Gene RTKA5 (M.brevicollis)
RTKA5
Species: M.brevicollis
Alias: RTKA5
External Links:
Annotation:
Sequence
Protein domains of RTKA5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Ldl_recept_a | RTKA5.AA | Ldl_recept_a | 371-392 | 41 | 1e-06 | 23.09 | Pfam | 18-41 (41) | Show / Hide |
Range on Protein: 371-392 Range on HMM: 18-41/41 Sequence Identity: 41% (10 aa) ISPTQLCDGTPDCPSAEDE--AGC |. ..||| ||| .|| ..| IHMSWVCDGDPDCHDGSDEWPENC |
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LDLa | RTKA5.AA | LDLa | 353-394 | 27 | 3.4e-05 | 20.61 | SMART | 1-47 (47) | Show / Hide |
Range on Protein: 353-394 Range on HMM: 1-47/47 Sequence Identity: 27% (13 aa) FCPPPVTPPMTCLSSSDPISPTQLCDGTPDCPSAEDE------AGCSF ||| .| .. |. ...||| .||. .|| ..|. TCPPDHPNQFQCGNGR-CIPKSWVCDGDNDCGDGSDEWPFFDPENCPQ |
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Kinase | RTKA5.AA | RTKA | 632-874 | 44 | 6.4e-176 | 590.72 | In-house | 1-314 (314) | Show / Hide |
Range on Protein: 632-874 Range on HMM: 1-314/314 Sequence Identity: 44% (141 aa) LAIQRVVGRGHFSVVHQV-MLDMG----SGPQPAALKQCA----EGSVTILSWLREIMLLQNFKGNQHIISLYGVSLSPDESRGQSHLGAVLEWAPHGNL .....|||.||||.|.|. ..||. .|||..|.|.|. ....|...|.||||||.......|||.|.||.|.......|||.|.|.||.||||| MQVRHVVGHGHFSQVYQASLQDMEDEMRQGPQCVAIKECDDLMLNDKTTLSAWMREIMLLHSMRDCPHIIGLHGVCLPREDKHHQSHCGMVCEWCPHGNL RDRVRSQP------------------------LSPTNIQIALLQMA-------EALTHLAQCGVIHRDVAARNVLVTSLMP-LVCKLADFGLSRVLPSSD ||.||..| ||......|||||. .|...||.||..|||||||||||.||.| ..|||||||||||.|||| RDFVRQHPHFSAPVVATIAMQHSGEPNASPKLLSEAQCHQALLQMCPCWAQVAQAMAYLAKCGIVHRDVAARNVLVMSLQPAFHCKLADFGLSRVMPSSD YYKSVSDEDMPFRWMALECLVERRYSEQSDVWSYGVLAWELATQGAVPWA------------------------------GCDVATIIVRLKAGDTLPLP ||||..|..|||||||.||..||||||.|||||.|||.|||.|.|..||. |||...||..||.|.|||.| YYKSRADDEMPFRWMAPECIMERRYSEHSDVWSFGVLVWELLTHGQTPWQNCESHQIVALLMRGERLTFAPTINAALRDSGCDLHHIIQMLKQGQTLPMP PQAPRLVQQFVSRM |..|...|.|.... PCCPPCLQRFCFWC |
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Kinase | RTKA5.AA | TK | 632-869 | 17 | 6.6e-71 | 236.72 | In-house | 1-463 (486) | Show / Hide |
Range on Protein: 632-869 Range on HMM: 1-463/486 Sequence Identity: 17% (81 aa) LAIQRVVGRGHFS---VVHQVMLDMGS-----------------------GPQPAALKQCAEGSVTILSW------------------LREIMLLQNFKG . . .. |.|.| .|.. .. ... |..| | |.. ||. . ..|...... .| ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG -NQHIISLYGVSLSPDESR------GQSHLGAVLEWAPHGN----LRDRVRSQP---------------------------------------------- ..|..||||.. ..... .| .. |.|..|||. ||| |. . HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY ------LSPTNIQIALLQM------------------------AEALTHLAQC------GVIHRDVAARNVLVTSLMP---------LVCKLADFG---- ..|. .. . | |... .|... ...|||.||||.||.. .. .|||.|||| DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ ----LSRVLPS------------------------SDYYKSVSDEDMPFRWMALECLV---------ERRYSEQSDVWSYGVLAWELATQGAVPWAG-CD |.| ..| .|||.. |. .|.|||| ||| .......|||||.||| ||. | |..|..| . GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS V---------ATIIVRLKAGDT------------LPLP--PQAP--------------RLVQQ . .. .|..| . ...| |..| .... NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYD |
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Kinase | RTKA5.AA | Pkinase_Tyr | 632-864 | 29 | 4.8e-65 | 220.92 | Pfam | 1-242 (270) | Show / Hide |
Range on Protein: 632-864 Range on HMM: 1-242/270 Sequence Identity: 29% (74 aa) LAIQRVVGRGHFSVVHQVMLD--MGSGPQPAALKQCAEGSVTI----LSWLREIMLLQNFKGNQHIISLYGVSLSPDESRGQSHLGAVLEWAPHGNLRDR . . .. |.|.| .|.. .. .... .| | | . ||. . .||. .. .. ...|..|||| .. .|. .. |.| .|||.|.| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLDY VRSQ---PLSPTNIQIAL--LQMAEALTHLAQCGVIHRDVAARNVLVTSLMPLVCKLADFGLSRVLPSSDYY-KSVSDEDMPFRWMALECLVERRYSEQS |.. . ..| .. .| |... .|.. . ||||.||||.|||. ..|.| .||||.| . . ||| .. .. ..| .|||.||. .......| LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE--NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKS DVWSYGVLAWELATQGAVP-WAGCDVATIIVRL-KAGDTLPLPPQAP ||||.||| ||. | |. | ..|.. . .. .. . | .| |. .| DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCP |
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Kinase | RTKA5.AA | TyrKc | 632-878 | 25 | 3e-55 | 190.77 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 632-878 Range on HMM: 1-280/280 Sequence Identity: 25% (75 aa) LAIQRVVGRGHFSVVHQVMLDMGSGPQPAALKQCAEGSVTILSWLREIMLLQNF-KGNQHIISLYGVSLSPDESRGQ---SHLGAVLEWAPHGNLRDRVR . .. |.|.| .|.. ... .. | | . |.. . .||. .. .. . ...|. |||| ... . | |.| .|||.|.|. | ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYLR SQP--LSPTNIQIALLQMAEALTHLAQCGVIHRDVAARNVLVTSLMPLVCKLADFGLSRVLPSS-------DYYKSVS--DED--MPFRWMALECLVERR . |.. .| |. .|.. ..|||| ||||.||.. ..| .|||||| . . |||.. . ... .| ||||.||. ... KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK YSEQSDVWSYGVLAWELATQGAVPWAG-----CDVATIIVRLKAGDTLPLPPQ--------APRLVQQFVSR--------------MPLRL ....|||||.||. ||. | |. |. | .. . .| ..|.|. .| || .| . | .. .. FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | RTKA5.AA | UTK | 632-841 | 27 | 9.9e-54 | 182.18 | In-house | 1-243 (296) | Show / Hide |
Range on Protein: 632-841 Range on HMM: 1-243/296 Sequence Identity: 27% (69 aa) LAIQRVVGRGHFSVVHQVMLDMGS---GPQPAALKQCAEGSV---TIL---SWLREIM---LLQNFKGNQHIISLYGVSLSPDESRGQSHLGAVLEWAPH ... | |.|.| .|| ... | . . |.|.| .... . ...| ....|.. .... |.|| .. . |.| .. VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP------WMIVTEYMEN GNLRDRVRSQPLSPT----------NIQIALLQMAEALTHLAQCGVIHRDVAARNVLVTSLM-----PLVCKLADFG---LSRVLP---------SSDYY |.||. .|... .| .. | .. |... .|..||..|||.||||.||.. .|||.|||| .|| .. .|.|| GDLRSYLRRHRPTPPACPHWLTLHQRLCMA-WDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYY KSVSDEDMPFRWMALECLVER-RYSEQSDVWSYGVLAWELATQGAVPWAG .. ... .|.|||| |.|... |....|||||.||. ||. | |..|..| MAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPG |
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Kinase | RTKA5.AA | RTKF | 690-872 | 40 | 5.8e-52 | 165.54 | In-house | 62-246 (272) | Show / Hide |
Range on Protein: 690-872 Range on HMM: 62-246/272 Sequence Identity: 40% (77 aa) HIISLYGVSLSPDESRGQSHLGAVLEWAPHGNLR---DRVRSQPLSPTNIQIALLQ-MAEALTHLAQCGVIHRDVAARNVLVTSLMP-LVCKLADFGLSR ||| ..|. .| | | . |.| |||| .| . .. | . | | .|||. . | .||||||||||| | . || |||| | HIIQFFGILMTPFE---QNEMAFVMEFAPHGDMRRYLQQHDVD-LGRAHMLDAAHQVVAEAMVFISRQGLVHRDVAARNVLVFEDQPRMYVKLTDFGLAR VLPSS-DYYKSVSDEDMPFRWMALECLVERRYSEQSDVWSYGVLAWELATQGAVPWAGCDVATIIVRLKAGDTLPLPPQAPRLVQQFVS || . ||| | ..|. |||||| | ||....|||||.|.. .|| | | ||... . .. | || .|. .| | ||| VLSQHQDYYRSMQNEELPFRWMAPEAIMHRRFTQKSDVWSFGMMLFELFTRGDVPYGNMPHPVVLQFIRRGKTLQMPDSCPPDVCRFVS |
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Kinase | RTKA5.AA | RTKL | 690-864 | 38 | 1.8e-51 | 134.07 | In-house | 60-231 (259) | Show / Hide |
Range on Protein: 690-864 Range on HMM: 60-231/259 Sequence Identity: 38% (70 aa) HIISLYGVSLSPDESRGQSHLGAVLEWAPHGNLRDRVRSQPLSPTNIQIA-----LLQMAEALTHLAQCGVIHRDVAARNVLVTSLMPLVCKLADFGLSR ||| ..|. . |. . .|| || |||| | . | |.| || . | .|||| |.|||| .. | ||||.|||||| HIIQMHGCTAVPQ------RMAMILELAPNGNLREYLRHDDAPSSSWPQRQRLQWLCQVAQALAYIHQRRMIHRDLASRNVLLVPMM--VCKLSDFGLSR VLPSS-DYYKSVSDEDMPFRWMALECLVERRYSEQSDVWSYGVLAWELATQGAVPWAGCDVATIIVRLKAGDTLPLPPQAP | ||| ....||||| .| |. |||| .||...| | | ||.|. | .. || | || | RLQNEQDYYRPQQNDHVPFRWMSPETLNGKPHTMASDVWAFGVVCYEVIT-GQVPYADTDMPQVVALLKNEGRLALPAGTP |
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Kinase | RTKA5.AA | TK-Unique | 632-862 | 27 | 1.9e-45 | 154.66 | In-house | 1-263 (294) | Show / Hide |
Range on Protein: 632-862 Range on HMM: 1-263/294 Sequence Identity: 27% (75 aa) LAIQRVVGRGHFSVVHQVMLD---MGSGPQ-PAALKQCA--EGSVTILSWLREIMLLQNFKGNQHIISLYGVSLSPDESRGQSHLGAVLEWAPHG----- | ...|.|.| |. |. .. .... | .|.|.. . .. |.|| .... . ..|....|.. ..| .. .. ..|..| | LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD---EPWMI--IMEYCPCGNLQHY ---------------NLR-------DRVRSQPLSPTNIQIALLQMAEALTHLAQ--CGVIHRDVAARNVLVTSLMPLVCKLADFGLSR-VLPSSDYYKSV ||. |..| |.|| . | | .. .||. ....|||..|||||.|. .|||..|||..| | .| .. LRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE--DKVCKICDFGMARDVYTNGVYSMMC SDEDMPFRWMALECLV--ERRY-SEQSDVWSYGVLAWELATQGAVPWAGCDVATIIVRLKAGDTLPLPPQ | . .| ||||.| | .. | ...|||||.||| ||..| || | | . . |. ....|...|.|.. SQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEH |
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Kinase | RTKA5.AA | RTKK | 632-841 | 34 | 4.2e-37 | 122.54 | In-house | 1-221 (272) | Show / Hide |
Range on Protein: 632-841 Range on HMM: 1-221/272 Sequence Identity: 34% (79 aa) LAIQRVVGRGHFSVVHQVMLDMGSGPQPAALKQCAEGSVTILS------WLREIMLLQNFKGNQHIISLYG-VSLSPDESRGQSHLGAVLEWAPHGNLRD ||| .| | | .| | . || || . .. | | || | |.. ||| . . | | . |.. |.|| || IEIQRTIGSGQFGIVYQAQVRKRDQWLTAAIKQPHVENPDEVDRQVNKDLLVEAYLLMYAKPHDHVVTLYGCFHMT-----GSSVA-MVMDMAKHGDLRM RVRS----QPLSPTNIQIAL------LQMAEALTHLAQCGVIHRDVAARNVLVTSLMPLVCKLADFGLSRVLPSSDYYKSVSDEDMPFRWMALECLVERR |. | . . . |.| | || ...||||| ||||| |. || . | || | . ||| | .|| ||. | |. || YLRQGAKRQSQVRFDKMVMVWYALIPAQIAQGLSHLHAKHIVHRDVACRNVLVMSSQPLHIVITDLGLARTIREQIYYKQTSKVAVPFPWMSPESLIHRR YSEQSDVWSYGVLAWELATQGAVPWAG .| ||||| |. ||| |. || | FSPASDVWSLGMTAWEICSNGQRPWEG |
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Kinase | RTKA5.AA | CTKA | 742-864 | 37 | 2.7e-36 | 119.39 | In-house | 139-262 (290) | Show / Hide |
Range on Protein: 742-864 Range on HMM: 139-262/290 Sequence Identity: 37% (47 aa) QMAEALTHLAQCGVIHRDVAARNVLVTSLMPLVCKLADFGLSRVLPSS-DYYKSVSDEDMPFRWMALECLVERRYSEQSDVWSYGVLAWELATQGAVPWA | | || | .||| |.||.|. . . |.||||..| | . || . | ||.|||| | | . ..| .||||..||| ||... | ||. QIAAGMNYLAEMGFVHRDLACRNCLLGQYC--HIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWR GCDVATIIVRLKAG--DTLPLPPQAP . . .. ||.|. .| HMSDQEVCQAYTSHGMRRLPVPRNCP |
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Kinase | RTKA5.AA | Ack | 690-865 | 37 | 6.3e-36 | 118.68 | In-house | 63-239 (266) | Show / Hide |
Range on Protein: 690-865 Range on HMM: 63-239/266 Sequence Identity: 37% (69 aa) HIISLYGVSLSPDESRGQSHLGAVLEWAPHGNLRDRVRSQPLSPTNIQIALL-----QMAEALTHLAQCGVIHRDVAARNVLVTSLMPLVCKLADFGLSR |.. |||| |. . . | | | || | | |. | .... |..| | |... | ... ||||.||||.|. | | .||||.| HLVRLYGVVLDQP-----M-LMMVTELAPCGSLLDCLRK-HCRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDD-RKVKICDFGLMR VLPS-SDYYKSVSDE--DMPFRWMALECLVERRYSEQSDVWSYGVLAWELATQGAVPWAGCDVATIIVRLK-AGDTLPLPPQAPR |. |||.. || |.| ||| |. | ||||..|| || . | ||||| . |. .. .| || |. |. ALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPE |
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Kinase | RTKA5.AA | FGTK | 713-831 | 43 | 4.7e-34 | 115.68 | In-house | 80-203 (302) | Show / Hide |
Range on Protein: 713-831 Range on HMM: 80-203/302 Sequence Identity: 43% (55 aa) VLEWAPHGNLRDRVR--SQPLSPTNIQIALLQMAEALTHLAQCGVIHRDVAARNVLV---T-SLMPLVCKLADFGLSRVLPS-SDYYKSVSDEDMPFRWM ||| | || || .| ..... ..| . . . | |. .|.. ||| |.||||. . . |.. ||||||||| . . |||. .. .||||||| VLEYADHGDLRSFLRQQDAHNQEMQLQW-MAHITSGLCHVHDCQLVHRDMACRNVLLFSRPHMACPQA-KLADFGLSRYVSDDHDYYRASQLDDMPFRWM ALECLVERRYSEQSDVWSYGVLAWEL |.| | .|.| ||||| ||..||. APEALRHGRFSPASDVWSLGVTIWEI |
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Kinase | RTKA5.AA | S_TKc | 632-878 | 20 | 2.1e-26 | 94.93 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 632-878 Range on HMM: 1-231/231 Sequence Identity: 20% (55 aa) LAIQRVVGRGHFSVVHQVMLDMGSGPQPAALKQCAEGSVTILSWLREIMLLQNFKGNQHIISLYGVSLSPDESRGQSHLGAVLEWAPH--GNLRDRVRSQ | |..|.| |..|... . |.|. . .||| .|.. . .|. ||.| . .|| |.| ... |.|.|. ... YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR P-------LSPTNIQIALLQMAEALTHLAQCGVIHRDVAARNVLVTSLMPLVCKLADFGLSRVLPSSDYYKSVSDEDMPFRWMALECLVERRYSE-QSDV . ... .. . |...|| .. . |.||||. |.|... . |..||||.|.| . .|| | | |. .|. GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDW WSYGVLAWELATQGAVPWAGCDVATIIVRLKAGDTLPLPPQAPRLVQQFVSRMPL--------R----------L || |.. .|... | |. ...... ... .|.| .... . | . . WSCGCILYEMLC-GYPPFP--QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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Kinase | RTKA5.AA | Pkinase | 676-874 | 17 | 2.7e-19 | 69.3 | Pfam | 46-273 (293) | Show / Hide |
Range on Protein: 676-874 Range on HMM: 46-273/293 Sequence Identity: 17% (44 aa) LR--EIMLLQNFKGNQHIISLYGVSLSPDESRGQSHLGAVLEWAPHG----NLRDRVR---SQPL--SPTNIQIALLQMAEALTHLAQCGVIHRDVAARN .| || ..... . .|. ||.. . .|. |.|....| | |... . .. |. .. ..|....| .. ..|.||||. | RRLSEIQIMKRL-NHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPEN VLVTSLMPLVC----KLADFGLSR---VLPSSDYYKSVSDEDMPFRWMALECLV-ERRYSEQSDVWSYGVLAWELATQGAVPWAGC----DVATIIVRLK .|. .. |..||||.. ..| .. . ..|| | . . |. .|.||.|.. .|... | |. |. . .. ..... ILID--NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP----WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMIC AGDTLPLPPQAP-----------------------RLVQQFVSRM ||. . | . ..|.... RIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC |
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Kinase | RTKA5.AA | FGTK | 632-651 | 30 | 0.000444 | 10.15 | In-house | 1-20 (302) | Show / Hide |
Range on Protein: 632-651 Range on HMM: 1-20/302 Sequence Identity: 30% (6 aa) LAIQRVVGRGHFSVVHQVML |..|.. | |.| .|... . LQDQPPLGKGNFGTVYKAIP |
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Kinase | RTKA5.AA | RTKF | 632-648 | 35 | 0.135159 | 0.61 | In-house | 1-17 (272) | Show / Hide |
Range on Protein: 632-648 Range on HMM: 1-17/272 Sequence Identity: 35% (6 aa) LAIQRVVGRGHFSVVHQ . . ..| ||| ||. IMLGEQLGHGHFGRVHH |