Gene RTKH1 (M.brevicollis)

RTKH1

Species: M.brevicollis
Alias: RTKH1
External Links:
Annotation:

Classification

Group: TK
Family: RTKH

Sequence

Name Sequence Type Origin Length Description Download
RTKH1.AA Protein None 2179 None Fasta, JSON
RTKH1.kin_dom Protein Kinase Domain None 272 None Fasta, JSON

Protein domain

Protein domains of RTKH1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
EGF_2 RTKH1.AA EGF_2 427-451 35 0.006845 12.53 Pfam 1-29 (29) Show / Hide 
Range on Protein: 427-451
Range on HMM: 1-29/29
Sequence Identity: 35% (11 aa)

CEGCEA-AGNCE----AVCVCPTG-WQGSNC
|  |    | |.     .|.|. | |||  |
C--CNGHHGTCNNQGCGKCQCDDGWWQGDHC
EGF RTKH1.AA EGF 421-452 24 0.043608 12.83 SMART 1-32 (32) Show / Hide 
Range on Protein: 421-452
Range on HMM: 1-32/32
Sequence Identity: 24% (10 aa)

LCLSTACE--------GCEAAGNCEAVCVCP-TGWQGSNCE
 |.   |.         |         | ||  |..| .||
ECA--PCHHGGCEQHGTCI-----SYTC-CPGPGYTG-RCE
EGF RTKH1.AA EGF 422-450 24 0.828252 5.77 Pfam 1-36 (36) Show / Hide 
Range on Protein: 422-450
Range on HMM: 1-36/36
Sequence Identity: 24% (9 aa)

CLSTACEGCEAAGNCEAV-----CVCPTG---WQGSN
| ..   .|   | |  .     | || |   ..| .
CNPNN-NPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF_CA RTKH1.AA EGF_CA 440-451 30 2.031687 3.89 Pfam 31-53 (53) Show / Hide 
Range on Protein: 440-451
Range on HMM: 31-53/53
Sequence Identity: 30% (7 aa)

CV---CPTGWQ--------GSNC
||   |. |..        | ||
CVNQDCMDGYEMISENNCDGTNC
EGF_CA RTKH1.AA EGF_CA 454-492 45 3.8e-15 57.56 SMART 1-34 (34) Show / Hide 
Range on Protein: 454-492
Range on HMM: 1-34/34
Sequence Identity: 45% (19 aa)

DVNECDGEANPCLNGG---SCTNTIGGYTCDCPATYTGSNCE
|..||     || |||    |.| .|.|.| ||. ||  .||
DIDEC-----PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE
EGF_CA RTKH1.AA EGF_CA 454-491 30 3.5e-12 40.89 Pfam 1-53 (53) Show / Hide 
Range on Protein: 454-491
Range on HMM: 1-53/53
Sequence Identity: 30% (16 aa)

DVNECDGEA-NPC---LNGGSCTNTIGGYTCD---CPATYT--------GSNC
||.||.. . . |    ....|.||||...|    |.. |.        | ||
DVDECADGTHHMCGDPHRNTWCINTIGSFECVNQDCMDGYEMISENNCDGTNC
EGF RTKH1.AA EGF 458-490 47 1.3e-10 38.49 Pfam 1-36 (36) Show / Hide 
Range on Protein: 458-490
Range on HMM: 1-36/36
Sequence Identity: 47% (17 aa)

CDGEANPCLNGGSCTNTIGGYTCDCPAT---YTGSN
|. . |||...| |..| |||||.||     ||| .
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF RTKH1.AA EGF 457-492 40 5.8e-09 37.03 SMART 1-32 (32) Show / Hide 
Range on Protein: 457-492
Range on HMM: 1-32/32
Sequence Identity: 40% (17 aa)

ECDGEANPCLNG-----GSCTNTIGGYTCDCP-ATYTGSNCE
||.    || .|     | |.    .||| || . ||| .||
ECA----PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE
EGF_2 RTKH1.AA EGF_2 458-491 27 0.00104 15.09 Pfam 1-29 (29) Show / Hide 
Range on Protein: 458-491
Range on HMM: 1-29/29
Sequence Identity: 27% (10 aa)

CDGEANPCLN-GGSCTNTIGG-YTCDCPAT-YTGSNC
|      | . .|.| |.  |   |.|.   ..|  |
C------CNGHHGTCNNQ--GCGKCQCDDGWWQGDHC
EGF_CA RTKH1.AA EGF_CA 494-532 45 1.5e-14 55.62 SMART 1-34 (34) Show / Hide 
Range on Protein: 494-532
Range on HMM: 1-34/34
Sequence Identity: 45% (19 aa)

DVNECDGEANPCLNGG---SCTNTIGDYTCDCPATYTGSNCE
|..||     || |||    |.| .| |.| ||. ||  .||
DIDEC-----PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE
EGF RTKH1.AA EGF 498-530 44 1e-10 38.89 Pfam 1-36 (36) Show / Hide 
Range on Protein: 498-530
Range on HMM: 1-36/36
Sequence Identity: 44% (16 aa)

CDGEANPCLNGGSCTNTIGDYTCDCPAT---YTGSN
|. . |||...| |..| |.|||.||     ||| .
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF_CA RTKH1.AA EGF_CA 494-531 30 8.4e-10 33.4 Pfam 1-53 (53) Show / Hide 
Range on Protein: 494-531
Range on HMM: 1-53/53
Sequence Identity: 30% (16 aa)

DVNECDGEA-NPC---LNGGSCTNTIGDYTCD---CPATYT--------GSNC
||.||.. . . |    ....|.|||| ..|    |.. |.        | ||
DVDECADGTHHMCGDPHRNTWCINTIGSFECVNQDCMDGYEMISENNCDGTNC
EGF RTKH1.AA EGF 497-532 40 9.8e-09 36.27 SMART 1-32 (32) Show / Hide 
Range on Protein: 497-532
Range on HMM: 1-32/32
Sequence Identity: 40% (17 aa)

ECDGEANPCLNG-----GSCTNTIGDYTCDCP-ATYTGSNCE
||.    || .|     | |.     ||| || . ||| .||
ECA----PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE
EGF_2 RTKH1.AA EGF_2 498-531 27 0.000145 17.77 Pfam 1-29 (29) Show / Hide 
Range on Protein: 498-531
Range on HMM: 1-29/29
Sequence Identity: 27% (10 aa)

CDGEANPCLN-GGSCTNTIGDYTCDCPAT-YTGSNC
|      | . .|.| |. |.  |.|.   ..|  |
C------CNGHHGTCNNQ-GCGKCQCDDGWWQGDHC
EGF_CA RTKH1.AA EGF_CA 534-572 45 4.4e-14 54.02 SMART 1-34 (34) Show / Hide 
Range on Protein: 534-572
Range on HMM: 1-34/34
Sequence Identity: 45% (19 aa)

DVNECNGEANPCLNGG---SCTNTIGDYTCDCPSTYTGSNCE
|..||     || |||    |.| .| |.| ||  ||  .||
DIDEC-----PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE
EGF RTKH1.AA EGF 538-570 47 1.4e-10 38.38 Pfam 1-36 (36) Show / Hide 
Range on Protein: 538-570
Range on HMM: 1-36/36
Sequence Identity: 47% (17 aa)

CNGEANPCLNGGSCTNTIGDYTCDCPST---YTGSN
|| . |||...| |..| |.|||.||     ||| .
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF_CA RTKH1.AA EGF_CA 534-571 30 9.3e-10 33.25 Pfam 1-53 (53) Show / Hide 
Range on Protein: 534-571
Range on HMM: 1-53/53
Sequence Identity: 30% (16 aa)

DVNECNGEA-NPC---LNGGSCTNTIGDYTCD---CPSTYT--------GSNC
||.||.. . . |    ....|.|||| ..|    |.. |.        | ||
DVDECADGTHHMCGDPHRNTWCINTIGSFECVNQDCMDGYEMISENNCDGTNC
EGF RTKH1.AA EGF 537-572 40 4.4e-08 34.11 SMART 1-32 (32) Show / Hide 
Range on Protein: 537-572
Range on HMM: 1-32/32
Sequence Identity: 40% (17 aa)

