Gene HMTK04 (M.brevicollis)

HMTK04

Species: M.brevicollis
Alias: HMTK04
External Links:
Annotation:

Classification

Group: TK
Family: HMTK

Sequence

Name Sequence Type Origin Length Description Download
HMTK04.AA Protein None 639 None Fasta, JSON
HMTK04.kin_dom Protein Kinase Domain None 267 None Fasta, JSON

Protein domain

Protein domains of HMTK04.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PTB HMTK04.AA PTB 1-130 16 0.000832 4.86 SMART 10-156 (156) Show / Hide 
Range on Protein: 1-130
Range on HMM: 10-156/156
Sequence Identity: 16% (26 aa)

YLGMVPVTELF-------GTDVVKRAVHRNFIERSRLNQRDSTAGLGDPVVVEVSMEAVRTIDKQSGSFI-----KNISYTCVLD----------AIDQT
|||.|.|..         |..|.... ..            .. . . ......|  .|. ||.|.. .|     ..||. |. |          . |. 
YLGCVEVPHHRNSMAPGKGMQVCQECMRKIR----------QHWKHWQKMHLHISVDGVKLIDPQTKQVIHHHPIHRISF-CAHDPYRWNTGGHHCCDDD

DVFAYIAVNKRMG-------TIHCHIYHVPKGSGNRAYAAINNAFKMLAADEKARGSNP
..|.||. ..            .||...  . . ..  ..|  || ......... . .
RCFGYICRHPNDRGSHRMTYWFRCHVFWCEDPHAEDIAQTIGQAF-QVCYQQCQKQRCQ
Kinase HMTK04.AA HMTK 155-420 54 2.6e-200 671.74 In-house 1-291 (291) Show / Hide 
Range on Protein: 155-420
Range on HMM: 1-291/291
Sequence Identity: 54% (159 aa)

LTAIQQIGAGQFG-----------------AVYIATHRIRLGKDQYAPEPVQ-RAVKLLRNAASTADKDEFTREAETMLVLDHPNLVKMIGVAVQQKPWL
|.||..|||||||                 .||.|......|.......... ||||.||..||..|..||.||||.|..|.|||||...||..||.|||
LKAIKVIGAGQFGMVQCLRLAPPDEGCTSLKVYLAEWSVKDGDGKDDSNQPHHRAVKMLRGDASHEDREEFLREAEVMCQLRHPNLVQLVGVCMQQRPWL

CVLEYMKYGDLKSFLSTCREKKIPLRYGEMIYFGEQLASGCGYLASQRMIHMDLAARNALVTDNNIVKVADFGLTRPMEPGVDYLLLREPM-KLALKWMA
||||||.||||...|.|||||.|.|.|.|..||..|.|||. |.|||||.||||||||.||..||.||.|||||||...|| || .||..| ||..||||
CVLEYMQYGDLRNVLKTCREKNIQLTYHEQLYFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYWHLRKHMVKLPIKWMA

PEGMD--KKYFSEKSDVWSFGVMLWEIASYGANPYS--QIKTQEIQLKVREGLRLS-KPPG-CSDEFYDVMNTCWEQDPDNRPNFRLLEMR
||.||  .|.||||||||.|||..|||..||..||.  |||..|.| .||||.||. .||. |.|.|.|.|.|||..||..||.|. |...
PEAMDGKRKIFSEKSDVWAFGVTMWEIWMYGEQPYESQQIKNKEVQRHVREGRRLTQPPPDDCPDDFWDLMCTCWHKDPHQRPTFAQLQKM
Kinase HMTK04.AA TK 155-421 22 1.7e-104 351.32 In-house 1-486 (486) Show / Hide 
Range on Protein: 155-421
Range on HMM: 1-486/486
Sequence Identity: 22% (110 aa)

LTAIQQIGAGQFG---AVYIATHRIR-LGKDQYA---------------PEPVQRAVKLLRNAASTADKDEFT-------------REAETMLVLD----
.| ....|.||||    || .. | |  .. ...                .... ||| |.  ........|              .||| | ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVKMIGVAVQQ------------KPWLCVLEYMKYGD----LKSFLSTCREKKIP-----------------------------------------
 |||.|...|| .|.            .||..|.|||..||    |...| .||.|...                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LRYGEMIYFGEQLASGCGYLASQ------RMIHMDLAARNALVTDNNI-----------VKVADFG---
                               |   ... .  |.|.|. ||.|.      ...|.|||||| ||..||.           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LTRPMEPGVDYLLLREPM-----------------------KLALKWMAPEGMD---------KKYFSEKSDVWSFGVMLWEIASYG-ANPYSQI
     |.| .... ||   ...                        || ..||||| ..         .. |..|||||||||..||| .|| . .| ..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

KT---------QEIQLKVREG--------------LRLSKPPGCS--------------DEFYDVMNTCWEQDPDNRPNFRLLEMRL
           ||.  ..|.|              .|. .||.|.              .|.||.|  ||. ||. ||.|. |  .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase HMTK04.AA Pkinase_Tyr 155-421 41 2.2e-102 347.39 Pfam 1-270 (270) Show / Hide 
Range on Protein: 155-421
Range on HMM: 1-270/270
Sequence Identity: 41% (114 aa)

LTAIQQIGAGQFGAVYIATHRIRLGKDQYAPEPVQRAVKLLRNAASTAD--KDEFTREAETMLVL-DHPNLVKMIGVAV-QQKP--WLCVLEYMKYGDLK
.| ....|.|.|| || .| .    ...    ||  ||| |.. |.  .  ...| |||..|  | .|||.|...|| . |..|  .. |.|||..|||.
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPV--AVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

SFLSTCREKKIPLRYGEMIYFGEQLASGCGYLASQRMIHMDLAARNALVTDNNIVKVADFGLTRPMEPGVDYL-LLREPMKLALKWMAPEGMDKKYFSEK
..| . || | ||   ... .  | |.|. ||.|...|| |||||| |||.||.||..||||.| .    ||    |.  ||  |||||| .  . |..|
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTK

SDVWSFGVMLWEIASYGANP-YSQIKTQEIQLKV-REGLRLSKPPGCSDEFYDVMNTCWEQDPDNRPNFRLLEMRL
|||||||| .||| .||. | |  .. .|.  .. ..| |. .|..|.|| ||.|  ||..||..|| |. .  .|
SDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase HMTK04.AA TyrKc 155-421 37 8.70000000001e-102 345.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 155-421
Range on HMM: 1-280/280
Sequence Identity: 37% (112 aa)

LTAIQQIGAGQFGAVYIATHRIRLGKDQYAPEPVQRAVKLLRNAASTADKDEFTREAETMLVL--DHPNLVKMIGVAVQQ-------KPWLCVLEYMKYG
.| ....| |.|| || .| .            .| ||| |.. |    . .| |||. |  |  .|||.|...||..||       .| . |.|||..|
ITLGKKLGEGAFGEVYKGTWK------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

DLKSFLSTCREKKIPLRYGEMIYFGEQLASGCGYLASQRMIHMDLAARNALVTDNNIVKVADFGLTRPMEPG------VDYLLLRE--PMK--LALKWMA
|||..|  .|.|   |   ....|  | |.|. ||.|.. || |||||| ||..|..||..||||.|  . .       ||   .|    |  | ..|||
DLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEGMDKKYFSEKSDVWSFGVMLWEIASYGANPYSQ-----IKTQEIQLKVREGLRLSKPPG--------CSDEFYDVMNTCWEQDPDNRPNFRLLEMRL
|| .... |..|||||||||..||| .||. ||.      .. ||.  .|..| |. .||         |.|| |..| .||. ||..||.|. .  ..
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase HMTK04.AA UTK 155-421 30 1.6e-80 273.83 In-house 1-296 (296) Show / Hide 
Range on Protein: 155-421
Range on HMM: 1-296/296
Sequence Identity: 30% (92 aa)

LTAIQQIGAGQFGAVYIATHRIRLGKDQYAPEPVQRAVKLLRNAAS-TADKD---EFTREAE---TMLVLD-HPNLVKMIGVAVQQKPWLCVLEYMKYGD
.   .|.|.|.|| |. |    |. .. .  . ...||| ... |. . ...   .| .||     |  .. |||.....|| .|..||. |.|||. ||
VQLGRQLGQGAFGEVHKA----RFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGD

LKSFLSTCREKKI----PLRYGEMIYFGEQLASGCGYLASQRMIHMDLAARNALVTDN-------NIVKVADFG---LTRPMEP--------GVDYLLLR
| |.| ..|..       |.  .....  . |.|  ||.|.. .| |||||| ||...       ...|.||||   ..| .          . .|   .
LRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQ

EPMKLALKWMAPEGMDKK-YFSEKSDVWSFGVMLWEIASYGANPYSQIKTQEIQLKVREG--LRLSKPPGCSDEFYDVMNTCWEQDPDNRPNFRLLEMRL
.  .....||||| ...   |..||||||||| .||| ..|. ||  . .... . |..|  .|. .|..|... |..|. ||..||..||.|. |. ..
HQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase HMTK04.AA Src 155-421 36 2.1e-79 269.42 In-house 1-255 (255) Show / Hide 
Range on Protein: 155-421
Range on HMM: 1-255/255
Sequence Identity: 36% (99 aa)

LTAIQQIGAGQFGAVYIATHRIRLGKDQYAPEPVQRAVKLLRNAASTADKDEFTREAETMLVLDHPNLVKMIGVAVQQKPWLCVLEYMKYGDLKSFLS-T
.. ....|.|||| |. .. . .          .. ||| |. .    . . | .||..|  |.|..||..  |  | .| . | |||. | |  .|  .
IKLCRKLGQGQFGEVWMGYWNGN----------TKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKD

CREKKIPLRYGEMIYFGEQLASGCGYLASQRMIHMDLAARNALVTDNNIVKVADFGLTRPMEPGVDYLLLREPMKLALKWMAPEGMDKKYFSEKSDVWSF
 ......|.  . |... | |.|  || |...|| |||||| || .||..||||||| | .. . |    |.  |.  ||.|||  .   |. |||||||
GEGRHLHLP--QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSF

GVMLWEIASYGANPYSQIKTQEIQLKVREGLRLSKPPGCSDEFYD-VMNTCWEQDPDNRPNFRLLEMRL
|. |.|| .||  ||   . .|   .|  | |. .|..| ||.|. .|  ||..||. || |  |   |
GILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase HMTK04.AA TK-Unique 155-421 32 4.2e-79 269.11 In-house 1-294 (294) Show / Hide 
Range on Protein: 155-421
Range on HMM: 1-294/294
Sequence Identity: 32% (98 aa)

LTAIQQIGAGQFGAVYIATHRIRLGKDQYAPEPVQRAVKLLRNAASTADKDEFTREAETMLVLD-HPNLVKMIGVAVQQK-PWLCVLEYMKYGDLKSFLS
|.  ..|| |.|| |. .. . .        .... |||.|.  |.  ||..|..|.. |  |. |||.|...|. .    ||. ..||. .|.| ..| 
LEVGDVIGEGAFGQVWRGEVWGIW---KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

TCR-------------------EKKIP---LRYGEMIYFGEQLASGCGYLASQRM--IHMDLAARNALVTDNNIVKVADFGLTRPMEPGVDYLLLREPMK
|||                   ..| .   . .. .. |. |.|.|  ||||||.  .|.||.||| |.|.....|..|||..|  . . .|   ..  .
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR

LALKWMAPEGMD--KKYF-SEKSDVWSFGVMLWEIASYGANPYSQIKTQEIQLKVREGLRLSKPPGC-SDEFYDVMNTCWEQDPDNRPNFRLLEMRL
. ..||||| .   .. . ..||||||||| .|||...|| ||....  .|. ..|.| |. .|..| |.|.| .| .||  .|. ||.|| .  ||
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase HMTK04.AA Abl 155-421 37 8.6e-71 235.27 In-house 1-252 (252) Show / Hide 
Range on Protein: 155-421
Range on HMM: 1-252/252
Sequence Identity: 37% (100 aa)

LTAIQQIGAGQFGAVYIATHRIRLGKDQYAPEPVQRAVKLLRNAASTADKDEFTREAETMLVLDHPNLVKMIGVAVQQKPWLCVLEYMKYGDLKSFLSTC
..  ...| ||.| || .  .      ..       ||| |.    | . .|| .||  |  . |||||...||  .  |.  . |.| || |  .|  |
IMMKHKLGGGQYGEVYEGVWK------RHD---CTVAVKTLKED--TMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLREC

REKKIPLRYGEMIYFGEQLASGCGYLASQRMIHMDLAARNALVTDNNIVKVADFGLTRPMEPGVDYLLLREPMKLALKWMAPEGMDKKYFSEKSDVWSFG
 ....|     ..|   |.|||  || ..  || |||||| || ...|||||||||.| |.   |    .   |  .|| |||..  . || ||||| ||
DREELPAVV--LLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMK--DDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFG

VMLWEIASYGANPYSQIKTQEIQLKVREGLRLSKPPGCSDEFYDVMNTCWEQDPDNRPNFRLLEMRL
|.||||| ||  ||  |  ...  |. .| |. .|.|| .. |..|  ||. ..  || |. .  ..
VLLWEIATYGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase HMTK04.AA CTKA 155-421 32 8.2e-69 230.31 In-house 1-290 (290) Show / Hide 
Range on Protein: 155-421
Range on HMM: 1-290/290
Sequence Identity: 32% (95 aa)

LTAIQQIGAGQFGAVYIATHRIRLG--KDQYAPEPVQRAVKLLRNAASTADKDEFTREAETML--VLDHPNLVKMIGVAVQQKPWLCVLEYMKYGDLKSF
.    .|| |..| |. |  . .    | |        ||| |.  |  .|  .|  || .     ..||| .  .||  | |||. . |.| ||||...
HCIMFKIGEGHYGQVFRAWLMPDPDDFKAQRK-KGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDLHCY

LSTCREKK------------------IPLRYGEMIYFGEQLASGCGYLASQRMIHMDLAARNALVTDNNIVKVADFGLTRPMEPGVDYLLLREPMKLALK
|  ||                     | ..  | .|   | | |  |||.  ..| |||.|| |.   . .|.||||. |  . .  |  .     .   
LRACRPADGQVCPARARRSIPRSFHPIEVHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVR

WMAPEGMDKKYFSEKSDVWSFGVMLWEIASYGANPYSQIKTQEIQLKVREG--LRLSKPPGCSDEFYDVMNTCWEQDPDNRPNFRLLEMRL
||||| .    ||  ||||.|||.||||.| |  |.    .||.   .  .   ||  |. | .  |  |..||   |  || |  |   |
WMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase HMTK04.AA Frk 155-425 36 5.9e-68 232.07 In-house 1-260 (260) Show / Hide 
Range on Protein: 155-425
Range on HMM: 1-260/260
Sequence Identity: 36% (100 aa)

LTAIQQIGAGQFGAVYIATHRIRLGKDQYAPEPVQRAVKLLRNAASTADKDEFTREAETMLVLDHPNLVKMIGVAVQQKPWLCVLEYMKYGDLKSFLSTC
.  |...|.|||| |.                ||  ||| |.  . |.| ..| |||  |  | || |...  |   ..| . . | |. | |. .| . 
IQLIRRLGSGQFGEVWEGLWNNTT--------PV--AVKTLK--PGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAI

REKKIPLRYGEMIYFGEQLASGCGYLASQRMIHMDLAARNALVTDNNIVKVADFGLTR-PMEPGVDYLLLREPMKLALKWMAPEGMDKKYFSEKSDVWSF
 .|   ..  ...    |.|.|  || ||  || |||||| || ..||.|.||||| |  |    |    |  ... .|| ||| .  . |. |||||||
NDKGRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSF

GVMLWEIASYGANPYSQIKTQEIQLKVREGLRLSKPPGCSDEFYDVMNTCWEQDPDNRPNFRLLEMRLSGIR
|..| ||  ||  ||. .  .|.   | .| |. .||.|  ..|..|  ||..||..|| |  |. .|    
GILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase HMTK04.AA Fer 155-422 31 2.6e-65 221.38 In-house 1-283 (283) Show / Hide 
Range on Protein: 155-422
Range on HMM: 1-283/283
Sequence Identity: 31% (90 aa)

LTAIQQIGAGQFGAVYIA-THRIRLGKDQYAP-EPVQRAVKLLRNAASTAD-KDEFTREAETMLV-LDHPNLVKMIGVAVQQKPWLCVLEYMKYGDLKSF
 | . ..| | || || .    ....|.  .  ..|  .|| .. ...|.. . || .||  |.  .|||| || .||.|.. | . |.|... |.|.|.
VTLGKKLGEGAFGEVYKGRR-TLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSY

LSTCREKKIPLRYGEMIYFGEQLASGCGYLASQRMIHMDLAARNALVTDNNIVK---VADFGLTRPMEPGVDYLLLR-EPMKLALKWMAPEGMDKKYFSE
| .  .| ....  | | .  | |.|  || |. .|| |.|||| |.......|   ..|||. |  . ..   ... . .|.  .|.||| .... .|.
LKKNKNKTVSDN--EKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSP

KSDVWSFGVMLWEIASYGANPYSQ---------IKTQEIQLKVREGLRLSKPPGCSDEFYDVMN-TCWEQDPDNRPNFRLLEMRLS
|.||||||||.||| . || ||           .|.| .. ....| ..  |... .|.. .|  .||..||..||..  .  .| 
KTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase HMTK04.AA Trk 155-421 35 3.4e-64 216.49 In-house 1-275 (275) Show / Hide 
Range on Protein: 155-421
Range on HMM: 1-275/275
Sequence Identity: 35% (98 aa)

LTAIQQIGAGQFGAVYIATHRIRLGKDQYAPEPVQRAVKLLRNAASTADKDEFTREAETMLVLDHPNLVKMIGVAVQQKPWLCVLEYMKYGDLKSFLS--
.  .. .| | || |..|     ....    ...  ||| |..|.  | || | |||| .  |.|.. ||. || . ..| | | |||| |||. .|   
IVLKWELGEGAFGKVFLAECYNLCPEQ----DKMMVAVKTLKDASENARKD-FQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQH

-------TCREK---KIPLRYGEMIYFGEQLASGCGYLASQRMIHMDLAARNALVTDNNIVKVADFGLTRPMEPGVDYLLLREPMKLALKWMAPEGMDKK
       .  .    . ||  ..| .  .| |||  |.||| ..| |.|.|| || .| |||..|||. | .    ||  .     |   || ||    .
GPDAMCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYR

YFSEKSDVWSFGVMLWEIASYGANPYSQIKTQEIQLKVREGLR-LSKPPGCSDEFYDVMNTCWEQDPDNRPNFRLLEMRL
 |.  ||||||||..||. .||  |. |   .|.   . .|   | .| .|  | ||.|  ||  .|  | | . .  ..
KFTYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase HMTK04.AA S_TKc 155-422 22 6.3e-37 129.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 155-422
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)

LTAIQQIGAGQFGAVYIATHRIRLGKDQYAPEPVQRAVKLLRNAASTADKDEFTREAETMLVLDHPNLVKMIGVAVQQKPWLCVLEYMKY--GDLKSFLS
 . ...|| | || || ..|.             . |.| ..        . . || . .   .|||.||...| .  .    |.||.    |||.... 
YEILRKIGKGAFGKVYKCRHKK---------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIK

TCREKK--IPLRYGEMIYFGEQLASGCGYLASQRMIHMDLAARNALVTDNNIVKVADFGLTRPMEPGVDYLLLREPMKLALKWMAPEGMDKKYFSE-KSD
 .. ..   |.   .  ..  |....  |. |.. || ||   | |...   .|..|||| | .            .   . .|||| .    ..  |.|
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCD

VWSFGVMLWEIASYGANPYSQIKTQEIQLKVREGLRLSKPPGCSDEFYDVMNTCWEQDPDNRPNFRLLE-------MRLS
.||.|..|.| .. |  |..    |..  |..           |.|. | .. |.. ||..||   .|.       .   
WWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase HMTK04.AA Pkinase 155-415 24 2.1e-30 108.56 Pfam 1-285 (293) Show / Hide 
Range on Protein: 155-415
Range on HMM: 1-285/293
Sequence Identity: 24% (75 aa)

LTAIQQIGAGQFGAVYIATHRIRLGKDQYAPEPVQRAVKLLRNAASTADKD-EFTR--EAETMLVLDHPNLVKMIGVAVQQKPWLC-VLEYMKYG----D
.. ...||.| || ||...|.             . ||| ..      .|| . .|  |.. |. |.||| |.....    |.... |.||.  |    |
YHIGRKIGSGSFGCVYKCHHKGTGK---------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMD

LKSFLSTCREKKIPL--RYGEMIYFGEQLASGCGYLASQRMIHMDLAARNALVTDNNIV----KVADFGLTRPMEPGVDYLLLREPMKLA--LKWMAPEG
|....||  ... ..   . | . .  |...|  |. |.. || ||   | |. .|. .    |..|||| . ..    |   . .. ..  . .|||| 
LFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEV

MD-KKYFSEKSDVWSFGVMLWEIASYGANPYSQI-------KTQEIQLKVREGLRLSKPPGCS-------------------DEFYDVMNTCWEQDPDNR
    .| . |.|.||.|..|.| .. |  |...        . | |... .  |. . |  ||                   .|. |... |...||  |
IRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR

PNFR
|...
PTAE