Gene HMTK02 (M.brevicollis)

HMTK02

Species: M.brevicollis
Alias: HMTK02
External Links:
Annotation:

Classification

Group: TK
Family: HMTK

Sequence

Name Sequence Type Origin Length Description Download
HMTK02.AA Protein None 831 None Fasta, JSON
HMTK02.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of HMTK02.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PTB HMTK02.AA PTB 102-230 19 2.6e-18 68.06 SMART 1-156 (156) Show / Hide 
Range on Protein: 102-230
Range on HMM: 1-156/156
Sequence Identity: 19% (30 aa)

IELGNFAAAYMGSVSVKHPE-------GSDVCADAILRIKAMKHALRRVQLVVTERGVFVLEGKSGEAIKSASIGNVSFVSIDP-----------EDKKL
..   | . |.|.| |.|.        |..||.... .|...... ... | .. .|| ..  .... | . .| ..||.. ||           .|...
PWGCCFNVWYLGCVEVPHHRNSMAPGKGMQVCQECMRKIRQHWKHWQKMHLHISVDGVKLIDPQTKQVIHHHPIHRISFCAHDPYRWNTGGHHCCDDDRC

FAYVTYEPDIN-------LYMCHAFQVKKQV-DRIPEALNEAFML-YSKQLDSKRP
|.|.. .|.          ..||.|. ..   ..|.... .||.. |.........
FGYICRHPNDRGSHRMTYWFRCHVFWCEDPHAEDIAQTIGQAFQVCYQQCQKQRCQ
PID HMTK02.AA PID 107-227 20 2e-17 62.93 Pfam 1-153 (153) Show / Hide 
Range on Protein: 107-227
Range on HMM: 1-153/153
Sequence Identity: 20% (32 aa)

FAAAYMGSVSVKHP------E-GSDVCADAILRIKAM---------------KHALRRVQLVVTERGVFVLEGKS---GEAIKSASIGNVSFVSI--DPE
|.. |.|.| |  .      . ....| ..|.|....               .... .. | .. .|| ..  |.   .| .    . |.||..   ||.
FEVRYLGCVEVPCHMRRPDKNTRMMQCQECIHRVCMQVPAKKINKIRGHRGHWQHWQKIDLHISTDGVKWIDEKTEAEQECMHDHPMRNISFCADGGDPH

-DKKLFAY-VTYEPDINLYMCHAFQVKK--QVDRIPEALNEAFML-YSKQLDS
 |.. ||| .. ... .  .||.|  .|  |  .| ... .||.. |.. |. 
VDMRYFAYDICRDGPCQRFACHVFWCCKTQQAQDIAQTVGQAFQVCYQQCLRA
PID HMTK02.AA PID 262-293 21 0.001444 14.31 Pfam 1-47 (153) Show / Hide 
Range on Protein: 262-293
Range on HMM: 1-47/153
Sequence Identity: 21% (10 aa)

YEARYLGSVAVNEP------------RGNEVALDAYQ---RIKNVIK
.|.||||.| | ..            ... .. ...|   . .| |.
FEVRYLGCVEVPCHMRRPDKNTRMMQCQECIHRVCMQVPAKKINKIR
PID HMTK02.AA PID 296-358 23 0.635971 5.03 Pfam 86-153 (153) Show / Hide 
Range on Protein: 296-358
Range on HMM: 86-153/153
Sequence Identity: 23% (16 aa)

PVMEISFTAV--HPK-DSKMMLV-ITNDARLGLKYCHAFQSRR-SKGAEILEMIATAFAAARQALEES
|.  ||| |.  .|. |...    |. | ...  .||.| .   . . .| . .  ||. . |   . 
PMRNISFCADGGDPHVDMRYFAYDICRDGPCQRFACHVFWCCKTQQAQDIAQTVGQAFQVCYQQCLRA
PTB HMTK02.AA PTB 401-529 23 5.4e-13 50.42 SMART 1-156 (156) Show / Hide 
Range on Protein: 401-529
Range on HMM: 1-156/156
Sequence Identity: 23% (36 aa)

IALGVYDAKYIGSVPVPELK-------GKPVVDHALHVARSMNKYAEGVVLTISEEGVRTIEGLTGEVITSILISDISFCTTAG-----------SKKEV
..   . ..|.|.|.||. .       |  |.. ...  |...|   ...| ||  ||. |   |..|| .  |  ||||               . . .
PWGCCFNVWYLGCVEVPHHRNSMAPGKGMQVCQECMRKIRQHWKHWQKMHLHISVDGVKLIDPQTKQVIHHHPIHRISFCAHDPYRWNTGGHHCCDDDRC

FAFINKDTRLK-------RITCHLYETFNAH--DITAVIGQAFKACQARAGNPFAP
|..| ...          .  ||.... ..|  || . |||||. |  .. .   .
FGYICRHPNDRGSHRMTYWFRCHVFWCEDPHAEDIAQTIGQAFQVCYQQCQKQRCQ
PID HMTK02.AA PID 406-519 23 4.4e-08 30.17 Pfam 1-146 (153) Show / Hide 
Range on Protein: 406-519
Range on HMM: 1-146/153
Sequence Identity: 23% (34 aa)

YDAKYIGSVPVPEL-------KGKPVVDHALHVARSM-------------NKYAEG--VVLTISEEGVRTIEGLT---GEVITSILISDISFCTTAGSKK
. ..|.|.|.||.         .  ..  ..| .. .             ..  ..  ..|.|| .||. |   |   .|..    .  ||||   | ..
FEVRYLGCVEVPCHMRRPDKNTRMMQCQECIHRVCMQVPAKKINKIRGHRGHWQHWQKIDLHISTDGVKWIDEKTEAEQECMHDHPMRNISFCADGGDPH

---EVFAF-INKDTRLKRITCHLYETFN---AHDITAVIGQAFKAC
     ||. | .| .. |  ||  ..     | ||.  .||||  |
VDMRYFAYDICRDGPCQRFACHVFWCCKTQQAQDIAQTVGQAFQVC
Kinase HMTK02.AA HMTK 551-806 53 5.5e-188 630.8 In-house 1-291 (291) Show / Hide 
Range on Protein: 551-806
Range on HMM: 1-291/291
Sequence Identity: 53% (156 aa)

LIAGKPIGAGQFG-----------------QVYLA---------KYKGNQV---AVKTVRQGASAEDIAEFTAESEVMLALRHNCLVQLLGVSMQQRPWL
|.|.|.|||||||                 .||||         |...||.   |||..|..||.||..||..|.|||..|||..|||| ||.|||||||
LKAIKVIGAGQFGMVQCLRLAPPDEGCTSLKVYLAEWSVKDGDGKDDSNQPHHRAVKMLRGDASHEDREEFLREAEVMCQLRHPNLVQLVGVCMQQRPWL

CVIEFMKYGDLREVLKTCKEKSLRLAYLEQLAFAVQISRGMAFIAQQRYVHMDLAARNVLISEGNRCKVADFGLTRRYDPGKDTYTLRKTA-KLPIRWMA
||.|.|.|||||.|||||.||...|.|.|||.|.||...|||.||.||.|||||||||.|....|..|.||||||||.|||.|...|||.. ||||.|||
CVLEYMQYGDLRNVLKTCREKNIQLTYHEQLYFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYWHLRKHMVKLPIKWMA

IEAMK--TKVFSEKSDVWAFGVTLHEIAAYGALPYA--GVKNRDVSKHILDGNRLAKPEDG-MQDDFFALAESCWQDDPAVRPTFKEATKS
.|||.  .|.|||||||||||||..||..||..||.  ..||..|..|. .|.||..|... ..|||..|...||..||. ||||....|.
PEAMDGKRKIFSEKSDVWAFGVTMWEIWMYGEQPYESQQIKNKEVQRHVREGRRLTQPPPDDCPDDFWDLMCTCWHKDPHQRPTFAQLQKM
Kinase HMTK02.AA TyrKc 551-807 34 1.5e-113 384.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 551-807
Range on HMM: 1-280/280
Sequence Identity: 34% (100 aa)

LIAGKPIGAGQFGQVYLAKYKGNQVAVKTVRQGASAEDIAEFTAESEVMLAL--RHNCLVQLLGVSMQQ-------RPWLCVIEFMKYGDLREVLKTCKE
.  || .| |.||.||....|  |||||... .|    ...|  | ..|  |  .| ..|.|.|| .||        | . | |.|..|||.. |. ...
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KSLRLAYLEQLAFAVQISRGMAFIAQQRYVHMDLAARNVLISEGNRCKVADFGLTRRYDPG------KDTYTLRK--TAK--LPIRWMAIEAMKTKVFSE
|   |   . | |..||..||.........| ||||||.|..|....|..||||.|  . .      ||.|. ..   .|  |||||||.|......|..
K---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KSDVWAFGVTLHEIAAYGALPYAG-----VKNRDVSKHILDGNRLAKPEDG-------MQDDFFALAESCWQDDPAVRPTFKEATKSL
|||||.|||.. ||  ||. || |     ..|..| ... .|.|. .|...       . |. . . ..||. ||. ||||.|  . .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase HMTK02.AA TK 551-807 21 6.2e-107 359.63 In-house 1-486 (486) Show / Hide 
Range on Protein: 551-807
Range on HMM: 1-486/486
Sequence Identity: 21% (106 aa)

LIAGKPIGAGQFG---QVYLAKYKGN---------------------------QVAVKTVRQGASAEDIAEFT-------------AESEVMLALR----
.. || .|.||||   .||.....|                            .||||... |..... ..|              .| |.|  ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HNCLVQLLGVSMQQ------------RPWLCVIEFMKYGD----LREVLKTCKEKSLR-----------------------------------------
 |  .|.|.||..|.            .||..| |.|..||    ||. |..|..|                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LAYLEQLAFAVQISRGMAFIAQQ------RYVHMDLAARNVLISEGNR-----------CKVADFGLTR
                               |   ..| ...||..||......      ..||.||||||.|..|.|.           ||.|||||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RYDPGKDTYTLRK------------------------TAKLPIRWMAIEAMKTKV---------FSEKSDVWAFGVTLHEIAAYGALPYAG-V
       |... .| |. ..                         .|||||||| |.....|         |..|||||.|||...||  ||. ||.| .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

KN---------RDVSKHILDG--------------NRLAKPEDGMQ-------------DDFFALAESCWQDDPAVRPTFKEATKSL
 |         ..| ... .|              .|...|..                .... |  .||. ||. ||||..  . |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase HMTK02.AA Pkinase_Tyr 551-807 38 3.5e-104 353.46 Pfam 1-270 (270) Show / Hide 
Range on Protein: 551-807
Range on HMM: 1-270/270
Sequence Identity: 38% (104 aa)

LIAGKPIGAGQFGQVYLAKYK------GNQVAVKTVRQGASAED--IAEFTAESEVMLAL-RHNCLVQLLGVSM-QQRP--WLCVIEFMKYGDLREVLKT
.. || .|.|.||.||....|      . .||||....||. |.  ...| .| ..|  | .|  .|.|.|| . |..|  .. | |.|..|||.. |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

CKEKSLRLAYLEQLAFAVQISRGMAFIAQQRYVHMDLAARNVLISEGNRCKVADFGLTRRYDPGKDTY-TLRKTAKLPIRWMAIEAMKTKVFSEKSDVWA
 .|   .|   . | ...||..||.. ......| ||||||.|..|.| .|..||||.|     .|.| . |. .||||.||| |......|..|||||.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVTLHEIAAYGALP-YAGVKNRDVSKHI-LDGNRLAKPEDGMQDDFFALAESCWQDDPAVRPTFKEATKSL
|||.. ||  ||. | |.|..| .| ..|  ||.|...|| .  |.   |  .||. ||. ||||.|    |
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPE-NCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase HMTK02.AA Src 551-807 39 1e-86 294.37 In-house 1-255 (255) Show / Hide 
Range on Protein: 551-807
Range on HMM: 1-255/255
Sequence Identity: 39% (103 aa)

LIAGKPIGAGQFGQVYLAKYKG-NQVAVKTVRQGASAEDIAEFTAESEVMLALRHNCLVQLLGVSMQQRPWLCVIEFMKYGDLREVLK-TCKEKSLRLAY
.   . .|.|||| |. ....|  .||||| ..|    . . | .| ..|  |||. ||||. |  |  | . | |.|. | | . || . ....|.|  
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHL--

LEQLAFAVQISRGMAFIAQQRYVHMDLAARNVLISEGNRCKVADFGLTRRYDPGKDTYTLRKTAKLPIRWMAIEAMKTKVFSEKSDVWAFGVTLHEIAAY
 ... .| |...|||.. ...|.| ||||||||..|.| |||||||| |  . ..| |. |. ||.||.|.| ||    .|. ||||| ||. |.||  |
PQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTY

GALPYAGVKNRDVSKHILDGNRLAKPEDGMQDDFFA-LAESCWQDDPAVRPTFKEATKSL
|  || | .|..| ...  | |. .|.    | ..  .   ||. ||  ||||.   . |
GRVPYPGMTNHEVLQQVERGYRMPCPHN-CPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase HMTK02.AA UTK 551-807 31 1.3e-84 287.37 In-house 1-296 (296) Show / Hide 
Range on Protein: 551-807
Range on HMM: 1-296/296
Sequence Identity: 31% (92 aa)

LIAGKPIGAGQFGQVYLAKYKG-------NQVAVKTVRQGASAEDIAE----FTAESE---VMLALR-HNCLVQLLGVSMQQRPWLCVIEFMKYGDLREV
.. |...|.|.||.|..|...         .||||. . .|.|..  |    |  |.    .| ... |  ...|.|| .|. ||. |.|.|. |||| .
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LKTCKEKSL-RLAYLE---QLAFAVQISRGMAFIAQQRYVHMDLAARNVLISEG-------NRCKVADFG---LTRRYDP--------GKDTYTLRKTAK
| .....   . ..|    .| .|..|.|||........|| ||||||.|. .        . ||.||||   ..||           . . |. .   .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

LPIRWMAIEAMKTK-VFSEKSDVWAFGVTLHEIAAYGALPYAGVKNRDVSKHILDGN-RLAKPEDGMQDDFFALAESCWQDDPAVRPTFKEATKSL
.|||||| ||.     |..|||||.|||...|| ..|.|||.|  |..| . ...|. .. .. ... .. . |  .||. ||. ||.|.. .. .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase HMTK02.AA TK-Unique 551-807 34 2.8e-84 286.28 In-house 1-294 (294) Show / Hide 
Range on Protein: 551-807
Range on HMM: 1-294/294
Sequence Identity: 34% (100 aa)

LIAGKPIGAGQFGQVYLAKYKG--------NQVAVKTVRQGASAEDIAEFTAESEVMLALR-HNCLVQLLGVSMQQR-PWLCVIEFMKYGDLREVLKTCK
|  |. || |.||||. ....|        ..||||... .|. .| ..|. | ..| .|  |  .||.||...    ||. ..|.. .|.|.  |.||.
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-------------------EKSLRLAYLE--QLA-FAVQISRGMAFIAQQRY--VHMDLAARNVLISEGNRCKVADFGLTRRYDPGKDTYTLRKTAKLPI
                   ... |....   .|. ||.|| .||...|.||.  ||.||.|||||..|...||..|||..|. . .... . ..  ..||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMAIEAMK--TKVF-SEKSDVWAFGVTLHEIAAYGALPYAGVKNRDVSKHILDGNRLAKPEDGMQDDFFALAESCWQDDPAVRPTFKEATKSL
|||| |..|  .... ..|||||.|||.. ||. .|| || |....|. ..| || |. .||    .... | .||||..|  ||.| . .. |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase HMTK02.AA SFK-Src 551-811 39 2e-79 234.94 In-house 1-259 (259) Show / Hide 
Range on Protein: 551-811
Range on HMM: 1-259/259
Sequence Identity: 39% (105 aa)

LIAGKPIGAGQFGQVYLAKYKGN-QVAVKTVRQGASAEDIAEFTAESEVMLALRHNCLVQLLGVSMQQRPWLCVIEFMKYGDLREVLKTCKEKSLRLAYL
    |  |.|||| |.  .  .  .||||| . ||  ..  || .|  ||  |||  |.||  |     |   . | |||| |   |.  . .|||.  |
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQL

EQLAFAVQISRGMAFIAQQRYVHMDLAARNVLISEGNRCKVADFGLTRRYDPGKDTYTLRKTAKLPIRWMAIEAMKTKVFSEKSDVWAFGVTLHEIAAYG
     | |.  |||.   | .|| ||||||||. . | |||.|||. |        || .. || ||.| | |||..  || |||||.||. . ||  ||
--VDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYG

ALPYAGVKNRDVSKHILD--GNRLAKPEDGMQDDFFALAESCWQDDPAVRPTFKEATKSLEGFA
  || |  |  | . .    | |. .|  .  | ....   |||  |  ||||      .| | 
RIPYPGMTNMEVLQQVDRPEGYRMPCPP-NCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase HMTK02.AA Abl 551-807 40 9.8e-73 241.86 In-house 1-252 (252) Show / Hide 
Range on Protein: 551-807
Range on HMM: 1-252/252
Sequence Identity: 40% (104 aa)

LIAGKPIGAGQFGQVYLAKYK--GNQVAVKTVRQGASAEDIAEFTAESEVMLALRHNCLVQLLGVSMQQRPWLCVIEFMKYGDLREVLKTCKEKSLRLAY
..  . .| ||.|.|| . .|  .. |||||..  . .  . || .|  .|  ..|  |||||||  .  |.  . ||| || | . |. |....|    
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTME--VHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVV

LEQLAFAVQISRGMAFIAQQRYVHMDLAARNVLISEGNRCKVADFGLTRRYDPGKDTYTLRKTAKLPIRWMAIEAMKTKVFSEKSDVWAFGVTLHEIAAY
|  |  | ||. || .. .. ..| |||||| |..| .  |||||||.|     .|||| .  || ||.| | |..  . || ||||||||| | ||| |
L--LYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMK--DDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATY

GALPYAGVKNRDVSKHILDGNRLAKPEDGMQDDFFALAESCWQDDPAVRPTFKEATKSL
|  || |.   .| . . .| |. .|| |  .. . |   ||| ... ||.|||  . .
GMSPYPGIDLSHVYHKLEKGYRMERPE-GCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase HMTK02.AA Fer 551-808 32 3.8e-72 244.97 In-house 1-283 (283) Show / Hide 
Range on Protein: 551-808
Range on HMM: 1-283/283
Sequence Identity: 32% (93 aa)

LIAGKPIGAGQFGQVYLAK-----YKG-----NQVAVKTVRQ---GASAEDIAEFTAESEVMLA-LRHNCLVQLLGVSMQQRPWLCVIEFMKYGDLREVL
 . || .| | || ||...     .||     |.||||...    .|..| |.|| .|  .|.  . |   |.. ||. .. | . |.||.. |.|.. |
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

KTCKEKSLRLAYLEQLAFAVQISRGMAFIAQQRYVHMDLAARNVLISE-GNRCK--VADFGLTRRYDPGKDTYTLR-KTAKLPIRWMAIEAMKTKVFSEK
|. |.|   .   | . .. |...||... ..  .| |.||||.|... .. .|  ..|||. |  . .. .|... |  |.||||.| |...|...|.|
KKNKNK--TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPK

SDVWAFGVTLHEIAAYGALPYAG----VKNRDV----SKHILDGNRLAKPEDGMQDDFFALAE-SCWQDDPAVRPTFKEATKSLE
.|||.|||.. || . || ||.|    .|.  |     | | ....  .....| ...  . . .||| ||  |||.||. . |.
TDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase HMTK02.AA Frk 551-811 37 2e-69 236.99 In-house 1-260 (260) Show / Hide 
Range on Protein: 551-811
Range on HMM: 1-260/260
Sequence Identity: 37% (98 aa)

LIAGKPIGAGQFGQVYLAKYKGNQ-VAVKTVRQGASAEDIAEFTAESEVMLALRHNCLVQLLGVSMQQRPWLCVIEFMKYGDLREVLKTCKEKSLRLAYL
.   . .|.||||.|.  ..  .  |||||.. |.   |  .| .|  .|  |||  |.||  |   . | . . | |. | | | |.. ..|  ..   
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTM--DPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQ

EQLAFAVQISRGMAFIAQQRYVHMDLAARNVLISEGNRCKVADFGLTR-RYDPGKDTYTLRKTAKLPIRWMAIEAMKTKVFSEKSDVWAFGVTLHEIAAY
...  | |.  |||.. .| |.| ||||||||. |.| ||.||||| |      .| |  |  |..||.| | ||.... |. |||||.||. | ||  |
QLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITY

GALPYAGVKNRDVSKHILDGNRLAKPEDGMQDDFFALAESCWQDDPAVRPTFKEATKSLEGFA
| .||.|. |..| . .  | |. .|  . .  .. .   ||. ||  ||||      || . 
GRMPYPGMTNAEVLQMVDHGYRMPQPP-NCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase HMTK02.AA CTKA 551-807 31 1e-68 229.96 In-house 1-290 (290) Show / Hide 
Range on Protein: 551-807
Range on HMM: 1-290/290
Sequence Identity: 31% (93 aa)

LIAGKPIGAGQFGQVYLA------------KYKGNQVAVKTVRQGASAEDIAEFTAESEVML--ALRHNCLVQLLGVSMQQRPWLCVIEFMKYGDLREVL
.     || |..|||. |            . ||  |||| ... |  ||  .| .|  |     . |   . ||||  |  ||. . |.| ||||. .|
HCIMFKIGEGHYGQVFRAWLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDLHCYL

KTCKEKS------------------LRLAYLEQLAFAVQISRGMAFIAQQRYVHMDLAARNVLISEGNRCKVADFGLTRRYDPGKDTYTLRKTAKLPIRW
. |   .                  . .   ||   | ||  || . |    || |||.||.|.  ..  |.||||. |  . .   |.. .   .|.||
RACRPADGQVCPARARRSIPRSFHPIEVHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRW

MAIEAMKTKVFSEKSDVWAFGVTLHEIAAYGALPYAGVKNRDVSKHILDG--NRLAKPEDGMQDDFFALAESCWQDDPAVRPTFKEATKSL
||.||...  ||  |||||||| | ||.  | .|...   . | . .. .   ||  |    |     . . ||.  |. ||||    ..|
MAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRLPVPRNCPQ-VLYHCMQECWKFEPNQRPTFETLQRML
Kinase HMTK02.AA S_TKc 551-811 22 5.3e-38 133.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 551-811
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)

LIAGKPIGAGQFGQVYLAKYKG--NQVAVKTVRQGASAEDIAEFTAESEVMLALRHNCLVQLLGVSMQQRPWLCVIEFMKY--GDLREVLKTCKEKSLR-
   ...|| | ||.||... |.   .||.| ..          .  | ...   .|  .|.|..|         | |..    |||....| .. . || 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LAYLEQLAFAVQISRGMAFIAQQRYVHMDLAARNVLISEGNRCKVADFGLTRRYDPGKDTYTLRKTAKLPIRWMAIEAMKTKVFSE-KSDVWAFGVTLH
 .   .   .. || ...... ... .| ||   |.|..|  . |..|||| |..          .|      .|| | .    ..  |.|.|..|..| 
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EIAAYGALPYAGVKNRDVSKHILDGNRLAKPEDGMQDDFFALAESCWQDDPAVRPTFKEATK-----SLEGFA
| .. |  |.       . |.|.             ...  . . |.| ||. |||  || .      .  . 
EMLC-GYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HMTK02.AA Pkinase 551-807 21 4.5e-33 118.02 Pfam 1-293 (293) Show / Hide 
Range on Protein: 551-807
Range on HMM: 1-293/293
Sequence Identity: 21% (64 aa)

LIAGKPIGAGQFGQVYLAKYKGNQ--VAVKTVRQGASAEDIAEFTA----ESEVMLALRHNCLVQLLGVSMQQRPWLC-VIEFMKYG----DLREVLKTC
.  |..||.| ||.||... ||..  ||||...   ....  . |.    | ..|. |.| . |.|... .  ..... | |..  |    || ....| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST-

KEKSLRL--AYLEQLAFAVQISRGMAFIAQQRYVHMDLAARNVLISEGNRC----KVADFGLTRRYDPGKDTYTLRKTAKLPIRWMAIEAMK-TKVFSEK
 ... ..   . |   .. || ||.... ... .| ||   |.||.. . .    |..|||| . .|     ..  .|    ...|| |  .  .  . |
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDVWAFGVTLHEIAAYGALPYAGV---KNRDVSKHILDGNRLAKPEDGMQ-----------------------DDFFALAESCWQDDPAVRPTFKEATKS
.|.|..|..|.| .  | .|. |    .| .  ..... .. ....   .                       ...  . ..|.. ||. |||.... ..
VDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF