Gene RTKB6 (M.brevicollis)

RTKB6

Species: M.brevicollis
Alias: RTKB6
External Links:
Annotation:

Classification

Group: TK
Family: RTKB

Sequence

Name Sequence Type Origin Length Description Download
RTKB6.AA Protein None 3541 None Fasta, JSON
RTKB6.kin_dom Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of RTKB6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SRCR RTKB6.AA SRCR 37-124 29 6.3e-22 75.47 Pfam 9-112 (112) Show / Hide 
Range on Protein: 37-124
Range on HMM: 9-112/112
Sequence Identity: 29% (31 aa)

GYLEISL-DNGTTWGGVCDD-N-FNYEEARVACRMLGLPTTGVRYVPTI--------VGGTTYFMDNVNCIGTETDLTDC--FYRSD--HD--CSSG-EH
| .|. . ..  .|| |||| . .. ..|.|.||.|| . ..|. ...          |.    ||||.| |.|| |..|     ..  |.  ||.. |.
GRVEVRYHNG--QWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPGTGPIWMDNVRCHGNETSLWQCPHSPWGWHRHNPMCSHSRED

VRAVCI
.  .| 
AGVICS
SR RTKB6.AA SR 23-124 28 2.4e-21 78.18 SMART 1-118 (118) Show / Hide 
Range on Protein: 23-124
Range on HMM: 1-118/118
Sequence Identity: 28% (35 aa)

LDLSTAASQVRQTRGYLEISLDN--GTTWGGVCDDNFNYEEARVACRMLGLPTTGVRYV------PTIVGGTT-YFMDNVNCIGTETDLTDCFY--RSDH
. |.   .   .  | .|. ...    .|| |||||.. ..|.|.||.||...    .        .  .|.. . ||||.| |||| |.||       |
VRLVGGNN---PCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWDCPHWGWGQH

D--CSS------GEHVRAVCI
.  ||.      .| .  || 
NNCCSHNHHRNRQEDAGVVCS
BNR RTKB6.AA BNR 40-49 50 2.374912 5.53 Pfam 1-10 (12) Show / Hide 
Range on Protein: 40-49
Range on HMM: 1-10/12
Sequence Identity: 50% (5 aa)

EISLDNGTTW
 .| |.| ||
YYSTDGGKTW
SRCR RTKB6.AA SRCR 134-220 27 7.9e-19 65.06 Pfam 11-112 (112) Show / Hide 
Range on Protein: 134-220
Range on HMM: 11-112/112
Sequence Identity: 27% (28 aa)

LQI-NYDGRWLGVCDD-S-FDRADATVACRTLG--LDARAPGYTTGI------TGNSSVFGADNLACSGNEDTLAICSQNALGD--ED--CGLN-DHVRV
...  ..|.|  |||| . .|..|| |.|| ||   .|     ...        | .. .  ||. |.|||..|. |.  ..|.   .  |. .  .. |
VEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPG-TGPIWMDNVRCHGNETSLWQCPHSPWGWHRHNPMCSHSREDAGV

DCA
 |.
ICS
SR RTKB6.AA SR 126-220 24 6.3e-10 40.22 SMART 1-118 (118) Show / Hide 
Range on Protein: 126-220
Range on HMM: 1-118/118
Sequence Identity: 24% (29 aa)

YRQLPGQ-----YLQINYDG----RWLGVCDDSFDRADATVACRTLGLDARAPGYT-----TGITGNSSV-FGADNLACSGNEDTLAICSQNALGDED--
 |   |.      ... ..|    .|  ||||..| .|| |.|| ||.   .  ..      .  |  |  .  ||  |.|.|..|. |. . .|  .  
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWDCPHWGWGQHNNC

CGL------NDHVRVDCA
|.       .  . | | 
CSHNHHRNRQEDAGVVCS
SRCR RTKB6.AA SRCR 232-324 28 6.4e-18 62.0 Pfam 10-112 (112) Show / Hide 
Range on Protein: 232-324
Range on HMM: 10-112/112
Sequence Identity: 28% (31 aa)

TLEL-Y-AFGAWHGVCDD-N-FNNNVAVVACRNLGY-TNATTATSTFTT--SI--TTDSDIFNLDLVETACSGTESTLDACAFLAFGN--EN--CRNS-E
..|. | . |.|. |||| . .... | |.|| ||.  .|  |.|. .          .  . .| |.  |.|.|..|. | . . |.   |  |  | |
RVEVRYHN-GQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPG-TGPIWMDNVR--CHGNETSLWQCPHSPWGWHRHNPMCSHSRE

HVRVYCQ
.. | |.
DAGVICS
SR RTKB6.AA SR 224-324 25 9.5e-16 59.57 SMART 1-118 (118) Show / Hide 
Range on Protein: 224-324
Range on HMM: 1-118/118
Sequence Identity: 25% (32 aa)

VRQSPVDL----TLELYAFG----AWHGVCDDNFNNNVAVVACRNLGYTNATTATS-------TFTTSITTDSDIFNLDLVETACSGTESTLDACAFLAF
|| .  .     ..| |  |    .|. |||||.. . | |.|| ||. .| .|..       .|    .         . .. |.|||..|  |..  .
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSG------PIWMDNVRCTGTETSLWDCPHWGW

GNEN--CRN------SEHVRVYCQ
|. |  |.       .| . | |.
GQHNNCCSHNHHRNRQEDAGVVCS
EGF_2 RTKB6.AA EGF_2 500-521 28 1.391913 5.31 Pfam 1-24 (29) Show / Hide 
Range on Protein: 500-521
Range on HMM: 1-24/29
Sequence Identity: 28% (8 aa)

CPMGCSN-LGRCT-PTG---CECDAP-Y
|   |..  | |  . |   |.|| . .
C---CNGHHGTCNNQ-GCGKCQCDDGWW
EGF RTKB6.AA EGF 500-521 25 2.903734 3.95 Pfam 1-32 (36) Show / Hide 
Range on Protein: 500-521
Range on HMM: 1-32/36
Sequence Identity: 25% (8 aa)

CPM---GCSNLGRCTPTG----CECDAP---Y
|.    .|.. |.|..|.    |.|  .   |
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGY
EGF_2 RTKB6.AA EGF_2 853-870 45 0.868985 5.95 Pfam 1-20 (29) Show / Hide 
Range on Protein: 853-870
Range on HMM: 1-20/29
Sequence Identity: 45% (10 aa)

CGVCGG-GGTCTAQG---CACP
|  |.| .|||  ||   | |.
C--CNGHHGTCNNQGCGKCQCD
EB RTKB6.AA EB 856-881 32 41.668771 0.17 Pfam 30-59 (59) Show / Hide 
Range on Protein: 856-881
Range on HMM: 30-59/59
Sequence Identity: 32% (10 aa)

CG---GGGTC--TAQGCACPVGATLSVAGLC
|    || .|  ... | || | .  . | |
CQAMWGGSHCHSMNGTCQCPEG-FTQHNGRC
BNR RTKB6.AA BNR 979-990 50 0.108785 9.88 Pfam 1-12 (12) Show / Hide 
Range on Protein: 979-990
Range on HMM: 1-12/12
Sequence Identity: 50% (6 aa)

MISTDDGVEWNK
..|||.|  |.|
YYSTDGGKTWSK
EB RTKB6.AA EB 1229-1248 45 0.001625 15.77 Pfam 38-59 (59) Show / Hide 
Range on Protein: 1229-1248
Range on HMM: 38-59/59
Sequence Identity: 45% (10 aa)

YC--TTGGCVCDTGFTLVNGKC
.|  . | | |..|||..||.|
HCHSMNGTCQCPEGFTQHNGRC
TIL RTKB6.AA TIL 1230-1252 40 0.083001 8.7 Pfam 40-63 (52) Show / Hide 
Range on Protein: 1230-1252
Range on HMM: 40-63/52
Sequence Identity: 40% (10 aa)

CTTGGCVCDTGFT-LVNG-KCVPAA
|. | |.|. |.  . |. ||||..
CVPG-CFCPPGYVFRDNDGKCVPPS
EGF RTKB6.AA EGF 1219-1249 24 0.363826 2.31 SMART 1-32 (32) Show / Hide 
Range on Protein: 1219-1249
Range on HMM: 1-32/32
Sequence Identity: 24% (9 aa)

TCNQGCGLA-----GYCTTGGCVCD-TGFTLVNGKCV
 |  .|.       | |..  | |   |.|.    |.
ECA-PCHHGGCEQHGTCISYTC-CPGPGYTG---RCE
EGF_2 RTKB6.AA EGF_2 1220-1242 32 0.461398 6.81 Pfam 1-25 (29) Show / Hide 
Range on Protein: 1220-1242
Range on HMM: 1-25/29
Sequence Identity: 32% (9 aa)

CNQGCGL-AGYCT---TGGCVCDTG-FT
|   |.   |.|    .| |.|| | ..
C---CNGHHGTCNNQGCGKCQCDDGWWQ
EGF_CA RTKB6.AA EGF_CA 1235-1248 21 0.615817 5.52 Pfam 31-53 (53) Show / Hide 
Range on Protein: 1235-1248
Range on HMM: 31-53/53
Sequence Identity: 21% (5 aa)

CV---CDTGFT------LVNGKC
||   |. |..       ....|
CVNQDCMDGYEMISENNCDGTNC
BNR RTKB6.AA BNR 1339-1350 41 8.150607 3.79 Pfam 1-12 (12) Show / Hide 
Range on Protein: 1339-1350
Range on HMM: 1-12/12
Sequence Identity: 41% (5 aa)

AASSDGGTTFDD
. | ||| |.  
YYSTDGGKTWSK
TIL RTKB6.AA TIL 1580-1596 44 0.407974 6.42 Pfam 29-46 (52) Show / Hide 
Range on Protein: 1580-1596
Range on HMM: 29-46/52
Sequence Identity: 44% (8 aa)

SGCFCDADYT-LDDAGRC
.||||.  |  .|. |.|
PGCFCPPGYVFRDNDGKC
BNR RTKB6.AA BNR 1693-1704 66 0.00671 13.81 Pfam 1-12 (12) Show / Hide 
Range on Protein: 1693-1704
Range on HMM: 1-12/12
Sequence Identity: 66% (8 aa)

AYSLDGGMTWST
.|| ||| |||.
YYSTDGGKTWSK
EGF_2 RTKB6.AA EGF_2 1933-1959 31 0.00017 17.55 Pfam 1-24 (29) Show / Hide 
Range on Protein: 1933-1959
Range on HMM: 1-24/29
Sequence Identity: 31% (10 aa)

CAVPGSAAPCGG-HGSCQ---AGTCVCDPS-F
|        |.| ||.|     | |.||.. .
C--------CNGHHGTCNNQGCGKCQCDDGWW
EB RTKB6.AA EB 1942-1966 36 0.000527 17.5 Pfam 30-59 (59) Show / Hide 
Range on Protein: 1942-1966
Range on HMM: 30-59/59
Sequence Identity: 36% (11 aa)

CG---GHGSC--QAGTCVCDPSFELVDGRC
|    |  .|  ..||| |.. |....|||
CQAMWGGSHCHSMNGTCQCPEGFTQHNGRC
EGF RTKB6.AA EGF 1932-1967 30 0.001543 19.0 SMART 1-32 (32) Show / Hide 
Range on Protein: 1932-1967
Range on HMM: 1-32/32
Sequence Identity: 30% (13 aa)

ECAVPGSAAPCGGH-----GSCQAGTCVCD-PSFELVDGRCV
|||      ||. .     | |.  || |  | ...   ||.
ECA------PCHHGGCEQHGTCISYTC-CPGPGYTG---RCE
EGF_CA RTKB6.AA EGF_CA 1953-1966 21 0.643479 5.46 Pfam 31-53 (53) Show / Hide 
Range on Protein: 1953-1966
Range on HMM: 31-53/53
Sequence Identity: 21% (5 aa)

CV---CDPSFE------LVDGRC
||   |.. .|       ... |
CVNQDCMDGYEMISENNCDGTNC
EGF RTKB6.AA EGF 1933-1963 26 3.219992 3.8 Pfam 1-36 (36) Show / Hide 
Range on Protein: 1933-1963
Range on HMM: 1-36/36
Sequence Identity: 26% (10 aa)

CAVPGSAAPCGGHGSCQAG----TCVCDPS---FELVD
|.  .   || .|| |. .    || | |    .   .
CNPNN--NPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
TIL RTKB6.AA TIL 1933-1970 27 13.39554 1.42 Pfam 18-50 (52) Show / Hide 
Range on Protein: 1933-1970
Range on HMM: 18-50/52
Sequence Identity: 27% (11 aa)

CAVPGSAAPCGGHGSCQAGTCVCDPSFE-LVDG-RCVPVA
|. | .   |     |. | |.|.| .  . .. .|||..
CDNP-P---CP--KQCVPG-CFCPPGYVFRDNDGKCVPPS
BNR RTKB6.AA BNR 2060-2071 50 3.900409 4.83 Pfam 1-12 (12) Show / Hide 
Range on Protein: 2060-2071
Range on HMM: 1-12/12
Sequence Identity: 50% (6 aa)

AYSLDGGHLWHF
.|| |||  |. 
YYSTDGGKTWSK
EGF_2 RTKB6.AA EGF_2 2454-2481 36 7.8e-07 24.87 Pfam 1-29 (29) Show / Hide 
Range on Protein: 2454-2481
Range on HMM: 1-29/29
Sequence Identity: 36% (12 aa)

CPNMCNN-RGRCM-PGP--RCVCDDG-FTGPAC
|   ||. .| |  . .  .|.|||| ..|. |
C---CNGHHGTCNNQ-GCGKCQCDDGWWQGDHC
EGF RTKB6.AA EGF 2453-2482 27 8.8e-05 23.13 SMART 1-32 (32) Show / Hide 
Range on Protein: 2453-2482
Range on HMM: 1-32/32
Sequence Identity: 27% (10 aa)

SCPNMCNNR-----GRCMPGPRCVCD-DGFTGPACT
 |   | .      |.|  ...| |  .|.||  | 
ECA-PCHHGGCEQHGTCI-SYTC-CPGPGYTG-RCE
EGF RTKB6.AA EGF 2454-2480 27 0.000508 16.5 Pfam 1-36 (36) Show / Hide 
Range on Protein: 2454-2480
Range on HMM: 1-36/36
Sequence Identity: 27% (10 aa)

CPN---MCNNRGRCMPGP---RCVCDDG---FTGPA
|.     |...|.|...|   .| |  |   .||. 
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
TIL RTKB6.AA TIL 2452-2476 38 1.649056 4.42 Pfam 16-37 (52) Show / Hide 
Range on Protein: 2452-2476
Range on HMM: 16-37/52
Sequence Identity: 38% (10 aa)

PSCPNM-CNNRGRCMPGPRCVCDDGF
|.| |. |.    | ||  |.|..|.
PTCDNPPCP--KQCVPG--CFCPPGY
EGF_CA RTKB6.AA EGF_CA 2469-2481 29 5.380347 2.56 Pfam 30-53 (53) Show / Hide 
Range on Protein: 2469-2481
Range on HMM: 30-53/53
Sequence Identity: 29% (7 aa)

RCV---CDDGFT--------GPAC
.||   |.||..        | .|
ECVNQDCMDGYEMISENNCDGTNC
BNR RTKB6.AA BNR 2564-2575 41 1.415595 6.26 Pfam 1-12 (12) Show / Hide 
Range on Protein: 2564-2575
Range on HMM: 1-12/12
Sequence Identity: 41% (5 aa)

AYSLDGGINFMT
.|| |||... .
YYSTDGGKTWSK
EGF RTKB6.AA EGF 2631-2672 21 0.000156 22.31 SMART 1-32 (32) Show / Hide 
Range on Protein: 2631-2672
Range on HMM: 1-32/32
Sequence Identity: 21% (10 aa)

PCVTNDGVAACRAH----DLTCYANSSTTFECDCA-PGFILTAGQCE
.|        |  .    . ||      ...| |. ||...   .||
ECA------PCHHGGCEQHGTCI-----SYTC-CPGPGYTG---RCE
EB RTKB6.AA EB 2658-2671 42 0.39761 7.32 Pfam 46-59 (59) Show / Hide 
Range on Protein: 2658-2671
Range on HMM: 46-59/59
Sequence Identity: 42% (6 aa)

CDCAPGFILTAGQC
| |..||..  |.|
CQCPEGFTQHNGRC
TIL RTKB6.AA TIL 2658-2671 31 2.289712 3.95 Pfam 31-46 (52) Show / Hide 
Range on Protein: 2658-2671
Range on HMM: 31-46/52
Sequence Identity: 31% (5 aa)

CDCAPGFI-LTAG-QC
| | ||.. .  . .|
CFCPPGYVFRDNDGKC
EGF RTKB6.AA EGF 2651-2666 31 8.867649 2.33 Pfam 16-30 (36) Show / Hide 
Range on Protein: 2651-2666
Range on HMM: 16-30/36
Sequence Identity: 31% (5 aa)

NSSTTFECDCAPGFIL
.. ....|.|.||. |
DTPGGYTCQCPPGY-L
EGF_CA RTKB6.AA EGF_CA 2655-2671 23 20.994693 0.7 Pfam 28-53 (53) Show / Hide 
Range on Protein: 2655-2671
Range on HMM: 28-53/53
Sequence Identity: 23% (6 aa)

TFECD---CAPGFI------LTAGQC
.|||    | .|.          ..|
SFECVNQDCMDGYEMISENNCDGTNC
EGF_CA RTKB6.AA EGF_CA 2707-2748 31 0.001205 4.08 SMART 6-38 (34) Show / Hide 
Range on Protein: 2707-2748
Range on HMM: 6-38/34
Sequence Identity: 31% (14 aa)

IDGCATNPCLDG---RSCTPGVASGSFTCGPCPSGLMPDGANGCT
|| |   ||  |     |.     ||..|  || | .    . |.
IDEC---PCQNGGPTGTCIN---PGSYRC--CPPGYT----RHCE
EGF RTKB6.AA EGF 2709-2748 28 0.030641 14.58 SMART 1-32 (32) Show / Hide 
Range on Protein: 2709-2748
Range on HMM: 1-32/32
Sequence Identity: 28% (13 aa)

GCATNPCLDGR-----SCTPGVASGSFTCGPCP-SGLMPDGANGCT
 ||  ||  |       |.      |.||  ||  | .      | 
ECA--PCHHGGCEQHGTCI------SYTC--CPGPGYTG----RCE
EGF RTKB6.AA EGF 2710-2732 32 1.519096 4.89 Pfam 1-23 (36) Show / Hide 
Range on Protein: 2710-2732
Range on HMM: 1-23/36
Sequence Identity: 32% (8 aa)

CATN--PCLDGRSCTPGVASGSFTC
|. |  ||. .  |...   |..||
CNPNNNPCHHHGTCVDTP--GGYTC
EGF_CA RTKB6.AA EGF_CA 2896-2943 34 5.7e-10 40.37 SMART 1-34 (34) Show / Hide 
Range on Protein: 2896-2943
Range on HMM: 1-34/34
Sequence Identity: 34% (17 aa)

DLDECSYQGACGYPG--AVCNNTPGTYKCYCPPGFVATGEAAAATAINSE
| |||     |.  |  ..| | || |.| ||||.            . |
DIDEC----PCQNGGPTGTCIN-PGSYRC-CPPGYT----------RHCE
EGF_CA RTKB6.AA EGF_CA 2896-2928 35 4.1e-08 28.1 Pfam 1-40 (53) Show / Hide 
Range on Protein: 2896-2928
Range on HMM: 1-40/53
Sequence Identity: 35% (14 aa)

DLDECSYQG--ACGYP--GAVCNNTPGTYKCY---CPPGF
|.|||   .   || |  ...|.|| |...|    |..|.
DVDECADGTHHMCGDPHRNTWCINTIGSFECVNQDCMDGY
EGF_CA RTKB6.AA EGF_CA 2855-2894 33 4.3e-07 24.89 Pfam 1-53 (53) Show / Hide 
Range on Protein: 2855-2894
Range on HMM: 1-53/53
Sequence Identity: 33% (18 aa)

DVNECDL-G--MC---SEHRECFNTVGGFSCG--LCAYGYV------ENGTTGC
||.||.  .  ||   ..  .|.||.|.|.|    |  ||       ..||. |
DVDECADGTHHMCGDPHRNTWCINTIGSFECVNQDCMDGYEMISENNCDGTN-C
EGF_CA RTKB6.AA EGF_CA 2855-2895 27 7.4e-07 30.0 SMART 1-34 (34) Show / Hide 
Range on Protein: 2855-2895
Range on HMM: 1-34/34
Sequence Identity: 27% (12 aa)

DVNECDLGMCSEH---RECFNTVGGFSCGLCAYGYVENGTTGCS
|..||    |. .     | | .|...|  |  ||     . | 
DIDEC---PCQNGGPTGTCIN-PGSYRC--CPPGYT----RHCE
EGF RTKB6.AA EGF 2814-2854 25 0.009889 16.32 SMART 1-32 (32) Show / Hide 
Range on Protein: 2814-2854
Range on HMM: 1-32/32
Sequence Identity: 25% (12 aa)

ACSPSPCDPLV-----TCTVGDDGLTAECGACP-NGYTTEDEGYTCR
 |.  ||..       ||.      . .|  || .|||      .| 
ECA--PCHHGGCEQHGTCI------SYTC--CPGPGYTG-----RCE
EGF RTKB6.AA EGF 2858-2895 20 0.048235 12.33 SMART 1-32 (32) Show / Hide 
Range on Protein: 2858-2895
Range on HMM: 1-32/32
Sequence Identity: 20% (9 aa)

ECDLGMCSEHR-----ECFNTVGGFSCGLCA-YGYVENGTTGCS
||.   |...      .|     ...|  |.  ||       | 
ECA--PCHHGGCEQHGTCI----SYTC--CPGPGYTG----RCE
EGF RTKB6.AA EGF 2899-2939 23 0.05668 11.53 SMART 1-32 (32) Show / Hide 
Range on Protein: 2899-2939
Range on HMM: 1-32/32
Sequence Identity: 23% (11 aa)

ECSYQGACGYPG----AVCNNTPGTYKCYCP-PGFVATGEAAAATA
||.    |.  |    ..|     .|.| || ||.           
ECA---PCHHGGCEQHGTCI----SYTC-CPGPGYTG------RCE
EGF RTKB6.AA EGF 2894-2928 28 0.099804 8.84 Pfam 1-32 (36) Show / Hide 
Range on Protein: 2894-2928
Range on HMM: 1-32/36
Sequence Identity: 28% (11 aa)

CSDL-DECSYQGACGYPGAVCNNTPGTYKCYCPPG---F
|..  . |.  | | ...       |.|.| ||||   .
CNPNNNPCHHHGTCVDTP-------GGYTCQCPPGYLGY
EGF RTKB6.AA EGF 2859-2879 34 1.696209 4.73 Pfam 1-23 (36) Show / Hide 
Range on Protein: 2859-2879
Range on HMM: 1-23/36
Sequence Identity: 34% (8 aa)

CDLG--MCSEHRECFNTVGGFSC
|.     |. | .|..| ||..|
CNPNNNPCHHHGTCVDTPGGYTC
EGF_2 RTKB6.AA EGF_2 2900-2928 33 6.434298 3.23 Pfam 1-24 (29) Show / Hide 
Range on Protein: 2900-2928
Range on HMM: 1-24/29
Sequence Identity: 33% (10 aa)

CSYQGACGYPGAVCNNTPGTYKCYCPPG-F
|     |.  . .|||. |. ||.|..| .
C-----CNGHHGTCNNQ-GCGKCQCDDGWW
EB RTKB6.AA EB 2899-2930 30 8.360233 2.64 Pfam 23-54 (59) Show / Hide 
Range on Protein: 2899-2930
Range on HMM: 23-54/59
Sequence Identity: 30% (11 aa)

ECSYQGACG--YPGAVC--NNTPGTYKCYCPPGFVA
.|.|   |   ..|..|  .|     .| ||.||..
GCQYDEQCQAMWGGSHCHSMN----GTCQCPEGFTQ
TIL RTKB6.AA TIL 2922-2929 75 19.940185 0.85 Pfam 31-38 (52) Show / Hide 
Range on Protein: 2922-2929
Range on HMM: 31-38/52
Sequence Identity: 75% (6 aa)

CYCPPGFV
|.||||.|
CFCPPGYV
EGF_CA RTKB6.AA EGF_CA 2836-2853 29 21.304188 0.68 Pfam 30-53 (53) Show / Hide 
Range on Protein: 2836-2853
Range on HMM: 30-53/53
Sequence Identity: 29% (7 aa)

ECG--ACPNGYT----TEDEGYTC
||   .|. ||.    . ..| .|
ECVNQDCMDGYEMISENNCDGTNC
EB RTKB6.AA EB 2840-2853 42 22.617615 1.11 Pfam 48-59 (59) Show / Hide 
Range on Protein: 2840-2853
Range on HMM: 48-59/59
Sequence Identity: 42% (6 aa)

CPNGYTTEDEGYTC
||.| .|...|. |
CPEG-FTQHNGR-C
TIL RTKB6.AA TIL 2882-2900 30 34.359748 0.07 Pfam 33-52 (52) Show / Hide 
Range on Protein: 2882-2900
Range on HMM: 33-52/52
Sequence Identity: 30% (6 aa)

CAYGYV-ENGTTGCSDLDEC
|  |||  ..   |  ...|
CPPGYVFRDNDGKCVPPSQC
Kinase RTKB6.AA RTKB 3109-3367 59 8.70000000001e-188 630.14 In-house 1-264 (264) Show / Hide 
Range on Protein: 3109-3367
Range on HMM: 1-264/264
Sequence Identity: 59% (157 aa)

VQLDEKLGEGAFGEVFKAYYREPGTN-ARLVAVKTLKTGAAYEDRQEFLDEVHLMKELNGHPNVLGIIGHCLLDEPYLLLVELCMHGNLRDLLRASRASS
|.|.||||.|||||||.|..|....| ....|.|.||.||.||.||.|..|...||||..||||.||||||| ||||.||||||..|||||.||..|||.
VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQ

SNMQ-FEFEQLRKFSMQICSGMAHLHQQGILHRDLAARNVLVSKGLHCKVADFGMSR--QHDEYRTTATRLPIKWMDIQSLADRIYTTKS-DVWSFGVTC
.|.| ....||..|..||..|||.|||....||||.||||||...||||..||||.|  .|..|.||.||||||||...|.|.||||||| ||||||||.
HNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTM

FEIFSLGGTPYPTYSNGQMLDLLRSGYRMPKPSQANQAIYDIMLLTWQEDPDHRPDFPALLALL
.||||||||||..|.||.....|.||.|.|||.|..||...||  .||....|||||..|....
WEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase RTKB6.AA Pkinase_Tyr 3109-3367 39 1.3e-116 395.61 Pfam 1-270 (270) Show / Hide 
Range on Protein: 3109-3367
Range on HMM: 1-270/270
Sequence Identity: 39% (108 aa)

VQLDEKLGEGAFGEVFKAYYR-EPGTNARLVAVKTLKTGAAYED--RQEFLDEVHLMKELNGHPNVLGIIGHCL-LDEP--YLLLVELCMHGNLRDLLRA
.....||||||||||.|.... .|. .   ||||.|| ||  |.  |..|. |. .||.|  |||..  .| |.  .||  ... .|.. ||.|.| ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

SRASSSNMQFEFEQLRKFSMQICSGMAHLHQQGILHRDLAARNVLVSKGLHCKVADFGMSRQH---DEY--RTTATRLPIKWMDIQSLADRIYTTKSDVW
 |  ... ..  ..| ....||..||..|..... ||||||||.||......|..|||..| .   |.|   .. ..||||||   .......|||||||
HR--EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SFGVTCFEIFSLGGTP-YPTYSNGQMLDLL-RSGYRMPKPSQANQAIYDIMLLTWQEDPDHRPDFPALLALL
||||...|||..|..| ||  || ...... ..|||||.|  . . |||.|.. |..||..|| | ...  |
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase RTKB6.AA TyrKc 3109-3367 36 1e-114 388.29 SMART 1-280 (280) Show / Hide 
Range on Protein: 3109-3367
Range on HMM: 1-280/280
Sequence Identity: 36% (107 aa)

VQLDEKLGEGAFGEVFKAYYREPGTNARLVAVKTLKTGAAYEDRQEFLDEVHLMKEL-NGHPNVLGIIGHCLLD-------EPYLLLVELCMHGNLRDLL
..|..||||||||||.|. ..      . ||||.|| .|    |..|..|  .|..|   |||.. ..| |. .       ||.....|.. ||.|.| |
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RASRASSSNMQFEFEQLRKFSMQICSGMAHLHQQGILHRDLAARNVLVSKGLHCKVADFGMSRQH----------DEYRTT---ATR--LPIKWMDIQSL
|..|       .  ..| .|. ||..||..||.... ||||||||.||......|..|||.|| .          | ||..    ..  |||.|| . ..
RKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

ADRIYTTKSDVWSFGVTCFEIFSLGGTPYPT-----YSNGQMLDLLRSGYRMPKPSQ--------ANQAIYDIMLLTWQEDPDHRPDFPALLALL
 ....|||||||||||...|||..|..|||       || ... ....|||||.|          . ...|.||.  |.|||. || | ..  ..
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase RTKB6.AA TK 3109-3367 23 6.2e-113 380.08 In-house 1-486 (486) Show / Hide 
Range on Protein: 3109-3367
Range on HMM: 1-486/486
Sequence Identity: 23% (113 aa)

VQLDEKLGEGAFG---EVFKAYYREPG----------------------TNARLVAVKTLKTGAAYEDRQ-------------EFLDEVHLMKELNG---
..| .|||||.||   ||.|. .|...                       .   ||||.|| |.| ....             .|| |.. || ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVLGIIGHCLLD------------EPYLLLVELCMHGN----LRDLLRASRASSSN-----------------------------------------
 |||.. ..|.|. .            ||.....|.. ||.    ||| ||..|   ..                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------MQFEFEQLRK-------------------FSMQICSGMAHLHQQ------GILHRDLAARNVLVSKGLH-----------CKVADFGMS--
         ... . .|                     ...||..||..||..      .. ||||||||.||.....           ||.||||.|  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

------RQH----DEYRTT------------------------ATRLPIKWMDIQSLADRI---------YTTKSDVWSFGVTCFEIFSLG-GTPYPTYS
      | .    | ||..                         ..|||.||   .|.||.         .|||||||||||...|||..| ...|.  |
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

N---------GQMLDLLRSG--------------YRMPKPSQAN--------------QAIYDIMLLTWQEDPDHRPDFPALLALL
|          .....||.|              .|||.| ..               ...||.|.  |..||..||.| .|.  |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RTKB6.AA UTK 3109-3367 36 5.1e-96 325.31 In-house 1-296 (296) Show / Hide 
Range on Protein: 3109-3367
Range on HMM: 1-296/296
Sequence Identity: 36% (109 aa)

VQLDEKLGEGAFGEVFKAYYREPG--TNARLVAVKTLKTGAAYEDRQE----FLDEVH---LMKELNGHPNVLGIIGHCLLDEPYLLLVELCMHGNLRDL
||| ..||.||||||.|| ....       .||||.....|. .. .|    |. |     .|| ...|||||. .| |. .|| ....|..  |.||..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRASRASSSNMQFEFE--QLRKFSMQICSGMAHLHQQGILHRDLAARNVLVSKG-------LHCKVADFG---MSRQHD------------EYRTT-ATR
|| .| .    .. .   |. .....| .||..||..|. ||||||||.|| .        . ||.||||   |||.              .|. . ..|
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

LPIKWMDIQSLADR-IYTTKSDVWSFGVTCFEIFSLGGTPYPTYSNGQMLDLLRSG--YRMPKPSQANQAIYDIMLLTWQEDPDHRPDFPALLALL
.||.||  ..|...  .|||||||||||.|.||.. | .||| .|| | .  .. |  ||||.| .   ..|..|.  |. ||. ||||. |.. .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase RTKB6.AA TK-Unique 3109-3367 36 4.2e-94 318.94 In-house 1-294 (294) Show / Hide 
Range on Protein: 3109-3367
Range on HMM: 1-294/294
Sequence Identity: 36% (106 aa)

VQLDEKLGEGAFGEVFKAYYREPG--TNAR-LVAVKTLKTGAAYEDRQEFLDEVHLMKELNGHPNVLGIIGHCLLD-EPYLLLVELCMHGNLRDLLRASR
. .....||||||.|... ....    ...  ||||.|| .|  .|.|.||.|  .||||  |||.. ..| |  . || ... | |. |||...|| .|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

--------------------ASSSNMQFEFEQLRKFSMQICSGMAHLHQ--QGILHRDLAARNVLVSKGLHCKVADFGMSR---QHDEYRTTAT--RLPI
                    .. ..     ..|  |  ||..||..|..  ..| ||||.|||||.. .. ||..||||.|    . .| .. .  |.||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWMDIQSLA--DRIY-TTKSDVWSFGVTCFEIFSLGGTPYPTYSNGQMLDLLRSGYRMPKPSQA-NQAIYDIMLLTWQEDPDHRPDFPALLALL
.||   ||   ...| |||||||||||. .|||.||..||| ... ......| |||||.|..  ....| .|  .||..|..||.| ...  |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase RTKB6.AA Fer 3109-3368 32 1.3e-83 284.14 In-house 1-283 (283) Show / Hide 
Range on Protein: 3109-3368
Range on HMM: 1-283/283
Sequence Identity: 32% (95 aa)

VQLDEKLGEGAFGEVFKAY-----YREPGTNARLVAVKTLKT-GA-AYED-RQEFLDEVHLMKE-LNGHPNVLGIIGHCLLDEPYLLLVELCMHGNLRDL
| |..||||||||||.|.      ... . . . ||||. |  .. | .. ..||. |  .|.  .. ||||  ..| | ...|.... |.| .|.|.. 
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYD-HPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSY

LRASRASSSNMQFEFEQLRKFSMQICSGMAHLHQQGILHRDLAARNVLVSK-GLHCK--VADFGMSRQ--HDEYRTT----ATRLPIKWMDIQSLADRIY
|. . .          .. ....|...||..||.....|||.||||.|..| .. .|  ..|||||||   ..|. .    |...||.|.   .. ..||
LKKNKNK----TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIY

TTKSDVWSFGVTCFEIFSLGGTPYPT----YSNGQM-----LDLLRSGYRMPKPSQANQAIYDIML-LTWQEDPDHRPDFPALLALLA
..|.|||||||.|.|||. | .|||.      ....         ..||.|| |...  .|. ||.   ||.||. || .  .   | 
SPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase RTKB6.AA Src 3109-3367 38 4.7e-81 275.12 In-house 1-255 (255) Show / Hide 
Range on Protein: 3109-3367
Range on HMM: 1-255/255
Sequence Identity: 38% (101 aa)

VQLDEKLGEGAFGEVFKAYYREPGTNARLVAVKTLKTGAAYEDRQEFLDEVHLMKELNGHPNVLGIIGHCLLDEPYLLLVELCMHGNLRDLLRASRASSS
..| .|||.| ||||...|..    .   ||||||| |    . . || |  .||.|  |.... .   |  .||..   |.  ||.| | |..   .. 
IKLCRKLGQGQFGEVWMGYWN----GNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLR-HEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK---DGE

NMQFEFEQLRKFSMQICSGMAHLHQQGILHRDLAARNVLVSKGLHCKVADFGMSRQHD----EY-RTTATRLPIKWMDIQSLADRIYTTKSDVWSFGVTC
  . ...||  .. |. .||| | .. . |||||||||||.... |||||||  |  .    ||   .  ..||||.    .  . .|.||||||||.  
GRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILL

FEIFSLGGTPYPTYSNGQMLDLLRSGYRMPKPSQANQAIYD-IMLLTWQEDPDHRPDFPALLALL
 ||.. | .|||  .| . |. .  |||||.|..  . .|. |||  |..||. || |  |   |
TEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase RTKB6.AA Tie 3117-3367 37 9.8e-79 239.13 In-house 1-267 (267) Show / Hide 
Range on Protein: 3117-3367
Range on HMM: 1-267/267
Sequence Identity: 37% (100 aa)

EGAFGEVFKAYYREPGTNARLVAVKTLKTGAAYEDRQEFLDEVHLMKELNGHPNVLGIIGHCLLDEPYLLLVELCMHGNLRDLLRASR----------AS
|| || |.||  .  |     ||.|..| .|. .|...|  |. .|  .  |||.. ..| |       . .|   .||| | || ||          . 
EGNFGQVMKAMIKKDGLKME-VAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAFAREH

SS------NMQFEFEQLRKFSMQICSGMAHLHQQGILHRDLAARNVLVSKGLHCKVADFGMSRQHDEY-RTTATRLPIKWMDIQSLADRIYTTKSDVWSF
..            .|. .|   .  || .| |....||||||||.||   . ||.||||.|| .. | ..|. |||..|| | ||   .|||||||||.
TTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSY

GVTCFEIFSLGGTPYPTYSNGQMLDLLRSGYRMPKPSQANQAIYDIMLLTWQEDPDHRPDFPALLALL
||  .|| |||||||      .. . |  |||| .|   .  .||.|   |.. |  || |  ..  |
GVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase RTKB6.AA KIN6 3152-3367 37 1.2e-67 222.54 In-house 61-305 (305) Show / Hide 
Range on Protein: 3152-3367
Range on HMM: 61-305/305
Sequence Identity: 37% (92 aa)

RQEFLDEVHLMKELNGHPNVLGIIGHCLLDEPYLLLVELCMHGNLRDLLRASR----------------ASSS----NMQFEFEQLRKFSMQICSGMAHL
...|. |  .|| |  || .    |     .. .|.||.| |..|   ||  .                  .|    .|   . .| .|. ||| ||  |
HHDFMHEIAFMKQLGHHPHLVNMLGCVTNSYKPCLVVEYCCHMDLLKYLRNRCQYMMNLDDLGINYHCPDENSRYDDMMCIRHKDLYMFAWQICDGMEYL

HQQGILHRDLAARNVLVSKGL---HCKVADFGMSR--QHDE--YRTTATR-LPIKWMDIQSLADRIYTTKSDVWSFGVTCFEIFSLGGTPYPTYS-NGQM
|. .. ||||||||||| .|.    ||. |||. |    |.  | . . | ||||||   .|.   . .|||||||||  ||.||||. |||.      |
HSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMDQFQYTSKGGRYLPIKWMAPECLKHYEFSYKSDVWSFGVLMFEMFSLGDVPYPEMQRPTEM

LDLLRSGYRMPKPSQANQAIYDIMLLTWQEDPDHRPDFPALLALL
.  .||| |. .|  .   ||||| . |||.|| ||.|  .  ..
IEHHRSGRRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF
Kinase RTKB6.AA VEGFR 3220-3367 43 8.3e-56 191.72 In-house 178-332 (332) Show / Hide 
Range on Protein: 3220-3367
Range on HMM: 178-332/332
Sequence Identity: 43% (68 aa)

FSMQICSGMAHLHQQGILHRDLAARNVLVSKGLHCKVADFGMSRQ---HD-EYRTTAT--RLPIKWMDIQSLADRIYTTKSDVWSFGVTCFEIFSLGGTP
.| |.  ||  |  . ..||||||||.|..     |  ||| .|     |  | .     ||||||| . |. |..|||.|||||.||   ||||||| |
YSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSP

YPTYS-NGQMLDLLRSGYRMPKPSQANQAIYDIMLLTWQEDPDHRPDFPALLALL
||. . .      |..|||| .|  ....||.|||  | ..|  || | .|   |
YPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase RTKB6.AA FGFR 3214-3367 42 6.1e-55 185.67 In-house 135-293 (293) Show / Hide 
Range on Protein: 3214-3367
Range on HMM: 135-293/293
Sequence Identity: 42% (67 aa)

FEQLRKFSMQICSGMAHLHQQGILHRDLAARNVLVSKGLHCKVADFGMSR--QHDEY--RTTATRLPIKWMDIQSLADRIYTTKSDVWSFGVTCFEIFSL
. .| ..  |.  ||  |  . . |||||||||||. .   |..||| .|  .. .|   ||  |||||||   .| ||.||..|||||.||   ||. .
QKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTY

GGTPYPTYS-NGQMLDLLRSGYRMPKPSQANQAIYDIMLLTWQEDPDHRPDFPALLALL
||.|||.     .. ..|..|.|| ||..  | || .|   | . |. || |  |   |
GGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase RTKB6.AA S_TKc 3109-3371 23 7.3e-47 162.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 3109-3371
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

VQLDEKLGEGAFGEVFKAYYREPGTNARLVAVKTLKTGAAYEDRQEFLDEVHLMKELNGHPNVLGIIGHCLLDEPYLLLVELCMH--GNLRDLLRASRAS
 .. .|.|.||||.|.|.. ..     |.||.| .|        . .. |. ..|.  .|||.  .....   . . .  |.| .  |.|.|...  .  
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

SSNMQFEFEQLRKFSMQICSGMAHLHQQGILHRDLAARNVLVSKGLHCKVADFGMSRQHDEYRTTATRLPIKWMDIQSLADRIYTT-KSDVWSFGVTCFE
  . .|   . |..  |||......|..||.||||   |.|...  | |..|||..||      |       .|    |    |.. |.|.||.|.. .|
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

IFSLGGTPYPTYSNGQMLDLLRSGYRMPKPSQANQAIYDIMLLTWQEDPDHRPDFPALLA-----LLARVT
 .. | .|.|     .|.....            .   |..   .| ||..||    .|.      .    
MLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RTKB6.AA Pkinase 3109-3266 26 1.4e-33 119.79 Pfam 1-163 (293) Show / Hide 
Range on Protein: 3109-3266
Range on HMM: 1-163/293
Sequence Identity: 26% (46 aa)

VQLDEKLGEGAFGEVFKAYYREPGTNARLVAVKTLKTGAAYE--DRQEFL-DEVHLMKELNGHPNVLGIIGHCLLDEPYLLLVELCMHG----NLRDLLR
 .. .|.|.|.||.|.|.. .  |    .||||..|   . .  |.. ..  |...||.| .|||.. ... .  .  . .  |.|..|     | |...
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

ASRASSSNMQF--EFEQLRKFSMQICSGMAHLHQQGILHRDLAARNVLVSKGLHC----KVADFGMSRQHD
.    ...  |  . ......  ||..|....|..||.||||   |.|...  |.    |..||| ..|.|
T----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD
Kinase RTKB6.AA FGFR 3109-3204 37 1.8e-20 66.43 In-house 1-100 (293) Show / Hide 
Range on Protein: 3109-3204
Range on HMM: 1-100/293
Sequence Identity: 37% (37 aa)

VQLDEKLGEGAFGEVFKAYYREPGTN----ARLVAVKTLKTGAAYEDRQEFLDEVHLMKELNGHPNVLGIIGHCLLDEPYLLLVELCMHGNLRDLLRASR
  | . ||||.||.| .| . .   .    .  |||| || ..  .|      |   ||    |.|..  .| |  . |   .||.| |||||| ||| |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR
Kinase RTKB6.AA VEGFR 3109-3204 32 9.9e-13 44.51 In-house 1-101 (332) Show / Hide 
Range on Protein: 3109-3204
Range on HMM: 1-101/332
Sequence Identity: 32% (33 aa)

VQLDEKLGEGAFGEVFKAY----YREPGTNARLVAVKTLKTGAAYEDRQEFLDEVHLMKELNGHPNVLGIIGHCLL---DEPYLLLVELCMHGNLRDLLR
 .|   ||.|||| | .|      .....  . |||| || ||  .   . . |  ... .  | ||    | |       |..  || | .||| . ||
LKLGKMLGRGAFGQVHEASAFGIRKMETC--TTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLR

ASR
. |
TKR
Kinase RTKB6.AA KIN6 3109-3125 52 4.9e-07 19.07 In-house 1-17 (305) Show / Hide 
Range on Protein: 3109-3125
Range on HMM: 1-17/305
Sequence Identity: 52% (9 aa)

VQLDEKLGEGAFGEVFK
.. |.|||.|||. |.|
IHKDHKLGHGAFCNVYK
Kinase RTKB6.AA Pkinase 3290-3367 15 0.000113 17.61 Pfam 189-293 (293) Show / Hide 
Range on Protein: 3290-3367
Range on HMM: 189-293/293
Sequence Identity: 15% (17 aa)

YTTKSDVWSFGVTCFEIFSLGGTPYPTY----SNGQMLDLLRSGYRMPKPSQAN-----------------------QAIYDIMLLTWQEDPDHRPDFPA
|..|.|.||.|....| .. | .|.|      .   .. ...   . | ...                         ..  |..   .. ||  || .. 
YGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LLAL--L
.|    .
ILQHPWF