Gene RTKJ1 (M.brevicollis)

RTKJ1

Species: M.brevicollis
Alias: RTKJ1
External Links:
Annotation:

Classification

Group: TK
Family: RTKJ

Sequence

Name Sequence Type Origin Length Description Download
RTKJ1.AA Protein None 962 None Fasta, JSON
RTKJ1.kin_dom Protein Kinase Domain None 272 None Fasta, JSON

Protein domain

Protein domains of RTKJ1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain RTKJ1.AA Recep_L_domain 51-168 23 3.4e-16 56.16 Pfam 3-121 (121) Show / Hide 
Range on Protein: 51-168
Range on HMM: 3-121/121
Sequence Identity: 23% (31 aa)

TVIHGSVHINLTGANPGLSWATKLEQ---ALGAITDIRGHLLVVNSDSILSDLSFFQNLRVIRAEDYYYFRDDTTPDNTETAMALVLMNYQTMTSIHLPK
|||.|...|.... .        ||.   ... |. |.|.||. .. . |..||||.|||.|| .  ..         .. |.. . . . ..... ...
TVIYGNLEITWRDEHNE------LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHD--------DNYALYIYDNPNMGLQELWMWN

LH---H-------FNNP--FACYPYR-IDWSRLG
|.   .       .|||    || .  |.|. ..
LKNITRKNGGVYIHNNPHPKLCYTHTEIMWWMIY
FU RTKJ1.AA FU 204-259 39 3.1e-10 41.27 SMART 1-48 (48) Show / Hide 
Range on Protein: 204-259
Range on HMM: 1-48/48
Sequence Identity: 39% (22 aa)

VEYCQSHTPCHEICGPIGTATCWGPGATQCQRCTSPNLLLAYNGSCVAACPDGYYA
   |    |||. |      .|||||..||. | . ..|.   | ||. ||.|||.
DGVC---KPCHPECAT----GCWGPGPDQCTSCPHGYYLHHN-GTCVSQCPPGYYP
FU RTKJ1.AA FU 261-307 38 5.9e-09 37.0 SMART 1-48 (48) Show / Hide 
Range on Protein: 261-307
Range on HMM: 1-48/48
Sequence Identity: 38% (19 aa)

DWICQPCVNDCET-CEGPELGACLSCPVDFLLEN-GRCKSVCTGDAVYG
|  |.||   |.| | ||  ..|.|||  ..| . |.| | |. .  |.
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCP-PGYYP
EGF RTKJ1.AA EGF 266-297 21 0.058657 11.36 SMART 1-32 (32) Show / Hide 
Range on Protein: 266-297
Range on HMM: 1-32/32
Sequence Identity: 21% (9 aa)

PCVNDCE--------TCEGPELGACLSCP-VDFLLENGRCK
.|  .|.        ||       |  ||   . .   ||.
ECA-PCHHGGCEQHGTCI---SYTC--CPGPGYTG---RCE
FU RTKJ1.AA FU 311-360 37 2.1e-11 45.14 SMART 1-48 (48) Show / Hide 
Range on Protein: 311-360
Range on HMM: 1-48/48
Sequence Identity: 37% (19 aa)

TRTCEDCHPQCTT-CTSPLSTTCTRCAEDFYLQPAPNNTVCAAECPMGYYA
...|. |||.| | |..|  ..|| |.. .||..     .| ..|| |||.
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHN---GTCVSQCPPGYYP
EGF RTKJ1.AA EGF 316-351 20 0.06488 10.86 SMART 1-32 (32) Show / Hide 
Range on Protein: 316-351
Range on HMM: 1-32/32
Sequence Identity: 20% (9 aa)

DCHPQCT--------TCTSPLSTTCTRCA-EDFYLQPAPNNTVCA
.|.  |         ||.   | ||  |. . ...        | 
ECA-PCHHGGCEQHGTCI---SYTC--CPGPGYTG-------RCE
FU RTKJ1.AA FU 364-415 25 0.000143 22.43 SMART 1-48 (48) Show / Hide 
Range on Protein: 364-415
Range on HMM: 1-48/48
Sequence Identity: 25% (14 aa)

EGSCLPCAAGCLA-CTG--PANCSLCDVSADMYRLVTDVAQVCRPVSQCDSGSFA
.| | || ..|.  |.|  | .|. |    ..  .      .| .  || .|...
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHN-----GTCVS--QCPPGYYP
EGF RTKJ1.AA EGF 483-515 29 7.1e-05 19.35 Pfam 1-36 (36) Show / Hide 
Range on Protein: 483-515
Range on HMM: 1-36/36
Sequence Identity: 29% (11 aa)

CSAT--PCENGGVCSLTTSGEFQCDCSNT--GFCGTI
|. .  || ..| |  |  |...|.|     |. |  
CNPNNNPCHHHGTCVDTP-GGYTCQCPPGYLGYTGKR
EGF RTKJ1.AA EGF 482-517 26 0.030211 14.65 SMART 1-32 (32) Show / Hide 
Range on Protein: 482-517
Range on HMM: 1-32/32
Sequence Identity: 26% (11 aa)

ACSATPCENG-----GVCSLTTSGEFQCDCSNTGFCGTICA
 |.  ||..|     |.|       ..| |   |. |  | 
ECA--PCHHGGCEQHGTCI-----SYTC-CPGPGYTG-RCE
Kinase RTKJ1.AA RTKJ 594-865 78 1.7e-249 835.1 In-house 1-278 (278) Show / Hide 
Range on Protein: 594-865
Range on HMM: 1-278/278
Sequence Identity: 78% (217 aa)

VTIGQQLGAGHFGTVSRGLLRK--SDGTGNMDVAVKQLKREADVDSDAADEFFHEMKLMMDLGHHQHVVSLVGVCTTEKPILMVIDFANGGDLLNHLRDA
|.|||||||||||.||||||||  .|.|||||||||||||..|||||..||||||||||||||||||||||||||..|.||||.|||||.|||..||||.
VVIGQQLGAGHFGIVSRGLLRKSITDNTGNMDVAVKQLKRDVDVDSDEVDEFFHEMKLMMDLGHHQHVVSLVGVCRREQPILMIIDFANKGDLMHHLRDC

RPNERREATLREDDFRDYCAQVAAGMEFLAFKRVIHRDLAARNVLVHDDG----NGVVLKVADFGLTVQLRNDEEFRVCEDDALPFKWLAPECFTDKTFS
|||.|||||||.|||.|||||.|||||||||.|.||||||||||||||||    ||.|||.||||||.|.|||...|.|||||.||||||.|||.|..||
RPNDRREATLRRDDFFDYCAQIAAGMEFLAFHRIIHRDLAARNVLVHDDGRTEINGYVLKIADFGLTRQARNDDNYRKCEDDAVPFKWLAIECFRDRVFS

QASDVWAFGVLMWEVYAFGQSPFPGIQNNEVYARLGEGMRMPRPADCSKQAYDIMMRCWKFDAAERPSFSTLLNELSA
|||||||||...||.|.|||||.|||||||.|.||..|.|||||.|||||.|||||.||||...|||.|||||||.|.
QASDVWAFGITCWEIYTFGQSPYPGIQNNEIYDRLVKGHRMPRPFDCSKQMYDIMMHCWKFNPRERPTFSTLLNEISP
Kinase RTKJ1.AA TyrKc 594-863 35 4.4e-123 416.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 594-863
Range on HMM: 1-280/280
Sequence Identity: 35% (108 aa)

VTIGQQLGAGHFGTVSRGLLRKSDGTGNMDVAVKQLKREADVDSDAADEFFHEMKLMMDLG-HHQHVVSLVGVCTTE-------KPILMVIDFANGGDLL
.| |..|| |.||.| .| ..       ..|||| || .|        .| .|...|. || ||...| |.||||..       .|...|  .. .|||.
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

NHLRDARPNERREATLREDDFRDYCAQVAAGMEFLAFKRVIHRDLAARNVLVHDDGNGVVLKVADFGLTVQLRND-------EEFRV----CEDDALPFK
..||. ||.      |  .|. ..| |.|.|||.|. |..|||||||||.||....   . |..||||.  . .|       .  |.    .... || .
DYLRKHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

WLAPECFTDKTFSQASDVWAFGVLMWEVYAFGQSPFPG-----IQNNEVYARLGEGMRMPRPAD--------CSKQAYDIMMRCWKFDAAERPSFSTLLN
|.||||. ...|. .||||.|||.|||.. .||.| ||     . | ||.... .|.|||.|..        |..  |.|| .||..|...||.||..  
WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

EL
..
CF
Kinase RTKJ1.AA TK 594-863 23 1.3e-118 399.45 In-house 1-486 (486) Show / Hide 
Range on Protein: 594-863
Range on HMM: 1-486/486
Sequence Identity: 23% (116 aa)

VTIGQQLGAGHFG---TVSRGLLRKSD---------------------GTGNMDVAVKQLKREADVDSDAADE--------------FFHEMKLMMD-LG
.|.|..||.|.||   .| .|..|  .                     . |...||||.|| ... ....  .              . .|||.|.  ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHQHVVSLVGVCTTE------------KPILMVIDFANGGD----LLNHLRDARPNERR-----------------------------------------
||...|.|.|||| .            .|...|  ....||    |...||. ||...                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------EATLREDDFRD-------------------YCAQVAAGMEFLAFK------RVIHRDLAARNVLVHDD--------GNGVVLKVADFG----
        . .|.. |. .                   .|.|.|.|||.|. |      ...||||||||.||...        |.| | |.||||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LTVQLRNDEEFRVCE------------------------DDALPFKWLAPECFT---------DKTFSQASDVWAFGVLMWEVYAFGQSPFPG-IQ
    |.  . .|.. .. .                        .. ||..|.||||..         ...|. .||||.|||||||.. .|| |..| . 
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

N---------NEVYARLGEG--------------MRMPRPADCS--------------KQAYDIMMRCWKFDAAERPSFSTLLNEL
|          ||. .| .|              ||||.|..|.              .  ||.|..||..|...||.||.|...|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RTKJ1.AA Pkinase_Tyr 594-863 41 1.8e-117 398.49 Pfam 1-270 (270) Show / Hide 
Range on Protein: 594-863
Range on HMM: 1-270/270
Sequence Identity: 41% (115 aa)

VTIGQQLGAGHFGTVSRGLLRKSDGTGNMDVAVKQLKREADVDSDA--ADEFFHEMKLMMDLGHHQHVVSLVGVCT-TEKP--ILMVIDFANGGDLLNHL
.|.|..||.|.||.| .| .. ... ....|||| ||   . ....   ..|..|.|.|. ||||...|.|.||||  ..|  |..|  .. .||||..|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RDARPNERREATLREDDFRDYCAQVAAGMEFLAFKRVIHRDLAARNVLVHDDGNGVVLKVADFGLTVQLRNDEEF-RVCEDDALPFKWLAPECFTDKTFS
|. |     .  |   |  ..|.|.|.|||.|. |. |||||||||.||..  |. | |..||||.  . ||..  |. ..  || ||.||||. .. |.
RKHR---EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE--NN-VVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFT

QASDVWAFGVLMWEVYAFGQSP-FPGIQNNEVYARL-GEGMRMPRPADCSKQAYDIMMRCWKFDAAERPSFSTLLNEL
 .||||.|||||||.. .|..| .||. |.|||...  .| |||.| .|..  ||.|..||..|...||.|| ....|
TKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase RTKJ1.AA UTK 594-863 33 8.8e-103 347.76 In-house 1-296 (296) Show / Hide 
Range on Protein: 594-863
Range on HMM: 1-296/296
Sequence Identity: 33% (100 aa)

VTIGQQLGAGHFGTVSRGLLRK-SDGTGNMDVAVKQLKREADVDSDAAD---EFFHEMK---LMMDLGHHQHVVSLVGVCTTEKPILMVIDFANGGDLLN
| .|.|||.|.||.|... ... |.  . ||||||... . ... .. .   .|  | .   .|. . .|..|. |||||| |.|...|. .. .|||..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ-HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRS

HLRDARPNER-REATLREDDFRDYCAQVAAGMEFLAFKRVIHRDLAARNVLVHDDG----NGVVLKVADFG---LTVQLR---------NDEEFRVCEDD
 ||..||. . ... |....  ......|.||..|. ....||||||||.|||...     . | |.||||   .. ..          ......  ..|
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQD

ALPFKWLAPECFTDK-TFSQASDVWAFGVLMWEVYAFGQSPFPGIQNNEVYARLGEG--MRMPRPADCSKQAYDIMMRCWKFDAAERPSFSTLLNEL
..|..| |||..|.  .|...||||.|||..||....|. |.||. | .| .....|   |||.|.||. . |..|.|||. | .|||.| .|. ..
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase RTKJ1.AA TK-Unique 594-863 31 3.2e-86 292.75 In-house 1-294 (294) Show / Hide 
Range on Protein: 594-863
Range on HMM: 1-294/294
Sequence Identity: 31% (93 aa)

VTIGQQLGAGHFGTVSRGLLRKSDGTGNMD--VAVKQLKREADVDSDAADEFFHEMKLMMDLGHHQHVVSLVGVCTTEK-PILMVIDFANGGDLLNHLRD
...|...| | ||.| || ... ... . .  ||||.||..|.  ...  .|. | ..|. || |...|...|.||.   | .... .. .|.|...|| 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQ--DFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRT

ARPN-------------------ERREATLREDDFRDYCAQVAAGMEFLAF--KRVIHRDLAARNVLVHDDGNGVVLKVADFGLTVQLRNDEEFRVC-ED
 ||.                   . |.... . |.  .. |.| |||.||   |...||||.|||||. .   . |.|..|||..  ......     . 
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE---DKVCKICDFGMARDVYTNGVYSMMCSQ

DALPFKWLAPECFT--DKTF-SQASDVWAFGVLMWEVYAFGQSPFPGIQNNEVYARLGEGMRMPRPADC-SKQAYDIMMRCWKFDAAERPSFSTLLNEL
  .| .|.||| .   .... .  ||||.|||||||.  .|. |.||. . ..  .. .|.|||.|. | |.. | .| .||. .. |||||......|
GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase RTKJ1.AA Src 594-863 37 1.2e-83 284.04 In-house 1-255 (255) Show / Hide 
Range on Protein: 594-863
Range on HMM: 1-255/255
Sequence Identity: 37% (103 aa)

VTIGQQLGAGHFGTVSRGLLRKSDGTGNMDVAVKQLKREADVDSDAADEFFHEMKLMMDLGHHQHVVSLVGVCTTEKPILMVIDFANGGDLLNHLRDARP
..  ..||.|.|| |  |. .     ||..|||| ||.       . . |  | ..|  |  |...|.|  ||..|.||. |  . . | ||  |..   
IKLCRKLGQGQFGEVWMGYWN-----GNTKVAVKTLKPGT----MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK---

NERREATLREDDFRDYCAQVAAGMEFLAFKRVIHRDLAARNVLVHDDGNGVVLKVADFGLTVQLR-NDEEFRVCEDDALPFKWLAPECFTDKTFSQASDV
 .... .|.  .  |  ||||.||..|  ...||||||||||||   |.. | |||||||   .  .|.|    ..  .| || |||...  .|.. |||
-DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLV---GENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDV

WAFGVLMWEVYAFGQSPFPGIQNNEVYARLGEGMRMPRPADCSKQAYD-IMMRCWKFDAAERPSFSTLLNEL
| ||.|..|.  .|. | || .| ||  ..  | |||.|. | .. |. ||..||. |. .|| | .| . |
WSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase RTKJ1.AA Fer 594-864 33 4.5e-83 282.3 In-house 1-283 (283) Show / Hide 
Range on Protein: 594-864
Range on HMM: 1-283/283
Sequence Identity: 33% (97 aa)

VTIGQQLGAGHFGTVSRG---LLRKSDGTGN-MDVAVKQLKREADVDSDA-ADEFFHEMKLMMD-LGHHQHVVSLVGVCTTEKPILMVIDFANGGDLLNH
||.| .|| |.||.| .|   | .| ... .  .||||. | ........   ||.||...|.  .  | .|| . |||. | ||. |. |.|||.|...
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYD-HPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSY

LRDARPNERREATLREDDFRDYCAQVAAGMEFLAFKRVIHRDLAARNVLVHDDGNGVVLK--VADFGLTVQ-LRNDEEFRVC-EDDALPFKWLAPECFTD
|.          |. ...  ..|.|.|.|||.|  | .||||.||||.|.|.|  .|..|  ..|||. .|  .. .  . . . . .| .|||||....
LKKNKNK-----TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKD--KVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQT

KTFSQASDVWAFGVLMWEVYAFGQSPFPG----IQNNEV-----YARLGEGMRMPRPADCSKQAYDIMM-RCWKFDAAERPSFSTLLNELS
...| ..|||.|||..||... |. |.||    .....|      .   .| .|| |  . .  . ||| .||. |  .||..... ..| 
GIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase RTKJ1.AA Ack 594-863 37 1.6e-78 264.51 In-house 1-266 (266) Show / Hide 
Range on Protein: 594-863
Range on HMM: 1-266/266
Sequence Identity: 37% (104 aa)

VTIGQQLGAGHFGTVSRGLLRKSDGTGNMDVAVKQLKREADVDSD-AADEFFHEMKLMMDLGHHQHVVSLVGVCTTEKPILMVIDFANGGDLLNHLRDAR
.| . .|| | || | ||.   . |.    |||| |...  . .. . |.|. |   |. |  | |.| | ||  . . . ||  .| .| ||  ||.. 
ITLCEKLGDGCFGVVWRGEWTNPGGK-HIQVAVKCLRSD-KMQQPNCMDDFLREVAIMHSL-DHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKH-

PNERREATLREDDFRDYCAQVAAGMEFLAFKRVIHRDLAARNVLVHDDGNGVVLKVADFGLTVQLRNDEE-FRVCEDD--ALPFKWLAPECFTDKTFSQA
    | | .      |.| |.| || .|  || |||||||||.|.  |      |..||||   |   |   |  .     .|| | |||| . ..|| |
---CRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDD--RKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHA

SDVWAFGVLMWEVYAFGQSPFPGIQNNEVYARLG-EGMRMPRPADCSKQAYDIMMRCWKFDAAERPSFSTLLNEL
||||.||| .||.  .|. |. |    ..  ... || | ||| .|..  |..||.||....|.||.|| .   |
SDVWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase RTKJ1.AA RTKB 594-863 33 2e-78 263.97 In-house 1-264 (264) Show / Hide 
Range on Protein: 594-863
Range on HMM: 1-264/264
Sequence Identity: 33% (90 aa)

VTIGQQLGAGHFGTVSRGLLRKSDGTGNMDVAVKQLKREADVDSDAADEFFHEMKLMMDLGHHQHVVSLVGVCTTEKPILMVIDFANGGDLLNHLRDARP
| .|..|| | || | ....| .   .   .|.|.||  ... . . ..|  || .| .|| |..|. ..| |  . | .  . ... | |   ||  | 
VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLK--PGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRA

NERREATLREDDFRDYCAQVAAGMEFLAFKRVIHRDLAARNVLVHDDGNGVVLKVADFGLTVQLRNDEEFRVCEDDALPFKWLAPECFTDKTFSQAS-DV
 . .  .|. .  .|.| |.| || ||  . ||||||.||||||   . .   |..|||.  .. ... .  |  ..|| ||.|||   .. ..  | ||
SQHNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLV---DQQLHCKICDFGMAREIDHECYETTC--TRLPIKWMAPESWAHRIYTTKSGDV

WAFGVLMWEVYAFGQSPFPGIQNNEVYARLGEGMRMPRPADCSKQAYDIMMRCWKFDAAERPSFSTLLNEL
|.||| |||.  .|  |..  .| ..   |  |.|.| |   . .|..|| .|| ..| .||.|. |. ..
WSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase RTKJ1.AA FGFR 712-863 45 4.7e-62 210.29 In-house 144-293 (293) Show / Hide 
Range on Protein: 712-863
Range on HMM: 144-293/293
Sequence Identity: 45% (70 aa)

QVAAGMEFLAFKRVIHRDLAARNVLVHDDGNGVVLKVADFGLTVQLRNDEEFRVCEDDALPFKWLAPECFTDKTFSQASDVWAFGVLMWEVYAFGQSPFP
||| |||.|| ...|||||||||||| ||    |.|..||||     . . .|   .  || || |||   |. .   |||| .|||.||.  .|..|.|
QVARGMEYLASRKCIHRDLAARNVLVTDD---YVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYP

GIQ-NNEVYARLGEGMRMPRPADCSKQAYDIMMRCWKFDAAERPSFSTLLNEL
.|    | |. | || || .|. ||.  | .|  ||.| . .||.| .|  .|
HIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase RTKJ1.AA VEGFR 712-863 45 5.9e-59 202.19 In-house 181-332 (332) Show / Hide 
Range on Protein: 712-863
Range on HMM: 181-332/332
Sequence Identity: 45% (70 aa)

QVAAGMEFLAFKRVIHRDLAARNVLVHDDGNGVVLKVADFGLTVQ-LRNDEEFRVCED-DALPFKWLAPECFTDKTFSQASDVWAFGVLMWEVYAFGQSP
||| |||||| . .|||||||||.|.  .    |.|  ||||    .  |      .|   || ||.|||   || ..  ||||..||..||. . | ||
QVARGMEFLASRKCIHRDLAARNILLCEN---NVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSP

FPGIQ-NNEVYARLGEGMRMPRPADCSKQAYDIMMRCWKFDAAERPSFSTLLNEL
 ||.| . | . || .|.|| .|  |  . |.||  ||  .  |||.|| |   |
YPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase RTKJ1.AA S_TKc 594-866 23 7e-52 179.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 594-866
Range on HMM: 1-231/231
Sequence Identity: 23% (66 aa)

VTIGQQLGAGHFGTVSRGLLRKSDGTGNMDVAVKQLKREADVDSDAADEFFHEMKLMMDLGHHQHVVSLVGVCTTEKPILMVIDFANG--GDLLNHLRDA
 .|....| | ||.| ..  .|     .  ||.|..|          . .  |.....   || ..| | .|. . . . || ....|  |||. .... 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

RPNERREATLREDDFRDYCAQVAAGMEFLAFKRVIHRDLAARNVLVHDDGNGVVLKVADFGLTVQLRNDEEFRVCEDDALPFKWLAPECFTDKTFSQ-AS
... .|   . | . | |..|.. ..|..  ...|||||   |.|. .     ..|..||||  ||                 ..||| .    ..  ..
GRHGLR-FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKC

DVWAFGVLMWEVYAFGQSPFPGIQNNEVYARLGEGMRMPRPADCSKQAYDIMMRCWKFDAAERPSFSTLLN-E-----LSAF
|.|..|....| .. |. |||  | .... ..|           |..| |....|...| ..||.   .|. |        |
DWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RTKJ1.AA Pkinase 594-753 26 7.3e-25 89.0 Pfam 1-158 (293) Show / Hide 
Range on Protein: 594-753
Range on HMM: 1-158/293
Sequence Identity: 26% (46 aa)

VTIGQQLGAGHFGTVSRGLLRKSDGTGNMDVAVKQLKREADVDSDAADEFFH--EMKLMMDLGHHQHVVSLVGVCTTEKPILMVIDFANGG----DLLNH
 .||...|.| ||.| ..  ...       ||||..|.. . .|.   . ..  | ..|  | .| ..| | ....... | || ....||    ||  .
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LRDARPNERREATL--REDDFRDYCAQVAAGMEFLAFKRVIHRDLAARNVLVHDDGNGVV---LKVADFGL
..      .|. ..   |.. ..|. |.. |.|..  ...|||||   |.|..   ||..   .|..||||
IST-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGL
Kinase RTKJ1.AA VEGFR 594-692 32 6.1e-15 52.94 In-house 1-101 (332) Show / Hide 
Range on Protein: 594-692
Range on HMM: 1-101/332
Sequence Identity: 32% (34 aa)

VTIGQQLGAGHFGTVSRGL---LRKSDGTGNMDVAVKQLKREADVDSDAADEFFHEMKLMMDLGHHQHVVSLVGVCTT---EKPILMVIDFANGGDLLNH
  .| .||.| || |  .    .||. ..    ||||.||  |. .  .|     |.|..  .|||  ||.. | ||     .| .. . . . | |.| 
LKLGKMLGRGAFGQVHEASAFGIRKMETC--TTVAVKMLKEGATASEHRA--LMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNY

LRDAR
||..|
LRTKR
Kinase RTKJ1.AA FGFR 594-696 32 5.5e-14 44.0 In-house 1-104 (293) Show / Hide 
Range on Protein: 594-696
Range on HMM: 1-104/293
Sequence Identity: 32% (34 aa)

VTIGQQLGAGHFGTVSRGLLR---KSDGTGNMDVAVKQLKREADVDSDAADEFFHEMKLMMDLGHHQHVVSLVGVCTTEKPILMVIDFANGGDLLNHLRD
 |.|. || | || | ..      ..    .. |||| || ..  | | .|    ||  |   | |. .. | |.|| | |   .. ..  | |   || 
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNH-TDKDLSD-LVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRA

ARPNER
 || ..
RRPPGM
Kinase RTKJ1.AA Pkinase 775-863 17 2.9e-12 44.44 Pfam 177-293 (293) Show / Hide 
Range on Protein: 775-863
Range on HMM: 177-293/293
Sequence Identity: 17% (21 aa)

WLAPECFT-DKTFSQASDVWAFGVLMWEVYAFGQSPFPGI----QNNEVYARLGEGMRMPRPADCS-----------------------KQAYDIMMRCW
..|||    ..  ....|.|..|....|..  |. ||||       .. .... . |. | . |..                       . . |.. .|.
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

KFDAAERPSFSTLLNE--L
..| ..||..  .|.   .
CKDPKKRPTAEQILQHPWF