Gene Abl1 (M.brevicollis)

Abl1

Species: M.brevicollis
Alias: Abl1
External Links:
Annotation:

Classification

Group: TK
Family: SFK-Abl

Sequence

Name Sequence Type Origin Length Description Download
Abl1.AA Protein None 634 None Fasta, JSON
Abl1.kin_dom Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of Abl1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 Abl1.AA SH3 64-120 36 7.4e-17 63.25 SMART 1-58 (58) Show / Hide 
Range on Protein: 64-120
Range on HMM: 1-58/58
Sequence Identity: 36% (21 aa)

DVFVGVYNFQGRTEPELSFERGEKLTLLRL-DENWWLMRSQRSGKEGYAPSNYIAPFK
 ... .|..|.... ||||..|...|.|.  |..||  | .|.|.||. ||||... .
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 Abl1.AA SH3_1 67-113 34 2.3e-12 44.72 Pfam 1-49 (49) Show / Hide 
Range on Protein: 67-113
Range on HMM: 1-49/49
Sequence Identity: 34% (17 aa)

VGVYNFQGRTEPELSFERGEKLTLLR-LDE-NWWLMRSQRSGKEGYAPS
|  | .|.... ||||..|......   |. .||  |....|.||. ||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 Abl1.AA SH3_2 65-119 15 7.4e-08 30.41 Pfam 1-68 (68) Show / Hide 
Range on Protein: 65-119
Range on HMM: 1-68/68
Sequence Identity: 15% (11 aa)

VFVGVYNFQG-RTEPE-----LSFERGEKLTLL----RLDENWWLM-RS--QRSGKE--GYAPSNYIAPF
... . .... . ..|     |.|..|......    . ..|||.  ..  .  |..  |..||..... 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWG--GRRMRGWFPSQWVEEC
SH2 Abl1.AA SH2 127-203 44 5e-38 113.46 Pfam 1-81 (81) Show / Hide 
Range on Protein: 127-203
Range on HMM: 1-81/81
Sequence Identity: 44% (36 aa)

WYHSNISRNTAEYLLKS--GVDGSFLVRESLSSPGEYSITLRCDG-KARXTHYRINHDARG-YFVAAGKFFATVEQLVAHH
||| .|||. || ||..  . ||.|||||| |.||.|....|.||   | .||||. ...| |... .. |... .|| |.
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 Abl1.AA SH2 125-209 38 1.1e-30 109.2 SMART 1-87 (87) Show / Hide 
Range on Protein: 125-209
Range on HMM: 1-87/87
Sequence Identity: 38% (35 aa)

NPWYHSNISRNTAEYLLKS--GVDGSFLVRESLSSPGEYSITLRCDGKARXTHYRINHDA-RGYFVAA--GKFFATVEQLVAHHAVVADG
 |||| ||||  || |||.  . ||.||||.| |.||.|....|..   .  ||||.... ..|...   .. | .. .||.|.   ..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK--GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase Abl1.AA SFK-Abl 243-493 79 4.6e-241 794.96 In-house 1-251 (251) Show / Hide 
Range on Protein: 243-493
Range on HMM: 1-251/251
Sequence Identity: 79% (199 aa)

IVLGHRLGEGQYGEVYVGEWGPHRVAIKTIKDGAMEAKDFMKEADIMKRMRHPNLVRLLGVCTRGGPLFIVTEFMNNGNLLDFLQSERGRAEIDPTSMMH
|.||||||||||||||.|.|..||||||||||..||.|||||||.|||||.|||||||.|||||.||..||.||||.|||||.|||...|..||..||||
IILGHRLGEGQYGEVYKGIWNNHRVAIKTIKDESMETKDFMKEAHIMKRMQHPNLVRLIGVCTREGPMYIVQEFMNYGNLLDYLQSPQSRIQIDHVSMMH

CALQIAEGMSFLEEKHFIHRDLAARNCLVGDNLQIKLADFGLARFVSSDFYEAAIGSKFPIKWTAPESLSLAIFTIKSDVWAFGVTLWEIATYGSAPYPG
||.|||.|||||||.|||||||||||||||||||||.||||.||||.||||||.||.|.||||||||||...|||||||||.||.|||||||||..||||
CAQQIADGMSFLEEQHFIHRDLAARNCLVGDNLQIKVADFGMARFVDSDFYEARIGTKMPIKWTAPESLCYDIFTIKSDVWSFGITLWEIATYGDVPYPG

IHHSKVLDKLMMGYRMQRPEGCPMEIYNIMLQCWDVNPDLRPSFHKLKRQL
|||..|...||||||||||..|||||||||.||||||||.|||||.|..||
IHHRDVINQLMMGYRMQRPQDCPMEIYNIMTQCWDVNPDERPSFHDLQHQL
Kinase Abl1.AA Pkinase_Tyr 243-493 47 1.2e-137 466.8 Pfam 1-270 (270) Show / Hide 
Range on Protein: 243-493
Range on HMM: 1-270/270
Sequence Identity: 47% (129 aa)

IVLGHRLGEGQYGEVYVGEWG------PHRVAIKTIKDGAMEA----KDFMKEADIMKRM-RHPNLVRLLGVCT-RGGP--LFIVTEFMNNGNLLDFLQS
|..|. ||||..|||| |.|          ||.|..|.|||.     .|||.|| ||| . .|||.|||.|||| .|.|  ..||.|.| .|.|||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E-RGRAEIDPTSMMHCALQIAEGMSFLEEKHFIHRDLAARNCLVGDNLQIKLADFGLARFV-SSDFY-EAAIGSKFPIKWTAPESLSLAIFTIKSDVWAF
   ..  ...  . . ..|||.||..||.|..||||||||||||..|...| .|||||| . . | |  .. |.|.||||.|||...  .||.|||||.|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVTLWEIATYGSAP-YPGIHHSKVLDKL-MMGYRMQRPEGCPMEIYNIMLQCWDVNPDLRPSFHKLKRQL
||..||| |||  | |||.  . |....   |||| .||.|| |||..|.|||. .|. ||.|  . .||
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Abl1.AA SFK-Src 243-497 49 7.4e-135 402.35 In-house 1-259 (259) Show / Hide 
Range on Protein: 243-497
Range on HMM: 1-259/259
Sequence Identity: 49% (128 aa)

IVLGHRLGEGQYGEVYVGEW-GPHRVAIKTIKDGAMEAKDFMKEADIMKRMRHPNLVRLLGVCTRGGPLFIVTEFMNNGNLLDFLQSERGRAEIDPTSMM
|.|  .||.||.|.|. | | .   ||.|| | ||| |. |..|| .||..|||||..|  ||| | |..|.|| | .| |||.|.. .||.   |. . 
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQ-LV

HCALQIAEGMSFLEEKHFIHRDLAARNCLVGDNLQIKLADFGLARFVSSD-F-YEAAIGSKFPIKWTAPESLSLAIFTIKSDVWAFGVTLWEIATYGSAP
  | |.| || .||.. |.|||||||| |||||  .| .|||..| .  |   |.|  | ||||||||||  .   | ||||||.||. . || |||  |
DMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIP

YPGIHHSKVLDKLMM--GYRMQRPEGCPMEIYNIMLQCWDVNPDLRPSFHKLKRQLQSLY
|||     || ..    ||||  | .|| | |.||..||  .|| || |  || |.   .
YPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase Abl1.AA TyrKc 243-493 42 2.7e-134 453.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 243-493
Range on HMM: 1-280/280
Sequence Identity: 42% (122 aa)

IVLGHRLGEGQYGEVYVGEWGPHRVAIKTIKDGAMEAKDFMKEADIMKRM--RHPNLVRLLGVCTRG-------GPLFIVTEFMNNGNLLDFLQSERGRA
|.||. ||||..|||| |.|    ||.|..|..|   .|||.|| ||..   .|||.|||.|||| .       .||.||.|.| .|.|.|.|.. |.. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

EIDPTSMMHCALQIAEGMSFLEEKHFIHRDLAARNCLVGDNLQIKLADFGLARFVSSD--------FYEAA--IGSK--FPIKWTAPESLSLAIFTIKSD
 . .  . . ..|||.||..|..|..|||||||||||||.|...| .||||.|.. .|         | ..   |.|  .||.|.|||..   .||.|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWAFGVTLWEIATYGSAPYPG-----IHHSKVLDKLMMGYRMQRPEG--------CPMEIYNIMLQCWDVNPDLRPSFHKLKRQL
||.|||..||| |||  ||||     .  . |. ... |||| .|.         || |.|.||.|||. .|. ||.|  .....
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Abl1.AA Abl 243-493 59 6.4e-131 439.24 In-house 1-252 (252) Show / Hide 
Range on Protein: 243-493
Range on HMM: 1-252/252
Sequence Identity: 59% (150 aa)

