Gene RTKH2 (M.brevicollis)
RTKH2
Species: M.brevicollis
Alias: RTKH2
External Links:
Annotation:
Sequence
Protein domains of RTKH2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| EGF_CA | RTKH2.AA | EGF_CA | 232-244 | 21 | 4.480358 | 2.81 | Pfam | 35-53 (53) | Show / Hide |
Range on Protein: 232-244 Range on HMM: 35-53/53 Sequence Identity: 21% (4 aa) ECPEGFA------CIDSAC .|..|. | . .| DCMDGYEMISENNCDGTNC |
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| EGF | RTKH2.AA | EGF | 250-282 | 44 | 2.7e-10 | 37.45 | Pfam | 1-36 (36) | Show / Hide |
Range on Protein: 250-282 Range on HMM: 1-36/36 Sequence Identity: 44% (16 aa) CDGEASPCLNGGSCTNTIGGYTCDCPAT---YTGSN |. . .||...| |..| |||||.|| ||| . CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR |
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| EGF_CA | RTKH2.AA | EGF_CA | 246-284 | 40 | 7.1e-10 | 40.06 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 246-284 Range on HMM: 1-34/34 Sequence Identity: 40% (17 aa) RQNPCDGEASPCLNGG---SCTNTIGGYTCDCPATYTGSNCE . | || ||| |.| .|.|.| ||. || .|| DIDEC-----PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE |
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| EGF | RTKH2.AA | EGF | 249-284 | 38 | 1.7e-08 | 35.47 | SMART | 1-32 (32) | Show / Hide |
Range on Protein: 249-284 Range on HMM: 1-32/32 Sequence Identity: 38% (16 aa) PCDGEASPCLNG-----GSCTNTIGGYTCDCP-ATYTGSNCE .|. || .| | |. .||| || . ||| .|| ECA----PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE |
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| EGF_CA | RTKH2.AA | EGF_CA | 250-283 | 26 | 3.2e-05 | 18.99 | Pfam | 5-53 (53) | Show / Hide |
Range on Protein: 250-283 Range on HMM: 5-53/53 Sequence Identity: 26% (13 aa) CDGEA-SPC---LNGGSCTNTIGGYTCD---CPATYT--------GSNC |.. . | ....|.||||...| |.. |. | || CADGTHHMCGDPHRNTWCINTIGSFECVNQDCMDGYEMISENNCDGTNC |
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| EGF_2 | RTKH2.AA | EGF_2 | 250-283 | 27 | 0.000758 | 15.52 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 250-283 Range on HMM: 1-29/29 Sequence Identity: 27% (10 aa) CDGEASPCLN-GGSCTNTIGG-YTCDCPAT-YTGSNC | | . .|.| |. | |.|. ..| | C------CNGHHGTCNNQ--GCGKCQCDDGWWQGDHC |
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| EGF_CA | RTKH2.AA | EGF_CA | 286-324 | 45 | 2.4e-15 | 58.23 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 286-324 Range on HMM: 1-34/34 Sequence Identity: 45% (19 aa) DVNECNRGVSPCLNGG---SCTNTIGGYTCDCPATYTGSNCE |..|| || ||| |.| .|.|.| ||. || .|| DIDEC-----PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE |
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| EGF_CA | RTKH2.AA | EGF_CA | 286-323 | 32 | 6.8e-11 | 36.83 | Pfam | 1-53 (53) | Show / Hide |
Range on Protein: 286-323 Range on HMM: 1-53/53 Sequence Identity: 32% (17 aa) DVNECNRGV-SPC---LNGGSCTNTIGGYTCD---CPATYT--------GSNC ||.||. | | ....|.||||...| |.. |. | || DVDECADGTHHMCGDPHRNTWCINTIGSFECVNQDCMDGYEMISENNCDGTNC |
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| EGF | RTKH2.AA | EGF | 290-322 | 47 | 7e-11 | 39.42 | Pfam | 1-36 (36) | Show / Hide |
Range on Protein: 290-322 Range on HMM: 1-36/36 Sequence Identity: 47% (17 aa) CNRGVSPCLNGGSCTNTIGGYTCDCPAT---YTGSN || ..||...| |..| |||||.|| ||| . CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR |
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| EGF | RTKH2.AA | EGF | 289-324 | 40 | 1.2e-08 | 36.0 | SMART | 1-32 (32) | Show / Hide |
Range on Protein: 289-324 Range on HMM: 1-32/32 Sequence Identity: 40% (17 aa) ECNRGVSPCLNG-----GSCTNTIGGYTCDCP-ATYTGSNCE || || .| | |. .||| || . ||| .|| ECA----PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE |
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| EGF_2 | RTKH2.AA | EGF_2 | 290-323 | 27 | 0.001514 | 14.58 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 290-323 Range on HMM: 1-29/29 Sequence Identity: 27% (10 aa) CNRGVSPCLN-GGSCTNTIGG-YTCDCPAT-YTGSNC | | . .|.| |. | |.|. ..| | C------CNGHHGTCNNQ--GCGKCQCDDGWWQGDHC |
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| EGF_CA | RTKH2.AA | EGF_CA | 326-364 | 38 | 1.6e-11 | 45.53 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 326-364 Range on HMM: 1-34/34 Sequence Identity: 38% (16 aa) DVNECDGEANPCLNGG---SCTNTIGGYTCDCPQHHSGPTCD |..|| || ||| |.| .|.|.| ||. .. ..|. DIDEC-----PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE |
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| EGF_CA | RTKH2.AA | EGF_CA | 326-356 | 31 | 1.4e-10 | 35.85 | Pfam | 1-38 (53) | Show / Hide |
Range on Protein: 326-356 Range on HMM: 1-38/53 Sequence Identity: 31% (12 aa) DVNECDGEA-NPC---LNGGSCTNTIGGYTCD---CPQ ||.||.. . . | ....|.||||...| |.. DVDECADGTHHMCGDPHRNTWCINTIGSFECVNQDCMD |
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| EGF | RTKH2.AA | EGF | 330-362 | 41 | 2.6e-09 | 34.2 | Pfam | 1-36 (36) | Show / Hide |
Range on Protein: 330-362 Range on HMM: 1-36/36 Sequence Identity: 41% (15 aa) CDGEANPCLNGGSCTNTIGGYTCDCPQH---HSGPT |. . |||...| |..| |||||.||.. .|.. CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR |
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| EGF | RTKH2.AA | EGF | 329-364 | 33 | 3.7e-07 | 31.02 | SMART | 1-32 (32) | Show / Hide |
Range on Protein: 329-364 Range on HMM: 1-32/32 Sequence Identity: 33% (14 aa) ECDGEANPCLNG-----GSCTNTIGGYTCDCP-QHHSGPTCD ||. || .| | |. .||| || . .| .| ECA----PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE |
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| EGF_2 | RTKH2.AA | EGF_2 | 330-363 | 27 | 0.000166 | 17.58 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 330-363 Range on HMM: 1-29/29 Sequence Identity: 27% (10 aa) CDGEANPCLN-GGSCTNTIGG-YTCDCPQH-HSGPTC | | . .|.| |. | |.|.. ..|..| C------CNGHHGTCNNQ--GCGKCQCDDGWWQGDHC |
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| EGF | RTKH2.AA | EGF | 393-426 | 35 | 3e-06 | 28.1 | SMART | 1-32 (32) | Show / Hide |
Range on Protein: 393-426 Range on HMM: 1-32/32 Sequence Identity: 35% (14 aa) PCALMTCYNG-----GTCIGDLYQGQCHCM-PGWVGSDCR .|| | .| |||| .| | ||. | | ECA--PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE |
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| EGF_2 | RTKH2.AA | EGF_2 | 394-425 | 34 | 1.2e-05 | 21.16 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 394-425 Range on HMM: 1-29/29 Sequence Identity: 34% (12 aa) CALMTCYN-GGTCIGDLYQ-GQCHCMPG-WVGSDC | | . .|||. . . |.|.| .| | | .| C----CNGHHGTCNNQ--GCGKCQCDDGWWQGDHC |
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| EGF | RTKH2.AA | EGF | 394-424 | 27 | 0.004677 | 13.28 | Pfam | 1-36 (36) | Show / Hide |
Range on Protein: 394-424 Range on HMM: 1-36/36 Sequence Identity: 27% (10 aa) CALM--TCYNGGTCIGDLYQGQCHCMPG---WVGSD |. | ..|||. .|.| || . | . CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR |
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| EGF_CA | RTKH2.AA | EGF_CA | 428-465 | 41 | 1.7e-09 | 38.76 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 428-465 Range on HMM: 1-34/34 Sequence Identity: 41% (17 aa) DQDECATFNPCANGA---TCHNVPGSFSCSCTALQSGPYCN | ||| || ||. ||.| |||..| | . . . | DIDEC----PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE |
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| EGF | RTKH2.AA | EGF | 432-463 | 30 | 1.9e-07 | 27.92 | Pfam | 1-36 (36) | Show / Hide |
Range on Protein: 432-463 Range on HMM: 1-36/36 Sequence Identity: 30% (11 aa) CATF-NPCANGATCHNVPGSFSCSCTAL---QSGPY |. ||| ...||...||...| |. .|.. CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR |
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| EGF_CA | RTKH2.AA | EGF_CA | 428-455 | 36 | 3.1e-07 | 25.32 | Pfam | 1-36 (53) | Show / Hide |
Range on Protein: 428-455 Range on HMM: 1-36/53 Sequence Identity: 36% (13 aa) DQDECATFN--PC---ANGATCHNVPGSFSCS---C | ||||.. | .....|.| |||.|. | DVDECADGTHHMCGDPHRNTWCINTIGSFECVNQDC |
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| EGF | RTKH2.AA | EGF | 431-465 | 31 | 1.8e-05 | 25.41 | SMART | 1-32 (32) | Show / Hide |
Range on Protein: 431-465 Range on HMM: 1-32/32 Sequence Identity: 31% (13 aa) ECATFNPCANG-----ATCHNVPGSFSCSCT-ALQSGPYCN ||| || .| .||. |..| | . .| .| ECA---PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE |
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| EGF_2 | RTKH2.AA | EGF_2 | 432-464 | 23 | 15.444812 | 2.04 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 432-464 Range on HMM: 1-29/29 Sequence Identity: 23% (9 aa) CATFNPCAN-GATCHNVPGSFS---CSCTALQ-SGPYC | | . . || | |.|. . .|..| C-----CNGHHGTCNNQ----GCGKCQCDDGWWQGDHC |
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| EGF | RTKH2.AA | EGF | 470-507 | 36 | 1e-05 | 26.23 | SMART | 1-32 (32) | Show / Hide |
Range on Protein: 470-507 Range on HMM: 1-32/32 Sequence Identity: 36% (16 aa) PCASEPCLNT-----GSCTWNQEQPTPSYTCTCP-GWTSGARCE .|| || . | |. |||| || .| ||| ECA--PCHHGGCEQHGTCI--------SYTC-CPGPGYTG-RCE |
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| EGF | RTKH2.AA | EGF | 471-505 | 30 | 0.000505 | 16.51 | Pfam | 1-36 (36) | Show / Hide |
Range on Protein: 471-505 Range on HMM: 1-36/36 Sequence Identity: 30% (12 aa) CASE--PCLNTGSCTWNQEQPTPSYTCTCPGW---TSGAR |... ||.. | |. . ..||| || .| | CNPNNNPCHHHGTCVDTP----GGYTCQCPPGYLGYTGKR |
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| FN3 | RTKH2.AA | FN3 | 1261-1364 | 15 | 0.000141 | 22.45 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 1261-1364 Range on HMM: 1-69/69 Sequence Identity: 15% (18 aa) PDSPPV---VARTMVHAR------GLTLELDDPVVANGPITRWPWSLSCADHTCPTVTGSTERSGSVQNGTANSTAELSEGGALLARELALGNLLPY--- |..|| . | | .. .||. . | |... . .| |. PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR--------------------------------------------YTVTGLKPGQYP -TQYTLEVSAATS--AGAG |.|. |.| .. || | WTEYEFRVRAVNGNDAGEG |
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| FN3 | RTKH2.AA | FN3 | 1378-1460 | 16 | 0.092037 | 6.28 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 1378-1460 Range on HMM: 1-69/69 Sequence Identity: 16% (16 aa) PSAPRH---VQVQRKLV-AGKNQYNVSLVWDMPAEVNGILVGYEVGINLNQSGMRTNTSGNATELGLWTTSPD----DVYQVRARTA----AGWS |..|.. ..| .. .. |.| |. | |||. . .|. |..| | ||.. PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR--------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG |
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| Kinase | RTKH2.AA | RTKH | 1531-1806 | 98 | 3.8e-260 | 870.52 | In-house | 1-276 (276) | Show / Hide |
Range on Protein: 1531-1806 Range on HMM: 1-276/276 Sequence Identity: 98% (273 aa) IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLHEHK |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLHEHK PSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSYASD |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| PSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSYASD VWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFEALSSLLHEVS |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||...|||||| VWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFEAIMRLLHEVS |
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| Kinase | RTKH2.AA | TK | 1531-1802 | 21 | 1.2e-105 | 355.23 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 1531-1802
Range on HMM: 1-486/486
Sequence Identity: 21% (105 aa)
IVLGKELGKGAYG---QVVQAVLKSH---------------------GSEAGVPVAVKMLTRGHGSRQQRQFA-------------FEMHIMKLLHR-AG
|.|||.||.|..| .| .. .... .... .|||||||. |... |...|. |...||.... .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
PHRNVLTICGQVTQE------------SPMMLATELMPLGN----LRDYLHEHKPSSNSNIEDGG-----------------------------------
| |.. . | .||. |.|. .|.||.|. |||||....| . . . ..
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------LSLPRLCDIAEGIASGMAFVSEL------RIVHRDLAARNVFVSRRLV-----------PKIGDFG---
|....|. .. ||.||.. ... ..|||||||||. |....| ||.|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-----LGVLLDKSQETFVDS-----C------------------QEGLPMRWLAPEVISSGV---------FSYASDVWSFGVLLYELFTHG-GMPYPGQ
| ...... ..| . . || ||.|||.. ..| |. .|||||||||..|.||.| ...|.|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
TN---------EQVAASVVGG--------------LRLSQPEDCP--------------DAVYGIMLQAFALKARHRPTFEALSSLL
.| ..| .. | .|. ||..|| ...| .|.| .......||||..| . |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | RTKH2.AA | Pkinase_Tyr | 1531-1802 | 38 | 3.5e-100 | 339.92 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 1531-1802 Range on HMM: 1-270/270 Sequence Identity: 38% (107 aa) IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQ--QRQFAFEMHIMKLLHRAGPHRNVLTICGQVT-QESP--MMLATELMPLGNLRDY |..||.||.||.|.|.....| ... ..||||||| |. ..| .. | |. ||| | | | |.. | .| |. | ... .|.||.|.|.|| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQL---GHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY LHEHKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLL-DKSQETFVDSCQEGLPMRWLAPEVISSGV |..|. ... |....|.... ||.||.. .. ...||||||||. |.. .| ||.|||| .. .... .. . || .|.|||.|. |. LRKHR------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK FSYASDVWSFGVLLYELFTHGGMP-YPGQTNEQVAASV-VGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFEALSSLL |. .|||||||||..|.|| |..| ||| .||.| . . | |. .||.||| .| .|.| . .. .||||... . | FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | RTKH2.AA | TyrKc | 1531-1802 | 34 | 2.9e-99 | 336.99 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1531-1802 Range on HMM: 1-280/280 Sequence Identity: 34% (105 aa) IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAG-PHRNVLTICGQVTQE-------SPMMLATELMPLGNL |.|||.|| ||.|.|.....| ..|||||| .. .. | |. ||. | | | |.. . | .||. |.|. .|.||.|.| ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKL---GGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL RDYLHEHKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKS-------QETFVDS--CQEG-LPM .|||..|.| |... |.... ||.||.. .. ...||||||||. |..... ||.|||| .. . . . . . || KDYLRKHRPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI RWLAPEVISSGVFSYASDVWSFGVLLYELFTHGGMPYPG-----QTNEQVAASVVGGLRLSQPED--------CPDAVYGIMLQAFALKARHRPTFEALS ||.|||.| |.|. .||||||||...|.|| |..|||| .|..| . | | |. ||.. |||..| ||.| . .. ||||... RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH SLL ... ECF |
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| Kinase | RTKH2.AA | Src | 1531-1802 | 38 | 5.7e-85 | 288.6 | In-house | 1-255 (255) | Show / Hide |
Range on Protein: 1531-1802
Range on HMM: 1-255/255
Sequence Identity: 38% (105 aa)
IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLHEHK
| | ..||.| .| | ... . . ..|||| | .|. .. .| | ||| | | ... . ..|| | ||.| |.| |||..
IKLCRKLGQGQFGEVWMGYWNGN-----TKVAVKTLKPGT--MSPEAFLQEAQIMKKLR----HEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK--
PSSNSNIEDGG-LSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSYAS
..|. |.||.| |.| .|.|||. .. ...||||||||| |. .| |..|||| |... . . . .|..| ||| |. |.|. |
------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKS
DVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYG-IMLQAFALKARHRPTFEALSSLL
||||||.||.|..|.| .|||| ||..| | | |. .|. ||| .| |||| ... ||||| | . |
DVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
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| Kinase | RTKH2.AA | UTK | 1531-1802 | 33 | 1.3e-80 | 274.09 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 1531-1802 Range on HMM: 1-296/296 Sequence Identity: 33% (102 aa) IVLGKELGKGAYGQVVQAVLKSHGSEAGV-PVAVKMLT-RGHGSRQQR---QFAFEMH---IMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNL . ||..||.||.|.| | .. ... |||| . .. . .... .| | .|| .| |.||| | .|||.|.|..||.|. |.| VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFH---WHPNVLRLVGVCTQEEPWMIVTEYMENGDL RDYLHEHKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRR-------LVPKIGDFG---LGVLLDK--------SQETFVD |.|| |.|. . ... |.| .. . | ||.||.. .. ..|||||||||..| . .| ||.||| . .. ... . RSYLRRHRPTPP--ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMA SCQEGLPMRWLAPEVISSG-VFSYASDVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGG--LRLSQPEDCPDAVYGIMLQAFALKARHRPTFEALSSL . |. .|.|| |||.. .. |. .||||||||...|..|.| .|||| .|.||...|. | .|. .|.|||..|| .|.. . . ||.|| | . QHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQ L . M |
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| Kinase | RTKH2.AA | TK-Unique | 1531-1802 | 31 | 4.5e-78 | 265.67 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 1531-1802 Range on HMM: 1-294/294 Sequence Identity: 31% (93 aa) IVLGKELGKGAYGQVVQAVLKS--HGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQES-PMMLATELMPLGNLRDYLH ...|...|.||.||| . ... .... . |||||| ... ....| | .|| | |.| |.....|. | . |.|.. | .| |||..||. LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKEL---GDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR EHKP---SS-------------NSNIEDGGLSLPRLCDIAEGIASGMAFVSE--LRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQ-E . .| .. .. .. .|. .| .| .||.||.. .. .||||||.||||......| ||.|||. ... . . .|. . TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQG GLPMRWLAPEVIS--SGVF-SYASDVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDC-PDAVYGIMLQAFALKARHRPTFEALSSLL .| ||.|||... |.. .. |||||||||..|.|| |..|||| .... . | |. ||| | ....| .| . . ... .||.|... . | RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | RTKH2.AA | RTKB | 1531-1802 | 36 | 6.1e-68 | 228.13 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 1531-1802 Range on HMM: 1-264/264 Sequence Identity: 36% (100 aa) IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLHEHK . ||..|| ||.|.| || .. .. .|.| | | .... .| ||..|| | |.| ||. | | |. | .| || ||||||||.. VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKEL---GWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCR PS-SNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSYAS | .|. |. | | . ||.|||| . ..||||.|||| |. | || |||. .... .. || .|.||| . . .. | ASQHNPQS----LKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAR---EIDHECYETTCTRLPIKWMAPESWAHRIYTTKS -DVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFEALSSLL ||||||| .| |. || ||. . | .. | || .|. | |...|| . .. | |||.|..| ... GDVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF |
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| Kinase | RTKH2.AA | Eph | 1531-1802 | 36 | 2.4e-65 | 218.42 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 1531-1802 Range on HMM: 1-264/264 Sequence Identity: 36% (100 aa) IVLGKELGKGAYGQVVQAVLKSHGSEAGV---PVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLH | . | .| | .| | . || .. | |||.|.| |. .|...| | || | |.. | ||. .|.| || | .| | ..| IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFD----HPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLR EHKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQ--ETFVDSCQEGLPMRWLAPEVISSGVF .| || .. .| . |||||| . |.. |||||||||. |. .|| |. ||||. .|.. . | . | || |||.|. . | QH---------DGQFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKF SYASDVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFEALSSLL . ||||||.|... | . | || .| | .. | || | ||| | . .||. . |||.|. . | | TSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL |
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| Kinase | RTKH2.AA | Frk | 1531-1806 | 36 | 2.1e-63 | 216.96 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 1531-1806 Range on HMM: 1-260/260 Sequence Identity: 36% (103 aa) IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLH--E | | ..|| | .|.| . .||||| | |. . | | ||| | | .. . | | |... |||| | | .|| . IQLIRRLGSGQFGEVWEGLW-----NNTTPVAVKTLK--PGTMDPNDFLREAQIMKKLR----HPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAIN HKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQE-TFVDSCQEGLPMRWLAPEVISSGVFSY .| .. . .. | |.| .|.|||.. . .||||||||| | .. || |||| .| | .| . . .|..| ||| . . |. DKGRQ--------CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTI ASDVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFEALSSLLHEVS |||||||.||.|. |.| ||||| || .| | | |. || .|| .| |||. . ....||||| | | . KSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF |
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| Kinase | RTKH2.AA | SrcB | 1531-1803 | 36 | 6e-62 | 208.3 | In-house | 1-251 (251) | Show / Hide |
Range on Protein: 1531-1803
Range on HMM: 1-251/251
Sequence Identity: 36% (101 aa)
IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLHEHK
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LKLVKKLGAGQFGEVWMGYYNNH-----MKVAVKTMKQGTMSPE--AFLAEANVMKTLQ----HDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTD-
PSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSYASD
| . ||||.| |.. || |||.. . .|||| | |. || |. || |||| ... | . . |..| ||| | |.| ||
-------EGSKLSLPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAK--FPIKWTAPEAINFGCFTIKSD
VWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFEALSSLLH
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VWSFGILLMEIVTYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
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| Kinase | RTKH2.AA | Fer | 1531-1803 | 27 | 3.6e-61 | 207.06 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 1531-1803 Range on HMM: 1-283/283 Sequence Identity: 27% (82 aa) IVLGKELGKGAYGQVVQA--VLKS---HGSE-AGVPVAVKML-TRGHGSRQQRQFAFEMHIMKL-LHRAGPHRNVLTICGQVTQESPMMLATELMPLGNL ..||| ||.||.| | .. .|| ... |.|.||.. . . . |.. | |. ||. . | || . | ..| | |. |... |.| VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYD----HPNVVKFYGVCVDEQPIMIVMEFCNGGSL RDYLHEHKPSSNSNIEDGG-LSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSR-RLV--PKIGDFGLGVLLDKSQETFVDS-CQEGLPMRWLAP ..|| . ... .|. . ... ..|.||.. . ..|||.||||. .. .. .|| |||. . ... ... . .. .| ||||| DSYLKK---------NKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAP EVISSGVFSYASDVWSFGVLLYELFTHGGMPYPG--------QT-NEQVAASVVGGLRLSQPEDCPDAVYGIML-QAFALKARHRPTFEALSSLLH |....|..|...|||||||...| || | |||| .. ...... ...| .. |. .|.... ||. | .. . |||. . |. ETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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| Kinase | RTKH2.AA | S_TKc | 1531-1806 | 19 | 2.6e-34 | 121.24 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1531-1806 Range on HMM: 1-231/231 Sequence Identity: 19% (55 aa) IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPL--GNLRDYLHE .....||||.|.| ... |. | ||.|.. ... |. |.| | |. .. . . . . .|... |.|.||... YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK HKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSY- ... . . ... . . .. |...... ...|.|||| |..... . ||.|||| .| ..||||. ... RGRHGL----RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKC ASDVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFEALSS-----LLHEVS ..|.||.|..|||... | |.| ..|. ..| .. . .. . . ..||| . .|. KCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | RTKH2.AA | Pkinase | 1531-1802 | 21 | 2.7e-33 | 118.81 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 1531-1802 Range on HMM: 1-293/293 Sequence Identity: 21% (68 aa) IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAF---EMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLG----NLR ...|. .|.|..|.| ... |. | |||| . . | . ...| .. | .||| |. | |.... . .. .. . . .|... | | YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN----HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF DYLHEHKPSSNSNIEDGGL--SLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVP----KIGDFGLGVLLDKSQETFVDSCQEGLP--MRWL ||.. ..|.. | ..... |..|... . .|.|||| |...... .. ||.|||| ..| . .| .. ... DYIST--------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYM APEVIS-SGVFSYASDVWSFGVLLYELFTHGGMPYPGQ------TNEQVAASVVG-GLRLSQPEDCP-------------------DAVYGIMLQAFALK ||||| . ....|.||.|..|||... | |.||. . |. . . | |. . |..|. .. .. .... APEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD ARHRPTFEALSSL--L |||.| . . PKKRPTAEQILQHPWF |
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