ECNGEANPCLNG-----GSCTNTIGDYTCDCP-STYTGSNCE
||     || .|     | |.     ||| ||   ||| .||
ECA----PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE
EGF RTKH1.AA EGF 574-594 54 3e-05 20.61 Pfam 13-36 (36) Show / Hide 
Range on Protein: 574-594
Range on HMM: 13-36/36
Sequence Identity: 54% (13 aa)

TCTNTIGGYTCDCPAT---YTGSN
||..| |||||.||     ||| .
TCVDTPGGYTCQCPPGYLGYTGKR
EGF_2 RTKH1.AA EGF_2 538-571 27 8.2e-05 18.54 Pfam 1-29 (29) Show / Hide 
Range on Protein: 538-571
Range on HMM: 1-29/29
Sequence Identity: 27% (10 aa)

CNGEANPCLN-GGSCTNTIGDYTCDCPST-YTGSNC
|      | . .|.| |. |.  |.|..  ..|  |
C------CNGHHGTCNNQ-GCGKCQCDDGWWQGDHC
EGF_CA RTKH1.AA EGF_CA 573-596 41 0.000102 12.72 SMART 9-34 (34) Show / Hide 
Range on Protein: 573-596
Range on HMM: 9-34/34
Sequence Identity: 41% (12 aa)

R-----TCTNTIGGYTCDCPATYTGSNCE
      ||.| .|.|.| ||. ||  .||
NGGPTGTCIN-PGSYRC-CPPGYT-RHCE
EGF_CA RTKH1.AA EGF_CA 574-595 33 0.000133 17.04 Pfam 21-53 (53) Show / Hide 
Range on Protein: 574-595
Range on HMM: 21-53/53
Sequence Identity: 33% (11 aa)

TCTNTIGGYTCD---CPATYT--------GSNC
.|.||||...|    |.. |.        | ||
WCINTIGSFECVNQDCMDGYEMISENNCDGTNC
EGF RTKH1.AA EGF 574-596 50 0.145944 6.84 SMART 15-32 (32) Show / Hide 
Range on Protein: 574-596
Range on HMM: 15-32/32
Sequence Identity: 50% (12 aa)

TCTNTIGGYTCDCP-ATYTGSNCE
||.    .||| || . ||| .||
TCI----SYTC-CPGPGYTG-RCE
EGF_2 RTKH1.AA EGF_2 574-595 33 1.509306 5.2 Pfam 8-29 (29) Show / Hide 
Range on Protein: 574-595
Range on HMM: 8-29/29
Sequence Identity: 33% (8 aa)

TCTNTIGG-YTCDCPAT-YTGSNC
|| |.  |   |.|.   ..|  |
TCNNQ--GCGKCQCDDGWWQGDHC
EGF_CA RTKH1.AA EGF_CA 598-636 38 1.6e-11 45.53 SMART 1-34 (34) Show / Hide 
Range on Protein: 598-636
Range on HMM: 1-34/34
Sequence Identity: 38% (16 aa)

DVNECDGEANPCLNGG---SCTNTIGGYTCDCPQHHSGPTCD
|..||     || |||    |.| .|.|.| ||. .. ..|.
DIDEC-----PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE
EGF_CA RTKH1.AA EGF_CA 598-628 31 1.4e-10 35.85 Pfam 1-38 (53) Show / Hide 
Range on Protein: 598-628
Range on HMM: 1-38/53
Sequence Identity: 31% (12 aa)

DVNECDGEA-NPC---LNGGSCTNTIGGYTCD---CPQ
||.||.. . . |    ....|.||||...|    |..
DVDECADGTHHMCGDPHRNTWCINTIGSFECVNQDCMD
EGF RTKH1.AA EGF 602-634 41 2.6e-09 34.2 Pfam 1-36 (36) Show / Hide 
Range on Protein: 602-634
Range on HMM: 1-36/36
Sequence Identity: 41% (15 aa)

CDGEANPCLNGGSCTNTIGGYTCDCPQH---HSGPT
|. . |||...| |..| |||||.||..    .|..
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF RTKH1.AA EGF 601-636 33 3.7e-07 31.02 SMART 1-32 (32) Show / Hide 
Range on Protein: 601-636
Range on HMM: 1-32/32
Sequence Identity: 33% (14 aa)