IVLGHRLGEGQYGEVYVGEWGPHR--VAIKTIKDGAMEAKDFMKEADIMKRMRHPNLVRLLGVCTRGGPLFIVTEFMNNGNLLDFLQSERGRAEIDPTSM
|.. |.|| |||||||.| |  |   ||.||.|. .|| ..|.||| ||| |.|||||.|||||||  | .|.|||| .|||||.|  | .| |...  .
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLR-ECDREELPAVVL

MHCALQIAEGMSFLEEKHFIHRDLAARNCLVGDNLQIKLADFGLARFVSSDFYEAAIGSKFPIKWTAPESLSLAIFTIKSDVWAFGVTLWEIATYGSAPY
.. | ||| |||.||..|||||||||||||||..  .|.|||||||..  | | |  | ||||||||||||    | .||||||||| |||||||| .||
LYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPY

PGIHHSKVLDKLMMGYRMQRPEGCPMEIYNIMLQCWDVNPDLRPSFHKLKRQL
|||  |.| .||  ||||.|||||| ..|..|.|||. ..  ||||... ...
PGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase Abl1.AA Src 243-493 51 7.1e-131 441.08 In-house 1-255 (255) Show / Hide 
Range on Protein: 243-493
Range on HMM: 1-255/255
Sequence Identity: 51% (131 aa)

IVLGHRLGEGQYGEVYVGEW-GPHRVAIKTIKDGAMEAKDFMKEADIMKRMRHPNLVRLLGVCTRGGPLFIVTEFMNNGNLLDFLQ-SERGRAEIDPTSM
| |  .||.||.|||. | | |   ||.||.| | |. ..| .|| ||| .||..||.|. ||... | .||||.|..|.|||.|. ...||. .  .  
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH-LHLPQL

MHCALQIAEGMSFLEEKHFIHRDLAARNCLVGDNLQIKLADFGLARFVS--SDFYEAAIGSKFPIKWTAPESLSLAIFTIKSDVWAFGVTLWEIATYGSA
   | |.||||..||.. .||||||||| |||.|.  | ||||||| .    | |.|  |.|||||||||| ..   |||||||| ||. |.|| |||  
IDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRV

PYPGIHHSKVLDKLMMGYRMQRPEGCPMEIYN-IMLQCWDVNPDLRPSFHKLKRQL
|||| .   ||.... |||| .|..|| |.|. ||||||.  |. || |  |   |
PYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Abl1.AA TK 243-493 26 4.8e-123 414.59 In-house 1-486 (486) Show / Hide 
Range on Protein: 243-493
Range on HMM: 1-486/486
Sequence Identity: 26% (131 aa)

IVLGHRLGEGQYG---EVYVGEW---------------------------GPHRVAIKTIKDG-AMEAKDFMK--------------EADIMKRMR----
|.||. |||||.|   ||| |||                           |...||.|..|.| ||....|.               || .|| |.    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVRLLGVCTRG------------GPLFIVTEFMNNGN----LLDFLQSERGRAE------------------------------------------
 |||.|||.||||.|            .|. ||.|.|..|.    |.|.|.. |...                                           
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IDPTSMMHCALQIAEGMSFLEEK------HFIHRDLAARNCLVGDNLQ-----------IKLADFG---
                               ...  .. ...|||.||..|..|      .|.||||||||||||.|..           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARFVSSD-FYEAAI------------------------GSKFPIKWTAPESLSLAI---------FTIKSDVWAFGVTLWEIATYGSAPYPG-I
     ||| . ||  | ..                         | |.||.|.|||.|   .         ||.|||||.|||..||| ||| .||.| .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

HH---------SKVLDKLMMG--------------YRMQRPEGCP--------------MEIYNIMLQCWDVNPDLRPSFHKLKRQL
..           |...| .|              .|| .|..||               |.| .|.|||. .|. ||.|  |..||
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Abl1.AA Tec 243-495 43 2.6e-107 362.8 In-house 1-254 (254) Show / Hide 
Range on Protein: 243-495
Range on HMM: 1-254/254
Sequence Identity: 43% (110 aa)

IVLGHRLGEGQYGEVYVGEW-GPHRVAIKTIKDGAMEAKDFMKEADIMKRMRHPNLVRLLGVCTRGGPLFIVTEFMNNGNLLDFLQSERGRAEIDPTSMM
. .   || ||.| |  |.| .   ||||.|| |.|   ||. || .|.   ||.||.| |||.   |..||||.| .| ||..| ..... . . .  .
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

HCALQIAEGMSFLEEKHFIHRDLAARNCLVGDNLQIKLADFGLARFVSSDFYEAAIGSKFPIKWTAPESLSLAIFTIKSDVWAFGVTLWEIATYGSAPYP
   ... ||| .||.. |||||||||||||||.  .| .|||..|.|  | |    |.|||.|| .|| ..   .  |||||||||  ||. . | .||.
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

GIHHSKVLDKLMMGYRMQRPEGCPMEIYNIMLQCWDVNPDLRPSFHKLKRQLQS
    | | ..   |.|. ||. |.|.|| || .||   |. ||.|..| ||.. 
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase Abl1.AA Frk 243-497 47 2.8e-107 362.69 In-house 1-260 (260) Show / Hide 
Range on Protein: 243-497
Range on HMM: 1-260/260
Sequence Identity: 47% (125 aa)

IVLGHRLGEGQYGEVYVGEWGPHR-VAIKTIKDGAMEAKDFMKEADIMKRMRHPNLVRLLGVCTRGGPLFIVTEFMNNGNLLDFLQ--SERGRAEIDPTS
| | .||| ||.|||. | |     ||.||.| |.|. .||..|| |||..||| |..|  |||.  |..|.|| | .| |...||  ...|| ..  . 
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGR-QCQMQQ

MMHCALQIAEGMSFLEEKHFIHRDLAARNCLVGDNLQIKLADFGLAR-FVSSDF--YEAAIGSKFPIKWTAPESLSLAIFTIKSDVWAFGVTLWEIATYG
..  | |.| || .||.. .||||||||| |||... .|.||||||| ..  .   ||.  | .|||||||||      ||||||||.||. | || |||
LVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYG

SAPYPGIHHSKVLDKLMMGYRMQRPEGCPMEIYNIMLQCWDVNPDLRPSFHKLKRQLQSLY
  ||||.   .||. .  |||| .| .|| ..|.|||.|| ..|. || |  |. .|.  .
RMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase Abl1.AA UTK 243-493 37 4.3e-107 362.08 In-house 1-296 (296) Show / Hide 
Range on Protein: 243-493
Range on HMM: 1-296/296
Sequence Identity: 37% (111 aa)

IVLGHRLGEGQYGEVYVGEWGP-------HRVAIKTIKDGAM---EAK---DFMKEAD---IMKRMR-HPNLVRLLGVCTRGGPLFIVTEFMNNGNLLDF
. || .||.|..|||..... .        .||.|. . .|.   |     |||.||    .||. . |||..||.||||...|. ||||.| ||.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LQSERGRAE-----IDPTSMMHCALQIAEGMSFLEEKHFIHRDLAARNCLVGDN-------LQIKLADFG---LARFVS---------SDFYEAAIG-SK
|.. |  ..      . ......|..||.||..|....|.|||||||||||...       ...|.||||   ..| |.         .. |. | .  .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

FPIKWTAPESLSLA-IFTIKSDVWAFGVTLWEIATYGSAPYPGIHHSKVLDKLMMG--YRMQRPEGCPMEIYNIMLQCWDVNPDLRPSFHKLKRQL
 ||.|.|||.|  .  ||.|||||.|||..||| |.|..||||. . .|.  .. |  ||| .|..||...|..|..||  .|. ||.|. |  |.
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase Abl1.AA Src-Unclassified 243-493 40 3.4e-106 359.11 In-house 1-284 (284) Show / Hide 
Range on Protein: 243-493
Range on HMM: 1-284/284
Sequence Identity: 40% (116 aa)

IVLGHRLGEGQYGEVYVGEWGP-HRVAIKTIKDG---AMEAKDFM--------KEADIMKRMRHPNLVRLLGVCTRGGPLFIVTEFMNNGNLLDFLQSER
. |   || || |||. | |     ||.|| . |    |    |         .|| ||| .||.||| |..||..  | .|.||.| || ||..|.   
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GRAEIDPTSM------------MHCALQIAEGMSFLEEKHFIHRDLAARNCLVGDNL-----QIKLADFGLA--RFVSSDFYEAAIGSKFPIKWTAPESL
|.       |               | |.| ||  ||.|  .|||||||| |.|.|        | .|||||  . .  | |..  |..||.||.|||  
GQY-LHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECF

SLAIFTIKSDVWAFGVTLWEIATYGSAPYPGIHHSKVLDKLMMGYRMQRP--EGCPMEIYN-IMLQCWDVNPDLRPSFHKLKRQL
   .|.|||||| .|. ||||.|.|  |||| |   ||  .  |||| .|  ..||  ||  ||..||.  |. || |  |   .
IYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase Abl1.AA SrcB 243-494 48 4e-103 348.92 In-house 1-251 (251) Show / Hide 
Range on Protein: 243-494
Range on HMM: 1-251/251
Sequence Identity: 48% (122 aa)

IVLGHRLGEGQYGEVYVGEWGPH-RVAIKTIKDGAMEAKDFMKEADIMKRMRHPNLVRLLGVCTRGGPLFIVTEFMNNGNLLDFLQSERGRAEIDPTSMM
. | ..|| ||.|||..| .  | .||.||.|.|.|  . |..|| .|| . |  ||||  | |.  |..|.||.|..| |||||... | . .    ..
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEG-SKLSLPKLI

HCALQIAEGMSFLEEKHFIHRDLAARNCLVGDNLQIKLADFGLARFVSSDFYEAAIGSKFPIKWTAPESLSLAIFTIKSDVWAFGVTLWEIATYGSAPYP
  . |||||| ..|.. .||||| | | || . |  |.||||||| . .. | |  | |||||||||| .   .||||||||.||. | || |||  |||
DMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYP

GIHHSKVLDKLMMGYRMQRPEGCPMEIYNIMLQCWDVNPDLRPSFHKLKRQLQ
|   . |.  |  |||| ||. || |.|||| .||   |. || |  |.  |.
GMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase Abl1.AA S_TKc 243-497 23 1.3e-55 192.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 243-497
Range on HMM: 1-231/231
Sequence Identity: 23% (62 aa)

IVLGHRLGEGQYGEVYVGEWGP--HRVAIKTIKDGAMEAKDFMKEADIMKRMRHPNLVRLLGVCTRGGPLFIVTEFMNN--GNLLDFLQSERGRAE---I
  ..  .|.| .|.|| . .    ..|||| ||      .....| .|.|. .|||.|.|..|.   . |..|.|....  |.|.|.... ...     .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

DPTSMMHCALQIAEGMSFLEEKHFIHRDLAARNCLVGDNLQIKLADFGLARFVSSDFYEAAIGSKFPIKWTAPESLSLAIFTI-KSDVWAFGVTLWEIAT
..    . . ||.... .. ....|||||   | |. .  .||..||||||..                . ||| |    ..  |.|.|..|..|.| ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

YGSAPYPGIHHSKVLDKLMMGYRMQRPEGCPMEIYNIMLQCWDVNPDLRPSFHKLKR-----QLQSLY
 |  |.|  .. ....|..           . |  ... .|....|. ||.  .. .      .    
-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Abl1.AA Pkinase 243-493 22 6e-44 156.48 Pfam 1-293 (293) Show / Hide 
Range on Protein: 243-493
Range on HMM: 1-293/293
Sequence Identity: 22% (67 aa)

IVLGHRLGEGQYGEVYVGEWGPHR--VAIKTIKDGAMEAKDFMK-----EADIMKRMRHPNLVRLLGVCTRGGPLFIVTEFMNNG----NLLDFLQ-SER
...| ..|.| .|.|| . .   .  ||.|.||    . .  .      |. ||||..||| |||........ . .|.|....|     | |... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRAEI--DPTSMMHCALQIAEGMSFLEEKHFIHRDLAARNCLVGDNLQI----KLADFGLAR---FVSSDFYEAAIGSKFPIKWTAPESLS-LAIFTIKS
|.  .  ..    ....||..|. .. .. .|||||   |.|. .| .|    |..|||||.     ..  .    |. .   . ||| .      . |.
GC--FYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKV

DVWAFGVTLWEIATYGSAPYPGI-------HHSKVLDKLMMGYRMQRPEGCP-------------------MEIYNIMLQCWDVNPDLRPSFHKLKRQ--
|.|..|..|.| .. |  |.||        .  ..  ...  .. ..|. |.                    |   ..  |....|  ||... ..    
DMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

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