583 60 1.7e-158 532.87 In-house 1-255 (255) Show / Hide 
Range on Protein: 331-583
Range on HMM: 1-255/255
Sequence Identity: 60% (154 aa)

IVLEKQLGEGQYGEVYKGRWNGTTEVAIKTLKSAATSAEEFLQEAQLMKKLQHDNLVKLHAVCTIGEPIFIITELCKFGSLLDYLR-SPAGESLRLPTLI
| |...||.||.|||..| |||.|.||.||||..  | | ||||||.||||.|..||.|.|||. .|||.|.||. . |||||||. .. | .|.||.||
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMASDVAHGMAYLEENNYIHRDLAARNILVGENNICKVADFGLARVVADREEGYTPETLAKFPVRWTAPEAMSTNTYSIKSDVWSFGILLTEIVTYGRKP
|||  || ||||||..|||||||||||.||||||.||||||||||.. . .. |.... ||||..|||||| . ....|||||||||||||||||||| |
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YEGMTNKEVVKFLDKGERMECPPGCPERLYK-LMLDCWRTTPSDRPAFGSLKFQL
|.||||.||.. ...| || ||..||..||. .|| ||. .| .|| |  |   |
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Src4.AA Pkinase_Tyr 331-583 45 1.4e-147 500.42 Pfam 1-270 (270) Show / Hide 
Range on Protein: 331-583
Range on HMM: 1-270/270
Sequence Identity: 45% (124 aa)

IVLEKQLGEGQYGEVYKGRWN-----GTTEVAIKTLKSAATSA----EEFLQEAQLMKKL-QHDNLVKLHAVCT-IGEP--IFIITELCKFGSLLDYLRS
|.. |.||||..||||||.|.     ....||.|.||  |..     |.|..||..||.| .|.|.|.|..|||  |||  |.|..|... |.||||||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

P--AGESLRLPTLIDMASDVAHGMAYLEENNYIHRDLAARNILVGENNICKVADFGLARVVADREEGY-TPETLAKFPVRWTAPEAMSTNTYSIKSDVWS
.   ...| ...|..|. ..| ||.|||..|.|||||||||.||.|||..|..|||||| .   .. | .  . .|.|..|.|||..... ...||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGILLTEIVTYGRKP-YEGMTNKEVVKFL-DKGERMECPPGCPERLYKLMLDCWRTTPSDRPAFGSLKFQL
||.|. ||.|||..| |.||.| ||.... ..|.||.||..||. .|.||..||.  |.||| |  .  ||
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Src4.AA TyrKc 331-583 41 1.2e-141 477.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 331-583
Range on HMM: 1-280/280
Sequence Identity: 41% (117 aa)

IVLEKQLGEGQYGEVYKGRWNGTTEVAIKTLKSAATSAEEFLQEAQLMKKL--QHDNLVKLHAVCTIG-------EPIFIITELCKFGSLLDYLRSPAGE
|.|.|.||||..||||||.|.  ..||.|.||. |   |.|..||..|.||  .|.|.|.|..||| .       ||..|..|... |.|.||||.. ..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

SLRLPTLIDMASDVAHGMAYLEENNYIHRDLAARNILVGENNICKVADFGLARVVADR------EEGYTPET--LAK--FPVRWTAPEAMSTNTYSIKSD
 | ...|.... ..| ||.||...|.|||||||||.|||||...|..||||.| . |       .. |.. .   .|  .|.||.|||.. ......|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILLTEIVTYGRKPYEG-----MTNKEVVKFLDKGERMECPPG--------CPERLYKLMLDCWRTTPSDRPAFGSLKFQL
|||||... || ||| .||.|     |.|.||......|.||..||         ||. .|..|..||.  |.||| |  .. ..
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Src4.AA Frk 331-587 58 4.1e-136 458.49 In-house 1-260 (260) Show / Hide 
Range on Protein: 331-587
Range on HMM: 1-260/260
Sequence Identity: 58% (151 aa)

IVLEKQLGEGQYGEVYKGRWNGTTEVAIKTLKSAATSAEEFLQEAQLMKKLQHDNLVKLHAVCTIGEPIFIITELCKFGSLLDYLR--SPAGESLRLPTL
| | ..|| ||.|||. |.|| || ||.||||. .   ..||.|||.||||.|  |..|.||||. |||.||||| . |||..||.  .  |.......|
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

IDMASDVAHGMAYLEENNYIHRDLAARNILVGENNICKVADFGLAR-VVADREEGYTPETLAKFPVRWTAPEAMSTNTYSIKSDVWSFGILLTEIVTYGR
.|||  || ||||||. |||||||||||.||||.||||.||||||| .. | |. |   . |.||..||||||. .| ..|||||||||||||||.||||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

KPYEGMTNKEVVKFLDKGERMECPPGCPERLYKLMLDCWRTTPSDRPAFGSLKFQLEDFF
 || ||||.||.. .|.| || .||.||..||..||.||.  |  || |  |...|||.|
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase Src4.AA SrcA 331-583 59 2.8e-131 417.26 In-house 1-250 (250) Show / Hide 
Range on Protein: 331-583
Range on HMM: 1-250/250
Sequence Identity: 59% (150 aa)

IVLEKQLGEGQYGEVYKGRWNGTTEVAIKTLKSAATSAEEFLQEAQLMKKLQHDNLVKLHAVCTIGEPIFIITELCKFGSLLDYLRSPAGESLRLPTLID
| ||..||.|..|||. | ||||| |||||||    | | ||.|||.||||.|| ||.| ||    |||.|.||    |||||.|. . |. |.|| |.|
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSE-EPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVD

MASDVAHGMAYLEENNYIHRDLAARNILVGENNICKVADFGLARVVADREEGYTPETLAKFPVRWTAPEAMSTNTYSIKSDVWSFGILLTEIVTYGRKPY
||  ||.||||.|  ||||||| | ||||||| |||.|||||||.. | |  ||..  ||||..||||||     . ||||||||||||||.|| || ||
MAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNE--YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPY

EGMTNKEVVKFLDKGERMECPPGCPERLYKLMLDCWRTTPSDRPAFGSLKFQL
 || |.||.   ..| .| ||..||| |. ||  |||  | .|| |  |.  |
PGMNNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase Src4.AA TK 331-583 27 3.6e-124 418.41 In-house 1-486 (486) Show / Hide 
Range on Protein: 331-583
Range on HMM: 1-486/486
Sequence Identity: 27% (134 aa)

IVLEKQLGEGQYG---EVYKGRWNGT--------------------------TEVAIKTLKS-AATSAEE--------------FLQEAQLMKKLQ----
|.|.|.|||||.|   |||||.|.|                           |.||.|.||. .|.|.||              ||.||. ||...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HDNLVKLHAVCTIG------------EPIFIITELCKFGS----LLDYLR--SPAGES-----------------------------------------
 |.|.|.|..||| |            ||. |..|... |.    |.||||  .| .                                           
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LRLPTLIDMASDVAHGMAYLEEN------NYIHRDLAARNILVGENNI-----------CKVADFG---
                               | ...|. |. ..| ||.||...      |..||||||||.||||||.           ||.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARVVADREEGYTPE-----------------------TLAKFPVRWTAPEAMS---------TNTYSIKSDVWSFGILLTEIVTYGRKPYEG-M
     ||| . .... |. .                       . .|.|.||.|||..          ......||||||||.|. ||.|||..|| | |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------KEVVKFLDKG--------------ERMECPPGCP--------------ERLYKLMLDCWRTTPSDRPAFGSLKFQL
.|         .||...| .|               ||..||.||              | .| ||..||.  |.||| |  |. ||
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Src4.AA SRM 332-584 51 1.3e-121 408.59 In-house 2-253 (253) Show / Hide 
Range on Protein: 332-584
Range on HMM: 2-253/253
Sequence Identity: 51% (131 aa)

VLEKQLGEGQYGEVYKGRWNGTTEVAIKTLKSAA-TSAEEFLQEAQLMKKLQHDNLVKLHAVCTIGEPIFIITELCKFGSLLDYLRSPAGESLRLPTLID
.| . |||| .|||. | | |  .||||  |..     ... .| | |||| |  ...|||||..|.|..||||| . |.|. |||.. .  |..| |.|
TLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLLD

MASDVAHGMAYLEENNYIHRDLAARNILVGENNICKVADFGLARVVADREEGYTPETLAKFPVRWTAPEAMSTNTYSIKSDVWSFGILLTEIVTYGRKPY
.|. || ||.|||| |||||||||||.|||.||.|||.|||||| .  ..  | |    . |..||||||..   ||.||||||||||| |. |||  ||
FACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLI--KDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPY

EGMTNKEVVKFLDKGERMECPPGCPERLYKLMLDCWRTTPSDRPAFGSLKFQLE
.|||| |     |.| || ||  ||   .||||.||.  | .||.|  |  .| 
PGMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase Src4.AA SrcB 331-584 55 4.5e-121 408.54 In-house 1-251 (251) Show / Hide 
Range on Protein: 331-584
Range on HMM: 1-251/251
Sequence Identity: 55% (142 aa)

IVLEKQLGEGQYGEVYKGRWNGTTEVAIKTLKSAATSAEEFLQEAQLMKKLQHDNLVKLHAVCTIGEPIFIITELCKFGSLLDYLRSPAGESLRLPTLID
. |.|.|| ||.|||. | .|. . ||.||.|  . | | ||.|| .||.|||| ||.|.|| |  |||.||||  . |.|||.|... |  | || |||
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTK-EPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

MASDVAHGMAYLEENNYIHRDLAARNILVGENNICKVADFGLARVVADREEGYTPETLAKFPVRWTAPEAMSTNTYSIKSDVWSFGILLTEIVTYGRKPY
|.  .| ||||.|. ||||||| | |||| |  .||.|||||||.. | |  ||    ||||..||||||.   .. ||||||||||||.||||||| ||
MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNE--YTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPY

EGMTNKEVVKFLDKGERMECPPGCPERLYKLMLDCWRTTPSDRPAFGSLKFQLE
 |||| ||.. |..| || .|  ||| ||..|  ||.  | .|| |  |.  |.
PGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase Src4.AA Src-Unclassified 331-582 43 3e-120 405.8 In-house 1-284 (284) Show / Hide 
Range on Protein: 331-582
Range on HMM: 1-284/284
Sequence Identity: 43% (125 aa)

IVLEKQLGEGQYGEVYKGRWNGTTEVAIKTLKSA---ATSAEEFL--------QEAQLMKKLQHDNLVKLHAVCTIGEPIFIITELCKFGSLLDYLRSPA
. | . || || |||..| | |  .||.||..       | | ||        ||||.|||..| |||.| |||.  ||..||||.   ||||..||   
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GESLRLPTL------------IDMASDVAHGMAYLEENNYIHRDLAARNILVGENN-----ICKVADFGLA--RVVADREEGYTPETLAKFPVRWTAPEA
|  | .. .            .|.|  || || |||.. |.||||||||.|.|.||     . ||.|||||  ....|  . | . | |.||. |.|||.
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQD--DNYCMRTGAMFPWKWMAPEC

MSTNTYSIKSDVWSFGILLTEIVTYGRKPYEGMTNKEVVKFLDKGERMECP--PGCPERLYK-LMLDCWRTTPSDRPAFGSL-KFQ
    . ||||||||.|||| || |.|. || || |.||.. .  | ||  |   .||. .|  .|. ||  .|  || |  | .. 
FIYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase Src4.AA Abl 331-583 50 3.8e-112 375.54 In-house 1-252 (252) Show / Hide 
Range on Protein: 331-583
Range on HMM: 1-252/252
Sequence Identity: 50% (129 aa)

IVLEKQLGEGQYGEVYKGRWNG-TTEVAIKTLKSAATSAEEFLQEAQLMKKLQHDNLVKLHAVCTIGEPIFIITELCKFGSLLDYLRSPAGESLRLPTLI
|.....|| |||||||.| |      ||.||||  .   .|||.|| .||...| |||.|  |||   | .||||   .| ||||||.   |.|   .|.
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

DMASDVAHGMAYLEENNYIHRDLAARNILVGENNICKVADFGLARVVADREEGYTPETLAKFPVRWTAPEAMSTNTYSIKSDVWSFGILLTEIVTYGRKP
 ||. .| || |||....||||||||| ||||..| |||||||||..  ... || .  ||||..|||||..  |..|.||||| ||.|| || |||  |
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMM--KDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSP

YEGMTNKEVVKFLDKGERMECPPGCPERLYKLMLDCWRTTPSDRPAFGSLKFQL
| |.  ..| . |.|| ||| |.|||.  |.||. ||.  ..|||.| .. ...
YPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase Src4.AA UTK 331-583 37 5.5e-111 375.03 In-house 1-296 (296) Show / Hide 
Range on Protein: 331-583
Range on HMM: 1-296/296
Sequence Identity: 37% (111 aa)

IVLEKQLGEGQYGEVYKGRWN------GTTEVAIKTLK---SAATSAE---EFLQEAQ---LMKKLQ-HDNLVKLHAVCTIGEPIFIITELCKFGSLLDY
. | .|||.|..|||.|.|..      ..  ||.|...   .| .. |   .|. ||.   .||... | |...| .||| .||. |.||... |.|..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR--SP----AGESLRLPTLIDMASDVAHGMAYLEENNYIHRDLAARNILVGEN-------NICKVADFG---LARVVAD-----REEG---YTPETLAK
||  .|    ....|.| ....||.|.|.||.||.. ...||||||||.||...       ..||.||||   ..| |..     |...   |..    .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

FPVRWTAPEAMSTN-TYSIKSDVWSFGILLTEIVTYGRKPYEGMTNKEVVKFLDKG--ERMECPPGCPERLYKLMLDCWRTTPSDRPAFGSLKFQL
 |.||.||||.  . ....||||||||... ||.|.||.||.||.| .|.... .|   ||.||..||...|.||..||...|..|| |  |  |.
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase Src4.AA S_TKc 331-587 24 1.3e-48 168.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 331-587
Range on HMM: 1-231/231
Sequence Identity: 24% (66 aa)

IVLEKQLGEGQYGEVYKGRWNG-TTEVAIKTLKSAATSAEEFLQEAQLMKKLQHDNLVKLHAVCTIGEPIFIITELCKF--GSLLDYLRSPAGES----L
  . ...|.| .|.|||.|...   .|||| .|      | ...| |..|| .|.|.|||. |.   . .....|.|    |.|.||...  ..     .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

RLPTLIDMASDVAHGMAYLEENNYIHRDLAARNILVGENNICKVADFGLARVVADREEGYTPETLAKFPVRWTAPEAMSTNTYSI-KSDVWSFGILLTEI
   .   ..  .. ...|. ... |||||   |||. |    |..||||||..          |       . ||| .    |.  |.|.||.|..| | 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

VTYGRKPYEGMTNKEVVKFLDKGERMECPPGCPERLYKLMLDCWRTTPSDRPAFGSLK-----FQLEDFF
.. |. |..     .. . ..|          .. .  ..  |..  |..||    .        .  .|
LC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Src4.AA Pkinase 331-574 23 3.3e-40 143.23 Pfam 1-282 (293) Show / Hide 
Range on Protein: 331-574
Range on HMM: 1-282/293
Sequence Identity: 23% (67 aa)

IVLEKQLGEGQYGEVYKGRWNGTTE-VAIKTLKSAATSAEEFLQ-----EAQLMKKLQHDNLVKLHAVCTIGEPIFIITELCKFG----SLLDYLRSPAG
.......|.| .|.|||... || . ||.|..|   .. ..  .     |.|.||.|.|.| |.|. ... .  | ...|.|  |    .| ||..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

ESL--RLPTLIDMASDVAHGMAYLEENNYIHRDLAARNILVGENNIC----KVADFGLARVVADREEGYTPETLAKFPV---RWTAPEAMS-TNTYSIKS
 ..     ......  .. |..|. ... |||||   |||. .|. .    |..|||||...      | . . .. ..   .. |||     . |. |.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSFGILLTEIVTYGRKPYEGM----TNKEVVKFLDKGERMECPPGCP-----------------------ERLYKLMLDCWRTTPSDRP
|.||.|..| | .. || |. |     .  .  . ...  . . .  .|                       | . ... .|..  |..||
DMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP