Gene RTKD3 (M.brevicollis)

RTKD3

Species: M.brevicollis
Alias: RTKD3
External Links:
Annotation:

Classification

Group: TK
Family: RTKD

Sequence

Name Sequence Type Origin Length Description Download
RTKD3.AA Protein None 1504 None Fasta, JSON
RTKD3.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of RTKD3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
EGF_2 RTKD3.AA EGF_2 55-67 35 0.037488 10.22 Pfam 16-29 (29) Show / Hide 
Range on Protein: 55-67
Range on HMM: 16-29/29
Sequence Identity: 35% (5 aa)

VCECHSG-FSGVSC
.|.|..| ..|  |
KCQCDDGWWQGDHC
EGF_2 RTKD3.AA EGF_2 74-102 29 0.00023 17.14 Pfam 1-29 (29) Show / Hide 
Range on Protein: 74-102
Range on HMM: 1-29/29
Sequence Identity: 29% (10 aa)

CASPKTCPT-NADCS---TGSCKCFSG-WAGAVC
|     |   .  |    .| |.| .| | |. |
C-----CNGHHGTCNNQGCGKCQCDDGWWQGDHC
NCD3G RTKD3.AA NCD3G 122-149 42 2.642158 2.87 Pfam 30-54 (54) Show / Hide 
Range on Protein: 122-149
Range on HMM: 30-54/54
Sequence Identity: 42% (12 aa)

PCPEGYFSHNGLSTSSLRCYPVTLGYWP
||||| .|.   .| |  | | ....||
PCPEGEYSN---TTDSYTCTPCPEDQWP
NCD3G RTKD3.AA NCD3G 309-332 33 1.6e-05 18.39 Pfam 28-54 (54) Show / Hide 
Range on Protein: 309-332
Range on HMM: 28-54/54
Sequence Identity: 33% (9 aa)

CVPCSTGSVAV--DN-ECIKCPSHTWS
|.|| .|..    |  .|..|| . |.
CIPCPEGEYSNTTDSYTCTPCPEDQWP
HYR RTKD3.AA HYR 612-661 40 0.047556 8.77 Pfam 1-54 (86) Show / Hide 
Range on Protein: 612-661
Range on HMM: 1-54/86
Sequence Identity: 40% (22 aa)

GDTKPPTFVWCENQ-FITVHSLGDTVNLSWVIPTAIDDSG---SVTVVGNHAPG
 || |||.  | |  | || .   ||| .|  ||| | ||    . .. .. ||
VDTTPPTVENCPNNIFRTVELGTSTVNVFWTEPTATDNSGDIQANLISRTAQPG
HYR RTKD3.AA HYR 674-692 45 4e-06 22.23 Pfam 67-86 (86) Show / Hide 
Range on Protein: 674-692
Range on HMM: 67-86/86
Sequence Identity: 45% (9 aa)

YKAFDPSGNEA-TCVMIITV
| ..|..||.| ||.  .||
YTFQDNAGNQADTCTFTVTV
HYR RTKD3.AA HYR 952-979 33 0.004633 12.1 Pfam 57-86 (86) Show / Hide 
Range on Protein: 952-979
Range on HMM: 57-86/86
Sequence Identity: 33% (10 aa)

LGVG-IYHVERTARDQVGNTR-SCNVTIFV
..|| .. |. |..|. ||.  .|..|. |
FPVGEQTTVTYTFQDNAGNQADTCTFTVTV
Kinase RTKD3.AA RTKD 1089-1343 65 1.4e-206 692.57 In-house 1-262 (262) Show / Hide 
Range on Protein: 1089-1343
Range on HMM: 1-262/262
Sequence Identity: 65% (171 aa)

IELLNPIGEGSMGMVNKAYLKN---KGATPILVAVKTMKNDTQELVMAMLREAVILNQFNHPNIVRLHGIVK--SPPIMVMEYCEHGALDAFVREN--DV
|..|.|||.|..|||.||.|..   ||....|||||.|||..||.||.|.|||....||||.|||||||.|.  .|.||||||||||.|.|..|||  |.
IKCLEPIGKGNWGMVFKAMLEEHIMKGIPGFLVAVKIMKNQSQEQVMEMTREAAFMAQFNHDNIVRLHGVVTTNQPHIMVMEYCEHGSLQAYLRENGEDM

DNGLRFRLARDVARGLAEVHDKGCLHGDIAGRNILIDSNMNAKIGDFGFTRQQPNGDSPFYIAHGRAIAVRWCPGEVLLELKFSQASDVWSWAVVVFEIW
||..|||.|||||.|||..|..||.|.|||.||||.|||..|||||||.||||.||||..||.||.||.||||..|||.|.|||||||||||||.|.|||
DNQHRFRMARDVAMGLAYLHFRGCCHRDIAARNILLDSNYRAKIGDFGLTRQQANGDSEYYISHGQAIPVRWCAPEVLEEHKFSQASDVWSWAVFVYEIW

SGGQLPYRRLHNEQVWAYVIQGNRLSQPMGCNRDIWRLCMDCWATIPADRPTMVQVVDRLTK
...|||||..||..||.|||||.||..||.|.||||.|.|||||..|..||.|.||||..||
TQAQLPYRDMHNQKVWHYVIQGYRLTRPMQCPRDIWALMMDCWAEDPKERPRMCQVVDQMTK
Kinase RTKD3.AA TK 1089-1341 17 1.5e-88 296.95 In-house 1-486 (486) Show / Hide 
Range on Protein: 1089-1341
Range on HMM: 1-486/486
Sequence Identity: 17% (87 aa)

IELLNPIGEGSMG---MVNKAYLKN----------------------KGATPILVAVKTMKNDTQELVMAMLR--------------EAVILNQFN----
|.|.. .|||  |   .| |. ...                      |. ... ||||..| .. .  ....               || .. ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVRLHGIV--------------KSPPIMVMEYCEHGA----LDAFVREND----------------------------------------------
 |||||||.|..              . |...||||..||     |. . |...                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VDNGLRFRLARDVARGLAEVHDK------GCLHGDIAGRNILIDSNMN-----------AKIGDFGFTR
                               ..   .   ....|.|..  |.|      .. |.|.| ||.|...|..           .||.||| .|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------QQPNGDSPFYIAH------------------------GRAIAVRWCPGEVLL---------ELKFSQASDVWSWAVVVFEIWSGG-QLPYRRL
          . |.  | ..                        |. . .||.. |.|.         . ||. .|||||. |...||.. | . .|  .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

HN---------EQVWAYVIQG--------------NRLSQPMGCN--------------RDIWRLCMDCWATIPADRPTMVQVVDRL
.|         ..|  |. .|              .|. ||..|                .. .|...||.  |.||||. |....|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RTKD3.AA Pkinase_Tyr 1089-1341 32 2.4e-84 286.28 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1089-1341
Range on HMM: 1-270/270
Sequence Identity: 32% (88 aa)

IELLNPIGEGSMGMVNKAYLK-NKGATPILVAVKTMKNDTQEL---VMAMLREAVILNQF-NHPNIVRLHGIVK---SP--PIMVMEYCEHGALDAFVRE
|...  .|||. |.| |...|  .. | | ||||..|... .      ...||| |. |. .|||||||.|..     |  ...||||..|| |. . |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N-----DVDNGLRFRLARDVARGLAEVHDKGCLHGDIAGRNILIDSNMNAKIGDFGFTRQQ-PNGDSPFYIAHGRAIAVRWCPGEVLLELKFSQASDVWS
.      ..       ....|.|..  ..|.| | |.| ||.|...|. .||.||| .|   . .   .. ..|  . ..|.. |.. . ||. .|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

WAVVVFEIWSGGQLP-YRRLHNEQVWAYV-IQGNRLSQPMGCNRDIWRLCMDCWATIPADRPTMVQVVDRL
  |. .|| . |. | |  . ||.| .|.  .|.|. .|..|  .| .| ..||.  |.||||. ... .|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase RTKD3.AA TyrKc 1089-1341 31 5.3e-84 286.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 1089-1341
Range on HMM: 1-280/280
Sequence Identity: 31% (92 aa)

IELLNPIGEGSMGMVNKAYLKNKGATPILVAVKTMKNDTQELVMAMLREAVILNQF--NHPNIVRLHGIVK---------SPPIMVMEYCEHGALDAFVR
|.|.  .|||  | | |. .|      | ||||..|.|.   .....||| |. ..  .|||||||.|..           |. .||||..||.|. . |
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

END--VDNGLRFRLARDVARGLAEVHDKGCLHGDIAGRNILIDSNMNAKIGDFGFTRQQPNGD-----SPFYIA----HGRA-IAVRWCPGEVLLELKFS
..   . .      . ..|.| .  |.|.| | |.| ||.|...|  .||.||| .|   ..|     .  | .    .|.. . .||.. |.. . ||.
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

QASDVWSWAVVVFEIWSGGQLPYRR-----LHNEQVWAYVIQGNRLSQPMG--------CNRDIWRLCMDCWATIPADRPTMVQVVDRL
 .|||||. |. .|| . || ||       . |..| .|| ||.|. ||          |  .. ..  .||.  |.||||. ......
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase RTKD3.AA UTK 1089-1341 30 5.1e-71 242.19 In-house 1-296 (296) Show / Hide 
Range on Protein: 1089-1341
Range on HMM: 1-296/296
Sequence Identity: 30% (91 aa)

IELLNPIGEGSMGMVNKAYLKNKG--ATPILVAVKTMK--NDTQELVM---AMLREAV---ILNQFN-HPNIVRLHGIVKS--PPIMVMEYCEHGALDAF
..|....|.|  |.|.|| ...    ..  .||||. .   |.|         ..||    .. ||. |||..|| |.. .  |...|.||.| | |...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

VR---------ENDVDNGLRFRLARDVARGLAEVHDKGCLHGDIAGRNILIDSN-------MNAKIGDFG---FTRQQP-------NGDSPFYIAHG-RA
.|         .  ...  |   |.|.|||..  | .|. |.|.| ||.|....       | .||.|||   ..|. .        ..|. | |.. ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IAVRWCPGEVLLEL-KFSQASDVWSWAVVVFEIWSGGQLPYRRLHNEQVWAYVIQG--NRLSQPMGCNRDIWRLCMDCWATIPADRPTMVQVVDRL
...||.  |.| .  .|...|||||. ||..|||..|.|||  . |.|||. |  |   |. .| .| ....|| ..||.. |..||.....|...
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase RTKD3.AA RTKC 1089-1341 35 1.4e-63 208.62 In-house 1-261 (261) Show / Hide 
Range on Protein: 1089-1341
Range on HMM: 1-261/261
Sequence Identity: 35% (92 aa)

IELLNPIGEGSMGMVNKAYLKNKG-ATPILVAVKTMKNDTQELVMA-MLREAVILNQFNHPNIVRLHGIV-KSPPIMV-MEYCEHGALDAFVREN-DVDN
. ||   | |  | | || |   | .  .|||.|  . . ..  .   | || .  ||.|||.|.| |.| .  || | .|.|| |.|  .. .| |.  
LTLLDELGRGAFGIVYKALLEEPGGMPGYLVACKSLHHTAMDNDRQELLEEAAVMAQFEHPNVVHLIGVVTVGKPILVVLEFCERGSLKSYLMNNPDCTE

GLRFRLARDVARGLAEVHDKGCLHGDIAGRNILIDSNMNAKIGDFGFTRQQPN---GDSPFYIAHGRAIAVRWCPGEVLLELKFSQASDVWSWAVVVFEI
  . | ....|.|.. .| .|  | |.| ||.|..| . .|. |||  | .|.   ..   | . .  . |||   | | . |||..||||.  .  .||
HQKVRFCYQCASGMEHIHSFGFIHRDVAARNVLLSSDLTCKVADFGLARESPCNDDSHEAYYRSRSGNLPVRWTAPEALDDRKFSEKSDVWAFGILMYEI

WSGGQLPYRRLHNEQVWAYVIQGNRLSQPMGCNRDIWRLCMDCWATIPADRPTMVQVVDRL
.  ...||   .|  ||  |  | || .| .|  ..  . ||||.  |.||||. .|| .|
YTKAEMPYDGWSNQRVWVEVCAGYRLPCPEDCHKEVYDMMMDCWMHTPHDRPTFSEVVHWL
Kinase RTKD3.AA Eph 1089-1341 37 5.7e-58 193.26 In-house 1-264 (264) Show / Hide 
Range on Protein: 1089-1341
Range on HMM: 1-264/264
Sequence Identity: 37% (99 aa)

IELLNPIGEGSMGMVNKAYLKNK-GATPI---LVAVKTMKN-DTQELVMAMLREAVILNQFNHPNIVRLHGIV-KSPPIM-VMEYCEHGALDAFVREND-
| .   ||.|. | | .  || . |.. .   .||.|| |   |    .  |.|| |. ||.||||.|| |.| || |.| | || |.|.||.| |..| 
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

-VDNGLRFRLARDVARGLAEVHDKGCLHGDIAGRNILIDSNMNAKIGDFGFTRQQPNGD--SPFYIAHGRAIAVRWCPGEVLLELKFSQASDVWSWAVVV
 .  .    . | .| |     | .  | | | ||||..||   |. |||..|.  . .  .. |   |  | .||   |..   ||. ||||||. .|.
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

FEIWSGGQLPYRRLHNEQVWAYVIQGNRLSQPMGCNRDIWRLCMDCWATIPADRPTMVQVVDRL
 |. | |  ||  . |  |   . || ||  ||.| . ...| .|||.  ...||.  |.|  |
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase RTKD3.AA TKL 1095-1341 20 3.4e-55 189.68 In-house 1-364 (364) Show / Hide 
Range on Protein: 1095-1341
Range on HMM: 1-364/364
Sequence Identity: 20% (77 aa)

IGEGSMGMVNKAYLKNKG-----ATPILVAVKTMKND--------------------------TQELVMAMLREAV-ILNQFNHPNIVRLHG--------
||.|. | | |..... |     .|   ||||..| .                          ...  .  ..| . ......|||||.. |        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-IVKSP------PIMVMEYCEHGA-LDAFVRENDVDNGLRFRLARDVARGLAEVHD--------KGCLHGDIAGRNILIDSNMN--------------AK
 .. .|      . .|||||..|  |. .         .|.|.|.|.|||..  |         .. .| |.  .|||.|.|..              .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IGDFGFTRQQPNGDSPFYI----------------AHGRAIAVRWCPGEVLLEL----------------KFSQASDVWSWAVVVFEIWSGGQLPYRRLH
|.|||. |   .  .   .                 . .    ||.. ||| .                 ..|...||.|...| .|| .. . ||. ..
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYYDYP

NE---------QVWAYVIQ-GNRLSQP------------MGCNRDIWRLCMDCWATIPADRPTMVQVVDRL
..         . ...|.. |.|.  |              | ... .|..|||.. | .||.. ....||
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase RTKD3.AA Fer 1089-1342 28 1e-52 177.88 In-house 1-283 (283) Show / Hide 
Range on Protein: 1089-1342
Range on HMM: 1-283/283
Sequence Identity: 28% (82 aa)

IELLNPIGEGSMGMVNKA------YL-KNKGATPILVAVKTM-KNDTQEL-VMAMLREAVILNQ-FNHPNIVRLHGI-VKSPPIM-VMEYCEHGALDAFV
..| . .|||  | | |.      .. |.   ... |.||..  .|...     ...|| |... ..|||.|...|. |   ||| |||.| .|.|| . 
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

REND---VDNGLRFRLARDVARGLAEVHDKGCLHGDIAGRNILIDS-NMNAK--IGDFGFTRQQPNGDSPFYIA-HGRAIAVRWCPGEVLLELKFSQASD
..|.   |    ..| . ..|.|..  | |.|.| ||| ||.|..  . . |  | |||  ||.  . .  . .   . . .|| . |..    .| ..|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSWAVVVFEIWSGGQLPYRR----LHNEQV----WAYVIQ-GNRLSQPMGCNRDIWRLCM-DCWATIPADRPTMVQVVDRLT
|||. |. .|| . |. ||      . . .|     . .|. |...  | ..  .| .. | .||.  | ||||| ... .| 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase RTKD3.AA Ack 1089-1341 32 2.8e-52 174.68 In-house 1-266 (266) Show / Hide 
Range on Protein: 1089-1341
Range on HMM: 1-266/266
Sequence Identity: 32% (86 aa)

IELLNPIGEGSMGMVNKAYLKNKGATPILVAVKTMKND---TQELVMAMLREAVILNQFNHPNIVRLHGIVKSPPI--MVMEYCEHGALDAFVRENDVDN
| |.  .|.|. | | ..  .| | . | ||||  . |     .  .  |||. |. . .||..|||.|.| . |   ||.| .. |.|    |. .   
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRK-HCRT

GLR-----FRLARDVARGLAEVHDKGCLHGDIAGRNILIDSN-MNAKIGDFGFTRQQPNGDSPFYIAHGR--AIAVRWCPGEVLLELKFSQASDVWSWAV
         . .. .| |..  . |.|.| | | ||||  |    .||.|||  |  . ..     .  |   .   ||. | |  ..|| |||||.  |
AFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGV

VVFEIWSGGQLPYRRLHNEQVWAYVI-QGNRLSQPMGCNRDIWRLCMDCWATIPADRPTMVQVVDRL
   |  |.|. |.  .  .|.   .   | || .|  | .||  . | ||.  |||||| ....| |
TLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase RTKD3.AA TK-Unique 1089-1341 25 2.6e-50 171.66 In-house 1-294 (294) Show / Hide 
Range on Protein: 1089-1341
Range on HMM: 1-294/294
Sequence Identity: 25% (76 aa)

IELLNPIGEGSMGMVNKAYLKNKG---ATPILVAVKTMK-NDTQELVMAMLREAVILNQFN-HPNIVRLHGIVK---SPPIMVMEYCEHGALDAFVREND
.|... ||||. | | .. ....      .. ||||. | | |.. ....|.|. ....   |||||.. |.      |. ..||||. | |. . |.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

---------------------------VDNGLRFRLARDVARGLAEVHD--KGCLHGDIAGRNILIDSNMNAKIGDFGFTR------QQPNGDSPFYIAH
                           .. .. .. | ..|.|..  .   |.. |.|.. ||.|. .. ..||.|||..|      .. . .| .    
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR---

GRAIAVRWCPGEVLL--ELKF-SQASDVWSWAVVVFEIWSGGQLPYRRLHNEQVWAYVIQGNRLSQPMGC-NRDIWRLCMDCWATIPADRPTMVQVVDRL
   | .||.. |.|.  .  . .  ||||| .|. .|| . |. ||... ....   . .| |. || .| ....  |   ||   | .||.  |...||
---IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase RTKD3.AA Axl 1089-1339 29 5.8e-41 142.4 In-house 1-267 (267) Show / Hide 
Range on Protein: 1089-1339
Range on HMM: 1-267/267
Sequence Identity: 29% (79 aa)

IELLNPIGEGSMGMVNKAYLKNKGATPILVAVKTMKND--TQELVMAMLREAVILNQFNHPNIVRLHGI---VKS-----PPIMVMEYCEHGALDAFVRE
. |   .|||  | |  . ||    . . ||||.|| |  ||  .   |.||. . .|.|||..|| |.   ...      |.... .  || | .|.  
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

NDVDNGLRF-------RLARDVARGLAEVHDKGCLHGDIAGRNILIDSNMNAKIGDFGFTRQQPNGDSPFYIAHGRA--IAVRWCPGEVLLELKFSQASD
  ....  .       .   |.| |.  .  .  .| |.| || ..  .|   . |||  ..  .||   |   |..  . |.|   | | .  .   ||
SRLGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGD---YYRQGCIAKMPVKWIAIESLADRVYTSKSD

VWSWAVVVFEIWSGGQLPYRRLHNEQVWAYVIQGNRLSQPMGCNRDIWRLCMDCWATIPADRPTMVQVVD
||.. | ..||   || ||  ..|. .. |.|.|.|| ||  |  ... |   || . | |||.  ..  
VWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase RTKD3.AA S_TKc 1089-1342 23 8.6e-39 136.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 1089-1342
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

IELLNPIGEGSMGMVNKAYLKNKGATPILVAVKTMKNDTQELVMAMLREAVILNQFNHPNIVRLHGIVK-SPPIMVMEYCEH--GALDAFVREND-----
 |.|..||.|..| | |.. |.   |  .||.| .|         ..||  || . .|||||.|...   .   ||||||..  | |  . ...      
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VDNGLRFRLARDVARGLAEVHDKGCLHGDIAGRNILIDSNMNAKIGDFGFTRQQPNGDSPFYIAHGRAIAVRWCPGEVLLELKFSQ-ASDVWSWAVVV
   .     .... ....|.  |..| .| |.   |||.|.  . ||.|||. ||           .       ... |||   ...  ..|.||  ...
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

FEIWSGGQLPYRRLHNEQVWAYVIQGNRLSQPMGCNRDIWRLCMDCWATIPADRPTMVQVVD--------RLT
.|  . |. |..   ..|.   .|            .. . . . |.   |..|||  ..             
YEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RTKD3.AA Pkinase 1089-1341 23 1.1e-32 116.6 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1089-1341
Range on HMM: 1-293/293
Sequence Identity: 23% (72 aa)

IELLNPIGEGSMGMVNKAYLKNKGATPILVAVKTMKNDTQELVMAML----REAVILNQFNHPNIVRLHGIV--KSPPIMVMEYCEHG----ALDAFVR-
.... .||.||.| | |.. |. |    .||||..| ....  . .     .|. |.. .||||||||....  |. . |||||||.|     | .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

--ENDV--DNGLRFRLARDVARGLAEVHDKGCLHGDIAGRNILIDSNMNA----KIGDFGFTRQ-QPNGDSPFYIAHGRAIAVRWCPGEVLL-ELKFSQA
  .. .  .     . .. ..|||.  |..|..| |.   |||||.|..     ||.|||. .| .     .   .....   .... ||..   . ...
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDVWSWAVVVFEIWSGGQLPYRRL-----HNEQVWAYVIQG--NRLSQPMGCN-------------------RDIWRLCMDCWATIPADRPTMVQVVDR-
.|.||  ....|  . |..|..       |....  . | |  .. . |  |.                   ..   .. .|..  |..|||  |..   
VDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

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WF