Gene RTKB3 (M.brevicollis)
RTKB3
Species: M.brevicollis
Alias: RTKB3
External Links:
Annotation:
Sequence
Protein domains of RTKB3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| HYR | RTKB3.AA | HYR | 529-606 | 29 | 9.4e-05 | 17.68 | Pfam | 1-86 (86) | Show / Hide |
Range on Protein: 529-606 Range on HMM: 1-86/86 Sequence Identity: 29% (25 aa) VDVTPPELTLAPNA---IVRFEALTNTFVYPTVTATDTSG-ERIVVTHTNNVQPD--EVG-TYDVTYSGEDSAKNKG-VLVVQVII || ||| . || | .. .| ....||||.|| .... ... . | || ...||| .|.| |.. ...| . VDTTPPTVENCPNNIFRTVELGTSTVNVFWTEPTATDNSGDIQANLISRTAQPGDFFPVGEQTTVTYTFQDNAGNQADTCTFTVTV |
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| GCC2_GCC3 | RTKB3.AA | GCC2_GCC3 | 406-444 | 35 | 0.001647 | 14.38 | Pfam | 1-37 (49) | Show / Hide |
Range on Protein: 406-444 Range on HMM: 1-37/49 Sequence Identity: 35% (15 aa) GTFHNTVR--CLSCGSGTYQDSASHLSTSCKTKSRCPAG-TY ||..|. | .|. ||||.... . ||. ||.| |. GTYYNKGQNPCEPCPRGTYQNEEGQD--SCI---PCPPGKTT |
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| GCC2_GCC3 | RTKB3.AA | GCC2_GCC3 | 448-477 | 29 | 0.004375 | 13.0 | Pfam | 1-29 (49) | Show / Hide |
Range on Protein: 448-477 Range on HMM: 1-29/49 Sequence Identity: 29% (9 aa) GGSSSSNT-NCLACPAGSYQDATNHLETSCK | ..... .| .|| |.||. . . ||. GTYYNKGQNPCEPCPRGTYQNEEGQD--SCI |
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| TNFR | RTKB3.AA | TNFR | 460-501 | 26 | 0.007584 | 15.72 | SMART | 1-50 (50) | Show / Hide |
Range on Protein: 460-501 Range on HMM: 1-50/50 Sequence Identity: 26% (13 aa) CP--AGSYQDATNHLE--TSCKTKT-NTCPV---GHYASNGGSTTSDRIC |. .| |.. ||. |. . .|| |.|.. .. ||...| CKCQEGHYCHHWNHTHYEPHCLPCRHTRCPPEHMGQYMKQPCTATSNTVC |
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| TNFR | RTKB3.AA | TNFR | 417-457 | 27 | 0.019319 | 11.47 | SMART | 1-50 (50) | Show / Hide |
Range on Protein: 417-457 Range on HMM: 1-50/50 Sequence Identity: 27% (14 aa) CG--SGTYQDSASHL---S--TSCKTKSRCPA---GTYDANGGSSSSNTNC | |.|... .|. . ..| .||| |.| ... ||| | CKCQEGHYCHHWNHTHYEPHCLPCR-HTRCPPEHMGQYMKQPCTATSNTVC |
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| GCC2_GCC3 | RTKB3.AA | GCC2_GCC3 | 486-529 | 31 | 17.30604 | 1.3 | Pfam | 1-33 (49) | Show / Hide |
Range on Protein: 486-529 Range on HMM: 1-33/49 Sequence Identity: 31% (14 aa) GHYASNGGSTTSDRICAVCPDACDLSHGAYQDQTGQTSCDGCGV |.| ..|. .| || .| ||.. ||.|| |.. GTYYNKGQ-----NPCEPCP------RGTYQNEEGQDSCIPCPP |
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| HYR | RTKB3.AA | HYR | 691-701 | 66 | 0.344112 | 5.94 | Pfam | 1-12 (86) | Show / Hide |
Range on Protein: 691-701 Range on HMM: 1-12/86 Sequence Identity: 66% (8 aa) VDTTPPGV-NVT |||||| | |.. VDTTPPTVENCP |
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| HYR | RTKB3.AA | HYR | 745-756 | 50 | 3.814148 | 2.5 | Pfam | 64-75 (86) | Show / Hide |
Range on Protein: 745-756 Range on HMM: 64-75/86 Sequence Identity: 50% (6 aa) TVDYMATDRSGN || | ..|..|| TVTYTFQDNAGN |
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| HYR | RTKB3.AA | HYR | 829-852 | 36 | 1.779882 | 3.59 | Pfam | 62-86 (86) | Show / Hide |
Range on Protein: 829-852 Range on HMM: 62-86/86 Sequence Identity: 36% (9 aa) DYSIVYTARDDVGNTA-HATRNLTV .... ||..| ||.| | . || QTTVTYTFQDNAGNQADTCTFTVTV |
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| HYR | RTKB3.AA | HYR | 1026-1046 | 36 | 7.620799 | 1.51 | Pfam | 58-79 (86) | Show / Hide |
Range on Protein: 1026-1046 Range on HMM: 58-79/86 Sequence Identity: 36% (8 aa) PAGSTYTVDFIVTDAAGNSD-S | | ..|| ...|.|||.. . PVGEQTTVTYTFQDNAGNQADT |
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| HYR | RTKB3.AA | HYR | 1154-1181 | 41 | 6.398754 | 1.76 | Pfam | 58-86 (86) | Show / Hide |
Range on Protein: 1154-1181 Range on HMM: 58-86/86 Sequence Identity: 41% (12 aa) PVGTLYVVNASVMDGAGNTA-TRTFRYLI ||| ..| . . | |||.| | ||. . PVGEQTTVTYTFQDNAGNQADTCTFTVTV |
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| HYR | RTKB3.AA | HYR | 1182-1188 | 85 | 10.733995 | 1.02 | Pfam | 1-7 (86) | Show / Hide |
Range on Protein: 1182-1188 Range on HMM: 1-7/86 Sequence Identity: 85% (6 aa) VDTTPPV ||||||. VDTTPPT |
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| HYR | RTKB3.AA | HYR | 1237-1261 | 37 | 3.556569 | 2.6 | Pfam | 60-86 (86) | Show / Hide |
Range on Protein: 1237-1261 Range on HMM: 60-86/86 Sequence Identity: 37% (10 aa) G-TYLVQYRTNDRYGNPA-EAARTVIV | .. |.| |. ||.| . || | GEQTTVTYTFQDNAGNQADTCTFTVTV |
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| Kinase | RTKB3.AA | RTKB | 1460-1722 | 70 | 4.1e-204 | 684.38 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 1460-1722 Range on HMM: 1-264/264 Sequence Identity: 70% (185 aa) VRLGEKLGNGAFGQVFRAWFCNRHSGEERSCAAKALKPGAPFRARQDFLSEMTVMKEIGAHPNIIGIFGHCLRDEPHILLVELAELGNLRDYLRKCRTSQ |.|||||||||||.||.||..|||...|.|||||.|||||....||||.||||||||.|.|||.|||.||||.|||.||||||.||||||||||.||.|| VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQ SKPQLLGSRQLADFCLQIASGMSFLERKNVIHRDLAARNVLLSQSLACKICDFGLARSIENEDYETTATKLPVKWMAPESLGYRIYTSKS-DVWSFGVTM ..|| | ..||.|||.|||.||.||...|||||||.|||||..|.|.|||||||.||.|..|.||||.|.||.|||||||...||||.|| ||||||||| HNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTM WEIFSLGGTPYVKHRNVDILSLLADGYRLPKPRQAPGQADAIARMCWMHEADNRPTFLELVDLL |||||||||||...||.||...|..|.|||||||.| .||.|..|||..||..||.| ||||.. WEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF |
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| Kinase | RTKB3.AA | TyrKc | 1460-1722 | 37 | 6e-120 | 405.71 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1460-1722 Range on HMM: 1-280/280 Sequence Identity: 37% (112 aa) VRLGEKLGNGAFGQVFRAWFCNRHSGEERSCAAKALKPGAPFRARQDFLSEMTVMKEIG-AHPNIIGIFGHCLRD-------EPHILLVELAELGNLRDY ..||.|||.||||.|... . .| | ||..| |.||..|. .|...| ||||. ..| |. . ||. ...|....|.|.|| ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY LRKCRTSQSKPQLLGSRQLADFCLQIASGMSFLERKNVIHRDLAARNVLLSQSLACKICDFGLARSIENE-------DYETT----ATK--LPVKWMAPE |||.| | ..| .||.|||.||..|..||.|||||||||.|.. . .||.||||.| |... || .. .| ||..||||| LRKHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE SLGYRIYTSKSDVWSFGVTMWEIFSLGGTPYVK-----HRNVDILSLLADGYRLPKPRQ--------APGQADAIARMCWMHEADNRPTFLELVDLL .. |...|.|||||||||.|||||..|..|| | ... .. .|||.|.| .| | ..||......|||| |..... CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | RTKB3.AA | Pkinase_Tyr | 1460-1722 | 43 | 4.4e-119 | 403.93 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 1460-1722 Range on HMM: 1-270/270 Sequence Identity: 43% (119 aa) VRLGEKLGNGAFGQVFRAWFCNRHSGEERSCAAKALKPGAPFRA--RQDFLSEMTVMKEIGAHPNIIGIFGHCL-RDEP--HILLVELAELGNLRDYLRK ...|.||| ||||.|... ..... .| | ||.|| .. |.||..|. .||..| ||||. | |. ..|| ... .|....|.|.||||| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK CRTSQSKPQLLGSRQLADFCLQIASGMSFLERKNVIHRDLAARNVLLSQSLACKICDFGLARSIENEDYE---TTATKLPVKWMAPESLGYRIYTSKSDV | . .| | .| ..|.|||.||..||.|| |||||||||.|.. .. .||||||||| |.|.|| .. .|||.||||||.. |...|.|||| HR---EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV WSFGVTMWEIFSLGGTP-YVKHRNVDILSLL-ADGYRLPKPRQAPGQADAIARMCWMHEADNRPTFLELVDLL |||||.|||||..|..| | | ... .. ||||.|.|. .| . ..||......|||| |.. | WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | RTKB3.AA | TK | 1460-1722 | 23 | 3.4e-116 | 391.23 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 1460-1722
Range on HMM: 1-486/486
Sequence Identity: 23% (115 aa)
VRLGEKLGNGAFG---QVFRAWFCNR---------------------HSGEERSCAAKALKPGAPFRARQDFL----------------SEMTVMKE-IG
..||.||| |.|| .|.... .| ..|.. .| | ||.|.. ... |. .|| .|.. .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
AHPNIIGIFGHCLRD------------EPHILLVELAELGN----LRDYLRKCRTSQSKPQL--------------------------------------
||||. ..|.|... || ....|....|. ||||||||| ...|
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------LGSRQLADFCLQIASGMSFLERK------NVIHRDLAARNVLLSQSLA-----------CKICDFG---
| .|| .|.|||.||..|..| |..||||||||.|..... |||.|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-----LARSIENEDYETTAT--------------------------KLPVKWMAPESLG---------YRIYTSKSDVWSFGVTMWEIFSLG-GTPYVKH
||| |...|. .... |||..|||||.| |...|.|||||||||.|||||..| ...| .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
RN---------VDILSLLADG--------------YRLPKPRQAP--------------GQADAIARMCWMHEADNRPTFLELVDLL
| ... .| .| .|.|.| ..| . . ..|| .... |||| .|.. |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | RTKB3.AA | TK-Unique | 1460-1722 | 39 | 2.4e-102 | 346.32 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 1460-1722
Range on HMM: 1-294/294
Sequence Identity: 39% (115 aa)
VRLGEKLGNGAFGQVFRAWFCN--RHSGEERSCAAKALKPGAPFRARQDFLSEMTVMKEIGAHPNIIGIFGHCLRD-EPHILLVELAELGNLRDYLRKCR
...|...| ||||||.|. ... |... .. | |.|| .| . .||||.| .|||.|.||||. ..| | .. ||. .. | .. |||..|||.||
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR
TS-----------------QSKPQL--LGSRQLADFCLQIASGMSFLER--KNVIHRDLAARNVLLSQSLACKICDFGLARSIEN-EDYETTAT--KLPV
.||.. . ...|. |. |||.||..|.. |...||||.||||||. . |||||||.|| ... ..|... . ..|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI
KWMAPESLG--YRIY-TSKSDVWSFGVTMWEIFSLGGTPYVKHRNVDILSLLADGYRLPKPRQA-PGQADAIARMCWMHEADNRPTFLELVDLL
.||||||| ...| |.|||||||||.|||||.||..|| . .. ||. .. ||||.|.| . . . . . || .|.. ||.| .... |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
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| Kinase | RTKB3.AA | UTK | 1460-1722 | 33 | 7.3e-95 | 321.46 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 1460-1722 Range on HMM: 1-296/296 Sequence Identity: 33% (98 aa) VRLGEKLGNGAFGQVFRAWFCN-RHSGEERSCAAKALKPGAPFRARQD----FLSEMT---VMKEIGAHPNIIGIFGHCLRDEPHILLVELAELGNLRDY |.||..|| ||||.|..| | . . ..| .| |.....|. . .. |. | . .|| |||... | |...|| ....|..| |.||.| VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY LRKCRTSQS-KPQLLGSRQLADFCLQIASGMSFLERKNVIHRDLAARNVLLSQS-------LACKICDFG---LARSIE---------NEDYETT--ATK ||..| .. | .| ..|. .....||.||..|......||||||||.|. .. . |||.||| ..| . . .|.. ... LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR LPVKWMAPESLGYR-IYTSKSDVWSFGVTMWEIFSLGGTPYVKHRNVDILSLLADG--YRLPKPRQAPGQADAIARMCWMHEADNRPTFLELVDLL .|..|||||.| .. .|.|||||||||..|||.. | .|| . |.... . .| ||.|.|.. | . . . ||. . ..||.| .||. . WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | RTKB3.AA | FGFR | 1460-1722 | 38 | 6.6e-87 | 295.02 | In-house | 1-293 (293) | Show / Hide |
Range on Protein: 1460-1722
Range on HMM: 1-293/293
Sequence Identity: 38% (113 aa)
VRLGEKLGNGAFGQVFRAWFC---NRHSGEERSCAAKALKPGAPFRARQDFLSEMTVMKEIGAHPNIIGIFGHCLRDEPHILLVELAELGNLRDYLRKCR
||. || |.|||| .| . . .| | | || .. . | ||| .|| || |.||| | | . | .||... |||||.||. |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR
-----TSQSKP-----------QL--------LGSRQLADFCLQIASGMSFLERKNVIHRDLAARNVLLSQSLACKICDFGLARSIENEDY--ETTATKL
... . | |....| . |.| || .|. . .||||||||||| . ||||||||| | . || || |
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL
PVKWMAPESLGYRIYTSKSDVWSFGVTMWEIFSLGGTPYVKHR-NVDILSLLADGYRLPKPRQAPGQADAIARMCWMHEADNRPTFLELVDLL
|.||||||.| |.||..|||||.|| .|||. .||.|| .. ..| |.|. || . . . . || ... |||| .||. |
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
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| Kinase | RTKB3.AA | Src | 1460-1722 | 37 | 9.7e-87 | 294.48 | In-house | 1-255 (255) | Show / Hide |
Range on Protein: 1460-1722 Range on HMM: 1-255/255 Sequence Identity: 37% (101 aa) VRLGEKLGNGAFGQVFRAWFCNRHSGEERSCAAKALKPGAPFRARQDFLSEMTVMKEIGAHPNIIGIFGHCLRDEPHILLVELAELGNLRDYLRKCRTSQ ..| .|||.| || |. . . .. | | |||| . ..|| | .||. |.... .. | ..|| |. . |.| |||.| . IKLCRKLGQGQFGEVWMGYWNGNT-----KVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----D SKPQLLGSRQLADFCLQIASGMSFLERKNVIHRDLAARNVLLSQSLACKICDFGLARSIE--NEDY-ETTATKLPVKWMAPESLGYRIYTSKSDVWSFGV .. . | .|| |. |.|.||..||..|.||||||||||| .....||..|||||| |. . | . |.|.||.||| . |. .| ||||||||. GEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGI TMWEIFSLGGTPYVKHRNVDILSLLADGYRLPKPRQAPGQADA-IARMCWMHEADNRPTFLELVDLL ..||.. | .|| .| . | . |||.|.|.. | . | ..|| ... |||| | . | LLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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| Kinase | RTKB3.AA | Fer | 1460-1723 | 32 | 1.8e-80 | 273.64 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 1460-1723 Range on HMM: 1-283/283 Sequence Identity: 32% (93 aa) VRLGEKLGNGAFGQVFRA----WFCNRHSGEERSCAAKALKP-GA-PFRA-RQDFLSEMTVMKEIGAHPNIIGIFGHCLRDEPHILLVELAELGNLRDYL | ||.|||.|||| |... ... . . ...| | | .. . .. ...|. |. .|. |||.. ..| | ..| .. |.. |.|..|| VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL RKCRTSQSKPQ-LLGSRQLADFCLQIASGMSFLERKNVIHRDLAARNVLLSQ-SLACK--ICDFGLARS--IENEDYETT--ATKLPVKWMAPESLGYRI .| ... .. ... ..|.|.|.|| .|. ||.||||.||||.|... . .| | |||..| . .||. |.|.|..|.|||.. ..| KK------NKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGI YTSKSDVWSFGVTMWEIFSLGGTPYVK------HRNVD---ILSLLADGYRLPKPRQAPGQADAIAR-MCWMHEADNRPTFLELVDLLT |..|.|||||||..||||. | .|| ||. . .||..| | ..| | .|| .. ..|||. |.. | YSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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| Kinase | RTKB3.AA | Ack | 1460-1722 | 39 | 1.1e-75 | 254.78 | In-house | 1-266 (266) | Show / Hide |
Range on Protein: 1460-1722 Range on HMM: 1-266/266 Sequence Identity: 39% (108 aa) VRLGEKLGNGAFGQVFRAWFCNRHSGEERSCAAKALKPG---APFRARQDFLSEMTVMKEIGAHPNIIGIFGHCLRDEPH-ILLVELAELGNLRDYLRKC ..|.||||.| || | |. | .|. . | | |... .| . .||| | .| . ||... .| .| | . |||..| | | ||| ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQP-NCMDDFLREVAIMHSL-DHPHLVRLYG-VVLDQPMLMMVTELAPCGSLLDCLRK- RTSQSKPQLLGSRQLADFCLQIASGMSFLERKNVIHRDLAARNVLLSQS-LACKICDFGLARSI-ENED-YETTATK---LPVKWMAPESLGYRIYTSKS . ... . | |||.|||.||..|| |. |||||||||.|| ||||||| |. .||| | . .. .| |.|||.| .| ...| HCRTAFFLI---HTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHAS DVWSFGVTMWEIFSLGGTPYVKHRNVDILSLLA-DGYRLPKPRQAPGQADAIARMCWMHEADNRPTFLELVDLL |||.||||.|| || | |.. . .|| .. .| |||.| | ... || |.. |||| ...|.| DVWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL |
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| Kinase | RTKB3.AA | Eph | 1460-1722 | 36 | 3.1e-73 | 245.32 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 1460-1722
Range on HMM: 1-264/264
Sequence Identity: 36% (99 aa)
VRLGEKLGNGAFGQVFRAWFCNRHSGEER---SCAAKALKPGAPFRARQDFLSEMTVMKEIGAHPNIIGIFGHCLRDEPHILLVELAELGNLRDYLRKCR
... . .| | || | . . .| | |.|| |.. ..| ||||| ..| ||||| | . .| ..| |.| | ..||.
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQF-DHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHD
TSQSKPQLLGSRQLADFCLQIASGMSFLERKNVIHRDLAARNVLLSQSLACKICDFGLARSIENED-----YETTATKLPVKWMAPESLGYRIYTSKSDV
. . || ||||| .| | .||||||||.|... | ||. |||| | .|... |.|. | |..| ||| . ||..|| |||
G------QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDV
WSFGVTMWEIFSLGGTPYVKHRNVDILSLLADGYRLPKPRQAPGQADAIARMCWMHEADNRPTFLELVDLL
||.|. |||. | | || | |... .||||| |. | . .. || . .||.| ..| |
WSYGIVMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
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| Kinase | RTKB3.AA | VEGFR | 1563-1722 | 46 | 9e-61 | 208.22 | In-house | 168-332 (332) | Show / Hide |
Range on Protein: 1563-1722 Range on HMM: 168-332/332 Sequence Identity: 46% (76 aa) QLLGSRQLADFCLQIASGMSFLERKNVIHRDLAARNVLLSQSLACKICDFGLARS-I-ENEDYETTAT--KLPVKWMAPESLGYRIYTSKSDVWSFGVTM . | . | . .|.| || ||. ...|||||||||.||. . |||||||||. | . || . .|| |||||||. ..||..|||||.|| . DPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFL WEIFSLGGTPYVKHR-NVDILSLLADGYRLPKPRQAPGQADAIARMCWMHEADNRPTFLELVDLL |||||||| || . . . | ||||. .| .. . | || | ||.| ||| | WEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL |
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| Kinase | RTKB3.AA | S_TKc | 1460-1726 | 23 | 7.1e-45 | 156.32 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1460-1726 Range on HMM: 1-231/231 Sequence Identity: 23% (64 aa) VRLGEKLGNGAFGQVFRAWFCNRHSGEERSCAAKALKPGAPFRARQDFLSEMTVMKEIGAHPNIIGIFGHCLRDEPHILLVELAEL--GNLRDYLRKCRT ....|.| ||||.|.... . | .| | .| .....|. ..|. ||||. ..... . . |... |.|.||..|... YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR SQSKPQLLGSRQLADFCLQIASGMSFLERKNVIHRDLAARNVLLSQSLACKICDFGLARSIENEDYETTATKLPVKWMAPESLGYRIYTS-KSDVWSFGV . ... . . . .. ||.... .. ....||||| |.||.. ||||||||| . | .|||| | |. |.|.||.|. -HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC TMWEIFSLGGTPYVKHRNVDILSLLADGYRLPKPRQAPGQADAIARMCWMHEADNRPTFLELVD-----LLTAFI ...| .. | .|. .. .. . .| . | |. . ..||| |. . .. ILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | RTKB3.AA | Pkinase | 1460-1669 | 26 | 6.8e-30 | 106.78 | Pfam | 1-212 (293) | Show / Hide |
Range on Protein: 1460-1669 Range on HMM: 1-212/293 Sequence Identity: 26% (61 aa) VRLGEKLGNGAFGQVFRAWFCNRHSGEERSCAAKALKPGAPFR--ARQDFL-SEMTVMKEIGAHPNIIGIFGHCLRDEPHILLV-ELAELG----NLRDY ..|.|.| |.||.|... .| |... | | .| ..... || .||.. ||||. ... . . ..|| .| |..| | | || YHIGRKIGSGSFGCVYKC----HHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDY LRKCRTSQSKPQLL--GSRQLADFCLQIASGMSFLERKNVIHRDLAARNVLLSQSLAC----KICDFGLARSI-ENEDYETTATKLPVKWMAPESLG-YR .. .. . ... ....||..|. .. ....||||| |.|... . ||||||||. . . . .| .|||| . .. IST-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQ IYTSKSDVWSFGVTMWEIFSLGGTPY |..|.|.||.|....| .. | .|. YYGPKVDMWSCGCILYEMLC-GRPPF |
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| Kinase | RTKB3.AA | VEGFR | 1460-1556 | 35 | 7.8e-11 | 37.29 | In-house | 1-101 (332) | Show / Hide |
Range on Protein: 1460-1556 Range on HMM: 1-101/332 Sequence Identity: 35% (36 aa) VRLGEKLGNGAFGQVFRAWFCN-RHSGEERSCAAKALKPGAPFRARQDFLSEMTVMKEIGAHPNIIGIFGHCLR---DEPHILLVELAELGNLRDYLRKC .|| || |||||| | . | . . | | ||.|| .||. ... || | | | | | || ||| .||| LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK R | R |
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