ECDGEANPCLNG-----GSCTNTIGGYTCDCP-QHHSGPTCD
||.    || .|     | |.    .||| || .  .| .| 
ECA----PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE
EGF_2 RTKH1.AA EGF_2 602-635 27 0.000166 17.58 Pfam 1-29 (29) Show / Hide 
Range on Protein: 602-635
Range on HMM: 1-29/29
Sequence Identity: 27% (10 aa)

CDGEANPCLN-GGSCTNTIGG-YTCDCPQH-HSGPTC
|      | . .|.| |.  |   |.|..  ..|..|
C------CNGHHGTCNNQ--GCGKCQCDDGWWQGDHC
EGF RTKH1.AA EGF 665-698 35 3e-06 28.1 SMART 1-32 (32) Show / Hide 
Range on Protein: 665-698
Range on HMM: 1-32/32
Sequence Identity: 35% (14 aa)

PCALMTCYNG-----GTCIGDLYQGQCHCM-PGWVGSDCR
.||   | .|     ||||      .| |  ||. |  | 
ECA--PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE
EGF_2 RTKH1.AA EGF_2 666-697 34 1.2e-05 21.16 Pfam 1-29 (29) Show / Hide 
Range on Protein: 666-697
Range on HMM: 1-29/29
Sequence Identity: 34% (12 aa)

CALMTCYN-GGTCIGDLYQ-GQCHCMPG-WVGSDC
|    | . .|||. .  . |.|.| .| | | .|
C----CNGHHGTCNNQ--GCGKCQCDDGWWQGDHC
EGF RTKH1.AA EGF 666-696 27 0.004677 13.28 Pfam 1-36 (36) Show / Hide 
Range on Protein: 666-696
Range on HMM: 1-36/36
Sequence Identity: 27% (10 aa)

CALM--TCYNGGTCIGDLYQGQCHCMPG---WVGSD
|.     | ..|||.      .|.| ||   . | .
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF_CA RTKH1.AA EGF_CA 700-737 41 1.7e-09 38.76 SMART 1-34 (34) Show / Hide 
Range on Protein: 700-737
Range on HMM: 1-34/34
Sequence Identity: 41% (17 aa)

DQDECATFNPCANGA---TCHNVPGSFSCSCTALQSGPYCN
| |||    || ||.   ||.| |||..| | .  . . | 
DIDEC----PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE
EGF RTKH1.AA EGF 704-735 30 1.9e-07 27.92 Pfam 1-36 (36) Show / Hide 
Range on Protein: 704-735
Range on HMM: 1-36/36
Sequence Identity: 30% (11 aa)

CATF-NPCANGATCHNVPGSFSCSCTAL---QSGPY
|.   ||| ...||...||...| |.      .|..
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF_CA RTKH1.AA EGF_CA 700-727 36 3.1e-07 25.32 Pfam 1-36 (53) Show / Hide 
Range on Protein: 700-727
Range on HMM: 1-36/53
Sequence Identity: 36% (13 aa)

DQDECATFN--PC---ANGATCHNVPGSFSCS---C
| ||||..    |   .....|.|  |||.|.   |
DVDECADGTHHMCGDPHRNTWCINTIGSFECVNQDC
EGF RTKH1.AA EGF 703-737 31 1.8e-05 25.41 SMART 1-32 (32) Show / Hide 
Range on Protein: 703-737
Range on HMM: 1-32/32
Sequence Identity: 31% (13 aa)

ECATFNPCANG-----ATCHNVPGSFSCSCT-ALQSGPYCN
|||   || .|     .||.    |..| |  .  .| .| 
ECA---PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE
EGF_2 RTKH1.AA EGF_2 704-736 23 15.444812 2.04 Pfam 1-29 (29) Show / Hide 
Range on Protein: 704-736
Range on HMM: 1-29/29
Sequence Identity: 23% (9 aa)

CATFNPCAN-GATCHNVPGSFS---CSCTALQ-SGPYC
|     | . . || |         |.|.  . .|..|
C-----CNGHHGTCNNQ----GCGKCQCDDGWWQGDHC
EGF RTKH1.AA EGF 742-779 36 1e-05 26.23 SMART 1-32 (32) Show / Hide 
Range on Protein: 742-779
Range on HMM: 1-32/32
Sequence Identity: 36% (16 aa)

PCASEPCLNT-----GSCTWNQEQPTPSYTCTCP-GWTSGARCE
.||  || .      | |.        |||| ||    .| |||
ECA--PCHHGGCEQHGTCI--------SYTC-CPGPGYTG-RCE
EGF RTKH1.AA EGF 743-777 30 0.000505 16.51 Pfam 1-36 (36) Show / Hide 
Range on Protein: 743-777
Range on HMM: 1-36/36
Sequence Identity: 30% (12 aa)

CASE--PCLNTGSCTWNQEQPTPSYTCTCPGW---TSGAR
|...  ||.. | |.  .    ..||| ||      .| |
CNPNNNPCHHHGTCVDTP----GGYTCQCPPGYLGYTGKR
FN3 RTKH1.AA FN3 1533-1636 15 0.000141 22.45 SMART 1-69 (69) Show / Hide 
Range on Protein: 1533-1636
Range on HMM: 1-69/69
Sequence Identity: 15% (18 aa)

PDSPPV---VARTMVHAR------GLTLELDDPVVANGPITRWPWSLSCADHTCPTVTGSTERSGSVQNGTANSTAELSEGGALLARELALGNLLPY---
|..||    .  | | ..       .||. . |      |...                                               . .| |.   
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR--------------------------------------------YTVTGLKPGQYP

-TQYTLEVSAATS--AGAG
 |.|.  |.| ..  || |
WTEYEFRVRAVNGNDAGEG
FN3 RTKH1.AA FN3 1650-1732 16 0.092037 6.28 SMART 1-69 (69) Show / Hide 
Range on Protein: 1650-1732
Range on HMM: 1-69/69
Sequence Identity: 16% (16 aa)

PSAPRH---VQVQRKLV-AGKNQYNVSLVWDMPAEVNGILVGYEVGINLNQSGMRTNTSGNATELGLWTTSPD----DVYQVRARTA----AGWS
|..|..   ..|       .. .. |.| |. |       |||.                      .   .|.      |..| |      ||..
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR--------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase RTKH1.AA RTKH 1803-2078 98 8.4e-259 866.05 In-house 1-276 (276) Show / Hide 
Range on Protein: 1803-2078
Range on HMM: 1-276/276
Sequence Identity: 98% (273 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLHEHK
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLHEHK

PSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSYASD
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
PSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSYASD

VWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFSAIMRLLQEVC
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||| || 
VWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFEAIMRLLHEVS
Kinase RTKH1.AA TK 1803-2074 21 2.2e-105 354.35 In-house 1-486 (486) Show / Hide 
Range on Protein: 1803-2074
Range on HMM: 1-486/486
Sequence Identity: 21% (105 aa)

IVLGKELGKGAYG---QVVQAVLKSH---------------------GSEAGVPVAVKMLTRGHGSRQQRQFA-------------FEMHIMKLLHR-AG
|.|||.||.|..|   .| .. ....                     .... .|||||||. |... |...|.              |...||.... .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHRNVLTICGQVTQE------------SPMMLATELMPLGN----LRDYLHEHKPSSNSNIEDGG-----------------------------------
 | |.. . | .||.             |.|. .|.||.|.    |||||....|  . . . ..                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSLPRLCDIAEGIASGMAFVSEL------RIVHRDLAARNVFVSRRLV-----------PKIGDFG---
                               |....|. ..  ||.||.. ...      ..|||||||||. |....|            ||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LGVLLDKSQETFVDS-----C------------------QEGLPMRWLAPEVISSGV---------FSYASDVWSFGVLLYELFTHG-GMPYPGQ
     |   ......  ..|     .                  .  || ||.|||.. ..|         |. .|||||||||..|.||.| ...|.| 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------EQVAASVVGG--------------LRLSQPEDCP--------------DAVYGIMLQAFALKARHRPTFSAIMRLL
.|         ..|   .. |              .|. ||..||              ...| .|.| .......|||||.. . |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RTKH1.AA Pkinase_Tyr 1803-2074 38 1.2e-100 341.52 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1803-2074
Range on HMM: 1-270/270
Sequence Identity: 38% (109 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQ--QRQFAFEMHIMKLLHRAGPHRNVLTICGQVT-QESP--MMLATELMPLGNLRDY
|..||.||.||.|.|.....|  ... ..|||||||  |. ..|  .. |  |. ||| |   | | |..   | .| |. |  ... .|.||.|.|.||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQL---GHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LHEHKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLL-DKSQETFVDSCQEGLPMRWLAPEVISSGV
|..|.       ... |....|....  ||.||.. .. ...||||||||. |.. .| ||.||||  .. ....  .. .    || .|.|||.|. |.
LRKHR------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK

FSYASDVWSFGVLLYELFTHGGMP-YPGQTNEQVAASV-VGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFSAIMRLL
|. .|||||||||..|.|| |..| ||| .||.| . .   | |. .||.||| .| .|.|  . .. .|||||.| . |
FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase RTKH1.AA TyrKc 1803-2074 35 1.1e-99 338.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 1803-2074
Range on HMM: 1-280/280
Sequence Identity: 35% (107 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAG-PHRNVLTICGQVTQE-------SPMMLATELMPLGNL
|.|||.|| ||.|.|.....|       ..||||||  ..    .. |  |. ||. |   |  | |.. . | .||.        |.|. .|.||.|.|
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKL---GGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

RDYLHEHKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKS-------QETFVDS--CQEG-LPM
.|||..|.|          |... |....  ||.||.. .. ...||||||||. |..... ||.||||   ..         .   . .  .  . || 
KDYLRKHRPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

RWLAPEVISSGVFSYASDVWSFGVLLYELFTHGGMPYPG-----QTNEQVAASVVGGLRLSQPED--------CPDAVYGIMLQAFALKARHRPTFSAIM
||.|||.|  |.|. .||||||||...|.|| |..||||      .|..| . |  | |. ||..        |||..| ||.|  . ..  |||||.| 
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

RLL
...
ECF
Kinase RTKH1.AA Src 1803-2074 37 1.3e-82 280.51 In-house 1-255 (255) Show / Hide 
Range on Protein: 1803-2074
Range on HMM: 1-255/255
Sequence Identity: 37% (103 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLHEHK
| | ..||.| .| | ... . .     ..|||| | .|.   .. .|  |  ||| |     | ... .   ..|| |    ||.|  |.| |||..  
IKLCRKLGQGQFGEVWMGYWNGN-----TKVAVKTLKPGT--MSPEAFLQEAQIMKKLR----HEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK--

PSSNSNIEDGG-LSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSYAS
       ..|. |.||.| |.|  .|.|||. .. ...||||||||| |.  .| |..||||  |...  .  . .    .|..| ||| |. |.|.  |
------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKS

DVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYG-IMLQAFALKARHRPTFSAIMRLL
||||||.||.|..|.| .|||| ||..|   |  | |. .|. ||| .|  ||||    ... ||||  .   |
DVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase RTKH1.AA UTK 1803-2074 33 1.9e-78 266.92 In-house 1-296 (296) Show / Hide 
Range on Protein: 1803-2074
Range on HMM: 1-296/296
Sequence Identity: 33% (100 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGV-PVAVKMLT-RGHGSRQQR---QFAFEMH---IMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNL
. ||..||.||.|.|  | ..     ...  |||| .  .. . ....   .|  |     .|| .|    |.|||   | .|||.|.|..||.|. |.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFH---WHPNVLRLVGVCTQEEPWMIVTEYMENGDL

RDYLHEHKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRR-------LVPKIGDFG---LGVLLDK--------SQETFVD
|.||  |.|. .  ...  |.| .. . |  ||.||.. .. ..|||||||||..| .        .| ||.|||   .  ..          ... .  
RSYLRRHRPTPP--ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMA

SCQEGLPMRWLAPEVISSG-VFSYASDVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGG--LRLSQPEDCPDAVYGIMLQAFALKARHRPTFSAIMRL
. |. .|.|| |||.. ..  |. .||||||||...|..|.| .|||| .|.||...|. |  .|. .|.|||..|| .|..  .   . ||.|  .   
QHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQ

L
.
M
Kinase RTKH1.AA TK-Unique 1803-2074 31 1.3e-77 264.2 In-house 1-294 (294) Show / Hide 
Range on Protein: 1803-2074
Range on HMM: 1-294/294
Sequence Identity: 31% (94 aa)

IVLGKELGKGAYGQVVQAVLKS--HGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQES-PMMLATELMPLGNLRDYLH
...|...|.||.|||  . ...   .... . |||||| ...   ....|  |  .|| |   |.| |.....|. |  . |.|.. | .| |||..||.
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKEL---GDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

EHKP---SS-------------NSNIEDGGLSLPRLCDIAEGIASGMAFVSE--LRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQ-E
. .|   ..             ..  ..  .|. .|  .| .||.||.. ..   .||||||.||||......| ||.|||.   ...  .  . .|. .
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQG

GLPMRWLAPEVIS--SGVF-SYASDVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDC-PDAVYGIMLQAFALKARHRPTFSAIMRLL
 .| ||.|||...   |.. .. |||||||||..|.|| |..||||  ....   .  | |. ||| | ....| .| . . ... .||.|..|   |
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase RTKH1.AA RTKB 1803-2074 36 4.4e-68 228.59 In-house 1-264 (264) Show / Hide 
Range on Protein: 1803-2074
Range on HMM: 1-264/264
Sequence Identity: 36% (99 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLHEHK
. ||..|| ||.|.| || ..  ..     .|.| |  |  .... .|  ||..|| |   |.| ||. | |   |. | .|  ||  ||||||||..  
VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKEL---GWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCR

PS-SNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSYAS
 | .|.      |.   | | .  ||.|||| .   ..||||.|||| |.  |  || |||.     .... ..      || .|.||| . .  ..  |
ASQHNPQS----LKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAR---EIDHECYETTCTRLPIKWMAPESWAHRIYTTKS

-DVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFSAIMRLL
 |||||||  .| |. || ||. . | ..      | || .|.  | |...|| .  .. | |||.|.......
GDVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase RTKH1.AA Eph 1803-2074 36 5.8e-65 217.13 In-house 1-264 (264) Show / Hide 
Range on Protein: 1803-2074
Range on HMM: 1-264/264
Sequence Identity: 36% (100 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGV---PVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLH
| . | .| | .| | .  ||    .. |   |||.|.|  |.  .|...|  |  ||        | |..   | ||. .|.|  || | .| | ..| 
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFD----HPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLR

EHKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQ--ETFVDSCQEGLPMRWLAPEVISSGVF
.|         || ..  .|  .  |||||| . |..  |||||||||. |. .|| |. ||||. .|.. .  |    .     | || |||.|. . |
QH---------DGQFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKF

SYASDVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFSAIMRLL
. ||||||.|... |  . |  ||   .|  |  ..  | ||  | ||| | . .||.  .    |||.|. |   |
TSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase RTKH1.AA Fer 1803-2075 28 4.6e-62 210.16 In-house 1-283 (283) Show / Hide 
Range on Protein: 1803-2075
Range on HMM: 1-283/283
Sequence Identity: 28% (83 aa)

IVLGKELGKGAYGQVVQA--VLKS---HGSE-AGVPVAVKML-TRGHGSRQQRQFAFEMHIMKL-LHRAGPHRNVLTICGQVTQESPMMLATELMPLGNL
..||| ||.||.| | ..  .||     ...   |.|.||.. . . .  |.. |  |. ||.  .     | ||  . |  ..| | |.  |... |.|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYD----HPNVVKFYGVCVDEQPIMIVMEFCNGGSL

RDYLHEHKPSSNSNIEDGG-LSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSR-RLV--PKIGDFGLGVLLDKSQETFVDS-CQEGLPMRWLAP
..|| .         ...  .|.  . ... ..|.||..  .  ..|||.||||. ..   ..  .|| |||. . ... ...  .   .. .| |||||
DSYLKK---------NKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAP

EVISSGVFSYASDVWSFGVLLYELFTHGGMPYPG--------QT-NEQVAASVVGGLRLSQPEDCPDAVYGIML-QAFALKARHRPTFSAIMRLLQ
|....|..|...|||||||...| || |  ||||        .. ...... ...| ..  |. .|.... ||. | .. .   |||.. | . | 
ETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase RTKH1.AA Frk 1803-2078 36 7.9e-62 211.73 In-house 1-260 (260) Show / Hide 
Range on Protein: 1803-2078
Range on HMM: 1-260/260
Sequence Identity: 36% (101 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLH--E
| | ..|| | .|.|          .  .||||| |    |.   . |  |  ||| |     |  .. .    | | |... ||||  | | .||   .
IQLIRRLGSGQFGEVWEGLW-----NNTTPVAVKTLK--PGTMDPNDFLREAQIMKKLR----HPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAIN

HKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQE-TFVDSCQEGLPMRWLAPEVISSGVFSY
.| ..        . .. | |.|  .|.|||.. .   .||||||||| |   .. || ||||  .| | .|  .    .  .|..| ||| . .  |. 
DKGRQ--------CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTI

ASDVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFSAIMRLLQEVC
 |||||||.||.|. |.| ||||| || .|   |  | |. || .||  .| |||. .  ....||||  .   |..  
KSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase RTKH1.AA SrcB 1803-2075 36 5.9e-60 201.48 In-house 1-251 (251) Show / Hide 
Range on Protein: 1803-2075
Range on HMM: 1-251/251
Sequence Identity: 36% (99 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLHEHK
. | | || | .| |  .  . |     . |||| . .|  | .   |  |  .|| |     |  .  .   ||.| |. . || |  | | |.|    
LKLVKKLGAGQFGEVWMGYYNNH-----MKVAVKTMKQGTMSPE--AFLAEANVMKTLQ----HDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTD-

PSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSYASD
       | . ||||.| |..  || |||.. .   .|||| | |. ||  |. || ||||  ...    |  .  .   |..| ||| |  |.|   ||
-------EGSKLSLPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAK--FPIKWTAPEAINFGCFTIKSD

VWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFSAIMRLLQ
|||||.||.|. |.| .|||| || .|  ..  | |. .|. ||. .| || . .  ..  ||||  .   |.
VWSFGILLMEIVTYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase RTKH1.AA Pkinase 1803-2074 21 7e-34 120.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1803-2074
Range on HMM: 1-293/293
Sequence Identity: 21% (68 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAF---EMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLG----NLR
...|. .|.|..|.| ... |. |      |||| . . | . ...| ..   | .||| |.    | |.... . .. .. . . .|... |     | 
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN----HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

DYLHEHKPSSNSNIEDGGL--SLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVP----KIGDFGLGVLLDKSQETFVDSCQEGLP--MRWL
||..          ..|..  |   .....  |..|...  . .|.||||   |...... ..    ||.||||  ..|    .  .|   ..    ...
DYIST--------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYM

APEVIS-SGVFSYASDVWSFGVLLYELFTHGGMPYPGQ------TNEQVAASVVG-GLRLSQPEDCP-------------------DAVYGIMLQAFALK
|||||  .   ....|.||.|..|||... |  |.||.      .  |. . . |  |. . |..|.                   ..   ..   ....
APEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD

ARHRPTFSAIMRL--L
   |||.  |.    .
PKKRPTAEQILQHPWF
Kinase RTKH1.AA S_TKc 1803-2074 19 9.8e-34 119.32 SMART 1-231 (231) Show / Hide 
Range on Protein: 1803-2074
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPL--GNLRDYLHE
  .....||||.|.| ... |.     |  ||.|..         ...  |. |.|       | |. .. .     . . . .|...   |.|.||...
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

HKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSY-
...  .    . ...  . . ..  |......  ...|.||||   |.....  . ||.||||  .|                  ..||||.    ... 
RGRHGL----RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKC

ASDVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFSAIMR---------LL
..|.||.|..|||... |  |.|   ..|.   ..|          .. .  .. . .    ..|||   ...          .
KCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF